Yedy Israel

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Quintanilla ME, Morales P, Santapau D, ?vila A, Ponce C, Berrios-C?rcamo P, Olivares B, Gallardo J, Ezquer M, Herrera-Marschitz M, Israel Y, Ezquer F. Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use. Int J Mol Sci. 2023 Dec 03; 24(23). PMID: 38069404.
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    2. Quezada M, Ponce C, Berr?os-C?rcamo P, Santapau D, Gallardo J, De Gregorio C, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M, Israel Y, Andr?s-Herrera P, Hip?lito L, Ezquer F. Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence. CNS Neurosci Ther. 2023 Nov 06. PMID: 37927136.
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    3. Quintanilla ME, Israel Y. Role of Metabolism on?Alcohol Preference, Addiction, and Treatment. Curr Top Behav Neurosci. 2023 May 24. PMID: 37221350.
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    4. Quintanilla ME, Quezada M, Morales P, Berr?os-C?rcamo P, Santapau D, Ezquer M, Herrera-Marschitz M, Israel Y, Ezquer F. Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence. Transl Psychiatry. 2022 11 04; 12(1):462. PMID: 36333316.
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    5. Ezquer F, Quintanilla ME, Morales P, Santapau D, Munita JM, Moya-Flores F, Ezquer M, Herrera-Marschitz M, Israel Y. A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player. Drug Alcohol Depend. 2022 07 01; 236:109466. PMID: 35489181.
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    6. Berr?os-C?rcamo P, Quezada M, Santapau D, Morales P, Olivares B, Ponce C, ?vila A, De Gregorio C, Ezquer M, Quintanilla ME, Herrera-Marschitz M, Israel Y, Ezquer F. A Novel Morphine Drinking Model of Opioid Dependence in Rats. Int J Mol Sci. 2022 Mar 31; 23(7). PMID: 35409269.
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    7. Quintanilla ME, Ezquer F, Morales P, Santapau D, Ezquer M, Herrera-Marschitz M, Israel Y. A dual mechanism fully blocks ethanol relapse: Role of vagal innervation. Addict Biol. 2022 03; 27(2):e13140. PMID: 35229957.
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    8. Lespay-Rebolledo C, Tapia-Bustos A, Perez-Lobos R, Vio V, Casanova-Ortiz E, Farfan-Troncoso N, Zamorano-Cataldo M, Redel-Villarroel M, Ezquer F, Quintanilla ME, Israel Y, Morales P, Herrera-Marschitz M. Sustained Energy Deficit Following Perinatal Asphyxia: A Shift towards the Fructose-2,6-bisphosphatase (TIGAR)-Dependent Pentose Phosphate Pathway and Postnatal Development. Antioxidants (Basel). 2021 Dec 29; 11(1). PMID: 35052577.
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    9. Quintanilla ME, Morales P, Ezquer F, Ezquer M, Herrera-Marschitz M, Israel Y. Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats. Front Behav Neurosci. 2020; 14:617418. PMID: 33633548.
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    10. Ezquer F, Quintanilla ME, Moya-Flores F, Morales P, Munita JM, Olivares B, Landskron G, Hermoso MA, Ezquer M, Herrera-Marschitz M, Israel Y. Innate gut microbiota predisposes to high alcohol consumption. Addict Biol. 2021 07; 26(4):e13018. PMID: 33508889.
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    11. Farf?n N, Carril J, Redel M, Zamorano M, Araya M, Monz?n E, Alvarado R, Contreras N, Tapia-Bustos A, Quintanilla ME, Ezquer F, Vald?s JL, Israel Y, Herrera-Marschitz M, Morales P. Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia. Int J Mol Sci. 2020 Oct 21; 21(20). PMID: 33096871.
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    12. Berr?os-C?rcamo P, Quezada M, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M, Israel Y, Ezquer F. Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules. Antioxidants (Basel). 2020 Sep 04; 9(9). PMID: 32899889.
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    13. Quintanilla ME, Ezquer F, Morales P, Ezquer M, Olivares B, Santapau D, Herrera-Marschitz M, Israel Y. N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection. Front Behav Neurosci. 2020; 14:122. PMID: 32848653.
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    14. Israel Y, Quintanilla ME, Ezquer F, Morales P, Santapau D, Berr?os-C?rcamo P, Ezquer M, Olivares B, Herrera-Marschitz M. Aspirin and N-acetylcysteine co-administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation-oxidative stress self-perpetuation. Addict Biol. 2021 01; 26(1):e12853. PMID: 31733014.
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    15. Quintanilla ME, Ezquer F, Morales P, Santapau D, Berr?os-C?rcamo P, Ezquer M, Herrera-Marschitz M, Israel Y. Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options. Stem Cell Res Ther. 2019 07 08; 10(1):205. PMID: 31286996.
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    16. Rivera-Meza M, V?squez D, Quintanilla ME, Lagos D, Rojas B, Herrera-Marschitz M, Israel Y. Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism? Neuropharmacology. 2019 03 01; 146:175-183. PMID: 30521820.
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    17. Ezquer F, Quintanilla ME, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y. Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addict Biol. 2019 09; 24(5):994-1007. PMID: 30239077.
