Thomas Jefferson University

Alain Mauviel

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
Phone215 5687294
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cocom-Chan B, Khakzad H, Konate M, Aguilar DI, Bello C, Valencia-Gallardo C, Zarrouk Y, Fattaccioli J, Mauviel A, Javelaud D, Tran Van Nhieu G. IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion. Life Sci Alliance. 2024 Aug; 7(8). PMID: 38834194.
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    2. Bertrand-Chapel A, Caligaris C, Fenouil T, Savary C, Aires S, Martel S, Huched? P, Chassot C, Chauvet V, Cardot-Ruffino V, Morel AP, Subtil F, Mohkam K, Mabrut JY, Tonon L, Viari A, Cassier P, Hervieu V, Castets M, Mauviel A, Sentis S, Bartholin L. SMAD2/3 mediate oncogenic effects of TGF-? in the absence of SMAD4. Commun Biol. 2022 10 07; 5(1):1068. PMID: 36207615.
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    3. Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME. GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression. Biochem J. 2020 09 18; 477(17):3131-3145. PMID: 32766732.
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    4. de Reyni?s A, Javelaud D, Elarouci N, Marsaud V, Gilbert C, Mauviel A. Large-scale pan-cancer analysis reveals broad prognostic association between TGF-? ligands, not Hedgehog, and GLI1/2 expression in tumors. Sci Rep. 2020 09 02; 10(1):14491. PMID: 32879407.
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    5. Pierrat MJ, Marsaud V, Mauviel A, Javelaud D. Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-? and the Kruppel-like transcription factor GLI2. J Dermatol Sci. 2019 Jun; 94(3):321-329. PMID: 31208857.
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    6. Javelaud D, De Reyni?s A, Mauviel A. How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection. J Investig Dermatol Symp Proc. 2018 Dec; 19(2):S87-S88. PMID: 30471761.
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    7. Ben Mimoun S, Mauviel A. Molecular mechanisms underlying TGF-?/Hippo signaling crosstalks - Role of baso-apical epithelial cell polarity. Int J Biochem Cell Biol. 2018 05; 98:75-81. PMID: 29544895.
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    8. Ju?rez P, Fournier PGJ, Mohammad KS, McKenna RC, Davis HW, Peng XH, Niewolna M, Mauviel A, Chirgwin JM, Guise TA. Halofuginone inhibits TGF-?/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis. Oncotarget. 2017 Oct 17; 8(49):86447-86462. PMID: 29156807.
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    9. Nallet-Staub F, Yin X, Gilbert C, Marsaud V, Ben Mimoun S, Javelaud D, Leof EB, Mauviel A. Cell density sensing alters TGF-? signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev Cell. 2015 Mar 09; 32(5):640-51. PMID: 25758862.
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    10. Sextius P, Marionnet C, Tacheau C, Bon FX, Bastien P, Mauviel A, Bernard BA, Bernerd F, Dubertret L. Analysis of gene expression dynamics revealed delayed and abnormal epidermal repair process in aged compared to young skin. Arch Dermatol Res. 2015 May; 307(4):351-64. PMID: 25740152.
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    11. Perrot CY, Gilbert C, Marsaud V, Postigo A, Javelaud D, Mauviel A. GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Nov; 26(6):861-73. PMID: 23890107.
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    12. Nallet-Staub F, Marsaud V, Li L, Gilbert C, Dodier S, Bataille V, Sudol M, Herlyn M, Mauviel A. Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma. J Invest Dermatol. 2014 Jan; 134(1):123-132. PMID: 23897276.
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    13. Perrot CY, Javelaud D, Mauviel A. Insights into the Transforming Growth Factor-? Signaling Pathway in Cutaneous Melanoma. Ann Dermatol. 2013 May; 25(2):135-44. PMID: 23717002.
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    14. Perrot CY, Javelaud D, Mauviel A. Overlapping activities of TGF-? and Hedgehog signaling in cancer: therapeutic targets for cancer treatment. Pharmacol Ther. 2013 Feb; 137(2):183-99. PMID: 23063491.
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    15. Ju?rez P, Mohammad KS, Yin JJ, Fournier PG, McKenna RC, Davis HW, Peng XH, Niewolna M, Javelaud D, Chirgwin JM, Mauviel A, Guise TA. Halofuginone inhibits the establishment and progression of melanoma bone metastases. Cancer Res. 2012 Dec 01; 72(23):6247-56. PMID: 23002206.
