Thomas Jefferson University

Jayasri Das Sarma

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kasle G, Das Sarma J. The Role of Coronavirus Spike Protein in Inducing Optic Neuritis in Mice: Parallels to the SARS-CoV-2 Virus. J Neuroophthalmol. 2024 Sep 01; 44(3):319-329. PMID: 39164897.
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    2. Biswas K, Chatterjee D, Addya S, Khan RS, Kenyon LC, Choe A, Cohrs RJ, Shindler KS, Das Sarma J. Corrigendum to "Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination" [Clinical Immunology 170 (2016) 9-19]. Clin Immunol. 2024 Jul 13; 110307. PMID: 39004598.
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    3. Ghosh S, Jana R, Jana S, Basu R, Chatterjee M, Ranawat N, Das Sarma J. Differential expression of cellular prion protein (PrPC) in mouse hepatitis virus induced neuroinflammation. J Neurovirol. 2024 Jun 26. PMID: 38922550.
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    4. Karmakar S, Das Sarma J. Human coronavirus OC43 infection remodels connexin 43-mediated gap junction intercellular communication in vitro. J Virol. 2024 May 31; e0047824. PMID: 38819132.
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    5. Hazra B, Das Sarma J. The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination. IUBMB Life. 2023 Dec 20. PMID: 38116887.
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    6. Easley KF, Edenfield RC, Lott MJ, Reed RC, Das Sarma J, Mehta AJ, Staitieh BS, Lipp EK, Cho IK, Johnson SK, Jones CA, Bebin-Blackwell AG, Levy JM, Tompkins SM, Easley Th CA, Koval M. Chronic alcohol use primes bronchial cells for altered inflammatory response and barrier dysfunction during SARS-CoV-2 infection. Am J Physiol Lung Cell Mol Physiol. 2023 Oct 03. PMID: 37786945.
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    7. Sharma M, Chakravarty D, Hussain A, Zalavadia A, Burrows A, Rayman P, Sharma N, Kenyon LC, Bergmann C, Sen GC, Das Sarma J. Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology. J Virol. 2023 Jul 28; e0074923. PMID: 37504572.
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    8. Kamble M, Saadi F, Kumar S, Saha B, Das Sarma J. Inducible nitric oxide synthase deficiency promotes murine-?-coronavirus induced demyelination. Virol J. 2023 Mar 25; 20(1):51. PMID: 36966345.
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    9. Mulchandani V, Banerjee A, Vadlamannati AV, Kumar S, Das Sarma J. Connexin 43 trafficking and regulation of gap junctional intercellular communication alters ovarian cancer cell migration and tumorigenesis. Biomed Pharmacother. 2023 Mar; 159:114296. PMID: 36701988.
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    10. Safiriyu AA, Mulchandani V, Anakkacheri MN, Pal D, Das Sarma J. Proline-Proline Dyad in the Fusion Peptide of the Murine ?-Coronavirus Spike Protein's S2 Domain Modulates Its Neuroglial Tropism. Viruses. 2023 Jan 12; 15(1). PMID: 36680255.
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    11. Bose A, Kasle G, Jana R, Maulik M, Thomas D, Mulchandani V, Mukherjee P, Koval M, Das Sarma J. Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine ?-coronavirus host cell response. J Biol Chem. 2023 02; 299(2):102836. PMID: 36572185.
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    12. Kumar S, Mulchandani V, Das Sarma J. Methanolic neem (Azadirachta indica) stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells in vitro. BMC Complement Med Ther. 2022 Sep 10; 22(1):239. PMID: 36088372.
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    13. Das Sarma J. Meeting in Mind and a Smile on the Face: A Tribute to Dr. Randall J Cohrs. Viruses. 2022 May 24; 14(6). PMID: 35746598.
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    14. Safiriyu AA, Singh M, Kishore A, Mulchandani V, Maity D, Behera A, Sinha B, Pal D, Das Sarma J. Two Consecutive Prolines in the Fusion Peptide of Murine ?-Coronavirus Spike Protein Predominantly Determine Fusogenicity and May Be Essential but Not Sufficient to Cause Demyelination. Viruses. 2022 04 17; 14(4). PMID: 35458565.
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    15. Saadi F, Chakravarty D, Kumar S, Kamble M, Saha B, Shindler KS, Das Sarma J. CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination. PLoS Pathog. 2021 12; 17(12):e1010059. PMID: 34898656.
