Thomas Jefferson University

Alex Krotulski

TitleInstructor ETO
InstitutionThomas Jefferson University
DepartmentJefferson College of Life Scie
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shastry S, Lin J, Aldy K, Brent J, Wax P, Krotulski A, Campleman S, Li S, Meyn A, Abston S, Logan B, Amaducci A, Judge B, Levine M, Calello D, Shulman J, Hughes A, Culbreth R, Schwarz E, Manini AF. Heroin or fentanyl: Prevalence of confirmed fentanyl in ED patients with suspected heroin overdose. J Am Coll Emerg Physicians Open. 2024 Aug; 5(4):e13235. PMID: 39161754.
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    2. Schwarz ES, Buchanan J, Aldy K, Shulman J, Krotulski A, Walton S, Logan B, Wax P, Campleman S, Brent J, Culbreth R, Manini AF. Notes from the Field: Detection of Medetomidine Among Patients Evaluated in Emergency Departments for Suspected Opioid Overdoses - Missouri, Colorado, and Pennsylvania, September 2020-December 2023. MMWR Morb Mortal Wkly Rep. 2024 Aug 01; 73(30):672-674. PMID: 39088371.
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    3. Gitto L, Wadsworth T, Isenschmid D, Krotulski AJ, Logan BK, Tarozzi I, Arunkumar P. MDMB-4en-PINACA-Related Deaths in Cook County Jail: Awareness and Preventive Measures. Am J Forensic Med Pathol. 2024 Jun 28. PMID: 39018467.
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    4. De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, Stove CP, Vandeputte MM. In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids. Arch Toxicol. 2024 Jun 14. PMID: 38877156.
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    5. Park JN, Serafinski R, Ujeneza M, McKenzie M, Tardif J, Krotulski AJ, Badea A, Grossman ER, Green TC. Xylazine awareness, desire, use and exposure: Preliminary findings from the Rhode Island community-based drug checking cohort study. Drug Alcohol Depend Rep. 2024 Jun; 11:100247. PMID: 38974777.
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    6. de Campos EG, Farrar DG, Krotulski AJ. Identification of ADB-5'Br-BINACA in plant material and analytical characterization using GC-MS, LC-QTOF-MS, NMR and ATR-FTIR. J Pharm Biomed Anal. 2024 Sep 01; 247:116254. PMID: 38810333.
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    7. Bade R, van Herwerden D, Rousis N, Adhikari S, Allen D, Baduel C, Bijlsma L, Boogaerts T, Burgard D, Chappell A, Driver EM, Sodre FF, Fatta-Kassinos D, Gracia-Lor E, Gracia-Mar?n E, Halden RU, Heath E, Jaunay E, Krotulski A, Lai FY, L?ve ASC, O'Brien JW, Oh JE, Pasin D, Castro MP, Psichoudaki M, Salgueiro-Gonzalez N, Gomes CS, Subedi B, Thomas KV, Thomaidis N, Wang D, Yargeau V, Samanipour S, Mueller J. Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater. J Hazard Mater. 2024 Mar 05; 469:133955. PMID: 38457976.
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    8. Hewes MP, Papsun DM, Logan BK, Krotulski AJ. Determination of fentanyl contamination on United States paper currency by LC-QQQ-MS. J Anal Toxicol. 2024 Feb 23. PMID: 38437879.
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    9. Bade R, Nadarajan D, Driver EM, Halden RU, Gerber C, Krotulski A, Hall W, Mueller JF. Wastewater-based monitoring of the nitazene analogues: First detection of protonitazene in wastewater. Sci Total Environ. 2024 Feb 13; 920:170781. PMID: 38360322.
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    10. Counts CJ, Spadaro AV, Cerbini TA, Krotulski AJ, Greller HA, Nelson LS, Ruck BE, Calello DP. Notes from the Field: Cluster of Severe Illness from Neptune's Fix Tianeptine Linked to Synthetic Cannabinoids - New Jersey, June-November 2023. MMWR Morb Mortal Wkly Rep. 2024 Feb 01; 73(4):89-90. PMID: 38300852.
