David Wiest

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    R29CA073656     (WIEST, DAVID L)Apr 1, 1997 - Mar 31, 2002
    NIH
    DEVELOPMENTAL CONTROL OF TCR EXPRESSION IN THYMOCYTES
    Role: Principal Investigator

    R01CA087047     (WIEST, DAVID L)Apr 13, 2001 - Mar 31, 2006
    NIH
    Analysis of pre-TCR Structure and Function
    Role: Principal Investigator

    R01CA100144     (WIEST, DAVID L)Mar 1, 2004 - Jun 30, 2009
    NIH
    Role of Egr Proteins in Thymocyte Development
    Role: Principal Investigator

    R01AI073920     (WIEST, DAVID L)Mar 1, 2007 - Sep 25, 2012
    NIH
    Role of RPL22 in Thymocyte Development
    Role: Principal Investigator

    R56AI073920     (WIEST, DAVID L)Mar 1, 2007 - Sep 25, 2013
    NIH
    Role of RPL22 in Thymocyte Development
    Role: Principal Investigator

    R01AI081314     (WIEST, DAVID L)Jul 1, 2009 - Jun 30, 2014
    NIH
    Control of alpha-beta/gamma-delta T Lineage Commitment
    Role: Principal Investigator

    R21CA141194     (WIEST, DAVID L)May 10, 2010 - Apr 30, 2012
    NIH
    Rpl22 as Biomarker of Prognosis and Therapeutic Response in T-ALL
    Role: Principal Investigator

    R21AI100381     (WIEST, DAVID L)Feb 15, 2012 - Jan 31, 2015
    NIH
    Role of Rpl22 in ER Stress and Colitis
    Role: Principal Investigator

    P01AI102853     (WIEST, DAVID L.)May 15, 2014 - Jul 31, 2024
    NIH
    Molecular basis of ?d T lineage specification
    Role: Principal Investigator

    R56AI110985     (WIEST, DAVID L)Jul 18, 2014 - Dec 31, 2014
    NIH
    Regulation of Hematopoiesis By Ribosomal Protein Paralogs
    Role: Principal Investigator

    R37AI110985     (WIEST, DAVID L.)Jul 18, 2014 - Jan 31, 2025
    NIH
    Regulation of hematopoiesis by ribosomal protein paralogs
    Role: Principal Investigator

    R21AI111208     (WIEST, DAVID L.)Sep 1, 2014 - Aug 31, 2017
    NIH
    Functional Analysis of Candidate Genes in Primary T Cell Immunodeficiencies
    Role: Principal Investigator

    R01AI110985     (WIEST, DAVID L.)Jan 1, 2015 - Feb 20, 2020
    NIH
    Regulation of Hematopoiesis by Ribosomal Protein Paralogs
    Role: Principal Investigator

    R13AI120569     (WIEST, DAVID L.)Mar 1, 2016 - Feb 28, 2017
    NIH
    The ThymUS 2016 International Conference on Lymphopoiesis
    Role: Principal Investigator

    R21CA216825     (WIEST, DAVID L.)Dec 15, 2017 - Nov 30, 2019
    NIH
    Rpl22-Like1 as a Novel Prognostic Marker in Colorectal Cancer
    Role: Principal Investigator

    R13AI150020     (WIEST, DAVID L.)Sep 8, 2020 - Aug 31, 2021
    NIH
    ThymUS 2020 International Conference on Lymphopoiesis
    Role: Principal Investigator

    R01CA283396     (WIEST, DAVID L.)Jul 6, 2023 - Jun 30, 2028
    NIH
    Divergent Functions of ERK Substrate Binding Domains in Pathogenesis of Myeloproliferative Neoplasms
    Role: Principal Investigator

