Rajarshi Chakrabarti

TitleAsst Professor
InstitutionThomas Jefferson University
Address1020 Locust St.
Philadelphia PA 19107
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    Collapse Biography 
    Collapse education and training
    University of Calcutta, India, Kolkata, IndiaB.S07/2007 Zoology
    University of Calcutta, India, Kolkata, IndiaM.S07/2009 Biophysics & Molecular Biology
    University of Calcutta, India, Kolkata, IndiaPh.D07/2016 Biochemistry
    Geisel School of Medicine, Dartmouth, US07/2022 Cytoskeletal regulation of mitochondrial function
    Collapse awards and honors
    2018Lucile E Smith award for excellence in Biochemistry, Geisel School of Medicine
    2018Future of Science award, Keystone, USA
    2010 - 2015CSIR Research Fellow, Govt. of India

    Collapse Overview 
    Collapse overview
    The broad focus of our lab is to investigate the dynamic, transient and lower-abundance organelle associated actin filaments in regulating inter-organelle communication and overall cellular homeostasis. Specifically, we focus on two dynamic pools of actin filaments, one assembled on the Endoplasmic Reticulum and the other on mitochondria and ask mechanistic questions to understand how these under-appreciated filament populations regulate cellular physiology and pathology.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rajarshi Chakrabarti #, Tak Shun Fung #, Taewook Kang , Pieti W Elonkirjo , Anu Suomalainen, Edward J Usherwood, Henry N Higgs. J. Cell. Biol. Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation. 2022; 221(11). View Publication.
    2. Shivaprasad H Sathyanarayana , Jasmine A Saunders , Jacob Slaughter , Kamran Tariq , Rajarshi Chakrabarti , Madhumala K Sadanandappa , Bryan W Luikart , Giovanni Bosco . Proc Natl Acad Sci, USA. Pten heterozygosity restores neuronal morphology in fragile X syndrome mice. 2022; 119(15). View Publication.
    3. Tak Shun Fung*, Rajarshi Chakrabarti*, Jana Kollasser, Klemens Rottner, Theresia E B Stradal, Frieda Kage, Henry N Higgs. Curr. Biol. Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria. 2022; 32(7):1577-1592. View Publication.
    4. Rajarshi Chakrabarti, Miriam Lee, Henry N Higgs. Curr. Biol. Multiple roles for actin in secretory and endocytic pathways. 2021; 31(10):R603-R618. View Publication.
    5. Rajarshi Chakrabarti, Henry N Higgs. Nature. Revolutionary view of two ways to split a mitochondrion. 2021; 593(7859):346-347. View Publication.
    6. Tamutenda Chidawanyika, Rajarshi Chakrabarti, Kathryn S Beauchemin, Henry N Higgs, Surachai Supattapone. J. Cell. Sci. SEC24A facilitates colocalization and Ca 2+ flux between the endoplasmic reticulum and mitochondria. 2021; 134(6). View Publication.
    7. Tak Shun Fung, Wei-Ke Ji, Henry N Higgs#, Rajarshi Chakrabarti#. J. Cell. Sci. Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors. 2019; 132(18). View Publication.
    8. Mu A, Tak Shun Fung, Arminja N Kettenbach, Rajarshi Chakrabarti, Henry N Higgs. Nat. Cell. Biol. A complex containing lysine-acetylated actin inhibits the formin INF2. 2019; 21(5):592-602. View Publication.
    9. Rajarshi Chakrabarti, Wei-Ke Ji, Radu V Stan, Jaime de Juan Sanz, Timothy A Ryan, Henry N Higgs. J. Cell. Biol. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. 2018; 217(1). View Publication.
    10. Wei-Ke Ji, Rajarshi Chakrabarti, Xintao Fan, Lori Schoenfeld, Stefan Strack, Henry N Higgs. J. Cell. Biol. Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. 2017; 216(12):4123-4139. View Publication.
    11. Rajarshi Chakrabarti, Sulagna Sanyal, Amit Ghosh, Kaushik Bhar, Chandrima Das, Anirban Siddhanta . J. Biol. Chem. Phosphatidylinositol-4-phosphate 5-Kinase 1a Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-a. 2015; 290(34):20893-20903. View Publication.
    12. Biochem Biophys Res Commun. Nuclear pool of phosphatidylinositol 4 phosphate 5 kinase 1a is modified by polySUMO-2 during apoptosis. 2013; 439(2):209-214. View Publication.
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