Thomas Jefferson University

Barbara Klinkhammer

TitleAcademic Dean
InstitutionPhiladelphia University
DepartmentOffice of the Dean
Address3243 School House Lane
Philadelphia PA 19144
Phone215-951-2899
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Baskaya F, Lemainque T, Klinkhammer B, Koletnik S, von Stillfried S, Talbot SR, Boor P, Schulz V, Lederle W, Kiessling F. Pathophysiologic Mapping of Chronic Liver Diseases With Longitudinal Multiparametric MRI in Animal Models. Invest Radiol. 2024 Apr 10. PMID: 38598653.
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    2. H?lscher DL, Goedertier M, Klinkhammer BM, Droste P, Costa IG, Boor P, B?low RD. tRigon: an R package and Shiny App for integrative (path-)omics data analysis. BMC Bioinformatics. 2024 Mar 05; 25(1):98. PMID: 38443821.
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    3. Xu T, Herkens L, Jia T, Klinkhammer BM, Kant S, Krusche CA, Buhl EM, Hayat S, Floege J, Strnad P, Kramann R, Djudjaj S, Boor P. The role of desmoglein-2 in kidney disease. Kidney Int. 2024 Feb 21. PMID: 38395410.
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    4. Firat EAM, Buhl EM, Bouteldja N, Smeets B, Eriksson U, Boor P, Klinkhammer BM. PDGF-D is dispensable for the development and progression of murine Alport syndrome. Am J Pathol. 2024 Feb 01. PMID: 38309427.
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    5. Droste P, Wong DWL, Hohl M, von Stillfried S, Klinkhammer BM, Boor P. Semiautomated pipeline for quantitative analysis of heart histopathology. J Transl Med. 2023 09 26; 21(1):666. PMID: 37752535.
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    6. Klinkhammer BM, Boor P. Kidney fibrosis: Emerging diagnostic and therapeutic strategies. Mol Aspects Med. 2023 10; 93:101206. PMID: 37541106.
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    7. Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function. Biochim Biophys Acta Mol Basis Dis. 2023 Aug 01; 1870(1):166825. PMID: 37536502.
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    8. Hoeft K, Schaefer GJL, Kim H, Schumacher D, Bleckwehl T, Long Q, Klinkhammer BM, Peisker F, Koch L, Nagai J, Halder M, Ziegler S, Liehn E, Kuppe C, Kranz J, Menzel S, Costa I, Wahida A, Boor P, Schneider RK, Hayat S, Kramann R. Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner. Cell Rep. 2023 Feb 17; 42(2):112131. PMID: 36807143.
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    9. H?lscher DL, Bouteldja N, Joodaki M, Russo ML, Lan YC, Sadr AV, Cheng M, Tesar V, Stillfried SV, Klinkhammer BM, Barratt J, Floege J, Roberts ISD, Coppo R, Costa IG, B?low RD, Boor P. Next-Generation Morphometry for pathomics-data mining in histopathology. Nat Commun. 2023 Jan 28; 14(1):470. PMID: 36709324.
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    10. Schumacher D, Curaj A, Staudt M, Simsekyilmaz S, Kanzler I, Boor P, Klinkhammer BM, Li X, Bucur O, Kaabi A, Xu Y, Zheng H, Nilcham P, Schuh A, Rusu M, Liehn EA. Endogenous Modulation of Extracellular Matrix Collagen during Scar Formation after Myocardial Infarction. Int J Mol Sci. 2022 Nov 23; 23(23). PMID: 36498897.
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    11. Ermert K, Buhl EM, Klinkhammer BM, Floege J, Boor P. Reduction of Endothelial Glycocalyx on Peritubular Capillaries in Chronic Kidney Disease. Am J Pathol. 2023 02; 193(2):138-147. PMID: 36414084.
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    12. Jia T, Xu T, Smeets B, Buhl EM, Moeller MJ, Floege J, Klinkhammer BM, Boor P. The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2023 02 01; 34(2):241-257. PMID: 36351762.
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    13. Bouteldja N, H?lscher DL, Klinkhammer BM, Buelow RD, Lotz J, Weiss N, Daniel C, Amann K, Boor P. Stain-Independent Deep Learning-Based Analysis of Digital Kidney Histopathology. Am J Pathol. 2023 01; 193(1):73-83. PMID: 36309103.
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    14. Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, B?hm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H. Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Redox Biol. 2022 10; 56:102459. PMID: 36099852.
