Vaccines, DNA

"Vaccines, DNA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.

Descriptor ID	D019444
MeSH Number(s)	D12.776.828.868.910 D20.215.894.865.910 D23.050.865.910
Concept/Terms	Vaccines, DNA Vaccines, DNA Recombinant DNA Vaccines DNA Vaccines, Recombinant DNA Vaccines Naked DNA Vaccines DNA Vaccines, Naked Vaccines, Naked DNA Vaccines, Recombinant DNA Polynucleotide Vaccines Polynucleotide Vaccines Vaccines, Polynucleotide Nucleic Acid Vaccines Nucleic Acid Vaccines Vaccines, Nucleic Acid

Below are MeSH descriptors whose meaning is more general than "Vaccines, DNA".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Recombinant Proteins [D12.776.828]
Vaccines, Synthetic [D12.776.828.868]
Vaccines, DNA [D12.776.828.868.910]
Complex Mixtures [D20]
Biological Products [D20.215]
Vaccines [D20.215.894]
Vaccines, Synthetic [D20.215.894.865]
Vaccines, DNA [D20.215.894.865.910]
Biological Factors [D23]
Antigens [D23.050]
Vaccines, Synthetic [D23.050.865]
Vaccines, DNA [D23.050.865.910]

Below are MeSH descriptors whose meaning is related to "Vaccines, DNA".

Below are MeSH descriptors whose meaning is more specific than "Vaccines, DNA".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Vaccines, DNA" by people in this website by year, and whether "Vaccines, DNA" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 1998 and 1999 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
1999	2	0	2
2000	1	0	1
2001	1	0	1
2003	1	0	1
2005	2	0	2
2009	1	0	1
2013	1	0	1
2017	1	0	1

Below are the most recent publications written about "Vaccines, DNA" by people in Profiles.

Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE. Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells. J Immunol. 2017 May 01; 198(9):3507-3514.

View in: PubMed
Guha R, Das S, Ghosh J, Naskar K, Mandala A, Sundar S, Dujardin JC, Roy S. Heterologous priming-boosting with DNA and vaccinia virus expressing kinetoplastid membrane protein-11 induces potent cellular immune response and confers protection against infection with antimony resistant and sensitive strains of Leishmania (Leishmania) donovani. Vaccine. 2013 Apr 8; 31(15):1905-15.

View in: PubMed
Sealy R, Slobod KS, Flynn P, Branum K, Surman S, Jones B, Freiden P, Lockey T, Howlett N, Hurwitz JL. Preclinical and clinical development of a multi-envelope, DNA-virus-protein (D-V-P) HIV-1 vaccine. Int Rev Immunol. 2009; 28(1):49-68.

View in: PubMed
Chen LH, Price CE, Goerke A, Lee AL, DePhillips PA. A reversed phase HPLC assay for the simultaneous quantitation of non-ionic and ionic surfactants in bioprocess intermediates. J Pharm Biomed Anal. 2006 Mar 3; 40(4):964-70.

View in: PubMed
Kerepesi LA, Keiser PB, Nolan TJ, Schad GA, Abraham D, Nutman TB. DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice. Infect Immun. 2005 Apr; 73(4):2298-305.

View in: PubMed
Hawkins WG, Trcka J, Segal N, Blachere NE, Gold JS, Moroi Y, Bowne WB, Lewis JJ, Wolchok JD, Houghton AN. The role of lipopolysaccharide in T-cell responses following DNA vaccination. Vaccine. 2003 Mar 28; 21(13-14):1548-53.

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Wolchok JD, Srinivasan R, Perales MA, Houghton AN, Bowne WB, Blachere NE. Alternative roles for interferon-gamma in the immune response to DNA vaccines encoding related melanosomal antigens. Cancer Immun. 2001 Aug 16; 1:9.

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Hawkins WG, Gold JS, Dyall R, Wolchok JD, Hoos A, Bowne WB, Srinivasan R, Houghton AN, Lewis JJ. Immunization with DNA coding for gp100 results in CD4 T-cell independent antitumor immunity. Surgery. 2000 Aug; 128(2):273-80.

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Bowne WB, Wolchok JD, Hawkins WG, Srinivasan R, Gregor P, Blachere NE, Moroi Y, Engelhorn ME, Houghton AN, Lewis JJ. Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects. Cytokines Cell Mol Ther. 1999 Dec; 5(4):217-25.

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Endresz V, Kari L, Berencsi K, Kari C, Gyulai Z, Jeney C, Pincus S, Rodeck U, Méric C, Plotkin SA, Gönczöl E. Induction of human cytomegalovirus (HCMV)-glycoprotein B (gB)-specific neutralizing antibody and phosphoprotein 65 (pp65)-specific cytotoxic T lymphocyte responses by naked DNA immunization. Vaccine. 1999 Jan; 17(1):50-8.

View in: PubMed

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