George Iliakis

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dueva R, Krieger LM, Li F, Luo D, Xiao H, Stuschke M, Metzen E, Iliakis G. Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response. Int J Mol Sci. 2023 Oct 06; 24(19). PMID: 37834389.
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    2. Mladenov E, Mladenova V, Stuschke M, Iliakis G. New Facets of DNA Double Strand Break Repair: Radiation Dose as Key Determinant of HR versus c-NHEJ Engagement. Int J Mol Sci. 2023 Oct 06; 24(19). PMID: 37834403.
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    3. Haberland VMM, Magin S, Iliakis G, Hartwig A. Impact of Manganese and Chromate on Specific DNA Double-Strand Break Repair Pathways. Int J Mol Sci. 2023 Jun 20; 24(12). PMID: 37373538.
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    4. Li F, Mladenov E, Sun Y, Soni A, Stuschke M, Timmermann B, Iliakis G. Low CDK Activity and Enhanced Degradation by APC/CCDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells. Cells. 2023 Jun 01; 12(11). PMID: 37296650.
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    5. Luo D, Mladenov E, Soni A, Stuschke M, Iliakis G. The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G2-Checkpoint Activation in Cells Exposed to Ionizing Radiation. Cells. 2023 05 14; 12(10). PMID: 37408221.
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    6. Soni A, Lin X, Mladenov E, Mladenova V, Stuschke M, Iliakis G. BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy. Cancers (Basel). 2022 Nov 16; 14(22). PMID: 36428712.
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    7. Pei X, Mladenov E, Soni A, Li F, Stuschke M, Iliakis G. PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination. Int J Mol Sci. 2022 Oct 25; 23(21). PMID: 36361678.
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    8. Tremi I, Havaki S, Georgitsopoulou S, Terzoudi G, Lykakis IN, Iliakis G, Georgakilas V, Gorgoulis VG, Georgakilas AG. Biological Response of Human Cancer Cells to Ionizing Radiation in Combination with Gold Nanoparticles. Cancers (Basel). 2022 Oct 17; 14(20). PMID: 36291870.
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    9. Mladenova V, Mladenov E, Chaudhary S, Stuschke M, Iliakis G. The high toxicity of DSB-clusters modelling high-LET-DNA damage derives from inhibition of c-NHEJ and promotion of alt-EJ and SSA despite increases in HR. Front Cell Dev Biol. 2022; 10:1016951. PMID: 36263011.
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    10. Xu S, Sak A, Niedermaier B, Erol YB, Groneberg M, Mladenov E, Kang M, Iliakis G, Stuschke M. Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy. Front Oncol. 2022; 12:999626. PMID: 36249060.
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    11. Khozooei S, Lettau K, Barletta F, Jost T, Rebholz S, Veerappan S, Franz-Wachtel M, Macek B, Iliakis G, Distel LV, Zips D, Toulany M. Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells. J Exp Clin Cancer Res. 2022 Aug 22; 41(1):256. PMID: 35989353.
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    12. Mladenov E, Paul-Konietzko K, Mladenova V, Stuschke M, Iliakis G. Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination. Int J Mol Sci. 2022 Aug 16; 23(16). PMID: 36012445.
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    13. Soni A, Duan X, Stuschke M, Iliakis G. ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions. Int J Mol Sci. 2022 Jul 06; 23(14). PMID: 35886852.
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    14. Xiao H, Li F, Mladenov E, Soni A, Mladenova V, Pan B, Dueva R, Stuschke M, Timmermann B, Iliakis G. Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Cells. 2022 07 02; 11(13). PMID: 35805183.
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    15. Hamidi A, Wolf A, Dueva R, Kaufmann M, G?pelt K, Iliakis G, Metzen E. Depletion of HIF-1a by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia. Cells. 2022 05 18; 11(10). PMID: 35626708.
