In Situ Nick-End Labeling

"In Situ Nick-End Labeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.

Descriptor ID	D020287
MeSH Number(s)	E05.393.475
Concept/Terms	In Situ Nick-End Labeling In Situ Nick-End Labeling TUNEL Nick-End Labeling, In Situ In Situ Nick End Labelling In Situ Nick End Labeling In Situ Nick End-Labelling In Situ Nick-End Labelling Nick End-Labeling, In Situ Nick End Labeling, In Situ Nick End-Labelling, In Situ Nick End Labelling, In Situ Nick-End Labelling, In Situ In Situ Nick End-Labeling

Below are MeSH descriptors whose meaning is more general than "In Situ Nick-End Labeling".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
In Situ Nick-End Labeling [E05.393.475]

Below are MeSH descriptors whose meaning is more specific than "In Situ Nick-End Labeling".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "In Situ Nick-End Labeling" by people in this website by year, and whether "In Situ Nick-End Labeling" was a major or minor topic of these publications.

Bar chart showing 80 publications over 17 distinct years, with a maximum of 11 publications in 2001

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1999	6	6
2000	3	3
2001	11	11
2002	4	4
2003	9	9
2004	3	3
2005	5	5
2006	7	7
2007	2	2
2008	7	7
2009	8	8
2010	3	3
2011	4	4
2012	1	1
2014	2	2
2015	3	3
2017	2	2

Below are the most recent publications written about "In Situ Nick-End Labeling" by people in Profiles.

Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Semin Oncol. 2017 06; 44(3):226-232.

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Wesseling-Perry K, M?kitie RE, V?lim?ki VV, Laine T, Laine CM, V?lim?ki MJ, Pereira RC, M?kitie O. Osteocyte Protein Expression Is Altered in Low-Turnover Osteoporosis Caused by Mutations in WNT1 and PLS3. J Clin Endocrinol Metab. 2017 07 01; 102(7):2340-2348.

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Gingras S, Earls LR, Howell S, Smeyne RJ, Zakharenko SS, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22; 35(29):10510-22.

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Lin Z, Zhao J, Nitoiu D, Scott CA, Plagnol V, Smith FJ, Wilson NJ, Cole C, Schwartz ME, McLean WH, Wang H, Feng C, Duo L, Zhou EY, Ren Y, Dai L, Chen Y, Zhang J, Xu X, O'Toole EA, Kelsell DP, Yang Y. Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. Am J Hum Genet. 2015 Mar 05; 96(3):440-7.

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Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics. 2015 Jan; 12(1):200-16.

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Schoenfelder KP, Montague RA, Paramore SV, Lennox AL, Mahowald AP, Fox DT. Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. Development. 2014 Sep; 141(18):3551-60.

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Chu HP, Liao Y, Novak JS, Hu Z, Merkin JJ, Shymkiv Y, Braeckman BP, Dorovkov MV, Nguyen A, Clifford PM, Nagele RG, Harrison DE, Ellis RE, Ryazanov AG. Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell. 2014 Mar 10; 28(5):561-572.

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Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I. Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann Neurol. 2012 Sep; 72(3):385-94.

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Figueroa JD, Cordero K, Baldeosingh K, Torrado AI, Walker RL, Miranda JD, Leon MD. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. J Neurotrauma. 2012 Feb 10; 29(3):551-66.

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Kase S, Meghpara BB, Ishida S, Rao NA. Expression of a-crystallin in the retina of human sympathetic ophthalmia. Mol Med Rep. 2012 02; 5(2):395-9.

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