David Cook

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    I01BX000420     (COOK, DAVID G)Oct 1, 2009 - Sep 30, 2013
    NIH
    Glutamate dyshomeostasis: The role of glutamate transport dysfunction in Alzheim
    Role: Principal Investigator

    I01BX002311     (COOK, DAVID G)Oct 1, 2013 - Dec 31, 2021
    NIH
    Building translationally relevant relationships between neuropathology and abnormal neuroimaging in Veterans and mechanisms of blast-induced neurotrauma in mice
    Role: Principal Investigator

    R01AG075338     (COOK, DAVID G)Apr 1, 2022 - Dec 31, 2026
    NIH
    Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease Pathogenesis
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ. Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function. Brain. 2024 Jun 03; 147(6):2214-2229. PMID: 38802114.
      Citations:    
    2. Li G, Iliff J, Shofer J, Mayer CL, Meabon J, Cook D, Pagulayan KF, Raskind MA, Zetterberg H, Blennow K, Peskind ER. CSF ?-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury. Neurology. 2024 Apr 09; 102(7):e209197. PMID: 38478804.
      Citations:    
    3. Brankovic A, Huang W, Cook D, Khanna S, Bialkowski K. Elucidating Discrepancy in Explanations of Predictive Models Developed Using EMR. Stud Health Technol Inform. 2024 Jan 25; 310:865-869. PMID: 38269932.
      Citations:    
    4. Elder GA, Gama Sosa MA, De Gasperi R, Perez Garcia G, Perez GM, Abutarboush R, Kawoos U, Zhu CW, Janssen WGM, Stone JR, Hof PR, Cook DG, Ahlers ST. The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma. Int J Mol Sci. 2024 Jan 17; 25(2). PMID: 38256223.
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    5. Stefanidis D, Cook D, Kalantar-Motamedi SM, Muret-Wagstaff S, Calhoun AW, Lauridsen KG, Paige JT, Lockey A, Donoghue A, Hall AK, Patocka C, Palaganas J, Gross IT, Kessler D, Vermylen J, Lin Y, Aebersold M, Chang TP, Duff J, Kolbe M, Rutherford-Hemming T, Decker S, Collings A, Toseef Ansari M. Society for Simulation in Healthcare Guidelines for Simulation Training. Simul Healthc. 2024 Jan 01; 19(1S):S4-S22. PMID: 38240614.
      Citations:    
    6. De Gasperi R, Gama Sosa MA, Perez Garcia G, Perez G, Pryor D, Morrison CL, Lind R, Abutarboush R, Kawoos U, Statz JK, Patterson J, Hof P, Zhu CW, Ahlers S, Cook D, Elder GA. Metabotropic glutamate receptor 2 expression is chronically elevated in male rats with post-traumatic stress disorder related behavioral traits following repetitive low-level blast exposure. J Neurotrauma. 2023 Nov 02. PMID: 37917117.
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    7. Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, Kawoos U, Hogg S, Ache B, Sowa A, Tetreault T, Varghese M, Cook DG, Zhu CW, Tappan SJ, Janssen WGM, Hof PR, Ahlers ST, Elder GA. Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures. Acta Neuropathol Commun. 2023 05 12; 11(1):81. PMID: 37173747.
      Citations:    
    8. Garcia GP, Perez GM, Gasperi R, Sosa MAG, Otero-Pagan A, Abutarboush R, Kawoos U, Statz JK, Patterson J, Zhu CW, Hof PR, Cook DG, Ahlers ST, Elder GA. (2R,6R)-Hydroxynorketamine Treatment of Rats Exposed to Repetitive Low-Level Blast Injury. Neurotrauma Rep. 2023; 4(1):197-217. PMID: 37020715.
      Citations:    
    9. Baskin BM, Logsdon AF, Janet Lee S, Foresi BD, Peskind E, Banks WA, Cook DG, Schindler AG. Timing matters: Sex differences in inflammatory and behavioral outcomes following repetitive blast mild traumatic brain injury. Brain Behav Immun. 2023 Mar 10; 110:222-236. PMID: 36907289.
