"Heteroduplex Analysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.
| Descriptor ID |
D020180
|
| MeSH Number(s) |
E05.393.661.250
|
| Concept/Terms |
Heteroduplex Analysis- Heteroduplex Analysis
- Analyses, Heteroduplex
- Analysis, Heteroduplex
- Heteroduplex Analyses
|
Below are MeSH descriptors whose meaning is more general than "Heteroduplex Analysis".
Below are MeSH descriptors whose meaning is more specific than "Heteroduplex Analysis".
This graph shows the total number of publications written about "Heteroduplex Analysis" by people in this website by year, and whether "Heteroduplex Analysis" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Heteroduplex Analysis" by people in Profiles.
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Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006 Sep 22; 126(6):1203-17.
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Rogers CD, Couch FJ, Brune K, Martin ST, Philips J, Murphy KM, Petersen G, Yeo CJ, Hruban RH, Goggins M. Genetics of the FANCA gene in familial pancreatic cancer. J Med Genet. 2004 Dec; 41(12):e126.
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Seo JH, Cho DY, Ahn SH, Yoon KS, Kang CS, Cho HM, Lee HS, Choe JJ, Choi CW, Kim BS, Shin SW, Kim YH, Kim JS, Son GS, Lee JB, Koo BH. BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. Hum Mutat. 2004 Oct; 24(4):350.
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Millard TP, Ashton GH, Kondeatis E, Vaughan RW, Hughes GR, Khamashta MA, Hawk JL, McGregor JM, McGrath JA. Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus. Br J Dermatol. 2002 Feb; 146(2):210-5.
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Sprecher E, Chavanas S, DiGiovanna JJ, Amin S, Nielsen K, Prendiville JS, Silverman R, Esterly NB, Spraker MK, Guelig E, de Luna ML, Williams ML, Buehler B, Siegfried EC, Van Maldergem L, Pfendner E, Bale SJ, Uitto J, Hovnanian A, Richard G. The spectrum of pathogenic mutations in SPINK5 in 19 families with Netherton syndrome: implications for mutation detection and first case of prenatal diagnosis. J Invest Dermatol. 2001 Aug; 117(2):179-87.
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Mellerio JE, Salas-Alanis JC, Amaya-Guerra M, Tamez E, Ashton GH, Mohammedi R, Eady RA, McGrath JA. A recurrent frameshift mutation in exon 19 of the type VII collagen gene (COL7A1) in Mexican patients with recessive dystrophic epidermolysis bullosa. Exp Dermatol. 1999 Feb; 8(1):22-9.
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Mellerio JE, Salas-Alanis JC, Talamantes ML, Horn H, Tidman MJ, Ashton GH, Eady RA, McGrath JA. A recurrent glycine substitution mutation, G2043R, in the type VII collagen gene (COL7A1) in dominant dystrophic epidermolysis bullosa. Br J Dermatol. 1998 Oct; 139(4):730-7.