"Pinacidil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Descriptor ID |
D020110
|
| MeSH Number(s) |
D02.078.370.729
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Pinacidil".
Below are MeSH descriptors whose meaning is more specific than "Pinacidil".
This graph shows the total number of publications written about "Pinacidil" by people in this website by year, and whether "Pinacidil" was a major or minor topic of these publications.
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Below are the most recent publications written about "Pinacidil" by people in Profiles.
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Patocskai B, Yoon N, Antzelevitch C. Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome. JACC Clin Electrophysiol. 2017 04; 3(4):353-363.
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Fish JM, Welchons DR, Kim YS, Lee SH, Ho WK, Antzelevitch C. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21; 113(11):1393-400.
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Di Diego JM, Cordeiro JM, Goodrow RJ, Fish JM, Zygmunt AC, P?rez GJ, Scornik FS, Antzelevitch C. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation. 2002 Oct 08; 106(15):2004-11.
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Di Diego JM, Antzelevitch C. Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation. 1993 Sep; 88(3):1177-89.
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Antzelevitch C, Di Diego JM. Role of K+ channel activators in cardiac electrophysiology and arrhythmias. Circulation. 1992 Apr; 85(4):1627-9.
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Abraham PA, Halstenson CE, Matzke GR, Keane WF. Comparison of antihypertensive, renal hemodynamic, and humoral effects of pinacidil and hydralazine monotherapy. J Clin Hypertens. 1987 Dec; 3(4):439-51.