      Citations:    
    10. Gasperi R, Sosa MAG, Garcia GSP, Perez GM, Abutarboush R, Kawoos U, Statz JK, Patterson J, Hof PR, Katsel P, Cook DG, Ahlers ST, Elder GA. Progressive Transcriptional Changes in the Amygdala Implicate Neuroinflammation in the Effects of Repetitive Low-Level Blast Exposure in Male Rats. J Neurotrauma. 2022 Dec 13. PMID: 36262047.
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    11. Lee SJ, Logsdon AF, Yagi M, Baskin BM, Peskind ER, Raskind MM, Cook DG, Schindler AG. The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma. J Neuroinflammation. 2022 Dec 03; 19(1):288. PMID: 36463243.
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    12. Brankovic A, Hassanzadeh H, Good N, Mann K, Khanna S, Abdel-Hafez A, Cook D. Author Correction: Explainable machine learning for real-time deterioration alert prediction to guide pre-emptive treatment. Sci Rep. 2022 Aug 05; 12(1):13467. PMID: 35931815.
      Citations:    
    13. Brankovic A, Hassanzadeh H, Good N, Mann K, Khanna S, Abdel-Hafez A, Cook D. Explainable machine learning for real-time deterioration alert prediction to guide pre-emptive treatment. Sci Rep. 2022 07 11; 12(1):11734. PMID: 35817885.
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    14. Baskin B, Lee SJ, Skillen E, Wong K, Rau H, Hendrickson RC, Pagulayan K, Raskind MA, Peskind ER, Phillips PEM, Cook DG, Schindler AG. Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice. Front Behav Neurosci. 2021; 15:792648. PMID: 35002648.
      Citations:    
    15. Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast Injury. Neurotrauma Rep. 2021; 2(1):548-563. PMID: 34901948.
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    16. Alonge KM, Herbert MJ, Yagi M, Cook DG, Banks WA, Logsdon AF. Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma. Front Behav Neurosci. 2021; 15:745288. PMID: 34776892.
      Citations:    
    17. Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, Kawoos U, Hogg S, Ache B, Janssen WG, Sowa A, Tetreault T, Cook DG, Tappan SJ, Gandy S, Hof PR, Ahlers ST, Elder GA. Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation. Acta Neuropathol Commun. 2021 10 15; 9(1):167. PMID: 34654480.
      Citations:    
    18. Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers A?42 in an Alzheimer Disease Transgenic Mouse Model. J Neurotrauma. 2021 11 15; 38(22):3146-3173. PMID: 34353119.
      Citations:    
    19. Wang C, Shao C, Zhang L, Siedlak SL, Meabon JS, Peskind ER, Lu Y, Wang W, Perry G, Cook DG, Zhu X. Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation. Antioxidants (Basel). 2021 Jun 15; 10(6). PMID: 34203583.
      Citations:    
    20. Schindler AG, Baskin B, Juarez B, Janet Lee S, Hendrickson R, Pagulayan K, Zweifel LS, Raskind MA, Phillips PEM, Peskind ER, Cook DG. Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans. Alcohol Clin Exp Res. 2021 05; 45(5):1051-1064. PMID: 33760264.
      Citations:    
    21. Perez Garcia G, De Gasperi R, Gama Sosa MA, Perez GM, Otero-Pagan A, Pryor D, Abutarboush R, Kawoos U, Hof PR, Dickstein DL, Cook DG, Gandy S, Ahlers ST, Elder GA. Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast. Acta Neuropathol Commun. 2021 03 01; 9(1):33. PMID: 33648608.
      Citations:    
    22. Perez Garcia G, Perez GM, De Gasperi R, Gama Sosa MA, Otero-Pagan A, Pryor D, Abutarboush R, Kawoos U, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Progressive Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast. J Neurotrauma. 2021 07 15; 38(14):2030-2045. PMID: 33115338.