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    16. Mladenova V, Mladenov E, Stuschke M, Iliakis G. DNA Damage Clustering after Ionizing Radiation and Consequences in the Processing of Chromatin Breaks. Molecules. 2022 Feb 24; 27(5). PMID: 35268641.
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    17. Li F, Mladenov E, Dueva R, Stuschke M, Timmermann B, Iliakis G. Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation. Cells. 2021 12 27; 11(1). PMID: 35011623.
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    18. Hassiepen C, Soni A, Rudolf I, Boron V, Oeck S, Iliakis G, Schramm A. NTRK1/TrkA Activation Overrides the G2/M-Checkpoint upon Irradiation. Cancers (Basel). 2021 Nov 30; 13(23). PMID: 34885133.
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    19. Krieger LM, Mladenov E, Soni A, Demond M, Stuschke M, Iliakis G. Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA. Int J Mol Sci. 2021 Oct 11; 22(20). PMID: 34681628.
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    20. Mladenova V, Mladenov E, Scholz M, Stuschke M, Iliakis G. Strong Shift to ATR-Dependent Regulation of the G2-Checkpoint after Exposure to High-LET Radiation. Life (Basel). 2021 Jun 14; 11(6). PMID: 34198619.
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    21. Murmann-Konda T, Soni A, Stuschke M, Iliakis G. Analysis of chromatid-break-repair detects a homologous recombination to non-homologous end-joining switch with increasing load of DNA double-strand breaks. Mutat Res Genet Toxicol Environ Mutagen. 2021 Jul; 867:503372. PMID: 34266628.
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    22. Nikolakopoulou A, Soni A, Habibi M, Karaiskos P, Pantelias G, Terzoudi GI, Iliakis G. G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells. Front Public Health. 2021; 9:675095. PMID: 34123995.
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    23. Iliakis GE. New Players in the Regulation of DNA-PK Activity: Survivin Joins the Crowd. Cancer Res. 2021 05 01; 81(9):2270-2271. PMID: 34003784.
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    24. Magin S, Meher PK, Iliakis G. Nucleoside Analogs Radiosensitize G0 Cells by Activating DNA End Resection and Alternative End-Joining. Radiat Res. 2021 05 01; 195(5):412-426. PMID: 33755161.
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    25. Soni A, Mladenov E, Iliakis G. Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses. DNA Repair (Amst). 2021 05; 101:103076. PMID: 33640756.
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    26. Liu Q, Palomero L, Moore J, Guix I, Esp?n R, Ayt?s A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH. Loss of TGF? signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Sci Transl Med. 2021 02 10; 13(580). PMID: 33568520.
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    27. Dueva R, Iliakis G. Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. NAR Cancer. 2020 Sep; 2(3):zcaa022. PMID: 34316690.
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    28. Li F, Mladenov E, Mortoga S, Iliakis G. SCFSKP2 regulates APC/CCDH1-mediated degradation of CTIP to adjust DNA-end resection in G2-phase. Cell Death Dis. 2020 07 18; 11(7):548. PMID: 32683422.
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    29. Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2020 05 21; 48(9):5200. PMID: 32239214.
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    30. Wang X, Guan J, Hu B, Weiss RS, Iliakis G, Wang Y. Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation. Nucleic Acids Res. 2020 04 06; 48(6):3396. PMID: 32095815.
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    31. Mladenov E, Staudt C, Soni A, Murmann-Konda T, Siemann-Loekes M, Iliakis G. Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52. Nucleic Acids Res. 2020 02 28; 48(4):1905-1924. PMID: 31832684.
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    32. Soni A, Murmann-Konda T, Siemann-Loekes M, Pantelias GE, Iliakis G. Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion. DNA Repair (Amst). 2020 05; 89:102828. PMID: 32143127.
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    33. Magin S, Georgoulis A, Papadimitriou K, Iliakis G, Vorgias CE. Complete Genome Sequence of the Deep-Sea Bacterium Moritella marina MP-1 (ATCC 15381). Microbiol Resour Announc. 2020 Jan 23; 9(4). PMID: 31974151.