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    11. Norman C, Webling K, Kyslychenko O, Reid R, Krotulski AJ, Farrell R, Deventer MH, Liu H, Connolly MJ, Guillou C, Vinckier IMJ, Logan BK, NicDa?id N, McKenzie C, Stove CP, Gr?en H. Detection in seized samples, analytical characterization, and in vitro metabolism of the newly emerged 5-bromo-indazole-3-carboxamide synthetic cannabinoid receptor agonists. Drug Test Anal. 2023 Nov 30. PMID: 38037247.
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    12. Amaducci A, Aldy K, Campleman SL, Li S, Meyn A, Abston S, Culbreth RE, Krotulski A, Logan B, Wax P, Brent J, Manini AF. Naloxone Use in Novel Potent Opioid and Fentanyl Overdoses in Emergency Department Patients. JAMA Netw Open. 2023 Aug 01; 6(8):e2331264. PMID: 37642962.
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    13. Norman C, Deventer MH, Dremann O, Reid R, Van Uytfanghe K, Guillou C, Vinckier IMJ, Nic Da?id N, Krotulski A, Stove CP. In vitro cannabinoid receptor activity, metabolism, and detection in seized samples of CH-PIATA, a new indole-3-acetamide synthetic cannabinoid. Drug Test Anal. 2023 Jul 25. PMID: 37491777.
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    14. Fogarty MF, Krotulski AJ, Papsun DM, Walton SE, Lamb M, Truver MT, Chronister CW, Goldberger BA, Logan BK. N, N-Dimethylpentylone (Dipentylone)-A New Synthetic Cathinone Identified in a Postmortem Forensic Toxicology Case Series. J Anal Toxicol. 2023 Jun 17. PMID: 37329303.
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    15. Palmquist KB, Truver MT, Shoff EN, Krotulski AJ, Swortwood MJ. Review of analytical methods for screening and quantification of fentanyl analogs and novel synthetic opioids in biological specimens. J Forensic Sci. 2023 May 23. PMID: 37221651.
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    16. Vandeputte MM, Walton SE, Shuda SA, Papsun DM, Krotulski AJ, Stove CP. Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs. Anal Bioanal Chem. 2023 May 13. PMID: 37173408.
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    17. Love JS, Levine M, Aldy K, Brent J, Krotulski AJ, Logan BK, Vargas-Torres C, Walton SE, Amaducci A, Calello D, Hendrickson R, Hughes A, Kurt A, Judge B, Pizon A, Schwarz E, Shulman J, Wiegan T, Wax P, Manini AF. Opioid overdoses involving xylazine in emergency department patients: a multicenter study. Clin Toxicol (Phila). 2023 03; 61(3):173-180. PMID: 37014353.
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    18. Walton SE, Krotulski AJ, Glatfelter GC, Walther D, Logan BK, Baumann MH. Plasma pharmacokinetics and pharmacodynamic effects of the 2-benzylbenzimidazole synthetic opioid, isotonitazene, in male rats. Psychopharmacology (Berl). 2023 Jan; 240(1):185-198. PMID: 36526866.
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    19. Velez A, Papsun DM, Scott KS, Krotulski AJ. Metabolic profile determination of 2F-viminol - A novel synthetic opioid identified in forensic investigations. J Forensic Sci. 2023 Jan; 68(1):212-221. PMID: 36372911.
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    20. Papsun DM, Krotulski AJ, Logan BK. Proliferation of Novel Synthetic Opioids in Postmortem Investigations After Core-Structure Scheduling for Fentanyl-Related Substances. Am J Forensic Med Pathol. 2022 Dec 01; 43(4):315-327. PMID: 36103391.
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    21. Mohr ALA, Logan BK, Fogarty MF, Krotulski AJ, Papsun DM, Kacinko SL, Huestis MA, Ropero-Miller JD. Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2017-2020: A Review. J Anal Toxicol. 2022 Jul 14; 46(6):e116-e185. PMID: 35445267.
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    22. Calello DP, Aldy K, Jefri M, Nguyen TT, Krotulski A, Logan B, Brent J, Wax P, Walton S, Manini AF. Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose. Clin Toxicol (Phila). 2022 09; 60(9):1067-1069. PMID: 35708103.