      Citations:    
    23. Cross DJ, Huber BR, Silverman MA, Cline MM, Gill TB, Cross CG, Cook DG, Minoshima S. Intranasal Paclitaxel Alters Alzheimer's Disease Phenotypic Features in 3xTg-AD Mice. J Alzheimers Dis. 2021; 83(1):379-394. PMID: 34308901.
      Citations:    
    24. Schindler AG, Terry GE, Wolden-Hanson T, Cline M, Park M, Lee J, Yagi M, Meabon JS, Peskind ER, Raskind MM, Phillips PEM, Cook DG. Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment. J Neurotrauma. 2021 04 01; 38(7):940-948. PMID: 33138684.
      Citations:    
    25. Pagulayan KF, Petrie EC, Cook DG, Hendrickson RC, Rau H, Reilly M, Mayer C, Meabon JS, Raskind MA, Peskind ER, Kleinhans N. Effect of blast-related mTBI on the working memory system: a resting state fMRI study. Brain Imaging Behav. 2020 Aug; 14(4):949-960. PMID: 30519997.
      Citations:    
    26. Meabon JS, Cook DG, Yagi M, Terry GE, Cross DJ, Muzi M, Pagulayan KF, Logsdon AF, Schindler AG, Ghai V, Wang K, Fallen S, Zhou Y, Kim TK, Lee I, Banks WA, Carlson ES, Mayer C, Hendrickson RC, Raskind MA, Marshall DA, Perl DP, Keene CD, Peskind ER. Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure. J Neurol Sci. 2020 Oct 15; 417:117049. PMID: 32758764.
      Citations:    
    27. Logsdon AF, Schindler AG, Meabon JS, Yagi M, Herbert MJ, Banks WA, Raskind MA, Marshall DA, Keene CD, Perl DP, Peskind ER, Cook DG. Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury. Sci Rep. 2020 06 10; 10(1):9420. PMID: 32523011.
      Citations:    
    28. Ghai V, Fallen S, Baxter D, Scherler K, Kim TK, Zhou Y, Meabon JS, Logsdon AF, Banks WA, Schindler AG, Cook DG, Peskind ER, Lee I, Wang K. Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury. J Neurotrauma. 2020 06 15; 37(12):1418-1430. PMID: 32024417.
      Citations:    
    29. Chen DH, Latimer C, Yagi M, Ndugga-Kabuye MK, Heigham E, Jayadev S, Meabon JS, Gomez CM, Keene CD, Cook DG, Raskind WH, Bird TD. Heterozygous STUB1 missense variants cause ataxia, cognitive decline, and STUB1 mislocalization. Neurol Genet. 2020 Apr; 6(2):1-13. PMID: 32211513.
      Citations:    
    30. Cross DJ, Meabon JS, Cline MM, Richards TL, Stump AJ, Cross CG, Minoshima S, Banks WA, Cook DG. Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice. J Alzheimers Dis. 2019; 67(3):859-874. PMID: 30664506.
      Citations:    
    31. Graves N, Barnett AG, Burn E, Cook D. Smaller clinical trials for decision making; using p-values could be costly. F1000Res. 2018; 7:1176. PMID: 36262673.
      Citations:    
    32. Logsdon AF, Meabon JS, Cline MM, Bullock KM, Raskind MA, Peskind ER, Banks WA, Cook DG. Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes. Sci Rep. 2018 07 27; 8(1):11344. PMID: 30054495.
      Citations:    
    33. Blythe R, Cook D, Graves N. Scepticaemia: The impact on the health system and patients of delaying new treatments with uncertain evidence; a case study of the sepsis bundle. F1000Res. 2018; 7:500. PMID: 29904596.
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    34. Maloney S, Foo J, Cook D, Walsh K. Cost, Value, and the Sustainability of Our Choices Concerning Simulation. Acad Med. 2018 03; 93(3):342-343. PMID: 29485496.