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    16. Sengupta S, Bhattacharyya D, Kasle G, Karmakar S, Sahu O, Ganguly A, Addya S, Das Sarma J. Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan ?-Coronaviruses. Front Cell Infect Microbiol. 2021; 11:729622. PMID: 34513735.
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    17. Chakravarty D, Das Sarma J. Murine-?-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2. J Neurovirol. 2021 04; 27(2):197-216. PMID: 33547593.
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    18. Das Sarma J, Burrows A, Rayman P, Hwang MH, Kundu S, Sharma N, Bergmann C, Sen GC. Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection. PLoS Pathog. 2020 11; 16(11):e1009034. PMID: 33253295.
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    19. Maulik M, Vasan L, Bose A, Dutta Chowdhury S, Sengupta N, Das Sarma J. Amyloid-? regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes. J Biol Chem. 2020 10 30; 295(44):15097-15111. PMID: 32868453.
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    20. Chakravarty D, Saadi F, Kundu S, Bose A, Khan R, Dine K, Kenyon LC, Shindler KS, Das Sarma J. CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation. J Virol. 2020 Jul 01; 94(14). PMID: 32404525.
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    21. Sarkar L, Putchala RK, Safiriyu AA, Das Sarma J. Azadirachta indica A. Juss Ameliorates Mouse Hepatitis Virus-Induced Neuroinflammatory Demyelination by Modulating Cell-to-Cell Fusion in an Experimental Animal Model of Multiple Sclerosis. Front Cell Neurosci. 2020; 14:116. PMID: 32477069.
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    22. Rout SS, Singh M, Shindler KS, Das Sarma J. One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration. J Biol Chem. 2020 05 15; 295(20):6926-6935. PMID: 32249210.
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    23. Singh M, Kishore A, Maity D, Sunanda P, Krishnarjuna B, Vappala S, Raghothama S, Kenyon LC, Pal D, Das Sarma J. A proline insertion-deletion in the spike glycoprotein fusion peptide of mouse hepatitis virus strongly alters neuropathology. J Biol Chem. 2019 Mar 01. PMID: 30824541.
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    24. Singh M, Khan RS, Dine K, Das Sarma J, Shindler KS. Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis. Front Cell Infect Microbiol. 2018; 8:311. PMID: 30234031.
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    25. Hussain A, Das Sarma S, Babu S, Pal D, Das Sarma J. Interaction of arsenic with gap junction protein connexin 43 alters gap junctional intercellular communication. Biochim Biophys Acta Mol Cell Res. 2018 Jul 19; 1865(10):1423-1436. PMID: 30031898.
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    26. Bose A, Basu R, Maulik M, Das Sarma J. Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection. Mol Neurobiol. 2018 Aug; 55(8):6558-6571. PMID: 29327203.
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    27. Mukherjee S, Dinda H, Chakraborty I, Bhattacharyya R, Das Sarma J, Shunmugam R. Engineering Camptothecin-Derived Norbornene Polymers for Theranostic Application. ACS Omega. 2017 Jun 30; 2(6):2848-2857. PMID: 30023678.
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    28. Basu R, Bose A, Thomas D, Das Sarma J. Microtubule-assisted altered trafficking of astrocytic gap junction protein connexin 43 is associated with depletion of connexin 47 during mouse hepatitis virus infection. J Biol Chem. 2017 09 08; 292(36):14747-14763. PMID: 28566289.
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    29. Ganivada MN, Kumar P, Babu A, Das Sarma J, Shunmugam R. Engineering a New Class of Multiarm Homopolymer for Sustainable Drug Delivery. ACS Biomater Sci Eng. 2017 Jun 12; 3(6):903-908. PMID: 33429562.
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    30. Mukherjee S, Das Sarma J, Shunmugam R. pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging. ACS Omega. 2016 Nov 30; 1(5):755-764. PMID: 30023490.
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    31. Bhattacharya S, Ganivada MN, Dinda H, Das Sarma J, Shunmugam R. Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin. ACS Omega. 2016 Jul 31; 1(1):108-117. PMID: 30023475.
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    32. Biswas K, Chatterjee D, Addya S, Khan RS, Kenyon LC, Choe A, Cohrs RJ, Shindler KS, Das Sarma J. Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination. Clin Immunol. 2016 Sep; 170:9-19. PMID: 27394164.
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    33. Kenyon LC, Biswas K, Shindler KS, Nabar M, Stout M, Hingley ST, Grinspan JB, Das Sarma J. Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus. Front Cell Neurosci. 2015; 9:488. PMID: 26733813.