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    16. Javelaud D, Pierrat MJ, Mauviel A. Crosstalk between TGF-? and hedgehog signaling in cancer. FEBS Lett. 2012 Jul 04; 586(14):2016-25. PMID: 22609357.
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    17. Pierrat MJ, Marsaud V, Mauviel A, Javelaud D. Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-?. J Biol Chem. 2012 May 25; 287(22):17996-8004. PMID: 22496449.
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    18. Widmer DS, Cheng PF, Eichhoff OM, Belloni BC, Zipser MC, Schlegel NC, Javelaud D, Mauviel A, Dummer R, Hoek KS. Systematic classification of melanoma cells by phenotype-specific gene expression mapping. Pigment Cell Melanoma Res. 2012 May; 25(3):343-53. PMID: 22336146.
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    19. Mauviel A, Nallet-Staub F, Varelas X. Integrating developmental signals: a Hippo in the (path)way. Oncogene. 2012 Apr 05; 31(14):1743-56. PMID: 21874053.
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    20. Javelaud D, Alexaki VI, Dennler S, Mohammad KS, Guise TA, Mauviel A. TGF-?/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res. 2011 Sep 01; 71(17):5606-10. PMID: 21862631.
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    21. Javelaud D, Alexaki VI, Pierrat MJ, Hoek KS, Dennler S, Van Kempen L, Bertolotto C, Ballotti R, Saule S, Delmas V, Mauviel A. GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells. Pigment Cell Melanoma Res. 2011 Oct; 24(5):932-43. PMID: 21801332.
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    22. Javelaud D, van Kempen L, Alexaki VI, Le Scolan E, Luo K, Mauviel A. Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. Mol Cancer. 2011 Jan 06; 10(1):2. PMID: 21211030.
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    23. Mohammad KS, Javelaud D, Fournier PG, Niewolna M, McKenna CR, Peng XH, Duong V, Dunn LK, Mauviel A, Guise TA. TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. Cancer Res. 2011 Jan 01; 71(1):175-84. PMID: 21084275.
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    24. DiVito KA, Trabosh VA, Chen YS, Chen Y, Albanese C, Javelaud D, Mauviel A, Simbulan-Rosenthal CM, Rosenthal DS. Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo. Pigment Cell Melanoma Res. 2010 Dec; 23(6):795-808. PMID: 20738806.
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    25. Alexaki VI, Javelaud D, Van Kempen LC, Mohammad KS, Dennler S, Luciani F, Hoek KS, Ju?rez P, Goydos JS, Fournier PJ, Sibon C, Bertolotto C, Verrecchia F, Saule S, Delmas V, Ballotti R, Larue L, Saiag P, Guise TA, Mauviel A. GLI2-mediated melanoma invasion and metastasis. J Natl Cancer Inst. 2010 Aug 04; 102(15):1148-59. PMID: 20660365.
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    26. Schiller M, Dennler S, Anderegg U, Kokot A, Simon JC, Luger TA, Mauviel A, B?hm M. Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions. J Biol Chem. 2010 Jan 01; 285(1):409-21. PMID: 19858184.
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    27. Dennler S, Andr? J, Verrecchia F, Mauviel A. Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. J Biol Chem. 2009 Nov 13; 284(46):31523-31. PMID: 19797115.
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    28. Sextius P, Marionnet C, Bon FX, de La Chapelle AL, Tacheau C, Lahfa M, Mauviel A, Bernard BA, Leclaire J, Bernerd F, Dubertret L. Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response. Exp Dermatol. 2010 Mar; 19(3):259-68. PMID: 19765057.
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    29. G?ller MC, Andr? J, Legrand A, Setterblad N, Mauviel A, Verrecchia F, Daniel F, Bernuau D. c-Fos accelerates hepatocyte conversion to a fibroblastoid phenotype through ERK-mediated upregulation of paxillin-Serine178 phosphorylation. Mol Carcinog. 2009 Jun; 48(6):532-44. PMID: 18973190.
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    30. Berrou J, Tostivint I, Verrecchia F, Berthier C, Boulanger E, Mauviel A, Marti HP, Wautier MP, Wautier JL, Rondeau E, Hertig A. Advanced glycation end products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells. Int J Mol Med. 2009 Apr; 23(4):513-20. PMID: 19288028.
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    31. Mauviel A. Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk. J Invest Dermatol. 2009 Jan; 129(1):7-9. PMID: 19078982.
