Alain Mauviel

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
Phone215 5687294
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bertrand-Chapel A, Caligaris C, Fenouil T, Savary C, Aires S, Martel S, Huched? P, Chassot C, Chauvet V, Cardot-Ruffino V, Morel AP, Subtil F, Mohkam K, Mabrut JY, Tonon L, Viari A, Cassier P, Hervieu V, Castets M, Mauviel A, Sentis S, Bartholin L. SMAD2/3 mediate oncogenic effects of TGF-? in the absence of SMAD4. Commun Biol. 2022 10 07; 5(1):1068. PMID: 36207615.
      Citations:    
    2. Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME. GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression. Biochem J. 2020 09 18; 477(17):3131-3145. PMID: 32766732.
      Citations:    
    3. de Reyni?s A, Javelaud D, Elarouci N, Marsaud V, Gilbert C, Mauviel A. Large-scale pan-cancer analysis reveals broad prognostic association between TGF-? ligands, not Hedgehog, and GLI1/2 expression in tumors. Sci Rep. 2020 09 02; 10(1):14491. PMID: 32879407.
      Citations:    
    4. Pierrat MJ, Marsaud V, Mauviel A, Javelaud D. Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor-? and the Kruppel-like transcription factor GLI2. J Dermatol Sci. 2019 Jun; 94(3):321-329. PMID: 31208857.
      Citations:    
    5. Javelaud D, De Reyni?s A, Mauviel A. How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection. J Investig Dermatol Symp Proc. 2018 Dec; 19(2):S87-S88. PMID: 30471761.
      Citations:    
    6. Ben Mimoun S, Mauviel A. Molecular mechanisms underlying TGF-?/Hippo signaling crosstalks - Role of baso-apical epithelial cell polarity. Int J Biochem Cell Biol. 2018 05; 98:75-81. PMID: 29544895.
      Citations:    
    7. Ju?rez P, Fournier PGJ, Mohammad KS, McKenna RC, Davis HW, Peng XH, Niewolna M, Mauviel A, Chirgwin JM, Guise TA. Halofuginone inhibits TGF-?/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis. Oncotarget. 2017 Oct 17; 8(49):86447-86462. PMID: 29156807.
      Citations:    
    8. Nallet-Staub F, Yin X, Gilbert C, Marsaud V, Ben Mimoun S, Javelaud D, Leof EB, Mauviel A. Cell density sensing alters TGF-? signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev Cell. 2015 Mar 09; 32(5):640-51. PMID: 25758862.
      Citations:    
    9. Sextius P, Marionnet C, Tacheau C, Bon FX, Bastien P, Mauviel A, Bernard BA, Bernerd F, Dubertret L. Analysis of gene expression dynamics revealed delayed and abnormal epidermal repair process in aged compared to young skin. Arch Dermatol Res. 2015 May; 307(4):351-64. PMID: 25740152.
      Citations:    
    10. Perrot CY, Gilbert C, Marsaud V, Postigo A, Javelaud D, Mauviel A. GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Nov; 26(6):861-73. PMID: 23890107.
      Citations:    
    11. Nallet-Staub F, Marsaud V, Li L, Gilbert C, Dodier S, Bataille V, Sudol M, Herlyn M, Mauviel A. Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma. J Invest Dermatol. 2014 Jan; 134(1):123-132. PMID: 23897276.
      Citations:    
    12. Perrot CY, Javelaud D, Mauviel A. Insights into the Transforming Growth Factor-? Signaling Pathway in Cutaneous Melanoma. Ann Dermatol. 2013 May; 25(2):135-44. PMID: 23717002.
      Citations:    
    13. Perrot CY, Javelaud D, Mauviel A. Overlapping activities of TGF-? and Hedgehog signaling in cancer: therapeutic targets for cancer treatment. Pharmacol Ther. 2013 Feb; 137(2):183-99. PMID: 23063491.
      Citations:    
    14. Ju?rez P, Mohammad KS, Yin JJ, Fournier PG, McKenna RC, Davis HW, Peng XH, Niewolna M, Javelaud D, Chirgwin JM, Mauviel A, Guise TA. Halofuginone inhibits the establishment and progression of melanoma bone metastases. Cancer Res. 2012 Dec 01; 72(23):6247-56. PMID: 23002206.
