Monocarboxylic Acid Transporters

"Monocarboxylic Acid Transporters" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.

Descriptor ID	D027501
MeSH Number(s)	D12.776.157.530.450.074.500.400 D12.776.543.585.450.074.500.300
Concept/Terms	Monocarboxylic Acid Transporters Monocarboxylic Acid Transporters Acid Transporters, Monocarboxylic Transporters, Monocarboxylic Acid Monocarboxylate Translocator Translocator, Monocarboxylate Monocarboxylic Acid Transport Proteins MCT Proteins Monocarboxylic Acid Transport Protein Erythrocyte Lactate Transporters Erythrocyte Lactate Transporters Lactate Transporters, Erythrocyte Transporters, Erythrocyte Lactate Erythrocyte Lactate Transporter Lactate Transporter, Erythrocyte Transporter, Erythrocyte Lactate Lactate Transport Proteins Lactate Transport Proteins Transport Proteins, Lactate Lactate Transport Protein Transport Protein, Lactate Lactate Transporter Transporter, Lactate Lactate Translocase Translocase, Lactate

Below are MeSH descriptors whose meaning is more general than "Monocarboxylic Acid Transporters".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Pumps [D12.776.157.530.450]
Anion Transport Proteins [D12.776.157.530.450.074]
Organic Anion Transporters [D12.776.157.530.450.074.500]
Monocarboxylic Acid Transporters [D12.776.157.530.450.074.500.400]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Ion Pumps [D12.776.543.585.450]
Anion Transport Proteins [D12.776.543.585.450.074]
Organic Anion Transporters [D12.776.543.585.450.074.500]
Monocarboxylic Acid Transporters [D12.776.543.585.450.074.500.300]

Below are MeSH descriptors whose meaning is related to "Monocarboxylic Acid Transporters".

Below are MeSH descriptors whose meaning is more specific than "Monocarboxylic Acid Transporters".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Monocarboxylic Acid Transporters" by people in this website by year, and whether "Monocarboxylic Acid Transporters" was a major or minor topic of these publications.

Bar chart showing 23 publications over 10 distinct years, with a maximum of 4 publications in 2003 and 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	3	1	4
2005	2	0	2
2007	1	0	1
2008	1	1	2
2009	2	0	2
2010	1	0	1
2011	3	1	4
2012	1	1	2
2016	0	1	1
2017	1	3	4

Below are the most recent publications written about "Monocarboxylic Acid Transporters" by people in Profiles.

Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U. Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development. Semin Oncol. 2017 06; 44(3):198-203.

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Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, Martinez-Outschoorn U. Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma. Semin Oncol. 2017 06; 44(3):204-217.

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Mikkilineni L, Whitaker-Menezes D, Domingo-Vidal M, Sprandio J, Avena P, Cotzia P, Dulau-Florea A, Gong J, Uppal G, Zhan T, Leiby B, Lin Z, Pro B, Sotgia F, Lisanti MP, Martinez-Outschoorn U. Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment. Semin Oncol. 2017 06; 44(3):218-225.

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Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Semin Oncol. 2017 06; 44(3):226-232.

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Knudsen ES, Balaji U, Freinkman E, McCue P, Witkiewicz AK. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget. 2016 Nov 29; 7(48):78396-78411.

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Sweeny L, Dean NR, Frederick JW, Magnuson JS, Carroll WR, Desmond RA, Rosenthal EL. CD147 expression in advanced cutaneous squamous cell carcinoma. J Cutan Pathol. 2012 Jun; 39(6):603-9.

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Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, Philp NJ, Lin Z, Gandara R, Sneddon S, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle. 2012 Mar 15; 11(6):1108-17.

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Castorino JJ, Gallagher-Colombo SM, Levin AV, Fitzgerald PG, Polishook J, Kloeckener-Gruissem B, Ostertag E, Philp NJ. Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):6774-84.

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Vogt SD, Curcio CA, Wang L, Li CM, McGwin G, Medeiros NE, Philp NJ, Kimble JA, Read RW. Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp Eye Res. 2011 Oct; 93(4):413-23.

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Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, Birbe RC, Howell A, Pavlides S, Gandara R, Pestell RG, Sotgia F, Philp NJ, Lisanti MP. Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle. 2011 Jun 1; 10(11):1772-83.

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