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    32. Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F. TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways. J Cell Physiol. 2008 Dec; 217(3):759-68. PMID: 18668519.
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    33. El Marsafy S, Bagot M, Bensussan A, Mauviel A. Dendritic cells in the skin--potential use for melanoma treatment. Pigment Cell Melanoma Res. 2009 Feb; 22(1):30-41. PMID: 19040502.
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    34. G?ller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 07; 14(41):6339-46. PMID: 19009649.
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    35. Tacheau C, Laboureau J, Mauviel A, Verrecchia F. TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling. J Cell Physiol. 2008 Aug; 216(2):438-44. PMID: 18297686.
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    36. Potier E, Ferreira E, Dennler S, Mauviel A, Oudina K, Logeart-Avramoglou D, Petite H. Desferrioxamine-driven upregulation of angiogenic factor expression by human bone marrow stromal cells. J Tissue Eng Regen Med. 2008 Jul; 2(5):272-8. PMID: 18512268.
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    37. Alexaki VI, Javelaud D, Mauviel A. JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis. Pigment Cell Melanoma Res. 2008 Aug; 21(4):429-38. PMID: 18541008.
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    38. Le Scolan E, Zhu Q, Wang L, Bandyopadhyay A, Javelaud D, Mauviel A, Sun L, Luo K. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res. 2008 May 01; 68(9):3277-85. PMID: 18451154.
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    39. Javelaud D, Alexaki VI, Mauviel A. Transforming growth factor-beta in cutaneous melanoma. Pigment Cell Melanoma Res. 2008 Apr; 21(2):123-32. PMID: 18426405.
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    40. Toualbi-Abed K, Daniel F, G?ller MC, Legrand A, Mauriz JL, Mauviel A, Bernuau D. Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1. Carcinogenesis. 2008 Mar; 29(3):536-43. PMID: 18174238.
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    41. Tacheau C, Michel L, Farge D, Mauviel A, Verrecchia F. Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices. Eur J Pharmacol. 2007 Nov 14; 573(1-3):65-9. PMID: 17706637.
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    42. Dennler S, Andr? J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007 Jul 15; 67(14):6981-6. PMID: 17638910.
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    43. Verrecchia F, Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol. 2007 Jun 14; 13(22):3056-62. PMID: 17589920.
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    44. Piddubnyak V, Rigou P, Michel L, Rain JC, Geneste O, Wolkenstein P, Vidaud D, Hickman JA, Mauviel A, Poyet JL. Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients. Cell Death Differ. 2007 Jun; 14(6):1222-33. PMID: 17380155.
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    45. Javelaud D, Mohammad KS, McKenna CR, Fournier P, Luciani F, Niewolna M, Andr? J, Delmas V, Larue L, Guise TA, Mauviel A. Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res. 2007 Mar 01; 67(5):2317-24. PMID: 17332363.
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    46. Roos N, Poulalhon N, Farge D, Madelaine I, Mauviel A, Verrecchia F. In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J Pharmacol Exp Ther. 2007 May; 321(2):583-9. PMID: 17272676.
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    47. Verrecchia F, Laboureau J, Verola O, Roos N, Porcher R, Bruneval P, Ertault M, Tiev K, Michel L, Mauviel A, Farge D. Skin involvement in scleroderma--where histological and clinical scores meet. Rheumatology (Oxford). 2007 May; 46(5):833-41. PMID: 17255134.
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    48. Toualbi K, G?ller MC, Mauriz JL, Labalette C, Buendia MA, Mauviel A, Bernuau D. Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. Oncogene. 2007 May 24; 26(24):3492-502. PMID: 17146436.
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    49. Urtreger AJ, Werbajh SE, Verrecchia F, Mauviel A, Puricelli LI, Kornblihtt AR, Bal de Kier Joff? ED. Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncol Rep. 2006 Dec; 16(6):1403-10. PMID: 17089068.
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    50. Poulalhon N, Farge D, Roos N, Tacheau C, Neuzillet C, Michel L, Mauviel A, Verrecchia F. Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent? J Biol Chem. 2006 Nov 03; 281(44):33045-52. PMID: 16914544.
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    51. Verrecchia F, Mauviel A, Farge D. Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmun Rev. 2006 Oct; 5(8):563-9. PMID: 17027893.
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    52. Schiller M, B?hm M, Dennler S, Ehrchen JM, Mauviel A. Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes. Oncogene. 2006 Jul 27; 25(32):4449-57. PMID: 16532028.
