"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
| Descriptor ID |
D020552
|
| MeSH Number(s) |
E05.196.401.153.150 E05.301.300.100.150 E05.393.560.150 E05.940.560.150
|
| Concept/Terms |
Comet Assay- Comet Assay
- Assay, Comet
- Assays, Comet
- Comet Assays
- Gel Electrophoresis, Single-Cell
- Electrophoreses, Single-Cell Gel
- Electrophoresis, Single-Cell Gel
- Gel Electrophoreses, Single-Cell
- Gel Electrophoresis, Single Cell
- Single-Cell Gel Electrophoreses
- Single-Cell Gel Electrophoresis
- Electrophoresis, Gel, Single-Cell
Alkaline Comet Assay- Alkaline Comet Assay
- Alkaline Comet Assays
- Assay, Alkaline Comet
- Assays, Alkaline Comet
- Comet Assay, Alkaline
- Comet Assays, Alkaline
- Alkaline Single-Cell Gel Electrophoresis Assay
- Alkaline Single Cell Gel Electrophoresis Assay
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Below are MeSH descriptors whose meaning is more general than "Comet Assay".
Below are MeSH descriptors whose meaning is more specific than "Comet Assay".
This graph shows the total number of publications written about "Comet Assay" by people in this website by year, and whether "Comet Assay" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Comet Assay" by people in Profiles.
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Zhang X, Mahajan JS, J Korley LT, Epps TH, Wu C. Reduced genotoxicity of lignin-derivable replacements to bisphenol A studied using in silico, in vitro, and in vivo methods. Mutat Res Genet Toxicol Environ Mutagen. 2023 Jan; 885:503577.
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Szymonowicz K, Oeck S, Krysztofiak A, van der Linden J, Iliakis G, Jendrossek V. Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells. Int J Mol Sci. 2018 Jul 31; 19(8).
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Carrillo AM, Hicks M, Khabele D, Eischen CM. Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells. Mol Cancer Res. 2015 Aug; 13(8):1197-205.
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Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res. 2010 Nov 1; 70(21):8802-11.
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Duan Y, Gross RA, Sheu SS. Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol. 2007 Dec 15; 585(Pt 3):741-58.