William Reenstra

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records and Publicatio - Thomas Jefferson University
Address833 Chestnut Street
Philadelphia PA 19107
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    R01HL070563     (REENSTRA, WILLIAM W)Sep 20, 2001 - Jun 30, 2006
    NIH
    Mechanisms of Kinase-dependent CFTR Activation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH. Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. Am J Physiol Cell Physiol. 2012 Jul 15; 303(2):C160-9. PMID: 22572847.
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    2. Zhang Z, Reenstra W, Weiner DJ, Louboutin JP, Wilson JM. The p38 mitogen-activated protein kinase signaling pathway is coupled to Toll-like receptor 5 to mediate gene regulation in response to Pseudomonas aeruginosa infection in human airway epithelial cells. Infect Immun. 2007 Dec; 75(12):5985-92. PMID: 17908812.
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    3. Reenstra WW, Crothers J, Forte JG. The conformation of H,K-ATPase determines the nucleoside triphosphate (NTP) selectivity for active proton transport. Biochemistry. 2007 Sep 04; 46(35):10145-52. PMID: 17696364.
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    4. Vais H, Gao GP, Yang M, Tran P, Louboutin JP, Somanathan S, Wilson JM, Reenstra WW. Novel adenoviral vectors coding for GFP-tagged wtCFTR and deltaF508-CFTR: characterization of expression and electrophysiological properties in A549 cells. Pflugers Arch. 2004 Dec; 449(3):278-87. PMID: 15452712.
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    5. Vais H, Zhang R, Reenstra WW. Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C737-45. PMID: 15140750.
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    6. Bhandari A, Crawford SE, Huang L, Reenstra WW. Effects of oral genistein in mice. Pediatr Pathol Mol Med. 2003 Mar-Apr; 22(2):131-41. PMID: 12556293.
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    7. Wang W, He Z, O'Shaughnessy TJ, Rux J, Reenstra WW. Domain-domain associations in cystic fibrosis transmembrane conductance regulator. Am J Physiol Cell Physiol. 2002 May; 282(5):C1170-80. PMID: 11940532.
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    8. Zhang Y, Reenstra WW, Chidekel A. Antibacterial activity of apical surface fluid from the human airway cell line Calu-3: pharmacologic alteration by corticosteroids and beta(2)-agonists. Am J Respir Cell Mol Biol. 2001 Aug; 25(2):196-202. PMID: 11509329.
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    9. Weyler RT, Yurko-Mauro KA, Rubenstein R, Kollen WJ, Reenstra W, Altschuler SM, Egan M, Mulberg AE. CFTR is functionally active in GnRH-expressing GT1-7 hypothalamic neurons. Am J Physiol. 1999 09; 277(3):C563-71. PMID: 10484343.
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    10. Fish SM, Proujansky R, Reenstra WW. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function. Gut. 1999 Aug; 45(2):191-8. PMID: 10403730.
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    11. Randak C, Auerswald EA, Assfalg-Machleidt I, Reenstra WW, Machleidt W. Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein. Biochem J. 1999 May 15; 340 ( Pt 1):227-35. PMID: 10229679.
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    12. He Z, Raman S, Guo Y, Reenstra WW. Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms. Am J Physiol. 1998 10; 275(4):C958-66. PMID: 9755049.
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    13. Yurko-Mauro KA, Reenstra WW. Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation. Am J Physiol. 1998 09; 275(3):C653-60. PMID: 9730948.
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    14. Hwang TC, Wang F, Yang IC, Reenstra WW. Genistein potentiates wild-type and delta F508-CFTR channel activity. Am J Physiol. 1997 Sep; 273(3 Pt 1):C988-98. PMID: 9316420.
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    15. Reenstra WW, Yurko-Mauro K, Dam A, Raman S, Shorten S. CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases. Am J Physiol. 1996 Aug; 271(2 Pt 1):C650-7. PMID: 8770006.
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    16. Illek B, Fischer H, Santos GF, Widdicombe JH, Machen TE, Reenstra WW. cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein. Am J Physiol. 1995 Apr; 268(4 Pt 1):C886-93. PMID: 7537452.
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    17. Bischof G, Illek B, Reenstra WW, Machen TE. Role for tyrosine kinases in carbachol-regulated Ca entry into colonic epithelial cells. Am J Physiol. 1995 Jan; 268(1 Pt 1):C154-61. PMID: 7840144.
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    18. Santos GF, Reenstra WW. Activation of the cystic fibrosis transmembrane regulator by cyclic AMP is not correlated with inhibition of endocytosis. Biochim Biophys Acta. 1994 Oct 12; 1195(1):96-102. PMID: 7522569.