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    34. Basu R, Banerjee K, Bose A, Das Sarma J. Mouse Hepatitis Virus Infection Remodels Connexin43-Mediated Gap Junction Intercellular Communication In Vitro and In Vivo. J Virol. 2015 Dec 16; 90(5):2586-99. PMID: 26676788.
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    35. N VR, Dinda H, Ganivada MN, Das Sarma J, Shunmugam R. Efficient approach to prepare multiple chemotherapeutic agent conjugated nanocarrier. Chem Commun (Camb). 2014 Nov 14; 50(88):13540-3. PMID: 25243250.
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    36. Mane SR, Dinda H, Sathyan A, Das Sarma J, Shunmugam R. Increased bioavailability of rifampicin from stimuli-responsive smart nano carrier. ACS Appl Mater Interfaces. 2014 Oct 08; 6(19):16895-902. PMID: 25199547.
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    37. Rao N V, Ganivada MN, Sarkar S, Dinda H, Chatterjee K, Dalui T, Das Sarma J, Shunmugam R. Magnetic norbornene polymer as multiresponsive nanocarrier for site specific cancer therapy. Bioconjug Chem. 2014 Feb 19; 25(2):276-85. PMID: 24364417.
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    38. Khan RS, Dine K, Das Sarma J, Shindler KS. SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease. Acta Neuropathol Commun. 2014 Jan 02; 2:3. PMID: 24383546.
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    39. Biswas K, Das Sarma J. Effect of microtubule disruption on neuronal spread and replication of demyelinating and nondemyelinating strains of mouse hepatitis virus in vitro. J Virol. 2014 Mar; 88(5):3043-7. PMID: 24352473.
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    40. Kishore A, Kanaujia A, Nag S, Rostami AM, Kenyon LC, Shindler KS, Das Sarma J. Different mechanisms of inflammation induced in virus and autoimmune-mediated models of multiple sclerosis in C57BL6 mice. Biomed Res Int. 2013; 2013:589048. PMID: 24083230.
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    41. Das Sarma J. Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology. J Neurovirol. 2014 Apr; 20(2):122-36. PMID: 23979705.
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    42. Chatterjee D, Biswas K, Nag S, Ramachandra SG, Das Sarma J. Microglia play a major role in direct viral-induced demyelination. Clin Dev Immunol. 2013; 2013:510396. PMID: 23864878.
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    43. Rao VN, Kishore A, Sarkar S, Das Sarma J, Shunmugam R. Norbornene-derived poly-D-lysine copolymers as quantum dot carriers for neuron growth. Biomacromolecules. 2012 Sep 10; 13(9):2933-44. PMID: 22867006.
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    44. Rao N V, Mane SR, Kishore A, Das Sarma J, Shunmugam R. Norbornene derived doxorubicin copolymers as drug carriers with pH responsive hydrazone linker. Biomacromolecules. 2012 Jan 09; 13(1):221-30. PMID: 22107051.
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    45. Shindler KS, Chatterjee D, Biswas K, Goyal A, Dutt M, Nassrallah M, Khan RS, Das Sarma J. Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. J Neuropathol Exp Neurol. 2011 Jun; 70(6):470-80. PMID: 21572336.
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    46. Das Sarma J. A mechanism of virus-induced demyelination. Interdiscip Perspect Infect Dis. 2010; 2010:109239. PMID: 20652053.
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    47. Das Sarma J, Kenyon LC, Hingley ST, Shindler KS. Mechanisms of primary axonal damage in a viral model of multiple sclerosis. J Neurosci. 2009 Aug 19; 29(33):10272-80. PMID: 19692601.
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    48. Das Sarma J, Ciric B, Marek R, Sadhukhan S, Caruso ML, Shafagh J, Fitzgerald DC, Shindler KS, Rostami A. Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2009; 6:14. PMID: 19400960.
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    49. Marek R, Caruso M, Rostami A, Grinspan JB, Das Sarma J. Magnetic cell sorting: a fast and effective method of concurrent isolation of high purity viable astrocytes and microglia from neonatal mouse brain tissue. J Neurosci Methods. 2008 Oct 30; 175(1):108-18. PMID: 18786564.
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    50. Shindler KS, Kenyon LC, Dutt M, Hingley ST, Das Sarma J. Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J Virol. 2008 Sep; 82(17):8882-6. PMID: 18579591.
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    51. Das Sarma J, Kaplan BE, Willemsen D, Koval M. Identification of rab20 as a potential regulator of connexin 43 trafficking. Cell Commun Adhes. 2008 May; 15(1):65-74. PMID: 18649179.