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    15. Moellmann J, Mann PA, Kappel BA, Kahles F, Klinkhammer BM, Boor P, Kramann R, Ghesquiere B, Lebherz C, Marx N, Lehrke M. The sodium-glucose co-transporter-2 inhibitor ertugliflozin modifies the signature of cardiac substrate metabolism and reduces cardiac mTOR signalling, endoplasmic reticulum stress and apoptosis. Diabetes Obes Metab. 2022 11; 24(11):2263-2272. PMID: 35801343.
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    16. Bouteldja N, Klinkhammer BM, Schlaich T, Boor P, Merhof D. Improving unsupervised stain-to-stain translation using self-supervision and meta-learning. J Pathol Inform. 2022; 13:100107. PMID: 36268068.
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    17. Gupta L, Klinkhammer BM, Seikrit C, Fan N, Bouteldja N, Gr?bel P, Gadermayr M, Boor P, Merhof D. Large-scale extraction of interpretable features provides new insights into kidney histopathology - A proof-of-concept study. J Pathol Inform. 2022; 13:100097. PMID: 36268111.
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    18. Klinkhammer BM, Buchtler S, Djudjaj S, Bouteldja N, Palsson R, Edvardsson VO, Thorsteinsdottir M, Floege J, Mack M, Boor P. Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease. Kidney Int. 2022 08; 102(2):307-320. PMID: 35483527.
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    19. Hemmers C, Schulte C, Wollenhaupt J, Wong DWL, Harlacher E, Orth-Alampour S, Klinkhammer BM, Schirmer SH, B?hm M, Marx N, Speer T, Boor P, Jankowski J, Noels H. Chemokine CCL9 Is Upregulated Early in Chronic Kidney Disease and Counteracts Kidney Inflammation and Fibrosis. Biomedicines. 2022 Feb 10; 10(2). PMID: 35203629.
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    20. Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, H?bner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, B?hm M. Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD. Circ Res. 2022 03 18; 130(6):814-828. PMID: 35130718.
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    21. Seikrit C, Lausberg E, Buhl EM, Gaspar R, Tabi T, Heffer M, Ducza E, Sztojkov-Ivanov A, Seres AB, Szucs K, Ivic V, Floege J, Vari SG, Boor P, Klinkhammer BM. A Hypercaloric Diet Induces Early Podocyte Damage in Aged, Non-Diabetic Rats. Cell Physiol Biochem. 2021 Dec 23; 55(S4):96-112. PMID: 34936286.
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    22. Kers J, B?low RD, Klinkhammer BM, Breimer GE, Fontana F, Abiola AA, Hofstraat R, Corthals GL, Peters-Sengers H, Djudjaj S, von Stillfried S, H?lscher DL, Pieters TT, van Zuilen AD, Bemelman FJ, Nurmohamed AS, Naesens M, Roelofs JJTH, Florquin S, Floege J, Nguyen TQ, Kather JN, Boor P. Deep learning-based classification of kidney transplant pathology: a retrospective, multicentre, proof-of-concept study. Lancet Digit Health. 2022 01; 4(1):e18-e26. PMID: 34794930.
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    23. Klinkhammer BM, Lammers T, Mottaghy FM, Kiessling F, Floege J, Boor P. Publisher Correction: Non-invasive molecular imaging of kidney diseases. Nat Rev Nephrol. 2021 Oct; 17(10):704. PMID: 34226719.
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    24. Gr?bel P, ?zkan ?, Crysandt M, Herwartz R, Baumann M, Klinkhammer BM, Boor P, Br?mmendorf TH, Merhof D. State of the Art Cell Detection in Bone Marrow Whole Slide Images. J Pathol Inform. 2021; 12:36. PMID: 34760333.
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    25. Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM, Wucherpfennig S, Cacchi C, Braunschweig T, Kn?chel-Clarke R, Jonigk D, Werlein C, B?low RD, Dahl E, von Stillfried S, Boor P. Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients. Cells. 2021 07 27; 10(8). PMID: 34440669.
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    26. Klinkhammer BM, Lammers T, Mottaghy FM, Kiessling F, Floege J, Boor P. Non-invasive molecular imaging of kidney diseases. Nat Rev Nephrol. 2021 Oct; 17(10):688-703. PMID: 34188207.
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    27. Solagna F, Tezze C, Lindenmeyer MT, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, Kilic T, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch JSZ, Turner JE, Wanner N, Nair V, Eichinger F, Menon R, Martin IV, Klinkhammer BM, Hoxha E, Cohen CD, Tharaux PL, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles VG, Patel K, Huber TB. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest. 2021 06 01; 131(11). PMID: 34060483.
