Theodore Taraschi

TitleSr Assoc Provost
InstitutionThomas Jefferson University
DepartmentResearch Support Services Adm
AddressNA
Phone215-503-5020
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    K01AA000088     (TARASCHI, THEODORE F)Sep 28, 1984 - Aug 31, 1989
    NIH
    EFFECTS OF ALCOHOL ON BIOLOGICAL MEMBRANES
    Role: Principal Investigator

    K02AA000088     (TARASCHI, THEODORE F)Sep 29, 1986 - Aug 31, 1994
    NIH
    EFFECTS OF ETHANOL AND ANESTHETICS ON BIOLOGIC MEMBRANES
    Role: Principal Investigator

    R22AI027247     (TARASCHI, THEODORE F)Aug 1, 1989 - Jul 31, 1992
    NIH
    MEMBRANE TRAFFICKING IN MALARIA INFECTED ERYTHROCYTES
    Role: Principal Investigator

    R01AI027247     (TARASCHI, THEODORE F)Aug 1, 1989 - Aug 31, 1996
    NIH
    MEMBRANE TRAFFICKING IN MALARIA INFECTED ERYTHROCYTES
    Role: Principal Investigator

    R01AI041761     (TARASCHI, THEODORE F)Jul 1, 1997 - Jan 31, 2010
    NIH
    Macromolecular Transport in Asexual Malaria Parasites
    Role: Principal Investigator

    R01AI048567     (TARASCHI, THEODORE F)May 1, 2001 - Mar 31, 2008
    NIH
    DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
    Role: Principal Investigator

    R21AI072723     (TARASCHI, THEODORE F)Jul 15, 2008 - Dec 31, 2011
    NIH
    DNA Mismatch Repair and Malaria Drug Resistance
    Role: Principal Investigator

