Receptor, Platelet-Derived Growth Factor alpha

"Receptor, Platelet-Derived Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.

Descriptor ID	D020796
MeSH Number(s)	D08.811.913.696.620.682.725.400.900.500 D12.776.543.750.630.625.300 D12.776.543.750.750.400.630.300
Concept/Terms	Receptor, Platelet-Derived Growth Factor alpha Receptor, Platelet-Derived Growth Factor alpha Platelet-Derived Growth Factor alpha Receptor Platelet Derived Growth Factor alpha Receptor Antigens, CD140a PDGFRalpha PDGF-R-alpha Receptor, PDGF alpha CD140a Antigen Antigen, CD140a PDGFR2 PDGF alpha Receptor CD140a Antigens

Below are MeSH descriptors whose meaning is more general than "Receptor, Platelet-Derived Growth Factor alpha".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
Receptor, Platelet-Derived Growth Factor alpha [D08.811.913.696.620.682.725.400.900.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.630.625.300]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]
Receptor, Platelet-Derived Growth Factor alpha [D12.776.543.750.750.400.630.300]

Below are MeSH descriptors whose meaning is related to "Receptor, Platelet-Derived Growth Factor alpha".

Below are MeSH descriptors whose meaning is more specific than "Receptor, Platelet-Derived Growth Factor alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in this website by year, and whether "Receptor, Platelet-Derived Growth Factor alpha" was a major or minor topic of these publications.

Bar chart showing 27 publications over 13 distinct years, with a maximum of 5 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	3	4
2006	2	3	5
2007	1	0	1
2008	2	0	2
2009	1	1	2
2011	1	2	3
2012	0	2	2
2013	1	1	2
2015	0	1	1
2016	0	1	1
2017	0	1	1
2018	1	0	1
2019	1	1	2

Below are the most recent publications written about "Receptor, Platelet-Derived Growth Factor alpha" by people in Profiles.

Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC. A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor. Clin Cancer Res. 2019 11 01; 25(21):6302-6308.

View in: PubMed
Kobayashi M, Inaguma S, Raffeld M, Kato H, Suzuki S, Wakasugi T, Mitsui A, Kuwabara Y, Lasota J, Ikeda H, Miettinen M, Takahashi S. Epithelioid variant of gastrointestinal stromal tumor harboring PDGFRA mutation and MLH1 gene alteration: A case report. Pathol Int. 2019 Sep; 69(9):541-546.

View in: PubMed
Behdad A, Allen P, Lu X, Zhou XA, Guitart J, Chen Q, Pro B. Cutaneous T-Cell Lymphoma, a Novel Manifestation of PDGFRA-Rearranged Neoplasm. Am J Dermatopathol. 2018 Aug; 40(8):610-613.

View in: PubMed
Miettinen M, Felisiak-Golabek A, Wang Z, Inaguma S, Lasota J. GIST Manifesting as a Retroperitoneal Tumor: Clinicopathologic Immunohistochemical, and Molecular Genetic Study of 112 Cases. Am J Surg Pathol. 2017 May; 41(5):577-585.

View in: PubMed
Boikos SA, Pappo AS, Killian JK, LaQuaglia MP, Weldon CB, George S, Trent JC, von Mehren M, Wright JA, Schiffman JD, Raygada M, Pacak K, Meltzer PS, Miettinen MM, Stratakis C, Janeway KA, Helman LJ. Molecular Subtypes of KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic. JAMA Oncol. 2016 Jul 01; 2(7):922-8.

View in: PubMed
Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath JA, Uitto J, Ishii M, Iizuka H, Kaneda Y. Transplanted bone marrow-derived circulating PDGFRa+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J Immunol. 2015 Feb 15; 194(4):1996-2003.

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Horv?th Z, Kovalszky I, Full?r A, Kiss K, Schaff Z, Iozzo RV, Baghy K. Decorin deficiency promotes hepatic carcinogenesis. Matrix Biol. 2014 Apr; 35:194-205.

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Baghy K, Horv?th Z, Regos E, Kiss K, Schaff Z, Iozzo RV, Kovalszky I. Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. FEBS J. 2013 May; 280(10):2150-64.

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Ocuin LM, Zeng S, Cavnar MJ, Sorenson EC, Bamboat ZM, Greer JB, Kim TS, Popow R, DeMatteo RP. Nilotinib protects the murine liver from ischemia/reperfusion injury. J Hepatol. 2012 Oct; 57(4):766-73.

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Bamboat ZM, Dematteo RP. Updates on the management of gastrointestinal stromal tumors. Surg Oncol Clin N Am. 2012 Apr; 21(2):301-16.

View in: PubMed

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