In Situ Nick-End Labeling

"In Situ Nick-End Labeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.

Descriptor ID	D020287
MeSH Number(s)	E05.393.475
Concept/Terms	In Situ Nick-End Labeling In Situ Nick-End Labeling TUNEL Nick-End Labeling, In Situ In Situ Nick End Labelling In Situ Nick End Labeling In Situ Nick End-Labelling In Situ Nick-End Labelling Nick End-Labeling, In Situ Nick End Labeling, In Situ Nick End-Labelling, In Situ Nick End Labelling, In Situ Nick-End Labelling, In Situ In Situ Nick End-Labeling

Below are MeSH descriptors whose meaning is more general than "In Situ Nick-End Labeling".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
In Situ Nick-End Labeling [E05.393.475]

Below are MeSH descriptors whose meaning is more specific than "In Situ Nick-End Labeling".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "In Situ Nick-End Labeling" by people in this website by year, and whether "In Situ Nick-End Labeling" was a major or minor topic of these publications.

Bar chart showing 41 publications over 18 distinct years, with a maximum of 8 publications in 2009

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1998	1	1
1999	1	1
2000	1	1
2001	5	5
2002	1	1
2003	5	5
2004	2	2
2005	3	3
2006	2	2
2007	1	1
2008	3	3
2009	8	8
2010	1	1
2011	2	2
2012	1	1
2014	1	1
2015	2	2
2017	1	1

Below are the most recent publications written about "In Situ Nick-End Labeling" by people in Profiles.

Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Semin Oncol. 2017 06; 44(3):226-232.

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Gingras S, Earls LR, Howell S, Smeyne RJ, Zakharenko SS, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22; 35(29):10510-22.

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Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics. 2015 Jan; 12(1):200-16.

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Schoenfelder KP, Montague RA, Paramore SV, Lennox AL, Mahowald AP, Fox DT. Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. Development. 2014 Sep; 141(18):3551-60.

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Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I. Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann Neurol. 2012 Sep; 72(3):385-94.

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Agrawal L, Louboutin JP, Reyes BA, Van Bockstaele EJ, Strayer DS. HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes. Neurobiol Dis. 2012 Feb; 45(2):657-70.

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Cho SH, Ahn AK, Bhargava P, Lee CH, Eischen CM, McGuinness O, Boothby M. Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15972-7.

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Louboutin JP, Reyes BA, Agrawal L, Maxwell CR, Van Bockstaele EJ, Strayer DS. Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes. Neurobiol Dis. 2010 May; 38(2):313-25.

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Qin F, Lennon-Edwards S, Lancel S, Biolo A, Siwik DA, Pimentel DR, Dorn GW, Kang YJ, Colucci WS. Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice. Circ Heart Fail. 2010 Mar; 3(2):306-13.

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Lin CL, Dumont AS, Su YF, Dai ZK, Cheng JT, Tsai YJ, Huang JH, Chang KP, Hwang SL. Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. J Neurosurg. 2009 Nov; 111(5):1014-22.

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