    R21AI090158     (TARASCHI, THEODORE F)Aug 15, 2011 - Jul 31, 2014
    NIH
    Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as Antimalarials
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Milani KJ, Schneider TG, Taraschi TF. Defining the morphology and mechanism of the hemoglobin transport pathway in Plasmodium falciparum-infected erythrocytes. Eukaryot Cell. 2015 Apr; 14(4):415-26. PMID: 25724884.
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    2. Castellini MA, Buguliskis JS, Casta LJ, Butz CE, Clark AB, Kunkel TA, Taraschi TF. Malaria drug resistance is associated with defective DNA mismatch repair. Mol Biochem Parasitol. 2011 Jun; 177(2):143-7. PMID: 21315772.
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    3. Ayong L, Raghavan A, Schneider TG, Taraschi TF, Fidock DA, Chakrabarti D. The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum. Eukaryot Cell. 2009 Sep; 8(9):1330-40. PMID: 19617396.
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    4. Lazarus MD, Schneider TG, Taraschi TF. A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum. J Cell Sci. 2008 Jun 01; 121(11):1937-49. PMID: 18477610.
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    5. Casta LJ, Buguliskis JS, Matsumoto Y, Taraschi TF. Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1). Mol Biochem Parasitol. 2008 Jan; 157(1):1-12. PMID: 17928073.
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    6. Buguliskis JS, Casta LJ, Butz CE, Matsumoto Y, Taraschi TF. Expression and biochemical characterization of Plasmodium falciparum DNA ligase I. Mol Biochem Parasitol. 2007 Oct; 155(2):128-37. PMID: 17688957.
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    7. Frankland S, Adisa A, Horrocks P, Taraschi TF, Schneider T, Elliott SR, Rogerson SJ, Knuepfer E, Cowman AF, Newbold CI, Tilley L. Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains. Eukaryot Cell. 2006 May; 5(5):849-60. PMID: 16682462.
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    8. Komatsu H, Westerman J, Snoek GT, Taraschi TF, Janes N. Effects of D-myo-inositol 1-phosphate on the transfer function of phosphatidylinositol transfer protein alpha. J Liposome Res. 2004; 14(3-4):141-53. PMID: 15676123.
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    9. Komatsu H, Westerman J, Snoek GT, Taraschi TF, Janes N. L-alpha-glycerylphosphorylcholine inhibits the transfer function of phosphatidylinositol transfer protein alpha. Biochim Biophys Acta. 2003 Dec 30; 1635(2-3):67-74. PMID: 14729069.
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    10. Taraschi TF, O'Donnell M, Martinez S, Schneider T, Trelka D, Fowler VM, Tilley L, Moriyama Y. Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. Blood. 2003 Nov 01; 102(9):3420-6. PMID: 12869498.
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    11. Taraschi TF, Trelka D, Martinez S, Schneider T, O'Donnell ME. Vesicle-mediated trafficking of parasite proteins to the host cell cytosol and erythrocyte surface membrane in Plasmodium falciparum infected erythrocytes. Int J Parasitol. 2001 Oct; 31(12):1381-91. PMID: 11566305.
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    12. Nicolas E, Beggs JM, Taraschi TF. Gelonin is an unusual DNA glycosylase that removes adenine from single-stranded DNA, normal base pairs and mismatches. J Biol Chem. 2000 Oct 06; 275(40):31399-406. PMID: 10906135.
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    13. Komatsu H, Bouma B, Wirtz KW, Taraschi TF, Janes N. Activity of phosphatidylinositol transfer protein is sensitive to ethanol and membrane curvature. Biochem J. 2000 Jun 15; 348 Pt 3:667-73. PMID: 10840000.
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    14. Trelka DP, Schneider TG, Reeder JC, Taraschi TF. Evidence for vesicle-mediated trafficking of parasite proteins to the host cell cytosol and erythrocyte surface membrane in Plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol. 2000 Feb 25; 106(1):131-45. PMID: 10743617.
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    15. Haltiwanger BM, Matsumoto Y, Nicolas E, Dianov GL, Bohr VA, Taraschi TF. DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. Biochemistry. 2000 Feb 01; 39(4):763-72. PMID: 10651642.
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    16. Haltiwanger BM, Karpinich NO, Taraschi TF. Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum. Biochem J. 2000 Jan 01; 345 Pt 1:85-9. PMID: 10600642.
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    17. Taraschi TF. Macromolecular transport in malaria-infected erythrocytes. Novartis Found Symp. 1999; 226:114-20; discussion 121-5. PMID: 10645542.
