Below are the most recent publications written about "Bioreactors" by people in Profiles.
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Reddy JV, Leibiger T, Singh SK, Lee KH, Papoutsakis E, Ierapetritou M. A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells. Biotechnol Bioeng. 2025 Apr; 122(4):761-778.
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Reddy JV, Singh SK, Leibiger T, Lee KH, Ierapetritou M, Papoutsakis ET. Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese hamster ovary (CHO) cell metabolism and N-linked glycosylation in the fab and Fc regions of the produced IgG. Metab Eng. 2025 Jan; 87:37-48.
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Reddy JV, Raudenbush K, Papoutsakis ET, Ierapetritou M. Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation. Biotechnol Adv. 2023 10; 67:108179.
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Cordova LT, Dahodwala H, Elliott KS, Baik J, Odenewelder DC, Nmagu D, Skelton BA, Uy L, Klaubert SR, Synoground BF, Chitwood DG, Dhara VG, Naik HM, Morris CS, Yoon S, Betenbaugh M, Coffman J, Swartzwelder F, Gillmeister MP, Harcum SW, Lee KH. Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing. Biotechnol Bioeng. 2023 03; 120(3):715-725.
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Hamaker NK, Min L, Lee KH. Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines. Biotechnol Bioeng. 2022 08; 119(8):2221-2238.
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Klaubert SR, Chitwood DG, Dahodwala H, Williamson M, Kasper R, Lee KH, Harcum SW. Method to transfer Chinese hamster ovary (CHO) batch shake flask experiments to large-scale, computer-controlled fed-batch bioreactors. Methods Enzymol. 2021; 660:297-320.
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Burns AB, Doris C, Vehar K, Saxena V, Bardliving C, Shamlou PA, Phillips MI. Novel low shear 3D bioreactor for high purity mesenchymal stem cell production. PLoS One. 2021; 16(6):e0252575.
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Chitwood DG, Wang Q, Elliott K, Bullock A, Jordana D, Li Z, Wu C, Harcum SW, Saski CA. Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures. BMC Biotechnol. 2021 01 08; 21(1):4.
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Bai Y, Moo-Young M, Anderson WA. A mechanistic model for gas-liquid mass transfer prediction in a rocking disposable bioreactor. Biotechnol Bioeng. 2019 08; 116(8):1986-1998.
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Radoniqi F, Zhang H, Bardliving CL, Shamlou P, Coffman J. Computational fluid dynamic modeling of alternating tangential flow filtration for perfusion cell culture. Biotechnol Bioeng. 2018 11; 115(11):2751-2759.