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    34. Iliakis G, Mladenov E, Mladenova V. Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers (Basel). 2019 Oct 28; 11(11). PMID: 31661831.
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    35. Mladenov E, Fan X, Paul-Konietzko K, Soni A, Iliakis G. DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells. Sci Rep. 2019 10 10; 9(1):14597. PMID: 31601897.
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    36. Richter C, Marquardt S, Li F, Spitschak A, Murr N, Edelh?user BAH, Iliakis G, P?tzer BM, Logotheti S. Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness. J Exp Clin Cancer Res. 2019 Jul 08; 38(1):292. PMID: 31287003.
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    37. Hamada N, Mothersill CE, Iliakis G. Preface to the IJRB 60th anniversary special issue "back to our future". Int J Radiat Biol. 2019 07; 95(7):799-801. PMID: 31156009.
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    38. Mladenov E, Fan X, Dueva R, Soni A, Iliakis G. Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase. Sci Rep. 2019 06 04; 9(1):8255. PMID: 31164689.
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    39. Iliakis G, Mladenova V, Sharif M, Chaudhary S, Mavragani IV, Soni A, Saha J, Schipler A, Mladenov E. DEFINED BIOLOGICAL MODELS OF HIGH-LET RADIATION LESIONS. Radiat Prot Dosimetry. 2019 May 01; 183(1-2):60-68. PMID: 30566664.
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    40. Soni A, Murmann-Konda T, Magin S, Iliakis G. A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks. Mutat Res. 2019 05; 815:10-19. PMID: 30999232.
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    41. Vaidya M, Jentsch JA, Peters S, Keul P, Weske S, Gr?ler MH, Mladenov E, Iliakis G, Heusch G, Levkau B. Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res. 2019 03; 60(3):506-515. PMID: 30655318.
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    42. Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, Brockmeier U, Metzen E. The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia. BMC Cancer. 2018 Nov 29; 18(1):1190. PMID: 30497423.
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    43. Oeck S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska B, Iliakis G, Timmermann B, Jendrossek V. Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak Protons. Int J Mol Sci. 2018 Nov 28; 19(12). PMID: 30486506.
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    44. Szymonowicz K, Oeck S, Krysztofiak A, van der Linden J, Iliakis G, Jendrossek V. Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells. Int J Mol Sci. 2018 Jul 31; 19(8). PMID: 30065170.
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    45. Soni A, Li F, Wang Y, Grabos M, Krieger LM, Chaudhary S, Hasan MSM, Ahmed M, Coleman CN, Teicher BA, Piekarz RL, Wang D, Iliakis GE. Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks. Mol Cancer Ther. 2018 10; 17(10):2206-2216. PMID: 29970481.
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    46. Suntharalingam S, Mladenov E, Sarabhai T, Wetter A, Kraff O, Quick HH, Forsting M, Iliakis G, Nassenstein K. Abdominopelvic 1.5-T and 3.0-T MR Imaging in Healthy Volunteers: Relationship to Formation of DNA Double-Strand Breaks. Radiology. 2018 08; 288(2):529-535. PMID: 29714683.
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    47. Mladenov E, Li F, Zhang L, Klammer H, Iliakis G. Intercellular communication of DNA damage and oxidative status underpin bystander effects. Int J Radiat Biol. 2018 08; 94(8):719-726. PMID: 29377786.
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    48. Mothersill C, Abend M, Br?chignac F, Iliakis G, Impens N, Kadhim M, M?ller AP, Oughton D, Powathil G, Saenen E, Seymour C, Sutcliffe J, Tang FR, Schofield PN. When a duck is not a duck; a new interdisciplinary synthesis for environmental radiation protection. Environ Res. 2018 04; 162:318-324. PMID: 29407763.