    R03CA286669     (ASTSATUROV, IGOR)Dec 13, 2023 - Nov 30, 2025
    NIH
    Divergent Functions of ERK2 Substrate Binding Domains in Pathogenesis of KRAS-Driven Pancreatic Cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kanefsky J, Basse M, Sokei J, di Martino O, Valin L, Jaspers Y, Martinez E, Huhn J, Di Marcantonio D, Magee JA, Goldman AR, Tang HY, Ferraro F, Kemp S, Wiest DL, Sykes SM. DISRUPTION OF POLYUNSATURATED FATTY ACID BIOSYNTHESIS DRIVES STING-DEPENDENT ACUTE MYELOID LEUKEMIA CELL MATURATION AND DEATH. J Biol Chem. 2024 Mar 22; 107214. PMID: 38522521.
      Citations:    
    2. Wang Y, He S, Calendo G, Bui T, Tian Y, Lee CY, Zhou Y, Zhao X, Abraham C, Mo W, Chen M, Sanders-Braggs R, Madzo J, Issa JJ, Hexner EO, Wiest DL, Reshef R, Xue HH, Zhang Y. Tissue-infiltrating Alloreactive T Cells Require Id3 to Deflect PD-1-mediated Immune Suppression during GVHD. Blood. 2023 Oct 23. PMID: 37871574.
      Citations:    
    3. Kappes D, Wiest DL. Doubling down to make killer T cells. Nat Immunol. 2023 Sep; 24(9):1407-1408. PMID: 37620604.
      Citations:    
    4. Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V. Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system. Nat Immunol. 2023 Jul 13. PMID: 37443284.
      Citations:    
    5. Harris B, Singh DK, Verma M, Fahl SP, Rhodes M, Sprinkle SR, Wang M, Zhang Y, Perrigoue J, Kessel R, Peri S, West J, Giricz O, Boultwood J, Pellagatti A, Ramesh KH, Montagna C, Pradhan K, Tyner JW, Kennedy BK, Holinstat M, Steidl U, Sykes S, Verma A, Wiest DL. Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism. bioRxiv. 2023 Jun 01. PMID: 37398007.
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    6. Sertori R, Zhang Y, Wiest DL. Zebrafish: A Tractable Model for Analysis of T Cell Development. Methods Mol Biol. 2023; 2580:355-377. PMID: 36374469.
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    7. Contreras AV, Wiest DL. Development of ?d T Cells: Soldiers on the Front Lines of Immune Battles. Methods Mol Biol. 2023; 2580:71-88. PMID: 36374451.
      Citations:    
    8. Ratiu JJ, Barclay WE, Lin E, Wang Q, Wellford S, Mehta N, Harnois MJ, DiPalma D, Roy S, Contreras AV, Shinohara ML, Wiest D, Zhuang Y. Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-? selection thymocytes. Nat Commun. 2022 10 06; 13(1):5901. PMID: 36202870.
      Citations:    
    9. Aghayev T, Mazitova AM, Fang JR, Peshkova IO, Rausch M, Hung M, White KF, Masia R, Titerina EK, Fatkhullina AR, Cousineau I, Turcotte S, Zhigarev D, Marchenko A, Khoziainova S, Makhov P, Tan YF, Kossenkov AV, Wiest DL, Stagg J, Wang XW, Campbell KS, Dzutsev AK, Trinchieri G, Hill JA, Grivennikov SI, Koltsova EK. IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma. Cancer Discov. 2022 08 05; 12(8):1960-1983. PMID: 35723626.
      Citations:    
    10. Sertori R, Lin JX, Martinez E, Rana S, Sharo A, Kazemian M, Sunderam U, Andrake M, Shinton S, Truong B, Dunbrack RM, Liu C, Srinivasan R, Brenner SE, Seroogy CM, Puck JM, Leonard WJ, Wiest DL. Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Front Immunol. 2022; 13:928252. PMID: 35967429.
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    11. Zhang Y, Truong B, Fahl SP, Martinez E, Cai KQ, Al-Saleem ED, Gong Y, Liebermann DA, Soboloff J, Dunbrack R, Levine RL, Fletcher S, Kappes D, Sykes SM, Shapiro P, Wiest DL. The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm. Blood. 2022 07 28; 140(4):359-373. PMID: 35436326.
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    12. Fahl SP, Sertori R, Zhang Y, Contreras AV, Harris B, Wang M, Perrigoue J, Balachandran S, Kennedy BK, Wiest DL. Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis. J Immunol. 2022 02 15; 208(4):870-880. PMID: 35046107.
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    13. Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE. A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation. Front Immunol. 2021; 12:788278. PMID: 34887873.
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    14. Chen ELY, Lee CR, Thompson PK, Wiest DL, Anderson MK, Z??iga-Pfl?cker JC. Ontogenic timing, T?cell receptor signal strength, and Notch signaling direct ?d T?cell functional differentiation in?vivo. Cell Rep. 2021 06 08; 35(10):109227. PMID: 34107257.