      Citations:    
    15. Javelaud D, Pierrat MJ, Mauviel A. Crosstalk between TGF-? and hedgehog signaling in cancer. FEBS Lett. 2012 Jul 04; 586(14):2016-25. PMID: 22609357.
      Citations:    
    16. Pierrat MJ, Marsaud V, Mauviel A, Javelaud D. Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-?. J Biol Chem. 2012 May 25; 287(22):17996-8004. PMID: 22496449.
      Citations:    
    17. Widmer DS, Cheng PF, Eichhoff OM, Belloni BC, Zipser MC, Schlegel NC, Javelaud D, Mauviel A, Dummer R, Hoek KS. Systematic classification of melanoma cells by phenotype-specific gene expression mapping. Pigment Cell Melanoma Res. 2012 May; 25(3):343-53. PMID: 22336146.
      Citations:    
    18. Javelaud D, Alexaki VI, Dennler S, Mohammad KS, Guise TA, Mauviel A. TGF-?/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res. 2011 Sep 01; 71(17):5606-10. PMID: 21862631.
      Citations:    
    19. Javelaud D, Alexaki VI, Pierrat MJ, Hoek KS, Dennler S, Van Kempen L, Bertolotto C, Ballotti R, Saule S, Delmas V, Mauviel A. GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells. Pigment Cell Melanoma Res. 2011 Oct; 24(5):932-43. PMID: 21801332.
      Citations:    
    20. Javelaud D, van Kempen L, Alexaki VI, Le Scolan E, Luo K, Mauviel A. Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. Mol Cancer. 2011 Jan 06; 10(1):2. PMID: 21211030.
      Citations:    
    21. Mohammad KS, Javelaud D, Fournier PG, Niewolna M, McKenna CR, Peng XH, Duong V, Dunn LK, Mauviel A, Guise TA. TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. Cancer Res. 2011 Jan 01; 71(1):175-84. PMID: 21084275.
      Citations:    
    22. DiVito KA, Trabosh VA, Chen YS, Chen Y, Albanese C, Javelaud D, Mauviel A, Simbulan-Rosenthal CM, Rosenthal DS. Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo. Pigment Cell Melanoma Res. 2010 Dec; 23(6):795-808. PMID: 20738806.
      Citations:    
    23. Alexaki VI, Javelaud D, Van Kempen LC, Mohammad KS, Dennler S, Luciani F, Hoek KS, Ju?rez P, Goydos JS, Fournier PJ, Sibon C, Bertolotto C, Verrecchia F, Saule S, Delmas V, Ballotti R, Larue L, Saiag P, Guise TA, Mauviel A. GLI2-mediated melanoma invasion and metastasis. J Natl Cancer Inst. 2010 Aug 04; 102(15):1148-59. PMID: 20660365.
      Citations:    
    24. Schiller M, Dennler S, Anderegg U, Kokot A, Simon JC, Luger TA, Mauviel A, B?hm M. Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions. J Biol Chem. 2010 Jan 01; 285(1):409-21. PMID: 19858184.
      Citations:    
    25. Dennler S, Andr? J, Verrecchia F, Mauviel A. Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. J Biol Chem. 2009 Nov 13; 284(46):31523-31. PMID: 19797115.
      Citations:    
    26. Sextius P, Marionnet C, Bon FX, de La Chapelle AL, Tacheau C, Lahfa M, Mauviel A, Bernard BA, Leclaire J, Bernerd F, Dubertret L. Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response. Exp Dermatol. 2010 Mar; 19(3):259-68. PMID: 19765057.
      Citations:    
    27. G?ller MC, Andr? J, Legrand A, Setterblad N, Mauviel A, Verrecchia F, Daniel F, Bernuau D. c-Fos accelerates hepatocyte conversion to a fibroblastoid phenotype through ERK-mediated upregulation of paxillin-Serine178 phosphorylation. Mol Carcinog. 2009 Jun; 48(6):532-44. PMID: 18973190.