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    49. Mladenov E, Saha J, Iliakis G. Processing-Challenges Generated by Clusters of DNA Double-Strand Breaks Underpin Increased Effectiveness of High-LET Radiation and Chromothripsis. Adv Exp Med Biol. 2018; 1044:149-168. PMID: 29956296.
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    50. Wieczorek SA, Breitenbuecher F, Soni A, Paul-Konietzko K, Ziegler S, Sak A, Iliakis G, Schuler M. Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer. J Cancer Res Clin Oncol. 2017 Sep; 143(9):1733-1744. PMID: 28432456.
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    51. Nikitaki Z, Nikolov V, Mavragani IV, Mladenov E, Mangelis A, Laskaratou DA, Fragkoulis GI, Hellweg CE, Martin OA, Emfietzoglou D, Hatzi VI, Terzoudi GI, Iliakis G, Georgakilas AG. Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET). Free Radic Res. 2016 Nov; 50(sup1):S64-S78. PMID: 27593437.
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    52. van den Boom J, Wolf M, Weimann L, Schulze N, Li F, Kaschani F, Riemer A, Zierhut C, Kaiser M, Iliakis G, Funabiki H, Meyer H. VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Mol Cell. 2016 10 06; 64(1):189-198. PMID: 27716483.
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    53. Mladenova V, Mladenov E, Iliakis G. Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological Effects of High LET Radiation. Front Oncol. 2016; 6:163. PMID: 27446809.
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    54. Schipler A, Mladenova V, Soni A, Nikolov V, Saha J, Mladenov E, Iliakis G. Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment. Nucleic Acids Res. 2016 09 19; 44(16):7673-90. PMID: 27257076.
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    55. Mladenov E, Magin S, Soni A, Iliakis G. DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation. Semin Cancer Biol. 2016 06; 37-38:51-64. PMID: 27016036.
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    56. Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S. "Praising What Is Lost. . . Radiat Res. 2015 Dec; 184(6):563-4. PMID: 27064149.
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    57. Cheng Y, Li F, Mladenov E, Iliakis G. The yield of DNA double strand breaks determined after exclusion of those forming from heat-labile lesions predicts tumor cell radiosensitivity to killing. Radiother Oncol. 2015 Sep; 116(3):366-73. PMID: 26303013.
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    58. Paul-Konietzko K, Thomale J, Arakawa H, Iliakis G. DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency. Photochem Photobiol. 2015 Sep-Oct; 91(5):1173-80. PMID: 26131740.
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    59. Soni A, Siemann M, Pantelias GE, Iliakis G. Marked contribution of alternative end-joining to chromosome-translocation-formation by stochastically induced DNA double-strand-breaks in G2-phase human cells. Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov; 793:2-8. PMID: 26520366.
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    60. Iliakis G, Murmann T, Soni A. Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations. Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov; 793:166-75. PMID: 26520387.
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    61. Arakawa H, Iliakis G. Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III. Genes (Basel). 2015 Jun 23; 6(2):385-98. PMID: 26110316.
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    62. Moscariello M, Wieloch R, Kurosawa A, Li F, Adachi N, Mladenov E, Iliakis G. Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining. DNA Repair (Amst). 2015 Jul; 31:29-40. PMID: 25973742.
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    63. Magin S, Papaioannou M, Saha J, Staudt C, Iliakis G. Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside-Nucleoside Analogue Radiosensitization. Mol Cancer Ther. 2015 Jun; 14(6):1424-33. PMID: 25840584.
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    64. Li F, Cheng Y, Iliakis G. The contribution of thermally labile sugar lesions to DNA double-strand break formation in cells grown in the presence of BrdU. Int J Radiat Biol. 2015 Apr; 91(4):312-20. PMID: 25510257.
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    65. Soni A, Siemann M, Grabos M, Murmann T, Pantelias GE, Iliakis G. Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining. Nucleic Acids Res. 2014 Jun; 42(10):6380-92. PMID: 24748665.
