John Halperin

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Greer DM, Kirschen MP, Lewis A, Gronseth GS, Rae-Grant A, Ashwal S, Babu MA, Bauer DF, Billinghurst L, Corey A, Partap S, Rubin MA, Shutter L, Takahashi C, Tasker RC, Varelas PN, Wijdicks E, Bennett A, Wessels SR, Halperin JJ. Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline: Report of the AAN Guidelines Subcommittee, AAP, CNS, and SCCM. Neurology. 2023 Oct 11. PMID: 37821233.
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    2. Nigrovic LE, Chun TH, Vargas SE, Caffrey AR, Halperin JJ, Race JA, Ott U, Morrison BL, Fuller BJ, VanBuren JM, Lyme Net P. Comparative effectiveness and complications of intravenous ceftriaxone compared with oral doxycycline in Lyme meningitis in children: a multicentre prospective cohort study. BMJ Open. 2023 Feb 28; 13(2):e071141. PMID: 36854594.
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    3. Halperin JJ. Nervous System Lyme Disease-Facts and Fallacies. Infect Dis Clin North Am. 2022 09; 36(3):579-592. PMID: 36116836.
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    4. Halperin JJ, Eikeland R, Branda JA, Dersch R. Lyme neuroborreliosis: known knowns, known unknowns. Brain. 2022 08 27; 145(8):2635-2647. PMID: 35848861.
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    5. Vaysbrot EE, Bannuru RR, Christopher MC, Osani MC, Halperin JJ. Papilledema Secondary to Neurologic Lyme Borreliosis: A Meta-Case Series. J Neuroophthalmol. 2021 12 01; 41(4):e498-e508. PMID: 34788244.
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    6. Eckman EA, Clausen DM, Herdt AR, Pacheco-Quinto J, Halperin JJ. Specificity and Diagnostic Utility of Cerebrospinal Fluid CXCL13 in Lyme Neuroborreliosis. Clin Infect Dis. 2021 05 18; 72(10):1719-1726. PMID: 32221538.
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    7. Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clin Infect Dis. 2021 01 23; 72(1):1-8. PMID: 33483734.
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    8. Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clin Infect Dis. 2021 01 23; 72(1):e1-e48. PMID: 33417672.
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    9. Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Neurology. 2021 02 09; 96(6):262-273. PMID: 33257476.
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    10. Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care Res (Hoboken). 2021 01; 73(1):1-9. PMID: 33251700.
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    11. Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Cody Meissner H, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Rheumatol. 2021 01; 73(1):12-20. PMID: 33251716.
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    12. Halperin JJ, Pascual-Leone A, Saper CB. Symptomatic Hydrocephalus with Normal Cerebrospinal Pressure and Alzheimer's Disease. Ann Neurol. 2020 10; 88(4):685-687. PMID: 32776341.
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    13. Sico JJ, Sarwal A, Benish SM, Busis NA, Cohen BH, Das RR, Finsilver S, Halperin JJ, Kelly AG, Meunier L, Phipps MS, Thirumala PD, Villanueva R, von Gaudecker J, Bennett A, Shenoy AM. Quality improvement in neurology: Neurology Outcomes Quality Measurement Set. Neurology. 2020 06 02; 94(22):982-990. PMID: 32398356.
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    14. Halperin JJ. A Neurologist's View of Lyme Disease and Other Tick-Borne Infections. Semin Neurol. 2019 08; 39(4):440-447. PMID: 31533184.
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    15. Halperin JJ. Lyme neuroborreliosis. Curr Opin Infect Dis. 2019 06; 32(3):259-264. PMID: 30921086.
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    16. Halperin JJ. Neuroborreliosis. Neurol Clin. 2018 11; 36(4):821-830. PMID: 30366557.
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    17. Halperin JJ. Neuroborreliosis and Neurosyphilis. Continuum (Minneap Minn). 2018 10; 24(5, Neuroinfectious Disease):1439-1458. PMID: 30273247.
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    18. Eckman EA, Pacheco-Quinto J, Herdt AR, Halperin JJ. Neuroimmunomodulators in Neuroborreliosis and Lyme Encephalopathy. Clin Infect Dis. 2018 06 18; 67(1):80-88. PMID: 29340592.
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    19. Halperin JJ. Diagnosis and management of Lyme neuroborreliosis. Expert Rev Anti Infect Ther. 2018 01; 16(1):5-11. PMID: 29278020.
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    20. Halperin J. A critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease. Diagn Microbiol Infect Dis. 2017 05; 88(1):107. PMID: 28238389.
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    21. Halperin JJ. Nervous System Abnormalities and Legionnaire's Disease. Infect Dis Clin North Am. 2017 03; 31(1):55-68. PMID: 27979685.