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    28. von Stillfried S, Villwock S, B?low RD, Djudjaj S, Buhl EM, Maurer A, Ortiz-Br?chle N, Celec P, Klinkhammer BM, Wong DWL, Cacchi C, Braunschweig T, Kn?chel-Clarke R, Dahl E, Boor P. SARS-CoV-2 RNA screening in routine pathology specimens. Microb Biotechnol. 2021 07; 14(4):1627-1641. PMID: 33993637.
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    29. Bouteldja N, Klinkhammer BM, B?low RD, Droste P, Otten SW, Freifrau von Stillfried S, Moellmann J, Sheehan SM, Korstanje R, Menzel S, Bankhead P, Mietsch M, Drummer C, Lehrke M, Kramann R, Floege J, Boor P, Merhof D. Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology. J Am Soc Nephrol. 2021 01; 32(1):52-68. PMID: 33154175.
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    30. Sato Y, Boor P, Fukuma S, Klinkhammer BM, Haga H, Ogawa O, Floege J, Yanagita M. Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys. Kidney Int. 2020 08; 98(2):448-463. PMID: 32473779.
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    31. Moellmann J, Klinkhammer BM, Droste P, Kappel B, Haj-Yehia E, Maxeiner S, Artati A, Adamski J, Boor P, Sch?tt K, Lopaschuk GD, Verma S, Marx N, Lehrke M. Empagliflozin improves left ventricular diastolic function of db/db mice. Biochim Biophys Acta Mol Basis Dis. 2020 08 01; 1866(8):165807. PMID: 32353614.
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    32. Shi C, Kim T, Steiger S, Mulay SR, Klinkhammer BM, B?uerle T, Melica ME, Romagnani P, M?ckel D, Baues M, Yang L, Brouns SLN, Heemskerk JWM, Braun A, Lammers T, Boor P, Anders HJ. Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism. Circ Res. 2020 04 10; 126(8):e37-e52. PMID: 32089086.
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    33. Klinkhammer BM, Djudjaj S, Kunter U, Palsson R, Edvardsson VO, Wiech T, Thorsteinsdottir M, Hardarson S, Foresto-Neto O, Mulay SR, Moeller MJ, Jahnen-Dechent W, Floege J, Anders HJ, Boor P. Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy. J Am Soc Nephrol. 2020 04; 31(4):799-816. PMID: 32086278.
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    34. Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Dysregulated mesenchymal PDGFR-? drives kidney fibrosis. EMBO Mol Med. 2020 03 06; 12(3):e11021. PMID: 31943786.
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    35. Majo J, Klinkhammer BM, Boor P, Tiniakos D. Pathology and natural history of organ fibrosis. Curr Opin Pharmacol. 2019 12; 49:82-89. PMID: 31671319.
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    36. Baues M, Klinkhammer BM, Ehling J, Gremse F, van Zandvoort MAMJ, Reutelingsperger CPM, Daniel C, Amann K, B?b?ckov? J, Kiessling F, Floege J, Lammers T, Boor P. A collagen-binding protein enables molecular imaging of kidney fibrosis in?vivo. Kidney Int. 2020 03; 97(3):609-614. PMID: 31784048.
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    37. Sun Q, Baues M, Klinkhammer BM, Ehling J, Djudjaj S, Drude NI, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank DC, Botnar RM, Kiessling F, Floege J, Lammers T, Boor P. Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med. 2019 04 03; 11(486). PMID: 30944168.
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    38. Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, B?hner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, M?ller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ. Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis. Kidney Int. 2019 08; 96(2):505-516. PMID: 31155155.
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    39. Gadermayr M, Gupta L, Appel V, Boor P, Klinkhammer BM, Merhof D. Generative Adversarial Networks for Facilitating Stain-Independent Supervised and Unsupervised Segmentation: A Study on Kidney Histology. IEEE Trans Med Imaging. 2019 10; 38(10):2293-2302. PMID: 30762541.
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    40. Gadermayr M, Dombrowski AK, Klinkhammer BM, Boor P, Merhof D. CNN cascades for segmenting sparse objects in gigapixel whole slide images. Comput Med Imaging Graph. 2019 01; 71:40-48. PMID: 30472409.
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    41. Moellmann J, Klinkhammer BM, Onstein J, St?hr R, Jankowski V, Jankowski J, Lebherz C, Tacke F, Marx N, Boor P, Lehrke M. Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy. Diabetes. 2018 11; 67(11):2410-2419. PMID: 30104246.