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    66. Riemer A, Dobrynin G, Dressler A, Bremer S, Soni A, Iliakis G, Meyer H. The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation. Cell Cycle. 2014; 13(6):919-27. PMID: 24429874.
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    67. Klammer H, Mladenov E, Li F, Iliakis G. Bystander effects as manifestation of intercellular communication of DNA damage and of the cellular oxidative status. Cancer Lett. 2015 Jan 01; 356(1):58-71. PMID: 24370566.
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    68. Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD. Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science. 2014 Jan 03; 343(6166):88-91. PMID: 24310611.
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    69. Wu W, Kong Z, Duan X, Zhu H, Li S, Zeng S, Liang Y, Iliakis G, Gui Z, Yang D. Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells. Biochem Biophys Res Commun. 2013 Dec 06; 442(1-2):127-32. PMID: 24239883.
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    70. Honke N, Shaabani N, Zhang DE, Iliakis G, Xu HC, H?ussinger D, Recher M, L?hning M, Lang PA, Lang KS. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog. 2013 Oct; 9(10):e1003650. PMID: 24204252.
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    71. Moscariello M, Iliakis G. Effects of chromatin decondensation on alternative NHEJ. DNA Repair (Amst). 2013 Nov; 12(11):972-81. PMID: 24051048.
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    72. Schipler A, Iliakis G. DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res. 2013 Sep; 41(16):7589-605. PMID: 23804754.
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    73. Mladenov E, Magin S, Soni A, Iliakis G. DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol. 2013; 3:113. PMID: 23675572.
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    74. Singh SK, Bencsik-Theilen A, Mladenov E, Jakob B, Taucher-Scholz G, Iliakis G. Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions. Radiat Oncol. 2013 Apr 02; 8:77. PMID: 23547740.
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    75. Paul K, Wang M, Mladenov E, Bencsik-Theilen A, Bednar T, Wu W, Arakawa H, Iliakis G. DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. PLoS One. 2013; 8(3):e59505. PMID: 23555685.
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    76. Magin S, Saha J, Wang M, Mladenova V, Coym N, Iliakis G. Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines. DNA Repair (Amst). 2013 Feb 01; 12(2):148-60. PMID: 23286905.
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    77. Singh SK, Wu W, Stuschke M, Bockisch A, Iliakis G. Reduced contribution of thermally-labile sugar lesions to DNA double-strand break formation after exposure to neutrons. Radiat Res. 2012 Dec; 178(6):581-90. PMID: 23088767.
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    78. Mothersill C, Antonelli F, Dahle J, Dini V, Hegyesi H, Iliakis G, K?m?r?inen K, Launonen V, Lumniczky K, Lyng F, Safrany G, Salomaa S, Schilling-T?th B, Tabocchini A, Kadhim MA. A laboratory inter-comparison of the importance of serum serotonin levels in the measurement of a range of radiation-induced bystander effects: overview of study and results presentation. Int J Radiat Biol. 2012 Oct; 88(10):763-9. PMID: 22891994.
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    79. Manova V, Singh SK, Iliakis G. Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome Integr. 2012 Aug 22; 3(1):4. PMID: 22908892.
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    80. Klammer H, Iliakis G. The impact of serotonin on the development of bystander damage assessed by ?-H2AX foci analysis. Int J Radiat Biol. 2012 Oct; 88(10):777-80. PMID: 22747498.
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    81. Singh SK, Bednar T, Zhang L, Wu W, Mladenov E, Iliakis G. Inhibition of B-NHEJ in plateau-phase cells is not a direct consequence of suppressed growth factor signaling. Int J Radiat Oncol Biol Phys. 2012 Oct 01; 84(2):e237-43. PMID: 22658216.