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    22. Halperin JJ. Neuroborreliosis. J Neurol. 2017 Jun; 264(6):1292-1297. PMID: 27885483.
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    23. Halperin JJ, Moran S, Prasek D, Richards A, Ruggiero C, Maund C. Reducing Hospital-Acquired Infections Among the Neurologically Critically Ill. Neurocrit Care. 2016 10; 25(2):170-7. PMID: 27350547.
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    24. Belt GH, Felberg RA, Rubin J, Halperin JJ. In-Transit Telemedicine Speeds Ischemic Stroke Treatment: Preliminary Results. Stroke. 2016 09; 47(9):2413-5. PMID: 27491742.
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    25. Halperin JJ. Editorial Commentary: Neuroborreliosis: What Is It, What Isn't It? Clin Infect Dis. 2016 08 01; 63(3):354-5. PMID: 27161776.
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    26. Halperin JJ, Gronseth G, Gloss D. Guideline authors' response to Dr Saper's idiopathic normal pressure hydrocephalus commentary. Ann Neurol. 2016 May; 79(5):865. PMID: 27004459.
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    27. Halperin JJ, Kurlan R, Schwalb JM, Cusimano MD, Gronseth G, Gloss D. Practice guideline: Idiopathic normal pressure hydrocephalus: Response to shunting and predictors of response: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2015 Dec 08; 85(23):2063-71. PMID: 26644048.
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    28. Halperin JJ. Nervous System Lyme Disease. Clin Lab Med. 2015 Dec; 35(4):779-95. PMID: 26593257.
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    29. Halperin JJ. Nervous system Lyme disease, chronic Lyme disease, and none of the above. Acta Neurol Belg. 2016 Mar; 116(1):1-6. PMID: 26377699.
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    30. Halperin JJ. Nervous system Lyme disease. Infect Dis Clin North Am. 2015 Jun; 29(2):241-53. PMID: 25999221.
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    31. Halperin JJ. Chronic Lyme disease: misconceptions and challenges for patient management. Infect Drug Resist. 2015; 8:119-28. PMID: 26028977.
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    32. Lantos PM, Shapiro ED, Auwaerter PG, Baker PJ, Halperin JJ, McSweegan E, Wormser GP. Unorthodox alternative therapies marketed to treat Lyme disease. Clin Infect Dis. 2015 Jun 15; 60(12):1776-82. PMID: 25852124.
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    33. Halperin JJ. Nervous system lyme disease. Curr Infect Dis Rep. 2015 Jan; 17(1):445. PMID: 25421861.
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    34. Gibson CM, Mehran R, Bode C, Halperin J, Verheugt F, Wildgoose P, van Eickels M, Lip GY, Cohen M, Husted S, Peterson E, Fox K. An open-label, randomized, controlled, multicenter study exploring two treatment strategies of rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment strategy in subjects with atrial fibrillation who undergo percutaneous coronary intervention (PIONEER AF-PCI). Am Heart J. 2015 Apr; 169(4):472-8.e5. PMID: 25819853.
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    35. Halperin JJ. Lyme disease: neurology, neurobiology, and behavior. Clin Infect Dis. 2014 May; 58(9):1267-72. PMID: 24571864.
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    36. Halperin JJ. Nervous system Lyme disease. Handb Clin Neurol. 2014; 121:1473-83. PMID: 24365431.
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    37. Baird RA, Wiebe S, Zunt JR, Halperin JJ, Roos KL. Author response. Neurology. 2013 Oct 15; 81(16):1475-6. PMID: 24278970.
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    38. Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ, Wormser GP. The reply. Am J Med. 2014 Feb; 127(2):e11-2. PMID: 24462014.
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    39. Halperin JJ, Baker PJ, Wormser GP. The reply. Am J Med. 2013 Aug; 126(8):e17-8. PMID: 23885683.
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    40. Halperin JJ. Nervous system lyme disease: diagnosis and treatment. Curr Treat Options Neurol. 2013 Aug; 15(4):454-64. PMID: 23666548.
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    41. Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ, Wormser GP. Treatment trials for post-Lyme disease symptoms revisited. Am J Med. 2013 Aug; 126(8):665-9. PMID: 23764268.
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    42. Wormser GP, Halperin JJ. Toward a better understanding of European lyme neuroborreliosis. Clin Infect Dis. 2013 Aug; 57(4):510-2. PMID: 23667261.
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    43. Baird RA, Wiebe S, Zunt JR, Halperin JJ, Gronseth G, Roos KL. Evidence-based guideline: treatment of parenchymal neurocysticercosis: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013 Apr 09; 80(15):1424-9. PMID: 23568997.
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    44. Halperin JJ, Baker P, Wormser GP. Common misconceptions about Lyme disease. Am J Med. 2013 Mar; 126(3):264.e1-7. PMID: 23321431.