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    15. Fahl SP, Contreras AV, Verma A, Qiu X, Harly C, Radtke F, Z??iga-Pfl?cker JC, Murre C, Xue HH, Sen JM, Wiest DL. The E protein-TCF1 axis controls ?d T?cell development and effector fate. Cell Rep. 2021 02 02; 34(5):108716. PMID: 33535043.
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    16. Cheng Y, Liao S, Xu G, Hu J, Guo D, Du F, Contreras A, Cai KQ, Peri S, Wang Y, Corney DC, Noronha AM, Chau LQ, Zhou G, Wiest DL, Bellacosa A, Wechsler-Reya RJ, Zhao Y, Yang ZJ. NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma. Cell Rep. 2020 06 23; 31(12):107782. PMID: 32579914.
      Citations:    
    17. Contreras AV, Wiest DL. Recent advances in understanding the development and function of ?d T cells. F1000Res. 2020; 9. PMID: 32399190.
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    18. Rao S, Peri S, Hoffmann J, Cai KQ, Harris B, Rhodes M, Connolly DC, Testa JR, Wiest DL. RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance. PLoS One. 2019; 14(10):e0222392. PMID: 31581233.
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    19. Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ. Functional genomic landscape of acute myeloid leukaemia. Nature. 2018 10; 562(7728):526-531. PMID: 30333627.
      Citations:    
    20. Wiest DL. Gadd45 stress sensors in suppression of leukemia. Oncotarget. 2018 Sep 28; 9(76):34191-34192. PMID: 30344933.
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    21. Zhang B, Jiao A, Dai M, Wiest DL, Zhuang Y. Id3 Restricts ?d NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol. 2018 09 01; 201(5):1452-1459. PMID: 30012846.
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    22. Zarin P, In TS, Chen EL, Singh J, Wong GW, Mohtashami M, Wiest DL, Anderson MK, Z??iga-Pfl?cker JC. Integration of T-cell receptor, Notch and cytokine signals programs mouse ?d T-cell effector differentiation. Immunol Cell Biol. 2018 10; 96(9):994-1007. PMID: 29754419.
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    23. Fahl SP, Wiest DL. Reply to Chien: Clarification of the effect of ligand on ?d-TCR repertoire selection. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3607-E3608. PMID: 29615510.
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    24. Fahl SP, Coffey F, Kain L, Zarin P, Dunbrack RL, Teyton L, Z??iga-Pfl?cker JC, Kappes DJ, Wiest DL. Role of a selecting ligand in shaping the murine ?d-TCR repertoire. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1889-1894. PMID: 29432160.
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    25. In TSH, Trotman-Grant A, Fahl S, Chen ELY, Zarin P, Moore AJ, Wiest DL, Z??iga-Pfl?cker JC, Anderson MK. HEB is required for the specification of fetal IL-17-producing ?d T cells. Nat Commun. 2017 12 08; 8(1):2004. PMID: 29222418.
      Citations:    
    26. Somech R, Lev A, Lee YN, Simon AJ, Barel O, Schiby G, Avivi C, Barshack I, Rhodes M, Yin J, Wang M, Yang Y, Rhodes J, Marcus N, Garty BZ, Stein J, Amariglio N, Rechavi G, Wiest DL, Zhang Y. Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B. J Immunol. 2017 12 15; 199(12):4036-4045. PMID: 29127144.
      Citations:    
    27. Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017 Sep 21; 171(1):103-119.e18. PMID: 28938112.
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    28. Wiest DL. THEMIS-tery is solved. Nat Immunol. 2017 03 22; 18(4):368-370. PMID: 28323266.
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    29. Tan Y, Sementino E, Xu J, Pei J, Liu Z, Ito TK, Cai KQ, Peri S, Klein-Szanto AJ, Wiest DL, Testa JR. The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling. Oncotarget. 2017 Feb 28; 8(9):14941-14956. PMID: 28122332.
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    30. Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 01 10; 18(2):545-556. PMID: 28076796.
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    31. Punwani D, Zhang Y, Yu J, Cowan MJ, Rana S, Kwan A, Adhikari AN, Lizama CO, Mendelsohn BA, Fahl SP, Chellappan A, Srinivasan R, Brenner SE, Wiest DL, Puck JM. Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. N Engl J Med. 2016 12 01; 375(22):2165-2176. PMID: 27959755.
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    32. Solanki NR, Stadanlick JE, Zhang Y, Duc AC, Lee SY, Lauritsen JP, Zhang Z, Wiest DL. Rpl22 Loss Selectively Impairs a? T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling. J Immunol. 2016 09 15; 197(6):2280-9. PMID: 27489283.