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    82. Klammer H, Zhang LH, Kadhim M, Iliakis G. Dependence of adaptive response and its bystander transmission on the genetic background of tested cells. Int J Radiat Biol. 2012 Oct; 88(10):720-6. PMID: 22574641.
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    83. Stankova K, Ivanova K, Mladenov E, Rosidi B, Sharma A, Boteva R, Iliakis G. Conformational transitions of proteins engaged in DNA double-strand break repair, analysed by tryptophan fluorescence emission and FRET. Biochem J. 2012 May 01; 443(3):701-9. PMID: 22338600.
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    84. Iliakis G, Mladenov E, Cheong N. In vitro rejoining of double strand breaks in genomic DNA. Methods Mol Biol. 2012; 920:471-84. PMID: 22941623.
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    85. Iliakis G, Mladenov E, Wang Y, Wang HY. Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication. Methods Mol Biol. 2012; 920:591-602. PMID: 22941629.
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    86. Arakawa H, Bednar T, Wang M, Paul K, Mladenov E, Bencsik-Theilen AA, Iliakis G. Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells. Nucleic Acids Res. 2012 Mar; 40(6):2599-610. PMID: 22127868.
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    87. Singh SK, Wang M, Staudt C, Iliakis G. Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Res. 2011 Oct; 39(19):8416-29. PMID: 21745815.
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    88. Mladenov E, Iliakis G. Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat Res. 2011 Jun 03; 711(1-2):61-72. PMID: 21329706.
      Citations:    
    89. Singh SK, Wu W, Zhang L, Klammer H, Wang M, Iliakis G. Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors. Int J Radiat Oncol Biol Phys. 2011 Feb 01; 79(2):540-8. PMID: 20950945.
      Citations:    
    90. Fan X, Cheong N, Iliakis G. Initial characterization of a low-molecular-weight factor enhancing the checkpoint response. Radiat Res. 2010 Oct; 174(4):424-35. PMID: 20731590.
      Citations:    
    91. Klammer H, Kadhim M, Iliakis G. Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells. Cancer Res. 2010 Nov 01; 70(21):8498-506. PMID: 20861183.
      Citations:    
    92. Iliakis G. New partners for Chk1. Cell Cycle. 2010 Jun 01; 9(11):2061-2. PMID: 20559029.
      Citations:    
    93. Iliakis G. The anatomy and cell cycle evolution of DNA damage signaling and repair foci. Cell Cycle. 2010 Feb 01; 9(3):444-5. PMID: 20130450.
      Citations:    
    94. Mart?n M, Terradas M, Iliakis G, Tusell L, Genesc? A. Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells. Genes Chromosomes Cancer. 2009 Sep; 48(9):745-59. PMID: 19455703.
      Citations:    
    95. Singh SK, Wu W, Wu W, Wang M, Iliakis G. Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK-dependent pathway of NHEJ after exclusion of heat-labile sites. Radiat Res. 2009 Aug; 172(2):152-64. PMID: 19630520.
      Citations:    
    96. Iliakis G. Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence. Radiother Oncol. 2009 Sep; 92(3):310-5. PMID: 19604590.
      Citations:    
    97. Raschke S, Guan J, Iliakis G. Application of alkaline sucrose gradient centrifugation in the analysis of DNA replication after DNA damage. Methods Mol Biol. 2009; 521:329-42. PMID: 19563115.
      Citations:    
    98. Terzoudi GI, Singh SK, Pantelias GE, Iliakis G. Premature chromosome condensation reveals DNA-PK independent pathways of chromosome break repair. Int J Oncol. 2008 Oct; 33(4):871-9. PMID: 18813802.
      Citations:    
    99. Wu W, Wang M, Mussfeldt T, Iliakis G. Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ. Radiat Res. 2008 Oct; 170(4):512-20. PMID: 19024658.
      Citations:    
    100. Kinner A, Wu W, Staudt C, Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008 Oct; 36(17):5678-94. PMID: 18772227.