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    18. Quintanilla ME, Morales P, Ezquer F, Ezquer M, Herrera-Marschitz M, Israel Y. Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. Alcohol Clin Exp Res. 2018 10; 42(10):1988-1999. PMID: 30035805.
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    19. Ezquer F, Morales P, Quintanilla ME, Santapau D, Lespay-Rebolledo C, Ezquer M, Herrera-Marschitz M, Israel Y. Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking. Sci Rep. 2018 03 22; 8(1):4325. PMID: 29567966.
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    20. Ezquer F, Quintanilla ME, Morales P, Ezquer M, Lespay-Rebolledo C, Herrera-Marschitz M, Israel Y. Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Addict Biol. 2019 01; 24(1):17-27. PMID: 29044813.
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    21. Israel Y, Karahanian E, Ezquer F, Morales P, Ezquer M, Rivera-Meza M, Herrera-Marschitz M, Quintanilla ME. Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line. Front Behav Neurosci. 2017; 11:57. PMID: 28420969.
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    22. Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats. Alcohol Alcohol. 2017 Jan; 52(1):1-4. PMID: 27651282.
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    23. Quintanilla ME, Rivera-Meza M, Berr?os-C?rcamo P, Salinas-Luypaert C, Herrera-Marschitz M, Israel Y. Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation. Alcohol Clin Exp Res. 2016 05; 40(5):1044-51. PMID: 27062046.
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    24. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
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    25. Karahanian E, Rivera-Meza M, Quintanilla ME, Mu?oz D, Fern?ndez K, Israel Y. PPARa Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver? Alcohol Alcohol. 2015 Nov; 50(6):717-8. PMID: 26041608.
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    26. Quintanilla ME, Rivera-Meza M, Berr?os-C?rcamo P, Cassels BK, Herrera-Marschitz M, Israel Y. (R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Addict Biol. 2016 11; 21(6):1063-1071. PMID: 26032572.
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    27. Israel Y, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M. The "first hit" toward alcohol reinforcement: role of ethanol metabolites. Alcohol Clin Exp Res. 2015 May; 39(5):776-86. PMID: 25828063.
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    28. Karahanian E, Quintanilla ME, Fernandez K, Israel Y. Fenofibrate--a lipid-lowering drug--reduces voluntary alcohol drinking in rats. Alcohol. 2014 Nov; 48(7):665-70. PMID: 25241056.
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    29. Quintanilla ME, Rivera-Meza M, Berrios-C?rcamo PA, Bustamante D, Buscaglia M, Morales P, Karahanian E, Herrera-Marschitz M, Israel Y. Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Alcohol. 2014 Sep; 48(6):551-9. PMID: 25086835.
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    30. Karahanian E, Rivera-Meza M, Tampier L, Quintanilla ME, Herrera-Marschitz M, Israel Y. Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats. Addict Biol. 2015 Mar; 20(2):336-44. PMID: 24571199.
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    31. Israel Y, Rivera-Meza M, Karahanian E, Quintanilla ME, Tampier L, Morales P, Herrera-Marschitz M. Gene specific modifications unravel ethanol and acetaldehyde actions. Front Behav Neurosci. 2013; 7:80. PMID: 23847486.
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    32. Tampier L, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y. The alcohol deprivation effect: marked inhibition by anticatalase gene administration into the ventral tegmental area in rats. Alcohol Clin Exp Res. 2013 Aug; 37(8):1278-85. PMID: 23527889.
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    33. Juricic MA, Berr?os-C?rcamo PA, Acevedo ML, Israel Y, Almod?var I, Cassels BK. Salsolinol and isosalsolinol: condensation products of acetaldehyde and dopamine. Separation of their enantiomers in the presence of a large excess of dopamine. J Pharm Biomed Anal. 2012 Apr 07; 63:170-4. PMID: 22370127.
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    34. Encina G, Ezquer F, Conget P, Israel Y. Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biol Res. 2011; 44(3):301-5. PMID: 22688918.
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    35. Quintanilla ME, Tampier L, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y. Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence. Alcohol Clin Exp Res. 2012 Mar; 36(3):517-22. PMID: 21895710.
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    36. Karahanian E, Quintanilla ME, Tampier L, Rivera-Meza M, Bustamante D, Gonzalez-Lira V, Morales P, Herrera-Marschitz M, Israel Y. Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res. 2011 Apr; 35(4):606-12. PMID: 21332529.
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    37. Israel Y, Rivera-Meza M, Quintanilla ME, Sapag A, Tampier L. Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? Alcohol Clin Exp Res. 2011 May; 35(5):806-10. PMID: 21284671.
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    38. Pautassi RM, Camarini R, Quadros IM, Miczek KA, Israel Y. Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. Alcohol Clin Exp Res. 2010 Jun; 34(6):976-87. PMID: 20374217.
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    39. Rivera-Meza M, Quintanilla ME, Tampier L, Mura CV, Sapag A, Israel Y. Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. FASEB J. 2010 Jan; 24(1):266-74. PMID: 19710201.