      Citations:    
    35. Pagulayan KF, Rau H, Madathil R, Werhane M, Millard SP, Petrie EC, Parmenter B, Peterson S, Sorg S, Hendrickson R, Mayer C, Meabon JS, Huber BR, Raskind M, Cook DG, Peskind ER. Retrospective and Prospective Memory Among OEF/OIF/OND Veterans With a Self-Reported History of Blast-Related mTBI. J Int Neuropsychol Soc. 2018 04; 24(4):324-334. PMID: 29284552.
      Citations:    
    36. Rau HK, Hendrickson RC, Roggenkamp HC, Peterson S, Parmenter B, Cook DG, Peskind E, Pagulayan KF. Fatigue - but not mTBI history, PTSD, or sleep quality - directly contributes to reduced prospective memory performance in Iraq and Afghanistan era Veterans. Clin Neuropsychol. 2018 Aug - Oct; 32(7):1319-1336. PMID: 29029579.
      Citations:    
    37. Cao J, Gaamouch FE, Meabon JS, Meeker KD, Zhu L, Zhong MB, Bendik J, Elder G, Jing P, Xia J, Luo W, Cook DG, Cai D. ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury. Sci Rep. 2017 09 12; 7(1):11372. PMID: 28900205.
      Citations:    
    38. Agoston D, Arun P, Bellgowan P, Broglio S, Cantu R, Cook D, da Silva UO, Dickstein D, Elder G, Fudge E, Gandy S, Gill J, Glenn JF, Gupta RK, Hinds S, Hoffman S, Lattimore T, Lin A, Lu KP, Maroon J, Okonkwo D, Perl D, Robinson M, Rosen C, Smith D. Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting. J Neurotrauma. 2017 09; 34(S1):S6-S17. PMID: 28937955.
      Citations:    
    39. Cline MM, Yumul JC, Hysa L, Murra D, Garwin GG, Cook DG, Ladiges WC, Minoshima S, Cross DJ. Novel application of a Radial Water Tread maze can distinguish cognitive deficits in mice with traumatic brain injury. Brain Res. 2017 02 15; 1657:140-147. PMID: 27923635.
      Citations:    
    40. Meabon JS, Huber BR, Cross DJ, Richards TL, Minoshima S, Pagulayan KF, Li G, Meeker KD, Kraemer BC, Petrie EC, Raskind MA, Peskind ER, Cook DG. Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction. Sci Transl Med. 2016 Jan 13; 8(321):321ra6. PMID: 26764157.
      Citations:    
    41. Banks WA, Gray AM, Erickson MA, Salameh TS, Damodarasamy M, Sheibani N, Meabon JS, Wing EE, Morofuji Y, Cook DG, Reed MJ. Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflammation. 2015 Nov 25; 12:223. PMID: 26608623.
      Citations:    
    42. Pilcher D, Gladkis L, Arcia B, Bailey M, Cook D, Cass Y, Opdam H. Estimating the Number of Organ Donors in Australian Hospitals--Implications for Monitoring Organ Donation Practices. Transplantation. 2015 Oct; 99(10):2203-9. PMID: 25919766.
      Citations:    
    43. Meeker KD, Meabon JS, Cook DG. Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 45(2):509-20. PMID: 25589729.
      Citations:    
    44. Scimemi A, Meabon JS, Woltjer RL, Sullivan JM, Diamond JS, Cook DG. Amyloid-?1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1. J Neurosci. 2013 Mar 20; 33(12):5312-8. PMID: 23516295.
      Citations:    
    45. Huber BR, Meabon JS, Martin TJ, Mourad PD, Bennett R, Kraemer BC, Cernak I, Petrie EC, Emery MJ, Swenson ER, Mayer C, Mehic E, Peskind ER, Cook DG. Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury. J Alzheimers Dis. 2013; 37(2):309-23. PMID: 23948882.
      Citations:    
    46. Meabon JS, Lee A, Meeker KD, Bekris LM, Fujimura RK, Yu CE, Watson GS, Pow DV, Sweet IR, Cook DG. Differential expression of the glutamate transporter GLT-1 in pancreas. J Histochem Cytochem. 2012 Feb; 60(2):139-51. PMID: 22114258.