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    53. Vozenin-Brotons MC, Mauviel A. [How to model the events in cutaneous fibrosis?]. Med Sci (Paris). 2006 Feb; 22(2):172-7. PMID: 16457758.
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    54. Dennler S, Laboureau J, Farge D, Mauviel A, Verrecchia F. [Involvement of TGFbeta1 in fibrotic diseases: role of its effectors, the Smad proteins]. Rev Med Interne. 2006 Jan; 27(1):46-9. PMID: 16330131.
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    55. Javelaud D, Delmas V, M?ller M, Sextius P, Andr? J, Menashi S, Larue L, Mauviel A. Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene. 2005 Nov 17; 24(51):7624-9. PMID: 16007121.
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    56. Javelaud D, Mauviel A. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene. 2005 Aug 29; 24(37):5742-50. PMID: 16123807.
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    57. Krakowski AR, Laboureau J, Mauviel A, Bissell MJ, Luo K. Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12437-42. PMID: 16109768.
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    58. Dennler S, Pendaries V, Tacheau C, Costas MA, Mauviel A, Verrecchia F. The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP. Oncogene. 2005 Mar 10; 24(11):1936-45. PMID: 15688032.
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    59. Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie. 2005 Mar-Apr; 87(3-4):361-8. PMID: 15781323.
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    60. Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol. 2005 Jan; 166(1):209-19. PMID: 15632013.
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    61. Mauviel A. Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med. 2005; 117:69-80. PMID: 16118446.
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    62. Verrecchia F, Mauviel A. TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression. Cell Signal. 2004 Aug; 16(8):873-80. PMID: 15157666.
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    63. Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci. 2004 Aug; 35(2):83-92. PMID: 15265520.
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    64. Javelaud D, Mauviel A. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Int J Biochem Cell Biol. 2004 Jul; 36(7):1161-5. PMID: 15109563.
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    65. Brellier F, Marionnet C, Chevallier-Lagente O, Toftgard R, Mauviel A, Sarasin A, Magnaldo T. Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process. Cancer Res. 2004 Apr 15; 64(8):2699-704. PMID: 15087382.
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    66. Javelaud D, Mauviel A. [Transforming growth factor-betas: smad signaling and roles in physiopathology]. Pathol Biol (Paris). 2004 Feb; 52(1):50-4. PMID: 14761714.
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    67. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem. 2004 Apr 09; 279(15):15167-76. PMID: 14732719.
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    68. Schiller M, Verrecchia F, Mauviel A. Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism. Oncogene. 2003 Dec 04; 22(55):8881-90. PMID: 14654784.
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    69. Marionnet C, Bernerd F, Dumas A, Verrecchia F, Mollier K, Compan D, Bernard B, Lahfa M, Leclaire J, Medaisko C, Mehul B, Seit? S, Mauviel A, Dubertret L. Modulation of gene expression induced in human epidermis by environmental stress in vivo. J Invest Dermatol. 2003 Dec; 121(6):1447-58. PMID: 14675196.
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    70. Pendaries V, Verrecchia F, Michel S, Mauviel A. Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner. Oncogene. 2003 Nov 06; 22(50):8212-20. PMID: 14603262.
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    71. Wendling J, Marchand A, Mauviel A, Verrecchia F. 5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation. Mol Pharmacol. 2003 Sep; 64(3):707-13. PMID: 12920208.
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    72. Laurent M, Martinerie C, Thibout H, Hoffman MP, Verrecchia F, Le Bouc Y, Mauviel A, Kleinman HK. NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism. FASEB J. 2003 Oct; 17(13):1919-21. PMID: 14519668.
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    73. Gabison EE, Chastang P, Menashi S, Mourah S, Doan S, Oster M, Mauviel A, Hoang-Xuan T. Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases. Ophthalmology. 2003 Aug; 110(8):1626-31. PMID: 12917183.
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    74. Javelaud D, Laboureau J, Gabison E, Verrecchia F, Mauviel A. Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing. J Biol Chem. 2003 Jul 04; 278(27):24624-8. PMID: 12730213.
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    75. Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S. [Metalloproteinases and angiogenesis]. Pathol Biol (Paris). 2003 Apr; 51(3):161-6. PMID: 12781798.
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    76. Higashi K, Inagaki Y, Suzuki N, Mitsui S, Mauviel A, Kaneko H, Nakatsuka I. Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma. J Biol Chem. 2003 Feb 14; 278(7):5156-62. PMID: 12446674.