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    42. Buchtler S, Grill A, Hofmarksrichter S, St?ckert P, Schiechl-Brachner G, Rodriguez Gomez M, Neumayer S, Schmidbauer K, Talke Y, Klinkhammer BM, Boor P, Medvinsky A, Renner K, Castrop H, Mack M. Cellular Origin and Functional Relevance of Collagen I Production in the Kidney. J Am Soc Nephrol. 2018 07; 29(7):1859-1873. PMID: 29777019.
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    43. Klinkhammer BM, Floege J, Boor P. PDGF in organ fibrosis. Mol Aspects Med. 2018 08; 62:44-62. PMID: 29155002.
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    44. Gadermayr M, Eschweiler D, Jeevanesan A, Klinkhammer BM, Boor P, Merhof D. Segmenting renal whole slide images virtually without training data. Comput Biol Med. 2017 11 01; 90:88-97. PMID: 28964977.
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    45. D?ring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schr?der K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, G?bel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation. 2017 Jul 25; 136(4):388-403. PMID: 28450349.
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    46. Klinkhammer BM, Goldschmeding R, Floege J, Boor P. Treatment of Renal Fibrosis-Turning Challenges into Opportunities. Adv Chronic Kidney Dis. 2017 03; 24(2):117-129. PMID: 28284377.
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    47. B?b?ckov? J, Klinkhammer BM, Buhl EM, Djudjaj S, Hoss M, Heymann F, Tacke F, Floege J, Becker JU, Boor P. Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney Int. 2017 01; 91(1):70-85. PMID: 27678159.
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    48. Buhl EM, Djudjaj S, Babickova J, Klinkhammer BM, Folestad E, Borkham-Kamphorst E, Weiskirchen R, Hudkins K, Alpers CE, Eriksson U, Floege J, Boor P. The role of PDGF-D in healthy and fibrotic kidneys. Kidney Int. 2016 Apr; 89(4):848-61. PMID: 26924050.
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    49. Djudjaj S, Lue H, Rong S, Papasotiriou M, Klinkhammer BM, Zok S, Klaener O, Braun GS, Lindenmeyer MT, Cohen CD, Bucala R, Tittel AP, Kurts C, Moeller MJ, Floege J, Ostendorf T, Bernhagen J, Boor P. Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74. J Am Soc Nephrol. 2016 06; 27(6):1650-64. PMID: 26453615.
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    50. Ehling J, B?b?ckov? J, Gremse F, Klinkhammer BM, Baetke S, Knuechel R, Kiessling F, Floege J, Lammers T, Boor P. Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases. J Am Soc Nephrol. 2016 Feb; 27(2):520-32. PMID: 26195818.
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    51. Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J. IL-6 Trans-Signaling Drives Murine Crescentic GN. J Am Soc Nephrol. 2016 Jan; 27(1):132-42. PMID: 26041841.
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    52. Papasotiriou M, Genovese F, Klinkhammer BM, Kunter U, Nielsen SH, Karsdal MA, Floege J, Boor P. Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases. Nephrol Dial Transplant. 2015 Jul; 30(7):1112-21. PMID: 25784725.
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    53. Nagayama Y, Braun GS, Jakobs CM, Maruta Y, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Raffetseder U, Trautwein C, G?rtz D, M?ller-Newen G, Ostendorf T, Floege J. Gp130-dependent signaling in the podocyte. Am J Physiol Renal Physiol. 2014 Aug 01; 307(3):F346-55. PMID: 24899055.
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    54. Klinkhammer BM, Kramann R, Mallau M, Makowska A, van Roeyen CR, Rong S, Buecher EB, Boor P, Kovacova K, Zok S, Denecke B, Stuettgen E, Otten S, Floege J, Kunter U. Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. PLoS One. 2014; 9(3):e92115. PMID: 24667162.
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    55. Kramann R, Kunter U, Brandenburg VM, Leisten I, Ehling J, Klinkhammer BM, Kn?chel R, Floege J, Schneider RK. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. J Bone Miner Res. 2013 Dec; 28(12):2523-34. PMID: 23703894.
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    56. Gaisa NT, Reinartz A, Schneider U, Klaus C, Heidenreich A, Jakse G, Kaemmerer E, Klinkhammer BM, Knuechel R, Gassler N. Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation. Histol Histopathol. 2013 03; 28(3):353-64. PMID: 23348389.
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