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    18. Nicolas E, Beggs JM, Haltiwanger BM, Taraschi TF. A new class of DNA glycosylase/apurinic/apyrimidinic lyases that act on specific adenines in single-stranded DNA. J Biol Chem. 1998 Jul 03; 273(27):17216-20. PMID: 9642291.
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    19. Taraschi TF, Trelka D, Schneider T, Matthews I. Plasmodium falciparum: characterization of organelle migration during merozoite morphogenesis in asexual malaria infections. Exp Parasitol. 1998 Mar; 88(3):184-93. PMID: 9562421.
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    20. Nicolas E, Goodyer ID, Taraschi TF. An additional mechanism of ribosome-inactivating protein cytotoxicity: degradation of extrachromosomal DNA. Biochem J. 1997 Oct 15; 327 ( Pt 2):413-7. PMID: 9359409.
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    21. Goodyer ID, Pouvelle B, Schneider TG, Trelka DP, Taraschi TF. Characterization of macromolecular transport pathways in malaria-infected erythrocytes. Mol Biochem Parasitol. 1997 Jul; 87(1):13-28. PMID: 9233670.
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    22. Goodyer ID, Taraschi TF. Plasmodium falciparum: a simple, rapid method for detecting parasite clones in microtiter plates. Exp Parasitol. 1997 Jun; 86(2):158-60. PMID: 9207746.
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    23. Victorov AV, Janes N, Taraschi TF, Hoek JB. Packing constraints and electrostatic surface potentials determine transmembrane asymmetry of phosphatidylethanol. Biophys J. 1997 Jun; 72(6):2588-98. PMID: 9168034.
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    24. Nicolas E, Beggs JM, Haltiwanger BM, Taraschi TF. Direct evidence for the deoxyribonuclease activity of the plant ribosome inactivating protein gelonin. FEBS Lett. 1997 Apr 07; 406(1-2):162-4. PMID: 9109409.
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    25. Victorov AV, Taraschi TF, Hoek JB. Phosphatidylethanol as a 13C-NMR probe for reporting packing constraints in phospholipid membranes. Biochim Biophys Acta. 1996 Sep 04; 1283(2):151-62. PMID: 8809094.
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    26. Channareddy S, Jose SS, Eryomin VA, Rubin E, Taraschi TF, Janes N. Saturable ethanol binding in rat liver microsomes. J Biol Chem. 1996 Jul 26; 271(30):17625-8. PMID: 8663606.
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    27. Dubey AK, Eryomin VA, Taraschi TF, Janes N. Alcohol binding to liposomes by 2H NMR and radiolabel binding assays: does partitioning describe binding? Biophys J. 1996 May; 70(5):2307-15. PMID: 9172754.
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    28. Lee YC, Zheng YO, Taraschi TF, Janes N. Hydrophobic alkyl headgroups strongly promote membrane curvature and violate the headgroup volume correlation due to "headgroup" insertion. Biochemistry. 1996 Mar 26; 35(12):3677-84. PMID: 8619987.
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    29. Baruch DI, Pasloske BL, Singh HB, Bi X, Ma XC, Feldman M, Taraschi TF, Howard RJ. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 1995 Jul 14; 82(1):77-87. PMID: 7541722.
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    30. Taraschi TF, Nicolas E. The parasitophorous duct pathway: new opportunities for antimalarial drug and vaccine development. Parasitol Today. 1994 Oct; 10(10):399-401. PMID: 15275547.
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    31. Pouvelle B, Farley PJ, Long CA, Taraschi TF. Taxol arrests the development of blood-stage Plasmodium falciparum in vitro and Plasmodium chabaudi adami in malaria-infected mice. J Clin Invest. 1994 Jul; 94(1):413-7. PMID: 7913713.
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    32. Pouvelle B, Gormley JA, Taraschi TF. Characterization of trafficking pathways and membrane genesis in malaria-infected erythrocytes. Mol Biochem Parasitol. 1994 Jul; 66(1):83-96. PMID: 7984190.
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    33. Taraschi TF, Pouvelle B. There is no ducking the duct. Parasitol Today. 1994 Jun; 10(6):212-3. PMID: 15275449.
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    34. Lee YC, Taraschi TF, Janes N. Support for the shape concept of lipid structure based on a headgroup volume approach. Biophys J. 1993 Oct; 65(4):1429-32. PMID: 8274636.
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    35. Pasloske BL, Baruch DI, van Schravendijk MR, Handunnetti SM, Aikawa M, Fujioka H, Taraschi TF, Gormley JA, Howard RJ. Cloning and characterization of a Plasmodium falciparum gene encoding a novel high-molecular weight host membrane-associated protein, PfEMP3. Mol Biochem Parasitol. 1993 May; 59(1):59-72. PMID: 8515784.
