CpG Islands

"CpG Islands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.

Descriptor ID	D018899
MeSH Number(s)	G02.111.570.080.380.160 G05.360.080.380.160 G05.360.340.024.159
Concept/Terms	CpG Islands CpG Islands CpG Island Island, CpG Islands, CpG CpG-Rich Islands CpG Rich Islands CpG-Rich Island Island, CpG-Rich Islands, CpG-Rich CpG Clusters CpG Clusters Cluster, CpG Clusters, CpG CpG Cluster

Below are MeSH descriptors whose meaning is more general than "CpG Islands".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
GC Rich Sequence [G02.111.570.080.380]
CpG Islands [G02.111.570.080.380.160]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
GC Rich Sequence [G05.360.080.380]
CpG Islands [G05.360.080.380.160]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
CpG Islands [G05.360.340.024.159]

Below are MeSH descriptors whose meaning is related to "CpG Islands".

Below are MeSH descriptors whose meaning is more specific than "CpG Islands".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CpG Islands" by people in this website by year, and whether "CpG Islands" was a major or minor topic of these publications.

Bar chart showing 15 publications over 9 distinct years, with a maximum of 3 publications in 2008 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	1	0	1
2005	0	1	1
2006	0	1	1
2007	0	1	1
2008	0	3	3
2011	0	2	2
2016	0	3	3
2018	0	2	2

Below are the most recent publications written about "CpG Islands" by people in Profiles.

Joyce BT, Zheng Y, Nannini D, Zhang Z, Liu L, Gao T, Kocherginsky M, Murphy R, Yang H, Achenbach CJ, Roberts LR, Hoxha M, Shen J, Vokonas P, Schwartz J, Baccarelli A, Hou L. DNA Methylation of Telomere-Related Genes and Cancer Risk. Cancer Prev Res (Phila). 2018 08; 11(8):511-522.

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Kresovich JK, Joyce BT, Gao T, Zheng Y, Zhang Z, Achenbach CJ, Murphy RL, Just AC, Shen J, Yang H, Vokonas P, Schwartz J, Baccarelli AA, Hou L. Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort. Epigenomics. 2018 06; 10(6):733-743.

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Geybels MS, Wright JL, Bibikova M, Klotzle B, Fan JB, Zhao S, Feng Z, Ostrander EA, Lin DW, Nelson PS, Stanford JL. Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy. Clin Epigenetics. 2016; 8:97.

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Zhao S, Geybels MS, Leonardson A, Rubicz R, Kolb S, Yan Q, Klotzle B, Bibikova M, Hurtado-Coll A, Troyer D, Lance R, Lin DW, Wright JL, Ostrander EA, Fan JB, Feng Z, Stanford JL. Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer. Clin Cancer Res. 2017 Jan 01; 23(1):311-319.

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Shui IM, Wong CJ, Zhao S, Kolb S, Ebot EM, Geybels MS, Rubicz R, Wright JL, Lin DW, Klotzle B, Bibikova M, Fan JB, Ostrander EA, Feng Z, Stanford JL. Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. Cancer. 2016 07 15; 122(14):2168-77.

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Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L. Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res. 2011 Apr 1; 17(7):1722-30.

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Kim SJ, Kelly WK, Fu A, Haines K, Hoffman A, Zheng T, Zhu Y. Genome-wide methylation analysis identifies involvement of TNF-a mediated cancer pathways in prostate cancer. Cancer Lett. 2011 Mar 1; 302(1):47-53.

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Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A. 2008 Sep 9; 105(36):13556-61.

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Novikova SI, He F, Bai J, Cutrufello NJ, Lidow MS, Undieh AS. Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One. 2008; 3(4):e1919.

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Foulds KE, Rotte MJ, Paley MA, Singh B, Douek DC, Hill BJ, O'Shea JJ, Watford WT, Seder RA, Wu CY. IFN-gamma mediates the death of Th1 cells in a paracrine manner. J Immunol. 2008 Jan 15; 180(2):842-9.

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