      Citations:    
    28. Mauviel A. Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk. J Invest Dermatol. 2009 Jan; 129(1):7-9. PMID: 19078982.
      Citations:    
    29. Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F. TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways. J Cell Physiol. 2008 Dec; 217(3):759-68. PMID: 18668519.
      Citations:    
    30. El Marsafy S, Bagot M, Bensussan A, Mauviel A. Dendritic cells in the skin--potential use for melanoma treatment. Pigment Cell Melanoma Res. 2009 Feb; 22(1):30-41. PMID: 19040502.
      Citations:    
    31. G?ller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F. c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 07; 14(41):6339-46. PMID: 19009649.
      Citations:    
    32. Tacheau C, Laboureau J, Mauviel A, Verrecchia F. TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling. J Cell Physiol. 2008 Aug; 216(2):438-44. PMID: 18297686.
      Citations:    
    33. Potier E, Ferreira E, Dennler S, Mauviel A, Oudina K, Logeart-Avramoglou D, Petite H. Desferrioxamine-driven upregulation of angiogenic factor expression by human bone marrow stromal cells. J Tissue Eng Regen Med. 2008 Jul; 2(5):272-8. PMID: 18512268.
      Citations:    
    34. Alexaki VI, Javelaud D, Mauviel A. JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis. Pigment Cell Melanoma Res. 2008 Aug; 21(4):429-38. PMID: 18541008.
      Citations:    
    35. Le Scolan E, Zhu Q, Wang L, Bandyopadhyay A, Javelaud D, Mauviel A, Sun L, Luo K. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res. 2008 May 01; 68(9):3277-85. PMID: 18451154.
      Citations:    
    36. Javelaud D, Alexaki VI, Mauviel A. Transforming growth factor-beta in cutaneous melanoma. Pigment Cell Melanoma Res. 2008 Apr; 21(2):123-32. PMID: 18426405.
      Citations:    
    37. Toualbi-Abed K, Daniel F, G?ller MC, Legrand A, Mauriz JL, Mauviel A, Bernuau D. Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1. Carcinogenesis. 2008 Mar; 29(3):536-43. PMID: 18174238.
      Citations:    
    38. Tacheau C, Michel L, Farge D, Mauviel A, Verrecchia F. Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices. Eur J Pharmacol. 2007 Nov 14; 573(1-3):65-9. PMID: 17706637.
      Citations:    
    39. Dennler S, Andr? J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007 Jul 15; 67(14):6981-6. PMID: 17638910.
      Citations:    
    40. Verrecchia F, Mauviel A. Transforming growth factor-beta and fibrosis. World J Gastroenterol. 2007 Jun 14; 13(22):3056-62. PMID: 17589920.
      Citations:    
    41. Javelaud D, Mohammad KS, McKenna CR, Fournier P, Luciani F, Niewolna M, Andr? J, Delmas V, Larue L, Guise TA, Mauviel A. Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis. Cancer Res. 2007 Mar 01; 67(5):2317-24. PMID: 17332363.
      Citations:    
    42. Roos N, Poulalhon N, Farge D, Madelaine I, Mauviel A, Verrecchia F. In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J Pharmacol Exp Ther. 2007 May; 321(2):583-9. PMID: 17272676.
      Citations:    
    43. Urtreger AJ, Werbajh SE, Verrecchia F, Mauviel A, Puricelli LI, Kornblihtt AR, Bal de Kier Joff? ED. Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncol Rep. 2006 Dec; 16(6):1403-10. PMID: 17089068.
      Citations:    
    44. Poulalhon N, Farge D, Roos N, Tacheau C, Neuzillet C, Michel L, Mauviel A, Verrecchia F. Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent? J Biol Chem. 2006 Nov 03; 281(44):33045-52. PMID: 16914544.
      Citations:    
    45. Verrecchia F, Mauviel A, Farge D. Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmun Rev. 2006 Oct; 5(8):563-9. PMID: 17027893.
      Citations:    
    46. Vozenin-Brotons MC, Mauviel A. [How to model the events in cutaneous fibrosis?]. Med Sci (Paris). 2006 Feb; 22(2):172-7. PMID: 16457758.