      Citations:    
    47. Lee A, Anderson AR, Rayfield AJ, Stevens MG, Poronnik P, Meabon JS, Cook DG, Pow DV. Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis. J Chem Neuroanat. 2012 Jan; 43(1):64-75. PMID: 21982839.
      Citations:    
    48. Pratt KG, Zimmerman EC, Cook DG, Sullivan JM. Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling. Nat Neurosci. 2011 Aug 14; 14(9):1112-4. PMID: 21841774.
      Citations:    
    49. Pratt KG, Zhu P, Watari H, Cook DG, Sullivan JM. A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons. J Neurosci. 2011 Jan 19; 31(3):899-906. PMID: 21248114.
      Citations:    
    50. Mookherjee P, Green PS, Watson GS, Marques MA, Tanaka K, Meeker KD, Meabon JS, Li N, Zhu P, Olson VG, Cook DG. GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model. J Alzheimers Dis. 2011; 26(3):447-55. PMID: 21677376.
      Citations:    
    51. Stewart TH, Eastman CL, Groblewski PA, Fender JS, Verley DR, Cook DG, D'Ambrosio R. Chronic dysfunction of astrocytic inwardly rectifying K+ channels specific to the neocortical epileptic focus after fluid percussion injury in the rat. J Neurophysiol. 2010 Dec; 104(6):3345-60. PMID: 20861444.
      Citations:    
    52. Halton KA, Cook D, Paterson DL, Safdar N, Graves N. Cost-effectiveness of a central venous catheter care bundle. PLoS One. 2010 Sep 17; 5(9). PMID: 20862246.
      Citations:    
    53. Woltjer RL, Duerson K, Fullmer JM, Mookherjee P, Ryan AM, Montine TJ, Kaye JA, Quinn JF, Silbert L, Erten-Lyons D, Leverenz JB, Bird TD, Pow DV, Tanaka K, Watson GS, Cook DG. Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. J Neuropathol Exp Neurol. 2010 Jul; 69(7):667-76. PMID: 20535038.
      Citations:    
    54. Peskind ER, Petrie EC, Cross DJ, Pagulayan K, McCraw K, Hoff D, Hart K, Yu CE, Raskind MA, Cook DG, Minoshima S. Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. Neuroimage. 2011 Jan; 54 Suppl 1:S76-82. PMID: 20385245.
      Citations:    
    55. Pow DV, Cook DG. Neuronal expression of splice variants of "glial" glutamate transporters in brains afflicted by Alzheimer's disease: unmasking an intrinsic neuronal property. Neurochem Res. 2009 Oct; 34(10):1748-57. PMID: 19319679.
      Citations:    
    56. Marques MA, Kulstad JJ, Savard CE, Green PS, Lee SP, Craft S, Watson GS, Cook DG. Peripheral amyloid-beta levels regulate amyloid-beta clearance from the central nervous system. J Alzheimers Dis. 2009; 16(2):325-9. PMID: 19221422.
      Citations:    
    57. Duerson K, Woltjer RL, Mookherjee P, Leverenz JB, Montine TJ, Bird TD, Pow DV, Rauen T, Cook DG. Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients. Brain Pathol. 2009 Apr; 19(2):267-78. PMID: 18624794.
      Citations:    
    58. Ramritu P, Halton K, Cook D, Whitby M, Graves N. Catheter-related bloodstream infections in intensive care units: a systematic review with meta-analysis. J Adv Nurs. 2008 Apr; 62(1):3-21. PMID: 18352960.
      Citations:    
    59. Ramritu P, Halton K, Collignon P, Cook D, Fraenkel D, Battistutta D, Whitby M, Graves N. A systematic review comparing the relative effectiveness of antimicrobial-coated catheters in intensive care units. Am J Infect Control. 2008 Mar; 36(2):104-17. PMID: 18313512.