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    23. Vandeputte MM, Krotulski AJ, Walther D, Glatfelter GC, Papsun D, Walton SE, Logan BK, Baumann MH, Stove CP. Pharmacological evaluation and forensic case series of N-pyrrolidino etonitazene (etonitazepyne), a newly emerging 2-benzylbenzimidazole 'nitazene' synthetic opioid. Arch Toxicol. 2022 06; 96(6):1845-1863. PMID: 35477798.
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    24. Vandeputte MM, Krotulski AJ, Hulpia F, Van Calenbergh S, Stove CP. Phenethyl-4-ANPP: A Marginally Active Byproduct Suggesting a Switch in Illicit Fentanyl Synthesis Routes. J Anal Toxicol. 2022 Apr 21; 46(4):350-357. PMID: 33822084.
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    25. Rodriguez Salas J, Krotulski AJ, Newman R, Thogmartin JR, Mohr ALA, Logan BK. Concentrations of para-Fluorofuranylfentanyl in Paired Central and Peripheral Blood Collected during Postmortem Death Investigations. J Anal Toxicol. 2022 Apr 21; 46(4):358-373. PMID: 33693685.
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    26. Holt AK, Karin KN, Butler SN, Ferreira AR, Krotulski AJ, Poklis JL, Peace MR. Cannabinoid-based vaping products and supplement formulations reported by consumers to precipitate adverse effects. Drug Test Anal. 2022 Mar 28. PMID: 35347865.
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    27. Walton SE, Krotulski AJ, Logan BK. A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS). J Anal Toxicol. 2022 Mar 21; 46(3):221-231. PMID: 34792157.
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    28. Fogarty MF, Vandeputte MM, Krotulski AJ, Papsun D, Walton SE, Stove CP, Logan BK. Toxicological and pharmacological characterization of novel cinnamylpiperazine synthetic opioids in humans and in vitro including 2-methyl AP-237 and AP-238. Arch Toxicol. 2022 06; 96(6):1701-1710. PMID: 35275255.
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    29. Krotulski AJ, Garibay N, Walther D, Walton SE, Mohr ALA, Logan BK, Baumann MH. Pharmacokinetics and pharmacodynamics of the synthetic cannabinoid, 5F-MDMB-PICA, in male rats. Neuropharmacology. 2021 11 01; 199:108800. PMID: 34547333.
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    30. Manini AF, Krotulski AJ, Schimmel J, Allen L, Hurd YL, Richardson LD, Vidal K, Logan BK. Respiratory failure in confirmed synthetic cannabinoid overdose. Clin Toxicol (Phila). 2022 Apr; 60(4):524-526. PMID: 34499005.
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    31. Chapman BP, Lai JT, Krotulski AJ, Fogarty MF, Griswold MK, Logan BK, Babu KM. A Case of Unintentional Opioid (U-47700) Overdose in a Young Adult After Counterfeit Xanax Use. Pediatr Emerg Care. 2021 Sep 01; 37(9):e579-e580. PMID: 30789871.
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    32. Aldy K, Mustaquim D, Campleman S, Meyn A, Abston S, Krotulski A, Logan B, Gladden MR, Hughes A, Amaducci A, Shulman J, Schwarz E, Wax P, Brent J, Manini A. Notes from the Field: Illicit Benzodiazepines Detected in Patients Evaluated in Emergency Departments for Suspected Opioid Overdose - Four States, October 6, 2020-March 9, 2021. MMWR Morb Mortal Wkly Rep. 2021 08 27; 70(34):1177-1179. PMID: 34437520.
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    33. Barenholtz E, Krotulski AJ, Morris P, Fitzgerald ND, Le A, Papsun DM, Logan BK, Hahn WE, Goldberger BA, Cottler LB, Palamar JJ. Online surveillance of novel psychoactive substances (NPS): Monitoring Reddit discussions as a predictor of increased NPS-related exposures. Int J Drug Policy. 2021 12; 98:103393. PMID: 34365124.
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    34. Krotulski AJ, Chapman BP, Marks SJ, Ontiveros ST, Devin-Holcombe K, Fogarty MF, Trieu H, Logan BK, Merchant RC, Babu KM. Sentanyl: a comparison of blood fentanyl concentrations and naloxone dosing after non-fatal overdose. Clin Toxicol (Phila). 2022 Feb; 60(2):197-204. PMID: 34278904.