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    77. Verrecchia F, Tacheau C, Wagner EF, Mauviel A. A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression. J Biol Chem. 2003 Jan 17; 278(3):1585-93. PMID: 12426318.
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    78. Verrecchia F, Wagner EF, Mauviel A. Distinct involvement of the Jun-N-terminal kinase and NF-kappaB pathways in the repression of the human COL1A2 gene by TNF-alpha. EMBO Rep. 2002 Nov; 3(11):1069-74. PMID: 12393755.
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    79. Arnulf B, Villemain A, Nicot C, Mordelet E, Charneau P, Kersual J, Zermati Y, Mauviel A, Bazarbachi A, Hermine O. Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood. 2002 Dec 01; 100(12):4129-38. PMID: 12393612.
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    80. Ferrigno O, Lallemand F, Verrecchia F, L'Hoste S, Camonis J, Atfi A, Mauviel A. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002 Jul 25; 21(32):4879-84. PMID: 12118366.
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    81. Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A. c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity. J Biol Chem. 2002 Aug 09; 277(32):29094-100. PMID: 12034730.
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    82. Verrecchia F, Mauviel A. Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep. 2002 Apr; 4(2):143-9. PMID: 11890880.
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    83. Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol. 2002 Feb; 118(2):211-5. PMID: 11841535.
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    84. Verrecchia F, Vindevoghel L, Lechleider RJ, Uitto J, Roberts AB, Mauviel A. Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner. Oncogene. 2001 Jun 07; 20(26):3332-40. PMID: 11423983.
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    85. Verrecchia F, Rossert J, Mauviel A. Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis. J Invest Dermatol. 2001 May; 116(5):755-63. PMID: 11348466.
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    86. Verrecchia F, Tacheau C, Schorpp-Kistner M, Angel P, Mauviel A. Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation. Oncogene. 2001 Apr 26; 20(18):2205-11. PMID: 11402315.
      Citations:    
    87. Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem. 2001 May 18; 276(20):17058-62. PMID: 11279127.
      Citations:    
    88. Gras MP, Verrecchia F, Uitto J, Mauviel A. Downregulation of human type VII collagen (COL7A1) promoter activity by dexamethasone. Identification of a glucocorticoid receptor binding region. Exp Dermatol. 2001 Feb; 10(1):28-34. PMID: 11168577.
      Citations:    
    89. Kouba DJ, Nakano H, Nishiyama T, Kang J, Uitto J, Mauviel A. Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblasts. J Biol Chem. 2001 Mar 02; 276(9):6214-24. PMID: 11087727.
      Citations:    
    90. Verrecchia F, Pessah M, Atfi A, Mauviel A. Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation. J Biol Chem. 2000 Sep 29; 275(39):30226-31. PMID: 10903323.
      Citations:    
    91. Teofoli P, Frezzolini A, Puddu P, De Pit? O, Mauviel A, Lotti T. The role of proopiomelanocortin-derived peptides in skin fibroblast and mast cell functions. Ann N Y Acad Sci. 1999 Oct 20; 885:268-76. PMID: 10816660.
      Citations:    
    92. Lotti T, Teofoli P, Bianchi B, Mauviel A. POMC and fibroblast biology. Ann N Y Acad Sci. 1999 Oct 20; 885:262-7. PMID: 10816659.
      Citations:    
    93. Kivirikko S, Mauviel A, Pihlajaniemi T, Uitto J. Cytokine modulation of type XV collagen gene expression in human dermal fibroblast cultures. Exp Dermatol. 1999 Oct; 8(5):407-12. PMID: 10536968.
      Citations:    
    94. Kouba DJ, Chung KY, Nishiyama T, Vindevoghel L, Kon A, Klement JF, Uitto J, Mauviel A. Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts. J Immunol. 1999 Apr 01; 162(7):4226-34. PMID: 10201951.
      Citations:    
    95. Kon A, Vindevoghel L, Kouba DJ, Fujimura Y, Uitto J, Mauviel A. Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression. Oncogene. 1999 Mar 11; 18(10):1837-44. PMID: 10086338.
      Citations:    
    96. Rodeck U, Nishiyama T, Mauviel A. Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells. Cancer Res. 1999 Feb 01; 59(3):547-50. PMID: 9973198.
      Citations:    
    97. Vindevoghel L, Lechleider RJ, Kon A, de Caestecker MP, Uitto J, Roberts AB, Mauviel A. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14769-74. PMID: 9843964.
