"RGS Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
| Descriptor ID |
D020710
|
| MeSH Number(s) |
D12.644.360.325.150.750 D12.776.476.325.150.750
|
| Concept/Terms |
RGS Proteins- RGS Proteins
- Regulators of G-Protein Signaling Proteins
- Regulators of G Protein Signaling Proteins
- RGS Protein (G-Protein Signaling)
|
Below are MeSH descriptors whose meaning is more general than "RGS Proteins".
Below are MeSH descriptors whose meaning is more specific than "RGS Proteins".
This graph shows the total number of publications written about "RGS Proteins" by people in this website by year, and whether "RGS Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 3 | 0 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "RGS Proteins" by people in Profiles.
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Ma P, Gupta S, Sampietro S, DeHelian D, Tutwiler V, Tang A, Stalker TJ, Brass LF. RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. Blood Adv. 2018 08 28; 2(16):2145-2155.
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Ma P, Cierniewska A, Signarvic R, Cieslak M, Kong H, Sinnamon AJ, Neubig RR, Newman DK, Stalker TJ, Brass LF. A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 2012 Feb 23; 119(8):1935-45.
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Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 2010 Dec 23; 116(26):6092-100.
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Chahdi A, Sorokin A. The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1330-5.
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Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Z??iga-Pfl?cker JC, Wiest DL. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009 Oct 16; 31(4):565-75.
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Takida S, Fischer CC, Wedegaertner PB. Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Mol Pharmacol. 2005 Jan; 67(1):132-9.
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Beyer CE, Ghavami A, Lin Q, Sung A, Rhodes KJ, Dawson LA, Schechter LE, Young KH. Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo. Brain Res. 2004 Oct 1; 1022(1-2):214-20.
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Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310.
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Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 2003 Aug 5; 42(30):9176-84.
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Carman CV, Parent JL, Day PW, Pronin AN, Sternweis PM, Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T. Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1999 Nov 26; 274(48):34483-92.