O(6)-Methylguanine-DNA Methyltransferase
"O(6)-Methylguanine-DNA Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.
| Descriptor ID |
D019853
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| MeSH Number(s) |
D08.811.913.555.500.800.650
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| Concept/Terms |
O(6)-Methylguanine-DNA Methyltransferase- O(6)-Methylguanine-DNA Methyltransferase
- Methylated-DNA-Protein-Cysteine S-Methyltransferase
- Methylated DNA Protein Cysteine S Methyltransferase
- S-Methyltransferase, Methylated-DNA-Protein-Cysteine
- O(6)-Methylguanine Methyltransferase
- O(6)-Alkylguanine-DNA Alkyltransferase
- O(6)-MeG-DNA Methyltransferase
- O(6)-Methylguanine DNA Transmethylase
- Guanine-O(6)-Alkyltransferase
- O(6)-AGT
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Below are MeSH descriptors whose meaning is more general than "O(6)-Methylguanine-DNA Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "O(6)-Methylguanine-DNA Methyltransferase".
This graph shows the total number of publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in this website by year, and whether "O(6)-Methylguanine-DNA Methyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in Profiles.
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Weingart J, Grossman SA, Carson KA, Fisher JD, Delaney SM, Rosenblum ML, Olivi A, Judy K, Tatter SB, Dolan ME. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. J Clin Oncol. 2007 Feb 1; 25(4):399-404.
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Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H. Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis. 2001 Oct; 22(10):1715-9.
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Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, Goggins M. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res. 2000 Apr 01; 60(7):1835-9.
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Ma Q, Alder H, Nelson KK, Chatterjee D, Gu Y, Nakamura T, Canaani E, Croce CM, Siracusa LD, Buchberg AM. Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6350-4.