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    40. Sapag A, Gonz?lez-Mart?nez G, Lobos-Gonz?lez L, Encina G, Tampier L, Israel Y, Quintanilla ME. Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. Pharmacogenet Genomics. 2009 Jul; 19(7):528-37. PMID: 19494790.
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    41. Cort?nez G, Sapag A, Israel Y. RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research. Alcohol. 2009 Mar; 43(2):97-104. PMID: 19251111.
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    42. Bustamante D, Quintanilla ME, Tampier L, Gonzalez-Lira V, Israel Y, Herrera-Marschitz M. Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats. Eur J Pharmacol. 2008 Sep 04; 591(1-3):153-8. PMID: 18611399.
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    43. Tampier L, Quintanilla ME, Israel Y. Tolerance to disulfiram induced by chronic alcohol intake in the rat. Alcohol Clin Exp Res. 2008 Jun; 32(6):937-41. PMID: 18445101.
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    44. Ocaranza P, Quintanilla ME, Tampier L, Karahanian E, Sapag A, Israel Y. Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Alcohol Clin Exp Res. 2008 Jan; 32(1):52-7. PMID: 18070247.
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    45. Quintanilla ME, Bustamante D, Tampier L, Israel Y, Herrera-Marschitz M. Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol. Eur J Pharmacol. 2007 Nov 14; 573(1-3):84-92. PMID: 17651729.
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    46. Quintanilla ME, Tampier L, Sapag A, Gerdtzen Z, Israel Y. Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2):E531-7. PMID: 17488809.
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    47. Quintanilla ME, Israel Y, Sapag A, Tampier L. The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. Addict Biol. 2006 Sep; 11(3-4):310-23. PMID: 16961761.
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    48. Ezquer F, N??ez MT, Rojas A, Asenjo J, Israel Y. Hereditary hemochromatosis: an opportunity for gene therapy. Biol Res. 2006; 39(1):113-24. PMID: 16629172.
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    49. Israel Y, Quintanilla ME, Sapag A, Tampier L. Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption. Alcohol Res Health. 2006; 29(4):281-5. PMID: 17718407.
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    50. Karahanian E, Ocaranza P, Israel Y. Aldehyde dehydrogenase (ALDH2) activity in hepatoma cells is reduced by an adenoviral vector coding for an ALDH2 antisense mRNA. Alcohol Clin Exp Res. 2005 Aug; 29(8):1384-9. PMID: 16131845.
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    51. Luo HR, Israel Y, Tu GC, Eriksson CJ, Zhang YP. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) in a Chinese population: gender, age, culture, and genotypes of ALDH2. Biochem Genet. 2005 Jun; 43(5-6):223-7. PMID: 16144299.
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    52. Quintanilla ME, Tampier L, Sapag A, Israel Y. Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet Genomics. 2005 Jun; 15(6):427-31. PMID: 15900217.
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    53. Ezquer F, N??ez MT, Israel Y. Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: potential application in hemochromatosis. Biochem Pharmacol. 2005 Jun 01; 69(11):1559-66. PMID: 15896335.
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    54. Quintanilla ME, Tampier L, Valle-Prieto A, Sapag A, Israel Y. Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats. FASEB J. 2005 Jan; 19(1):36-42. PMID: 15629893.
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    55. Ponnappa BC, Israel Y, Aini M, Zhou F, Russ R, Cao QN, Hu Y, Rubin R. Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides. Biochem Pharmacol. 2005 Feb 15; 69(4):569-77. PMID: 15670576.
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    56. Rodriguez DA, Moncada C, N??ez MT, Lavandero S, Ponnappa BC, Israel Y. Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells. Alcohol. 2004 May; 33(1):9-15. PMID: 15353169.
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    57. Videla LA, Tapia G, Varela P, Cornejo P, Guerrero J, Israel Y, Fern?ndez V. Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappaB, cytokine gene expression, and liver injury in the rat. Antioxid Redox Signal. 2004 Apr; 6(2):471-80. PMID: 15025948.
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    58. Anni H, Pristatsky P, Israel Y. Binding of acetaldehyde to a glutathione metabolite: mass spectrometric characterization of an acetaldehyde-cysteinylglycine conjugate. Alcohol Clin Exp Res. 2003 Oct; 27(10):1613-21. PMID: 14574232.
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    59. Moncada C, Fuentes N, Lladser A, Encina G, Sapag A, Karahanian E, Israel Y. Use of an "acetaldehyde clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells. Alcohol. 2003 Aug-Oct; 31(1-2):19-24. PMID: 14615007.
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    60. Fernandez V, Videla LA, Tapia G, Israel Y. Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat. Free Radic Res. 2002 Jul; 36(7):719-25. PMID: 12180121.
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    61. Ponnappa BC, Israel Y. Targeting Kupffer cells with antisense oligonucleotides. Front Biosci. 2002 May 01; 7:e223-33. PMID: 11991849.
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    62. Israel Y, Lieber CS. The Research Society on Alcoholism. Addiction. 2002 May; 97(5):483-6. PMID: 12033649.
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    63. Anni H, Israel Y. Proteomics in alcohol research. Alcohol Res Health. 2002; 26(3):219-32. PMID: 12875051.
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