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    45. Usmani-Brown S, Halperin JJ, Krause PJ. Neurological manifestations of human babesiosis. Handb Clin Neurol. 2013; 114:199-203. PMID: 23829910.
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    46. Halperin JJ. Lyme disease: a multisystem infection that affects the nervous system. Continuum (Minneap Minn). 2012 Dec; 18(6 Infectious Disease):1338-50. PMID: 23221844.
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    47. Halperin JJ. Bell's palsy treatment strategies: Antivirals may help some patients. Neurol Clin Pract. 2012 Sep; 2(3):245-247. PMID: 29443302.
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    48. Halperin JJ. Nervous system lyme disease: is there a controversy? Semin Neurol. 2011 Jul; 31(3):317-24. PMID: 21964848.
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    49. Auwaerter PG, Bakken JS, Dattwyler RJ, Dumler JS, Halperin JJ, McSweegan E, Nadelman RB, O'Connell S, Shapiro ED, Sood SK, Steere AC, Weinstein A, Wormser GP. Antiscience and ethical concerns associated with advocacy of Lyme disease. Lancet Infect Dis. 2011 Sep; 11(9):713-9. PMID: 21867956.
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    50. Halperin JJ. Neurologic manifestations of lyme disease. Curr Infect Dis Rep. 2011 Aug; 13(4):360-6. PMID: 21484219.
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    51. Auwaerter PG, Bakken JS, Dattwyler RJ, Dumler JS, Halperin JJ, McSweegan E, Nadelman RB, O'Connell S, Sood SK, Weinstein A, Wormser GP. Scientific evidence and best patient care practices should guide the ethics of Lyme disease activism. J Med Ethics. 2011 Feb; 37(2):68-73. PMID: 21097940.
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    52. Lupski JR, Reid JG, Gonzaga-Jauregui C, Rio Deiros D, Chen DC, Nazareth L, Bainbridge M, Dinh H, Jing C, Wheeler DA, McGuire AL, Zhang F, Stankiewicz P, Halperin JJ, Yang C, Gehman C, Guo D, Irikat RK, Tom W, Fantin NJ, Muzny DM, Gibbs RA. Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. N Engl J Med. 2010 Apr 01; 362(13):1181-91. PMID: 20220177.
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    53. Halperin JJ. A tale of two spirochetes: lyme disease and syphilis. Neurol Clin. 2010 Feb; 28(1):277-91. PMID: 19932386.
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    54. Halperin JJ. Nervous system lyme disease: diagnosis and treatment. Rev Neurol Dis. 2009; 6(1):4-12. PMID: 19367218.
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    55. Wormser GP, Halperin JJ. Oral doxycycline for neuroborreliosis. Lancet Neurol. 2008 Aug; 7(8):665-6. PMID: 18567540.
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    56. Halperin JJ. Nervous system Lyme disease. Infect Dis Clin North Am. 2008 Jun; 22(2):261-74, vi. PMID: 18452800.
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    57. Halperin JJ. Infectious disease. Rev Neurol Dis. 2008; 5(2):106-8. PMID: 18660748.
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    58. Halperin JJ. Prolonged Lyme disease treatment: enough is enough. Neurology. 2008 Mar 25; 70(13):986-7. PMID: 17928578.
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    59. Halperin JJ. Diagnosis and treatment of the neuromuscular manifestations of lyme disease. Curr Treat Options Neurol. 2007 Mar; 9(2):93-100. PMID: 17298770.
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    60. Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2006 Nov 01; 43(9):1089-134. PMID: 17029130.
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    61. Halperin JJ. Is neuroborreliosis a medical emergency? Neurocrit Care. 2006; 4(3):260-6. PMID: 16757836.
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    62. Halperin JJ. Central nervous system Lyme disease. Curr Neurol Neurosci Rep. 2005 Nov; 5(6):446-52. PMID: 16263055.
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    63. Kalina P, Decker A, Kornel E, Halperin JJ. Lyme disease of the brainstem. Neuroradiology. 2005 Dec; 47(12):903-7. PMID: 16158278.
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    64. Halperin JJ. Central Nervous System Lyme Disease. Curr Infect Dis Rep. 2004 Aug; 6(4):298-304. PMID: 15265459.
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    65. Halperin JJ. Facial nerve palsy associated with lyme disease. Muscle Nerve. 2003 Oct; 28(4):516-7. PMID: 14506728.
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    66. Halperin JJ. Lyme disease and the peripheral nervous system. Muscle Nerve. 2003 Aug; 28(2):133-43. PMID: 12872317.
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    67. Halperin JJ. Nervous system Lyme disease. Vector Borne Zoonotic Dis. 2002; 2(4):241-7. PMID: 12804165.
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