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    36. Wang DC, Taraschi TF, Rubin E, Janes N. Configurational entropy is the driving force of ethanol action on membrane architecture. Biochim Biophys Acta. 1993 Jan 18; 1145(1):141-8. PMID: 8380716.
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    37. Gormley JA, Howard RJ, Taraschi TF. Trafficking of malarial proteins to the host cell cytoplasm and erythrocyte surface membrane involves multiple pathways. J Cell Biol. 1992 Dec; 119(6):1481-95. PMID: 1469045.
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    38. Janes N, Hsu JW, Rubin E, Taraschi TF. Nature of alcohol and anesthetic action on cooperative membrane equilibria. Biochemistry. 1992 Oct 06; 31(39):9467-72. PMID: 1390729.
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    39. Handunnetti SM, Pasloske BL, van Schravendijk MR, Aguiar JC, Taraschi TF, Gormley JA, Howard RJ. The characterization of two monoclonal antibodies which react with high molecular weight antigens of asexual Plasmodium falciparum. Mol Biochem Parasitol. 1992 Sep; 54(2):231-46. PMID: 1435861.
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    40. Pouvelle B, Spiegel R, Hsiao L, Howard RJ, Morris RL, Thomas AP, Taraschi TF. Direct access to serum macromolecules by intraerythrocytic malaria parasites. Nature. 1991 Sep 05; 353(6339):73-5. PMID: 1715521.
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    41. Cardellach F, Taraschi TF, Ellingson JS, Stubbs CD, Rubin E, Hoek JB. Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment. Biochem J. 1991 Mar 01; 274 ( Pt 2):565-73. PMID: 1848761.
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    42. Ellingson JS, Janes N, Taraschi TF, Rubin E. The effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositol in rat liver microsomes as determined by gas chromatography and 1H-NMR. Biochim Biophys Acta. 1991 Feb 25; 1062(2):199-205. PMID: 1848450.
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    43. Hsiao LL, Howard RJ, Aikawa M, Taraschi TF. Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum. Biochem J. 1991 Feb 15; 274 ( Pt 1):121-32. PMID: 2001227.
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    44. Taraschi TF, Lee YC, Janes N, Rubin E. Anesthetic potency and conformational stability in membranes. Ann N Y Acad Sci. 1991; 625:698-706. PMID: 2058917.
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    45. Taraschi TF, Ellingson JS, Janes N, Rubin E. The role of anionic phospholipids in membrane adaptation to ethanol. Alcohol Alcohol Suppl. 1991; 1:241-5. PMID: 1845543.
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    46. Frank ED, Honet J, Torjman M, Janes N, Rubin E, Barber M, Taraschi T. Effects of chronic exposure to nitrous oxide on membrane fluidity in rats. Ann N Y Acad Sci. 1991; 625:545-7. PMID: 2058906.
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    47. Hoek JB, Taraschi TF, Higashi K, Rubin E, Thomas AP. Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding. Biochem J. 1990 Nov 15; 272(1):59-64. PMID: 2176085.
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    48. Janes N, Rubin E, Taraschi TF. 1H NMR dipolar echo decay spectroscopy: a sensitive probe of membrane structure. Biochemistry. 1990 Sep 11; 29(36):8385-8. PMID: 2252900.
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    49. Taraschi TF, Ellingson JS, Wu-Sun A, Rubin E. Rats withdrawn from ethanol rapidly re-acquire membrane tolerance after resumption of ethanol feeding. Biochim Biophys Acta. 1990 Jan 15; 1021(1):51-5. PMID: 2294963.
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    50. Stubbs CD, Williams BW, Boni LT, Hoek JB, Taraschi TF, Rubin E. On the use of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine in the study of lipid polymorphism. Biochim Biophys Acta. 1989 Nov 17; 986(1):89-96. PMID: 2819099.
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    51. Ellingson JS, Taraschi TF, Wu A, Zimmerman R, Rubin E. Cardiolipin from ethanol-fed rats confers tolerance to ethanol in liver mitochondrial membranes. Proc Natl Acad Sci U S A. 1988 May; 85(10):3353-7. PMID: 3368447.
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    52. Hoek JB, Taraschi TF, Rubin E. Functional implications of the interaction of ethanol with biologic membranes: actions of ethanol on hormonal signal transduction systems. Semin Liver Dis. 1988 Feb; 8(1):36-46. PMID: 2834828.
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    53. Van der Steen AT, Taraschi TF, Voorhout WF, De Kruijff B. Barrier properties of glycophorin-phospholipid systems prepared by different methods. Biochim Biophys Acta. 1983 Aug 24; 733(1):51-64. PMID: 6688359.
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