      Citations:    
    98. Vindevoghel L, Kon A, Lechleider RJ, Uitto J, Roberts AB, Mauviel A. Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta. J Biol Chem. 1998 May 22; 273(21):13053-7. PMID: 9582342.
      Citations:    
    99. Higashi K, Kouba DJ, Song YJ, Uitto J, Mauviel A. A proximal element within the human alpha 2(I) collagen (COL1A2) promoter, distinct from the tumor necrosis factor-alpha response element, mediates transcriptional repression by interferon-gamma. Matrix Biol. 1998 Mar; 16(8):447-56. PMID: 9550262.
      Citations:    
    100. Teofoli P, Motoki K, Lotti TM, Uitto J, Mauviel A. Propiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: modulation by cytokines. Exp Dermatol. 1997 Jun; 6(3):111-5. PMID: 9226132.
      Citations:    
    101. Schumann H, Hammami-Hauasli N, Pulkkinen L, Mauviel A, K?ster W, L?thi U, Owaribe K, Uitto J, Bruckner-Tuderman L. Three novel homozygous point mutations and a new polymorphism in the COL17A1 gene: relation to biological and clinical phenotypes of junctional epidermolysis bullosa. Am J Hum Genet. 1997 Jun; 60(6):1344-53. PMID: 9199555.
      Citations:    
    102. Vindevoghel L, Chung KY, Davis A, Kouba D, Kivirikko S, Alder H, Uitto J, Mauviel A. A GT-rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene (COL7A1) in fibroblasts and keratinocytes. J Biol Chem. 1997 Apr 11; 272(15):10196-204. PMID: 9092567.
      Citations:    
    103. Iozzo RV, Pillarisetti J, Sharma B, Murdoch AD, Danielson KG, Uitto J, Mauviel A. Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element. J Biol Chem. 1997 Feb 21; 272(8):5219-28. PMID: 9030592.
      Citations:    
    104. Mauviel A, Korang K, Santra M, Tewari D, Uitto J, Iozzo RV. Identification of a bimodal regulatory element encompassing a canonical AP-1 binding site in the proximal promoter region of the human decorin gene. J Biol Chem. 1996 Oct 04; 271(40):24824-9. PMID: 8798756.
      Citations:    
    105. Sawamura D, Ohta T, Hanada K, Ishikawa H, Tamai K, Yazima H, Meng X, Nomura K, Hashimoto I, Mauviel A, Uitto J. Involvement of the AP-1 site within the 5'-flanking region of the stromelysin-1 gene in induction of the gene expression by UVA irradiation. Arch Dermatol Res. 1996 Sep; 288(10):628-32. PMID: 8919048.
      Citations:    
    106. Mauviel A, Chung KY, Agarwal A, Tamai K, Uitto J. Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes. J Biol Chem. 1996 May 03; 271(18):10917-23. PMID: 8631909.
      Citations:    
    107. Chung KY, Agarwal A, Uitto J, Mauviel A. An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta. J Biol Chem. 1996 Feb 09; 271(6):3272-8. PMID: 8621730.
      Citations:    
    108. Korang K, Christiano AM, Uitto J, Mauviel A. Differential cytokine modulation of the genes LAMA3, LAMB3, and LAMC2, encoding the constitutive polypeptides, alpha 3, beta 3, and gamma 2, of human laminin 5 in epidermal keratinocytes. FEBS Lett. 1995 Jul 24; 368(3):556-8. PMID: 7635220.
      Citations:    
    109. Mauviel A, Santra M, Chen YQ, Uitto J, Iozzo RV. Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha. J Biol Chem. 1995 May 12; 270(19):11692-700. PMID: 7744809.
      Citations:    
    110. Tamai K, Ishikawa H, Mauviel A, Uitto J. Interferon-gamma coordinately upregulates matrix metalloprotease (MMP)-1 and MMP-3, but not tissue inhibitor of metalloproteases (TIMP), expression in cultured keratinocytes. J Invest Dermatol. 1995 Mar; 104(3):384-90. PMID: 7861007.
      Citations:    
    111. Li L, Gotta S, Mauviel A, Varga J. L-tryptophan induces expression of collagenase gene in human fibroblasts: demonstration of enhanced AP-1 binding and AP-1 binding site-driven promoter activity. Cell Mol Biol Res. 1995; 41(5):361-8. PMID: 8867782.