      Citations:    
    101. Rosidi B, Wang M, Wu W, Sharma A, Wang H, Iliakis G. Histone H1 functions as a stimulatory factor in backup pathways of NHEJ. Nucleic Acids Res. 2008 Mar; 36(5):1610-23. PMID: 18250087.
      Citations:    
    102. Iliakis G, Wu W, Wang M. DNA double strand break repair inhibition as a cause of heat radiosensitization: re-evaluation considering backup pathways of NHEJ. Int J Hyperthermia. 2008 Feb; 24(1):17-29. PMID: 18214766.
      Citations:    
    103. Wu W, Wang M, Wu W, Singh SK, Mussfeldt T, Iliakis G. Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2. DNA Repair (Amst). 2008 Feb 01; 7(2):329-38. PMID: 18155970.
      Citations:    
    104. Windhofer F, Wu W, Iliakis G. Low levels of DNA ligases III and IV sufficient for effective NHEJ. J Cell Physiol. 2007 Nov; 213(2):475-83. PMID: 17492771.
      Citations:    
    105. Windhofer F, Wu W, Wang M, Singh SK, Saha J, Rosidi B, Iliakis G. Marked dependence on growth state of backup pathways of NHEJ. Int J Radiat Oncol Biol Phys. 2007 Aug 01; 68(5):1462-70. PMID: 17674976.
      Citations:    
    106. Wang H, Wang M, Reiss K, Darbinian-Sarkissian N, Johnson EM, Iliakis G, Amini S, Khalili K, Rappaport J. Evidence for the involvement of Puralpha in response to DNA replication stress. Cancer Biol Ther. 2007 Apr; 6(4):596-602. PMID: 17374989.
      Citations:    
    107. Tamulevicius P, Wang M, Iliakis G. Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response. Radiat Res. 2007 Jan; 167(1):1-11. PMID: 17214519.
      Citations:    
    108. Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 2006; 34(21):6170-82. PMID: 17088286.
      Citations:    
    109. B?cker W, Iliakis G. Computational Methods for analysis of foci: validation for radiation-induced gamma-H2AX foci in human cells. Radiat Res. 2006 Jan; 165(1):113-24. PMID: 16392969.
      Citations:    
    110. Iliakis G, Rosidi B, Wang M, Wang H. Plasmid-based assays for DNA end-joining in vitro. Methods Mol Biol. 2006; 314:123-31. PMID: 16673879.
      Citations:    
    111. Iliakis G, Cheong N. In vitro rejoining of double-strand breaks in genomic DNA. Methods Mol Biol. 2006; 314:95-108. PMID: 16673877.
      Citations:    
    112. Iliakis G, Wang Y, Wang HY. Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication. Methods Mol Biol. 2006; 314:61-71. PMID: 16673874.
      Citations:    
    113. Terzoudi GI, Manola KN, Pantelias GE, Iliakis G. Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells. Cancer Res. 2005 Dec 15; 65(24):11292-6. PMID: 16357135.
      Citations:    
    114. Harder D, Iliakis G. Wolfgang Pohlit (1928-2005). Radiat Res. 2005 Dec; 164(6):830-2. PMID: 16296892.
      Citations:    
    115. Mart?n M, Genesc? A, Latre L, Jaco I, Taccioli GE, Egozcue J, Blasco MA, Iliakis G, Tusell L. Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts. Cancer Res. 2005 Nov 15; 65(22):10223-32. PMID: 16288010.
      Citations:    
    116. Banaz-Yasar F, Tischka R, Iliakis G, Winterhager E, Gellhaus A. Cell line specific modulation of connexin43 expression after exposure to ionizing radiation. Cell Commun Adhes. 2005 Jul-Dec; 12(5-6):249-59. PMID: 16531320.
      Citations:    
    117. Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F, Iliakis G. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 2005 May 15; 65(10):4020-30. PMID: 15899791.