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    33. Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Barel O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R. Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects. J Exp Med. 2016 07 25; 213(8):1429-40. PMID: 27432940.
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    34. Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balma?a J, Serra V, Johnson N. The BRCA1-?11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin. Cancer Res. 2016 05 01; 76(9):2778-90. PMID: 27197267.
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    35. Rao S, Cai KQ, Stadanlick JE, Greenberg-Kushnir N, Solanki-Patel N, Lee SY, Fahl SP, Testa JR, Wiest DL. Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma. Cancer Res. 2016 06 01; 76(11):3387-96. PMID: 27197189.
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    36. Zhang Y, Wiest DL. Using the Zebrafish Model to Study T Cell Development. Methods Mol Biol. 2016; 1323:273-92. PMID: 26294415.
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    37. Wiest DL. Development of ?d T Cells, the Special-Force Soldiers of the Immune System. Methods Mol Biol. 2016; 1323:23-32. PMID: 26294395.
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    38. Tan Y, Xin X, Coffey FJ, Wiest DL, Dong LQ, Testa JR. Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016 May; 231(5):1142-50. PMID: 26445298.
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    39. Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One. 2015; 10(7):e0131908. PMID: 26161877.
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    40. Fahl SP, Wang M, Zhang Y, Duc AC, Wiest DL. Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks. Crit Rev Immunol. 2015; 35(5):379-400. PMID: 26853850.
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    41. Fahl SP, Harris B, Coffey F, Wiest DL. Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. J Immunol. 2015 Jan 01; 194(1):200-9. PMID: 25416806.
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    42. Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Z??iga-Pfl?cker JC, Kappes DJ, Wiest DL. Noncanonical mode of ERK action controls alternative a? and ?d T cell lineage fates. Immunity. 2014 Dec 18; 41(6):934-46. PMID: 25526308.
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    43. Fahl SP, Coffey F, Wiest DL. Origins of ?d T cell effector subsets: a riddle wrapped in an enigma. J Immunol. 2014 Nov 01; 193(9):4289-94. PMID: 25326547.
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    44. Smeets MF, Wiest DL, Izon DJ. Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes ?d T-cell commitment by enhancing TCR signal strength. Eur J Immunol. 2014 Sep; 44(9):2617-24. PMID: 24935715.
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    45. Zarin P, Wong GW, Mohtashami M, Wiest DL, Z??iga-Pfl?cker JC. Enforcement of ?d-lineage commitment by the pre-T-cell receptor in precursors with weak ?d-TCR signals. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5658-63. PMID: 24706811.
      Citations:    
    46. Coffey F, Lee SY, Buus TB, Lauritsen JP, Wong GW, Joachims ML, Thompson LF, Z??iga-Pfl?cker JC, Kappes DJ, Wiest DL. The TCR ligand-inducible expression of CD73 marks ?d lineage commitment and a metastable intermediate in effector specification. J Exp Med. 2014 Feb 10; 211(2):329-43. PMID: 24493796.
      Citations:    
    47. O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK. The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS Genet. 2013; 9(8):e1003708. PMID: 23990801.
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    48. Zhang Y, Duc AC, Rao S, Sun XL, Bilbee AN, Rhodes M, Li Q, Kappes DJ, Rhodes J, Wiest DL. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell. 2013 Feb 25; 24(4):411-25. PMID: 23449473.
      Citations:    
    49. Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL. A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol. 2013 Mar 01; 190(5):2121-8. PMID: 23355739.
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    50. Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16264-9. PMID: 22988097.