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    19. Reenstra WW. Inhibition of cAMP- and Ca-dependent Cl- secretion by phorbol esters: inhibition of basolateral K+ channels. Am J Physiol. 1993 Jan; 264(1 Pt 1):C161-8. PMID: 7679250.
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    20. Reenstra WW, Pinkus LM, Bailey J, Smith WL, Droppleman D, Sancilio LF, Forte JG. AHR-9294: a novel inhibitor of H,K-ATPase antagonizes gastric HCl secretion in vivo. J Pharmacol Exp Ther. 1992 May; 261(2):737-45. PMID: 1315865.
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    21. McCray PB, Reenstra WW, Louie E, Johnson J, Bettencourt JD, Bastacky J. Expression of CFTR and presence of cAMP-mediated fluid secretion in human fetal lung. Am J Physiol. 1992 Apr; 262(4 Pt 1):L472-81. PMID: 1373570.
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    22. Reenstra WW, Sabolic I, Bae HR, Verkman AS. Protein kinase A dependent membrane protein phosphorylation and chloride conductance in endosomal vesicles from kidney cortex. Biochemistry. 1992 Jan 14; 31(1):175-81. PMID: 1310027.
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    23. Crothers JM, Reenstra WW, Forte JG. Ontogeny of gastric H(+)-K(+)-ATPase in suckling rabbits. Am J Physiol. 1990 Dec; 259(6 Pt 1):G913-21. PMID: 2175554.
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    24. Reenstra WW, Forte JG. Characterization of K+ and Cl- conductances in apical membrane vesicles from stimulated rabbit oxyntic cells. Am J Physiol. 1990 Nov; 259(5 Pt 1):G850-8. PMID: 1700627.
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    25. Reenstra WW, Forte JG. Isolation of H+,K(+)-ATPase-containing membranes from the gastric oxyntic cell. Methods Enzymol. 1990; 192:151-65. PMID: 1963662.
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    26. Negulescu PA, Reenstra WW, Machen TE. Intracellular Ca requirements for stimulus-secretion coupling in parietal cell. Am J Physiol. 1989 Feb; 256(2 Pt 1):C241-51. PMID: 2465690.
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    27. Reenstra WW, Bettencourt JD, Forte JG. Kinetic studies of the gastric H,K-ATPase. Evidence for simultaneous binding of ATP and inorganic phosphate. J Biol Chem. 1988 Dec 25; 263(36):19618-25. PMID: 2848835.
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    28. Reenstra WW, Bettencourt JD, Forte JG. Mechanisms of active Cl- secretion by frog gastric mucosa. Am J Physiol. 1987 Apr; 252(4 Pt 1):G543-7. PMID: 3031995.
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    29. Reenstra WW, Bettencourt JD, Forte JG. Active K+ absorption by the gastric mucosa: inhibition by omeprazole. Am J Physiol. 1986 Apr; 250(4 Pt 1):G455-60. PMID: 3485923.
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    30. Reenstra WW, Forte JG. Mechanism of inhibition of gastric acid secretion by SCN-: interrelation of SCN- flux and inhibition. Am J Physiol. 1986 Jan; 250(1 Pt 1):G76-84. PMID: 3484614.
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    31. Reenstra WW, Shortridge B, Forte JG. Inhibition of the gastric (H+ + K+)-ATPase by fenoctimine. Biochem Pharmacol. 1985 Jul 01; 34(13):2331-4. PMID: 2990481.
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    32. Reenstra WW, Forte JG. Action of thiocyanate on pH gradient formation by gastric microsomal vesicles. Am J Physiol. 1983 Mar; 244(3):G308-13. PMID: 6829771.
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    33. Forte JG, Reenstra WW, Wolosin JM. H+ transport in gastric vesicles--mechanism of SCN- inhibition. Prog Clin Biol Res. 1983; 126:141-58. PMID: 6310638.
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    34. Warnock DG, Reenstra WW, Yee VJ. Na+/H+ antiporter of brush border vesicles: studies with acridine orange uptake. Am J Physiol. 1982 Jun; 242(6):F733-9. PMID: 6283903.
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    35. Reenstra WW, Warnock DG, Yee VJ, Forte JG. Proton gradients in renal cortex brush-border membrane vesicles. Demonstration of a rheogenic proton flux with acridine orange. J Biol Chem. 1981 Nov 25; 256(22):11663-6. PMID: 7298622.
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    36. Reenstra WW, Forte JG. H+/ATP stoichiometry for the gastric (K+ + H+)-ATPase. J Membr Biol. 1981; 61(1):55-60. PMID: 6267286.
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    37. Reenstra WW, Patel L, Rottenberg H, Kaback HR. Electrochemical proton gradient in inverted membrane vesicles from Escherichia coli. Biochemistry. 1980 Jan 08; 19(1):1-9. PMID: 6986161.
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