      Citations:    
    112. Bernstein EF, Chen YQ, Tamai K, Shepley KJ, Resnik KS, Zhang H, Tuan R, Mauviel A, Uitto J. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol. 1994 Aug; 103(2):182-6. PMID: 8040608.
      Citations:    
    113. Mauviel A, Halcin C, Vasiloudes P, Parks WC, Kurkinen M, Uitto J. Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture. J Cell Biochem. 1994 Apr; 54(4):465-72. PMID: 8014195.
      Citations:    
    114. Chen YQ, Mauviel A, Ryyn?nen J, Sollberg S, Uitto J. Type VII collagen gene expression by human skin fibroblasts and keratinocytes in culture: influence of donor age and cytokine responses. J Invest Dermatol. 1994 Feb; 102(2):205-9. PMID: 8106749.
      Citations:    
    115. Varga J, Li L, Mauviel A, Jeffrey J, Jimenez SA. L-Tryptophan in supraphysiologic concentrations stimulates collagenase gene expression in human skin fibroblasts. Lab Invest. 1994 Feb; 70(2):183-91. PMID: 8139260.
      Citations:    
    116. Mauviel A, Lapi?re JC, Halcin C, Evans CH, Uitto J. Differential cytokine regulation of type I and type VII collagen gene expression in cultured human dermal fibroblasts. J Biol Chem. 1994 Jan 07; 269(1):25-8. PMID: 8276802.
      Citations:    
    117. Mauviel A. Cytokine regulation of metalloproteinase gene expression. J Cell Biochem. 1993 Dec; 53(4):288-95. PMID: 8300745.
      Citations:    
    118. Mauviel A, Qiu Chen Y, Dong W, Evans CH, Uitto J. Transcriptional interactions of transforming growth-factor-beta with pro-inflammatory cytokines. Curr Biol. 1993 Dec 01; 3(12):822-31. PMID: 15335815.
      Citations:    
    119. Mauviel A, Chen YQ, K?h?ri VM, Ledo I, Wu M, Rudnicka L, Uitto J. Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo. J Biol Chem. 1993 Mar 25; 268(9):6520-4. PMID: 8454621.
      Citations:    
    120. R?dini F, Mauviel A, Pronost S, Loyau G, Pujol JP. Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression. Arthritis Rheum. 1993 Jan; 36(1):44-50. PMID: 8424835.
      Citations:    
    121. Mauviel A, Reitamo S, Remitz A, Lapi?re JC, Ceska M, Baggiolini M, Walz A, Evans CH, Uitto J. Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity. J Immunol. 1992 Nov 01; 149(9):2969-76. PMID: 1401924.
      Citations:    
    122. Mauviel A, K?h?ri VM, Kurkinen M, Evans CH, Uitto J. Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation. J Cell Biochem. 1992 Sep; 50(1):53-61. PMID: 1429874.
      Citations:    
    123. Mauviel A, Evans CH, Uitto J. Leukoregulin down-regulates type I collagen mRNA levels and promoter activity in human dermal fibroblasts, and counteracts the up-regulation elicited by transforming growth factor-beta. Biochem J. 1992 Jun 15; 284 ( Pt 3):629-32. PMID: 1622385.
      Citations:    
    124. Mauviel A, K?h?ri VM, Evans CH, Uitto J. Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin. J Biol Chem. 1992 Mar 15; 267(8):5644-8. PMID: 1372007.
      Citations:    
    125. Mauviel A, K?h?ri VM, Chen YQ, Kurkinen M, Evans CH, Uitto J. Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin. Trans Assoc Am Physicians. 1992; 105:100-9. PMID: 1308987.
      Citations:    
    126. Mauviel A, Temime N, Charron D, Loyau G, Pujol JP. Induction of interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and tumor necrosis factor-alpha. Involvement of protein kinase-dependent and adenylate cyclase-dependent regulatory pathways. J Cell Biochem. 1991 Oct; 47(2):174-83. PMID: 1661739.
      Citations:    
    127. Redini F, Daireaux M, Mauviel A, Galera P, Loyau G, Pujol JP. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-beta (TGF-beta). Biochim Biophys Acta. 1991 Jul 10; 1093(2-3):196-206. PMID: 1863600.
      Citations:    
    128. Mauviel A, R?dini F, Hartmann DJ, Pujol JP, Evans CH. Modulation of human dermal fibroblast extracellular matrix metabolism by the lymphokine leukoregulin. J Cell Biol. 1991 Jun; 113(6):1455-62. PMID: 1646205.