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    51. Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012 Nov 01; 120(18):3764-73. PMID: 22976955.
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    52. Roberts JL, Buckley RH, Luo B, Pei J, Lapidus A, Peri S, Wei Q, Shin J, Parrott RE, Dunbrack RL, Testa JR, Zhong XP, Wiest DL. CD45-deficient severe combined immunodeficiency caused by uniparental disomy. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10456-61. PMID: 22689986.
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    53. del Blanco B, Garc?a-Mariscal A, Wiest DL, Hern?ndez-Munain C. Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling. J Immunol. 2012 Apr 01; 188(7):3278-93. PMID: 22357628.
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    54. Stadanlick JE, Zhang Z, Lee SY, Hemann M, Biery M, Carleton MO, Zambetti GP, Anderson SJ, Oravecz T, Wiest DL. Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors. J Immunol. 2011 Jul 15; 187(2):664-75. PMID: 21690328.
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    55. Hu T, Gimferrer I, Simmons A, Wiest D, Alberola-Ila J. The Ras/MAPK pathway is required for generation of iNKT cells. PLoS One. 2011 May 10; 6(5):e19890. PMID: 21572967.
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    56. Jin Y, Xia M, Saylor CM, Narayan K, Kang J, Wiest DL, Wang Y, Xiong N. Cutting edge: Intrinsic programming of thymic ?dT cells for specific peripheral tissue localization. J Immunol. 2010 Dec 15; 185(12):7156-60. PMID: 21068400.
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    57. Tan Y, You H, Coffey FJ, Wiest DL, Testa JR. Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis. 2010 Sep; 48(9):531-9. PMID: 20665729.
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    58. Park K, He X, Lee HO, Hua X, Li Y, Wiest D, Kappes DJ. TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes. EMBO J. 2010 Jul 21; 29(14):2329-41. PMID: 20551904.
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    59. Xia M, Qi Q, Jin Y, Wiest DL, August A, Xiong N. Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells. J Immunol. 2010 Jun 15; 184(12):6807-14. PMID: 20483745.
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    60. Wiest DL. Origins of gammadeltaT cells: a forum for opposing perspectives. Semin Immunol. 2010 Aug; 22(4):191-2. PMID: 20471283.
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    61. Lee SY, Stadanlick J, Kappes DJ, Wiest DL. Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Semin Immunol. 2010 Aug; 22(4):237-46. PMID: 20471282.
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    62. Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Z??iga-Pfl?cker JC, Wiest DL. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009 Oct 16; 31(4):565-75. PMID: 19833086.
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    63. Timakhov RA, Tan Y, Rao M, Liu Z, Altomare DA, Pei J, Wiest DL, Favorova OO, Knepper JE, Testa JR. Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice. Genes Chromosomes Cancer. 2009 Sep; 48(9):786-94. PMID: 19530243.
      Citations:    
    64. Wiest DL. Identification of the last cog in a ligand-independent signaling machine? J Immunol. 2009 May 01; 182(9):5163-4. PMID: 19380757.
      Citations:    
    65. Paul E, Cronan R, Weston PJ, Boekelheide K, Sedivy JM, Lee SY, Wiest DL, Resnick MB, Klysik JE. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome. 2009 Feb; 20(2):92-108. PMID: 19145458.
      Citations:    
    66. Xu M, Sharma A, Wiest DL, Sen JM. Pre-TCR-induced beta-catenin facilitates traversal through beta-selection. J Immunol. 2009 Jan 15; 182(2):751-8. PMID: 19124717.
      Citations:    
    67. Xu M, Sharma A, Hossain MZ, Wiest DL, Sen JM. Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. J Immunol. 2009 Jan 15; 182(2):759-65. PMID: 19124718.
      Citations:    
    68. Lauritsen JP, Kurella S, Lee SY, Lefebvre JM, Rhodes M, Alberola-Ila J, Wiest DL. Egr2 is required for Bcl-2 induction during positive selection. J Immunol. 2008 Dec 01; 181(11):7778-85. PMID: 19017967.
      Citations:    
    69. Gururajan M, Simmons A, Dasu T, Spear BT, Calulot C, Robertson DA, Wiest DL, Monroe JG, Bondada S. Early growth response genes regulate B cell development, proliferation, and immune response. J Immunol. 2008 Oct 01; 181(7):4590-602. PMID: 18802061.
      Citations:    