      Citations:    
    47. Javelaud D, Delmas V, M?ller M, Sextius P, Andr? J, Menashi S, Larue L, Mauviel A. Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene. 2005 Nov 17; 24(51):7624-9. PMID: 16007121.
      Citations:    
    48. Javelaud D, Mauviel A. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene. 2005 Aug 29; 24(37):5742-50. PMID: 16123807.
      Citations:    
    49. Krakowski AR, Laboureau J, Mauviel A, Bissell MJ, Luo K. Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12437-42. PMID: 16109768.
      Citations:    
    50. Dennler S, Pendaries V, Tacheau C, Costas MA, Mauviel A, Verrecchia F. The steroid receptor co-activator-1 (SRC-1) potentiates TGF-beta/Smad signaling: role of p300/CBP. Oncogene. 2005 Mar 10; 24(11):1936-45. PMID: 15688032.
      Citations:    
    51. Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie. 2005 Mar-Apr; 87(3-4):361-8. PMID: 15781323.
      Citations:    
    52. Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol. 2005 Jan; 166(1):209-19. PMID: 15632013.
      Citations:    
    53. Mauviel A. Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med. 2005; 117:69-80. PMID: 16118446.
      Citations:    
    54. Verrecchia F, Mauviel A. TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression. Cell Signal. 2004 Aug; 16(8):873-80. PMID: 15157666.
      Citations:    
    55. Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci. 2004 Aug; 35(2):83-92. PMID: 15265520.
      Citations:    
    56. Javelaud D, Mauviel A. Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles. Int J Biochem Cell Biol. 2004 Jul; 36(7):1161-5. PMID: 15109563.
      Citations:    
    57. Brellier F, Marionnet C, Chevallier-Lagente O, Toftgard R, Mauviel A, Sarasin A, Magnaldo T. Ultraviolet irradiation represses PATCHED gene transcription in human epidermal keratinocytes through an activator protein-1-dependent process. Cancer Res. 2004 Apr 15; 64(8):2699-704. PMID: 15087382.
      Citations:    
    58. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A. Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem. 2004 Apr 09; 279(15):15167-76. PMID: 14732719.
      Citations:    
    59. Schiller M, Verrecchia F, Mauviel A. Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism. Oncogene. 2003 Dec 04; 22(55):8881-90. PMID: 14654784.
      Citations:    
    60. Marionnet C, Bernerd F, Dumas A, Verrecchia F, Mollier K, Compan D, Bernard B, Lahfa M, Leclaire J, Medaisko C, Mehul B, Seit? S, Mauviel A, Dubertret L. Modulation of gene expression induced in human epidermis by environmental stress in vivo. J Invest Dermatol. 2003 Dec; 121(6):1447-58. PMID: 14675196.
      Citations:    
    61. Pendaries V, Verrecchia F, Michel S, Mauviel A. Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner. Oncogene. 2003 Nov 06; 22(50):8212-20. PMID: 14603262.
      Citations:    
    62. Wendling J, Marchand A, Mauviel A, Verrecchia F. 5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation. Mol Pharmacol. 2003 Sep; 64(3):707-13. PMID: 12920208.
      Citations:    
    63. Gabison EE, Chastang P, Menashi S, Mourah S, Doan S, Oster M, Mauviel A, Hoang-Xuan T. Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases. Ophthalmology. 2003 Aug; 110(8):1626-31. PMID: 12917183.
      Citations:    
    64. Javelaud D, Laboureau J, Gabison E, Verrecchia F, Mauviel A. Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing. J Biol Chem. 2003 Jul 04; 278(27):24624-8. PMID: 12730213.
      Citations:    
    65. Ferrigno O, Lallemand F, Verrecchia F, L'Hoste S, Camonis J, Atfi A, Mauviel A. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002 Jul 25; 21(32):4879-84. PMID: 12118366.
      Citations:    
    66. Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A. c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity. J Biol Chem. 2002 Aug 09; 277(32):29094-100. PMID: 12034730.
      Citations:    
    67. Verrecchia F, Mauviel A. Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis. Curr Rheumatol Rep. 2002 Apr; 4(2):143-9. PMID: 11890880.
      Citations:    
    Mauviel's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (354)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _