1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
| Descriptor ID |
D019307
|
| MeSH Number(s) |
D02.886.590.700.545 D03.383.606.527 D03.633.100.531.400
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
Below are MeSH descriptors whose meaning is more specific than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
This graph shows the total number of publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in this website by year, and whether "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in Profiles.
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Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85.
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Rattan S, Patel CA. Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G687-93.
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Rattan S, Fan YP, Puri RN. Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. Life Sci. 2002 Mar 22; 70(18):2147-64.
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Zhang D, Wang Z, Jin N, Li L, Rhoades RA, Yancey KW, Swartz DR. Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle. J Muscle Res Cell Motil. 2001; 22(2):193-200.
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Lee MM, Fink BD, Grunwald GB. Evidence that tyrosine phosphorylation regulates N-cadherin turnover during retinal development. Dev Genet. 1997; 20(3):224-34.
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Chalfant ML, Civan JM, Peterson-Yantorno K, DiBona DR, O'Brien TG, Civan MM. Regulation of epithelial Na+ permeability by protein kinase C is tissue specific. J Membr Biol. 1996 Aug; 152(3):207-15.
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Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. Autonomic modulation of action potential and tension in guinea pig papillary muscles. Eur J Pharmacol. 1994 Dec 27; 271(2-3):309-17.
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Mizumoto K, Rothman RJ, Farber JL. Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide. Mol Pharmacol. 1994 Nov; 46(5):890-5.
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Kim CM, Dion SB, Onorato JJ, Benovic JL. Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system. Receptor. 1993; 3(1):39-55.
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Mauviel A, Temime N, Charron D, Loyau G, Pujol JP. Induction of interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and tumor necrosis factor-alpha. Involvement of protein kinase-dependent and adenylate cyclase-dependent regulatory pathways. J Cell Biochem. 1991 Oct; 47(2):174-83.