      Citations:    
    60. Ting JT, Kelley BG, Lambert TJ, Cook DG, Sullivan JM. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):353-8. PMID: 17185415.
      Citations:    
    61. White H, Cook D, Venkatesh B. The use of hypertonic saline for treating intracranial hypertension after traumatic brain injury. Anesth Analg. 2006 Jun; 102(6):1836-46. PMID: 16717334.
      Citations:    
    62. Watson GS, Cholerton BA, Reger MA, Baker LD, Plymate SR, Asthana S, Fishel MA, Kulstad JJ, Green PS, Cook DG, Kahn SE, Keeling ML, Craft S. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry. 2005 Nov; 13(11):950-8. PMID: 16286438.
      Citations:    
    63. Fishel MA, Watson GS, Montine TJ, Wang Q, Green PS, Kulstad JJ, Cook DG, Peskind ER, Baker LD, Goldgaber D, Nie W, Asthana S, Plymate SR, Schwartz MW, Craft S. Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch Neurol. 2005 Oct; 62(10):1539-44. PMID: 16216936.
      Citations:    
    64. Hoffman AR, Biller BM, Cook D, Baptista J, Silverman BL, Dao L, Attie KM, Fielder P, Maneatis T, Lippe B. Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency. J Clin Endocrinol Metab. 2005 Dec; 90(12):6431-40. PMID: 16159930.
      Citations:    
    65. Cook DG, Li X, Cherry SD, Cantrell AR. Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons. J Neurophysiol. 2005 Dec; 94(6):4421-9. PMID: 16148264.
      Citations:    
    66. Kulstad JJ, McMillan PJ, Leverenz JB, Cook DG, Green PS, Peskind ER, Wilkinson CW, Farris W, Mehta PD, Craft S. Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque. J Neuropathol Exp Neurol. 2005 Feb; 64(2):139-46. PMID: 15751228.
      Citations:    
    67. Hoffman AR, Kuntze JE, Baptista J, Baum HB, Baumann GP, Biller BM, Clark RV, Cook D, Inzucchi SE, Kleinberg D, Klibanski A, Phillips LS, Ridgway EC, Robbins RJ, Schlechte J, Sharma M, Thorner MO, Vance ML. Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2004 May; 89(5):2048-56. PMID: 15126520.
      Citations:    
    68. Yang Y, Kinney GA, Spain WJ, Breitner JC, Cook DG. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem. 2004 Mar; 88(6):1361-72. PMID: 15009636.
      Citations:    
    69. Craft S, Asthana S, Cook DG, Baker LD, Cherrier M, Purganan K, Wait C, Petrova A, Latendresse S, Watson GS, Newcomer JW, Schellenberg GD, Krohn AJ. Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology. 2003 Aug; 28(6):809-22. PMID: 12812866.
      Citations:    
    70. Huse JT, Byant D, Yang Y, Pijak DS, D'Souza I, Lah JJ, Lee VM, Doms RW, Cook DG. Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation. J Biol Chem. 2003 May 09; 278(19):17141-9. PMID: 12551920.
      Citations:    
    71. Cook DG, Leverenz JB, McMillan PJ, Kulstad JJ, Ericksen S, Roth RA, Schellenberg GD, Jin LW, Kovacina KS, Craft S. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol. 2003 Jan; 162(1):313-9. PMID: 12507914.
      Citations:    
    72. Yuen K, Ong K, Husbands S, Chatelain P, Fryklund L, Gluckman P, Ranke M, Cook D, Rosenfeld R, Wass J, Dunger D. The effects of short-term administration of two low doses versus the standard GH replacement dose on insulin sensitivity and fasting glucose levels in young healthy adults. J Clin Endocrinol Metab. 2002 May; 87(5):1989-95. PMID: 11994330.
      Citations:    
    73. Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport. 2002 Mar 25; 13(4):455-9. PMID: 11930160.
      Citations:    
    74. Kunzelmann K, Schreiber R, Cook D. Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. Pflugers Arch. 2002 May; 444(1-2):220-6. PMID: 11976935.
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