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    35. Vandeputte MM, Krotulski AJ, Papsun DM, Logan BK, Stove CP. The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament. J Anal Toxicol. 2021 Jul 08. PMID: 34233349.
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    36. Krotulski AJ, Papsun DM, Walton SE, Logan BK. Metonitazene in the United States-Forensic toxicology assessment of a potent new synthetic opioid using liquid chromatography mass spectrometry. Drug Test Anal. 2021 Oct; 13(10):1697-1711. PMID: 34137194.
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    37. Mohr ALA, Fogarty MF, Krotulski AJ, Logan BK. Evaluating Trends in Novel Psychoactive Substances Using a Sentinel Population of Electronic Dance Music Festival Attendees. J Anal Toxicol. 2021 May 14; 45(5):490-497. PMID: 32860703.
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    38. Papsun DM, Krotulski AJ, Homan J, Temporal KDH, Logan BK. Flualprazolam Blood Concentrations in 197 Forensic Investigation Cases. J Anal Toxicol. 2021 Mar 12; 45(3):226-232. PMID: 32542312.
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    39. Krotulski AJ, Bishop-Freeman SC, Mohr ALA, Logan BK. Evaluation of Synthetic Cannabinoid Metabolites in Human Blood in the Absence of Parent Compounds: A Stability Assessment. J Anal Toxicol. 2021 Feb 06; 45(1):60-68. PMID: 32435808.
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    40. Krotulski AJ, Papsun DM, Chronister CW, Homan J, Crosby MM, Hoyer J, Goldberger BA, Logan BK. Eutylone Intoxications-An Emerging Synthetic Stimulant in Forensic Investigations. J Anal Toxicol. 2021 Feb 06; 45(1):8-20. PMID: 33325503.
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    41. Norman C, Halter S, Haschimi B, Acreman D, Smith J, Krotulski AJ, Mohr ALA, Logan BK, NicDa?id N, Auw?rter V, McKenzie C. A transnational perspective on the evolution of the synthetic cannabinoid receptor agonists market: Comparing prison and general populations. Drug Test Anal. 2021 Apr; 13(4):841-852. PMID: 33463894.
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    42. Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ. U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market. Brain Sci. 2020 Nov 23; 10(11). PMID: 33238449.
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    43. Krotulski AJ, Papsun DM, Noble C, Kacinko SL, Logan BK. Brorphine-Investigation and quantitation of a new potent synthetic opioid in forensic toxicology casework using liquid chromatography-mass spectrometry. J Forensic Sci. 2021 Mar; 66(2):664-676. PMID: 33201526.
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    44. Krotulski AJ, Cannaert A, Stove C, Logan BK. The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent-4en and but-3en analogues including MDMB-4en-PINACA. Drug Test Anal. 2021 Feb; 13(2):427-438. PMID: 32997377.
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    45. Krotulski AJ, Papsun DM, Kacinko SL, Logan BK. Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework. J Anal Toxicol. 2020 Jul 31; 44(6):521-530. PMID: 32091095.
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    46. Strathmann FG, Lynch KL, Krotulski A, Negri P, Cichelli J, Meyer MR. Challenges of High-Resolution Mass Spectrometry For Detecting Designer Drugs. Clin Chem. 2020 07 01; 66(7):868-874. PMID: 32628756.
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    47. Krotulski AJ, Mohr ALA, Logan BK. Emerging Synthetic Cannabinoids: Development and Validation of a Novel Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry Assay for Real-Time Detection. J Anal Toxicol. 2020 Apr 30; 44(3):207-217. PMID: 31909808.
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    48. Krotulski AJ, Mohr ALA, Diamond FX, Logan BK. Detection and characterization of the new synthetic cannabinoid APP-BINACA in forensic casework. Drug Test Anal. 2020 Jan; 12(1):136-144. PMID: 31788963.
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    49. Krotulski AJ, Varnum SJ, Logan BK. Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances. J Forensic Sci. 2020 Mar; 65(2):550-562. PMID: 31498433.