      Citations:    
    129. Mauviel A, Loyau G, Pujol JP. [Effect of unsaponifiable extracts of avocado and soybean (Piascl?dine) on the collagenolytic action of cultures of human rheumatoid synoviocytes and rabbit articular chondrocytes treated with interleukin-1]. Rev Rhum Mal Osteoartic. 1991 Apr; 58(4):241-5. PMID: 1647544.
      Citations:    
    130. Mauviel A, Heino J, K?h?ri VM, Hartmann DJ, Loyau G, Pujol JP, Vuorio E. Comparative effects of interleukin-1 and tumor necrosis factor-alpha on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts. J Invest Dermatol. 1991 Feb; 96(2):243-9. PMID: 1991984.
      Citations:    
    131. Pujol JP, Galera P, Redini F, Mauviel A, Loyau G. Role of cytokines in osteoarthritis: comparative effects of interleukin 1 and transforming growth factor-beta on cultured rabbit articular chondrocytes. J Rheumatol Suppl. 1991 Feb; 27:76-9. PMID: 2027137.
      Citations:    
    132. Rapala K, Laato M, Niinikoski J, Kujari H, S?der O, Mauviel A, Pujol JP. Tumor necrosis factor alpha inhibits wound healing in the rat. Eur Surg Res. 1991; 23(5-6):261-8. PMID: 1802728.
      Citations:    
    133. Mauviel A, Redini F, Loyau G, Pujol JP. Modulation of extracellular matrix metabolism in rabbit articular chondrocytes and human rheumatoid synovial cells by the non-steroidal anti-inflammatory drug etodolac. I: Collagen synthesis. Agents Actions. 1990 Nov; 31(3-4):345-52. PMID: 2150740.
      Citations:    
    134. Redini F, Mauviel A, Loyau G, Pujol JP. Modulation of extracellular matrix metabolism in rabbit articular chondrocytes and human rheumatoid synovial cells by the non-steroidal anti-inflammatory drug etodolac. II: Glycosaminoglycan synthesis. Agents Actions. 1990 Nov; 31(3-4):358-67. PMID: 2150741.
      Citations:    
    135. Mauviel A, Daireaux M, Hartmann DJ, Galera P, Loyau G, Pujol JP. [Effects of unsaponifiable extracts of avocado/soy beans (PIAS) on the production of collagen by cultures of synoviocytes, articular chondrocytes and skin fibroblasts]. Rev Rhum Mal Osteoartic. 1989 Feb; 56(2):207-11. PMID: 2727601.
      Citations:    
    136. Mauviel A, Temime N, Charron D, Loyau G, Pujol JP. Interleukin-1 alpha and beta induce interleukin-1 beta gene expression in human dermal fibroblasts. Biochem Biophys Res Commun. 1988 Nov 15; 156(3):1209-14. PMID: 3263855.
      Citations:    
    137. Mauviel A, Daireaux M, R?dini F, Galera P, Loyau G, Pujol JP. Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts. FEBS Lett. 1988 Aug 15; 236(1):47-52. PMID: 3165348.
      Citations:    
    138. Redini F, Galera P, Mauviel A, Loyau G, Pujol JP. Transforming growth factor beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEBS Lett. 1988 Jul 04; 234(1):172-6. PMID: 3164687.
      Citations:    
    139. Mauviel A, Teyton L, Bhatnagar R, Penfornis H, Laurent M, Hartmann D, Bonaventure J, Loyau G, Saklatvala J, Pujol JP. Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells. Biochem J. 1988 May 15; 252(1):247-55. PMID: 2844146.
      Citations:    
    140. Heino J, K?h?ri VM, Mauviel A, Krusius T. Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein. Biochem J. 1988 May 15; 252(1):309-12. PMID: 3262337.
      Citations:    
    141. Mauviel A, K?h?ri VM, Heino J, Daireaux M, Hartmann DJ, Loyau G, Pujol JP. Gene expression of fibroblast matrix proteins is altered by indomethacin. FEBS Lett. 1988 Apr 11; 231(1):125-9. PMID: 3360117.
      Citations:    
    142. Bhatnagar R, Penfornis H, Mauviel A, Loyau G, Saklatvala J, Pujol JP. Interleukin-1 inhibits the synthesis of collagen by fibroblasts. Biochem Int. 1986 Oct; 13(4):709-20. PMID: 3492206.
      Citations:    
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