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    52. Das Sarma J, Iacono K, Gard L, Marek R, Kenyon LC, Koval M, Weiss SR. Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism. J Virol. 2008 Jun; 82(11):5519-26. PMID: 18385249.
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    53. Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J, Gran B, Zhang GX, Rostami A. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007 Sep 1; 179(5):3268-75. PMID: 17709543.
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    54. Qiu Z, Hingley ST, Simmons G, Yu C, Das Sarma J, Bates P, Weiss SR. Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry. J Virol. 2006 Jun; 80(12):5768-76. PMID: 16731916.
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    55. Constantinescu CS, Tani M, Ransohoff RM, Wysocka M, Hilliard B, Fujioka T, Murphy S, Tighe PJ, Das Sarma J, Trinchieri G, Rostami A. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem. 2005 Oct; 95(2):331-40. PMID: 16086689.
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    56. Das Sarma J, Das S, Koval M. Regulation of connexin43 oligomerization is saturable. Cell Commun Adhes. 2005 Jul-Dec; 12(5-6):237-47. PMID: 16531319.
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    57. Maza J, Das Sarma J, Koval M. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem. 2005 Jun 03; 280(22):21115-21. PMID: 15817491.
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    58. Fu L, Gonzales DM, Das Sarma J, Lavi E. A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination. J Neurovirol. 2004 Feb; 10(1):41-51. PMID: 14982727.
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    59. Gonzales DM, Fu L, Li Y, Das Sarma J, Lavi E. Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals. J Neuroimmunol. 2004 Jan; 146(1-2):140-3. PMID: 14698856.
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    60. Maza J, Mateescu M, Das Sarma J, Koval M. Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):319-22. PMID: 14681035.
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    61. Das Sarma J, Scheen E, Seo SH, Koval M, Weiss SR. Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. J Neurovirol. 2002 Oct; 8(5):381-91. PMID: 12402164.
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    62. Das Sarma J, Wang F, Koval M. Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization. J Biol Chem. 2002 Jun 07; 277(23):20911-8. PMID: 11929864.
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    63. Das Sarma J, Meyer RA, Wang F, Abraham V, Lo CW, Koval M. Multimeric connexin interactions prior to the trans-Golgi network. J Cell Sci. 2001 Nov; 114(Pt 22):4013-24. PMID: 11739633.
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    64. Das Sarma J, Fu L, Hingley ST, Lai MM, Lavi E. Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis. J Neurovirol. 2001 Oct; 7(5):432-6. PMID: 11582515.
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    65. Das Sarma J, Fu L, Hingley ST, Lavi E. Mouse hepatitis virus type-2 infection in mice: an experimental model system of acute meningitis and hepatitis. Exp Mol Pathol. 2001 Aug; 71(1):1-12. PMID: 11502093.
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    66. Navas S, Seo SH, Chua MM, Das Sarma J, Lavi E, Hingley ST, Weiss SR. Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis. J Virol. 2001 Mar; 75(5):2452-7. PMID: 11160748.
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    67. Navas S, Seo SH, Chua MM, Das Sarma J, Hingley ST, Lavi E, Weiss SR. Role of the spike protein in murine coronavirus induced hepatitis: an in vivo study using targeted RNA recombination. Adv Exp Med Biol. 2001; 494:139-44. PMID: 11774458.
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    68. Fu LI, Das Sarma J, Lavi E. Differential expression of tumor necrosis factor in primary glial cell cultures infected with demyelinating and non-demyelinating MHVs. Adv Exp Med Biol. 2001; 494:663-8. PMID: 11774542.
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    69. Das Sarma J, Lo CW, Koval M. Cx43/beta-gal inhibits Cx43 transport in the Golgi apparatus. Cell Commun Adhes. 2001; 8(4-6):249-52. PMID: 12064597.
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    70. Das Sarma J, Fu L, Weiss SR, Lavi E. Demyelination determinants in the S gene of MHV. Adv Exp Med Biol. 2001; 494:133-7. PMID: 11774457.
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    71. Das Sarma J, Fu L, Lavi E. The effect of the T1087N S gene mutation on MHV-A59 pathogenesis. Adv Exp Med Biol. 2001; 494:155-7. PMID: 11774461.
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    72. Das Sarma J, Fu L, Tsai JC, Weiss SR, Lavi E. Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus. J Virol. 2000 Oct; 74(19):9206-13. PMID: 10982367.
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    73. Lavi E, Das Sarma J, Weiss SR. Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology. 1999 Mar-Apr; 67(2):75-83. PMID: 10023135.
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