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    50. Krotulski AJ, Mohr ALA, Kacinko SL, Fogarty MF, Shuda SA, Diamond FX, Kinney WA, Menendez MJ, Logan BK. 4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework. J Forensic Sci. 2019 Sep; 64(5):1451-1461. PMID: 31260580.
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    51. Lee J, Krotulski AJ, Fogarty MF, Papsun DM, Logan BK. Chromatographic separation of the isobaric compounds cyclopropylfentanyl, crotonylfentanyl, methacrylfentanyl, and para-methylacrylfentanyl for specific confirmation by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 15; 1118-1119:164-170. PMID: 31054450.
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    52. Fogarty MF, Logan BK, Diamond FX, Mickolas L, Shuda SA, Krotulski AJ. Letter to Editor-NBOH Derivatization for the Analysis of Seized Drug Casework by GC-MS. J Forensic Sci. 2019 May; 64(3):958-960. PMID: 30990909.
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    53. Fiorentin TR, Krotulski AJ, Martin DM, Browne T, Triplett J, Conti T, Logan BK. Detection of Cutting Agents in Drug-Positive Seized Exhibits within the United States. J Forensic Sci. 2019 May; 64(3):888-896. PMID: 30485426.
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    54. Nacca N, Schult R, Loflin R, Weltler A, Gorodetsky R, Kacinko S, Moran J, Krotulski A, Wiegand T. Coma, Seizures, Atrioventricular Block, and Hypoglycemia in an ADB-FUBINACA Body-Packer. J Emerg Med. 2018 Dec; 55(6):788-791. PMID: 30297193.
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    55. Krotulski AJ, Mohr ALA, Fogarty MF, Logan BK. The Detection of Novel Stimulants in Oral Fluid from Users Reporting Ecstasy, Molly and MDMA Ingestion. J Anal Toxicol. 2018 Oct 01; 42(8):544-553. PMID: 30371847.
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    56. Krotulski AJ, Papsun DM, De Martinis BS, Mohr ALA, Logan BK. N-Ethyl Pentylone (Ephylone) Intoxications: Quantitative Confirmation and Metabolite Identification in Authentic Human Biological Specimens. J Anal Toxicol. 2018 Sep 01; 42(7):467-475. PMID: 29618077.
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    57. Krotulski AJ, Mohr ALA, Papsun DM, Logan BK. Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens. J Anal Toxicol. 2018 Sep 01; 42(7):437-445. PMID: 29554274.
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    58. Krotulski AJ, Papsun DM, Friscia M, Swartz JL, Holsey BD, Logan BK. Fatality Following Ingestion of Tetrahydrofuranylfentanyl, U-49900 and Methoxy-Phencyclidine. J Anal Toxicol. 2018 Apr 01; 42(3):e27-e32. PMID: 29186585.
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    59. Krotulski AJ, Mohr ALA, Friscia M, Logan BK. Field Detection of Drugs of Abuse in Oral Fluid Using the Alere? DDS?2 Mobile Test System with Confirmation by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). J Anal Toxicol. 2018 Apr 01; 42(3):170-176. PMID: 29301050.
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    60. Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman BP, Varma N, Boyer EW, Logan BK, Babu KM. A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose. J Med Toxicol. 2017 Dec; 13(4):287-292. PMID: 28971325.
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    61. Logan BK, Mohr ALA, Friscia M, Krotulski AJ, Papsun DM, Kacinko SL, Ropero-Miller JD, Huestis MA. Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2013-2016: A Review. J Anal Toxicol. 2017 Sep 01; 41(7):573-610. PMID: 28459969.
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    62. Krotulski AJ, Mohr ALA, Papsun DM, Logan BK. Metabolism of novel opioid agonists U-47700 and U-49900 using human liver microsomes with confirmation in authentic urine specimens from drug users. Drug Test Anal. 2018 Jan; 10(1):127-136. PMID: 28608586.
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    63. Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman B, Boyer EW, Logan BK, Babu KM. Self-identification of nonpharmaceutical fentanyl exposure following heroin overdose. Clin Toxicol (Phila). 2018 Jan; 56(1):37-42. PMID: 28681615.
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