    70. Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR. A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 2008 Mar 01; 68(5):1296-302. PMID: 18316591.
      Citations:    
    71. Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Z??iga-Pfl?cker JC, Izon DJ. Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. Int Immunol. 2007 Dec; 19(12):1421-30. PMID: 17981791.
      Citations:    
    72. Koltsova EK, Ciofani M, Benezra R, Miyazaki T, Clipstone N, Z??iga-Pfl?cker JC, Wiest DL. Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. J Immunol. 2007 Oct 01; 179(7):4694-703. PMID: 17878368.
      Citations:    
    73. Anderson SJ, Lauritsen JP, Hartman MG, Foushee AM, Lefebvre JM, Shinton SA, Gerhardt B, Hardy RR, Oravecz T, Wiest DL. Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. Immunity. 2007 Jun; 26(6):759-72. PMID: 17555992.
      Citations:    
    74. Schrum AG, Gil D, Dopfer EP, Wiest DL, Turka LA, Schamel WW, Palmer E. High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry. Sci STKE. 2007 Jun 05; 2007(389):pl2. PMID: 17551170.
      Citations:    
    75. Carter JH, Lefebvre JM, Wiest DL, Tourtellotte WG. Redundant role for early growth response transcriptional regulators in thymocyte differentiation and survival. J Immunol. 2007 Jun 01; 178(11):6796-805. PMID: 17513727.
      Citations:    
    76. Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol. 2007 May 01; 178(9):5443-53. PMID: 17442925.
      Citations:    
    77. Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J, Blazar BR. Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery. Mol Ther. 2007 Jul; 15(7):1273-9. PMID: 17457319.
      Citations:    
    78. Roberts JL, Lauritsen JP, Cooney M, Parrott RE, Sajaroff EO, Win CM, Keller MD, Carpenter JH, Carabana J, Krangel MS, Sarzotti M, Zhong XP, Wiest DL, Buckley RH. T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex. Blood. 2007 Apr 15; 109(8):3198-206. PMID: 17170122.
      Citations:    
    79. Ke J, Gururajan M, Kumar A, Simmons A, Turcios L, Chelvarajan RL, Cohen DM, Wiest DL, Monroe JG, Bondada S. The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells. J Biol Chem. 2006 Dec 29; 281(52):39806-18. PMID: 17065146.
      Citations:    
    80. Ciofani M, Knowles GC, Wiest DL, von Boehmer H, Z??iga-Pfl?cker JC. Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity. 2006 Jul; 25(1):105-16. PMID: 16814577.
      Citations:    
    81. Lauritsen JP, Haks MC, Lefebvre JM, Kappes DJ, Wiest DL. Recent insights into the signals that control alphabeta/gammadelta-lineage fate. Immunol Rev. 2006 Feb; 209:176-90. PMID: 16448543.
      Citations:    
    82. Zayed H, McIvor RS, Wiest DL, Blazar BR. In vitro functional correction of the mutation responsible for murine severe combined immune deficiency by small fragment homologous replacement. Hum Gene Ther. 2006 Feb; 17(2):158-66. PMID: 16454649.
      Citations:    
    83. Yamasaki S, Ishikawa E, Sakuma M, Ogata K, Sakata-Sogawa K, Hiroshima M, Wiest DL, Tokunaga M, Saito T. Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol. 2006 Jan; 7(1):67-75. PMID: 16327787.
      Citations:    
    84. Lefebvre JM, Haks MC, Carleton MO, Rhodes M, Sinnathamby G, Simon MC, Eisenlohr LC, Garrett-Sinha LA, Wiest DL. Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection. J Immunol. 2005 May 15; 174(10):6184-94. PMID: 15879115.
      Citations:    
    85. Haks MC, Lefebvre JM, Lauritsen JP, Carleton M, Rhodes M, Miyazaki T, Kappes DJ, Wiest DL. Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Immunity. 2005 May; 22(5):595-606. PMID: 15894277.
      Citations:    
    86. Dionne CJ, Tse KY, Weiss AH, Franco CB, Wiest DL, Anderson MK, Rothenberg EV. Subversion of T lineage commitment by PU.1 in a clonal cell line system. Dev Biol. 2005 Apr 15; 280(2):448-66. PMID: 15882585.
      Citations:    
    87. La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA. Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation. J Immunol. 2004 Mar 15; 172(6):3662-9. PMID: 15004169.
      Citations:    
    88. Haks MC, Belkowski SM, Ciofani M, Rhodes M, Lefebvre JM, Trop S, Hugo P, Z??iga-Pfl?cker JC, Wiest DL. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol. 2003 Mar 15; 170(6):2853-61. PMID: 12626535.
      Citations:    
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