      Citations:    
    118. Wang H, Wang M, Wang H, B?cker W, Iliakis G. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. J Cell Physiol. 2005 Feb; 202(2):492-502. PMID: 15389585.
      Citations:    
    119. Wu WZ, Sun HC, Shen YF, Chen J, Wang L, Tang ZY, Iliakis G, Liu KD. Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways. J Cancer Res Clin Oncol. 2005 Mar; 131(3):169-78. PMID: 15662525.
      Citations:    
    120. Wang H, Wang H, Powell SN, Iliakis G, Wang Y. ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining. Cancer Res. 2004 Oct 01; 64(19):7139-43. PMID: 15466211.
      Citations:    
    121. Perrault R, Wang H, Wang M, Rosidi B, Iliakis G. Backup pathways of NHEJ are suppressed by DNA-PK. J Cell Biochem. 2004 Jul 01; 92(4):781-94. PMID: 15211575.
      Citations:    
    122. Wang X, Guan J, Hu B, Weiss RS, Iliakis G, Wang Y. Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation. Nucleic Acids Res. 2004; 32(2):767-75. PMID: 14762204.
      Citations:    
    123. Wang H, Boecker W, Wang H, Wang X, Guan J, Thompson LH, Nickoloff JA, Iliakis G. Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks. Oncogene. 2004 Jan 22; 23(3):824-34. PMID: 14737117.
      Citations:    
    124. Wu WZ, Sun HC, Gao YQ, Li Y, Wang L, Zhou K, Liu KD, Iliakis G, Tang ZY. Reduction in p48-ISGFgamma levels confers resistance to interferon-alpha2a in MHCC97 cells. Oncology. 2004; 67(5-6):428-40. PMID: 15714000.
      Citations:    
    125. Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G. Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res. 2003 Sep 15; 31(18):5377-88. PMID: 12954774.
      Citations:    
    126. Iliakis G, Wang Y, Guan J, Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene. 2003 Sep 01; 22(37):5834-47. PMID: 12947390.
      Citations:    
    127. Wang X, Khadpe J, Hu B, Iliakis G, Wang Y. An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J Biol Chem. 2003 Aug 15; 278(33):30869-74. PMID: 12791699.
      Citations:    
    128. Dicker AP, Williams TL, Iliakis G, Grant DS. Targeting angiogenic processes by combination low-dose paclitaxel and radiation therapy. Am J Clin Oncol. 2003 Jun; 26(3):e45-53. PMID: 12796615.
      Citations:    
    129. Wang H, Wang X, Iliakis G, Wang Y. Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing. Radiat Res. 2003 Mar; 159(3):420-5. PMID: 12600245.
      Citations:    
    130. Wang X, Wang H, Iliakis G, Wang Y. Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks. Radiat Res. 2003 Mar; 159(3):426-32. PMID: 12600246.
      Citations:    
    131. Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene. 2003 Jan 09; 22(1):131-46. PMID: 12527915.
      Citations:    
    132. Zhou XY, Wang X, Wang H, Chen DJ, Li GC, Iliakis G, Wang Y. Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene. 2002 Sep 12; 21(41):6377-81. PMID: 12214278.
      Citations:    
    133. Wang H, Wang X, Zhou XY, Chen DJ, Li GC, Iliakis G, Wang Y. Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. Cancer Res. 2002 May 01; 62(9):2483-7. PMID: 11980637.
      Citations:    
    134. Zhou XY, Wang X, Hu B, Guan J, Iliakis G, Wang Y. An ATM-independent S-phase checkpoint response involves CHK1 pathway. Cancer Res. 2002 Mar 15; 62(6):1598-603. PMID: 11912127.
      Citations:    
    135. Guan J, Stavridi E, Leeper DB, Iliakis G. Effects of hyperthermia on p53 protein expression and activity. J Cell Physiol. 2002 Mar; 190(3):365-74. PMID: 11857452.
      Citations:    
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