Robert Witt

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    R01DE022969     (FARACH-CARSON, MARY C)Jul 17, 2012 - Jun 30, 2017
    NIH
    Functional Assembly of Salivary Cells to Relieve Xerostomia
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hoffman HT, Koch M, Witt RL, Ryan WR, Zenk J, Katz P, Rahmati R, Rassekh C, Donato F, McCulloch TM, Joshi AS, Chang JL, Gillespie MB, Pichardo PFA, Orloff LA, Marcelino A, Wenzel P, Cohen D, Fundakowski CE, Cognetti DM, Walvekar RR, Bertelli A, Quon H, Anderson C, Policeni B, Siegel G. Proposal for standardized ultrasound analysis of the salivary glands: Part 1 submandibular gland. Laryngoscope Investig Otolaryngol. 2024 Feb; 9(1):e1224. PMID: 38362174.
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    2. Metkari AS, Fowler EW, Witt RL, Jia X. Matrix Degradability Contributes to the Development of Salivary Gland Progenitor Cells with Secretory Functions. ACS Appl Mater Interfaces. 2023 Jul 12; 15(27):32148-32161. PMID: 37364369.
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    3. Fowler EW, van Venrooy EJ, Witt RL, Jia X. A TGF?R inhibitor represses keratin-7 expression in 3D cultures of human salivary gland progenitor cells. Sci Rep. 2022 Sep 02; 12(1):15008. PMID: 36056161.
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    4. Fowler EW, Ravikrishnan A, Witt RL, Pradhan-Bhatt S, Jia X. RGDSP-Decorated Hyaluronate Hydrogels Facilitate Rapid 3D Expansion of Amylase-Expressing Salivary Gland Progenitor Cells. ACS Biomater Sci Eng. 2021 12 13; 7(12):5749-5761. PMID: 34781679.
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    5. Wu D, Lombaert IMA, DeLeon M, Pradhan-Bhatt S, Witt RL, Harrington DA, Trombetta MG, Passineau MJ, Farach-Carson MC. Immunosuppressed Miniswine as a Model for Testing Cell Therapy Success: Experience With Implants of Human Salivary Stem/Progenitor Cell Constructs. Front Mol Biosci. 2021; 8:711602. PMID: 34660692.
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    6. Buchholzer S, Faure F, Tcheremissinoff L, Herrmann FR, Lombardi T, Ng SK, Lopez JM, Borner U, Witt RL, Irvine R, Abboud O, Cernea CR, Ghan S, Matsunobu T, Ahmad Z, Morton R, Anicin A, Magdy EA, Al Abri R, Konstantinidis I, Capaccio P, Klein H, Poorten VV, Lombardi D, Lyons B, Al Rand H, Liao G, Kim JK, Subha S, Su RY, Su CH, Boselie F, Andre R, Seebach JD, Marchal F. Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus. Laryngoscope. 2022 02; 132(2):322-331. PMID: 34236085.
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    7. Coca KK, Gillespie MB, Beckmann NA, Zhu R, Nelson TM, Witt RL. Sialendoscopy and Sjogren's Disease: A Systematic Review. Laryngoscope. 2021 07; 131(7):1474-1481. PMID: 33141438.
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    8. Soldatova L, Rassekh CH, Baloch ZW, Jalaly JB, Sedora-Roman NI, Loevner LL, Cognetti DM, Witt RL, Dulguerov P. Salivary gland disease in the era of COVID-19 pandemic. Head Neck. 2020 Apr 28. PMID: 32343454.
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    9. Wu D, Witt RL, Harrington DA, Farach-Carson MC. Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated a1?1 Integrin-Mediated Motility. Front Cell Dev Biol. 2019; 7:224. PMID: 31750298.
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    10. Cornett A, Athwal HK, Hill E, Murphy G, Yeoh K, Moskaluk CA, Witt RL, D'Silva NJ, Agarwal S, Lombaert IMA. Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation. EBioMedicine. 2019 Mar; 41:175-184. PMID: 30765319.
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    11. Palmer JD, Schneider CJ, Hockstein N, Hanlon AL, Silberg J, Strasser J, Mauer EA, Dzeda M, Witt R, Raben A. Combination of post-operative radiotherapy and cetuximab for high-risk cutaneous squamous cell cancer of the head and neck: A propensity score analysis. Oral Oncol. 2018 03; 78:102-107. PMID: 29496036.
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    12. Roth MY, Witt RL, Steward DL. Molecular testing for thyroid nodules: Review and current state. Cancer. 2018 03 01; 124(5):888-898. PMID: 29278433.
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    13. Witt RL. In reference to Does mutational analysis influence the management of differentiated thyroid cancers? Laryngoscope. 2018 02; 128(2):E84. PMID: 28865093.
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    14. Ozdemir T, Srinivasan PP, Zakheim DR, Harrington DA, Witt RL, Farach-Carson MC, Jia X, Pradhan-Bhatt S. Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function. Biomaterials. 2017 Oct; 142:124-135. PMID: 28734180.
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    15. Sagiv D, Witt RL, Glikson E, Mansour J, Shalmon B, Yakirevitch A, Wolf M, Alon EE, Slonimsky G, Talmi YP. Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. Eur Arch Otorhinolaryngol. 2017 Apr; 274(4):1993-1996. PMID: 28013343.
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    16. Dominguez GA, Condamine T, Mony S, Hashimoto A, Wang F, Liu Q, Forero A, Bendell J, Witt R, Hockstein N, Kumar P, Gabrilovich DI. Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody. Clin Cancer Res. 2017 Jun 15; 23(12):2942-2950. PMID: 27965309.
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    17. Witt RL. Targeted Next Generation Sequencing with ThyroSeq v2.1 for Indeterminate Thyroid Nodules in Clinical Practice. Del Med J. 2016 Dec; 88(12):366-372. PMID: 29461717.
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    18. Ozdemir T, Fowler EW, Liu S, Harrington DA, Witt RL, Farach-Carson MC, Pradhan-Bhatt S, Jia X. Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D. ACS Biomater Sci Eng. 2016 Dec 12; 2(12):2217-2230. PMID: 27990487.
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    19. Srinivasan PP, Patel VN, Liu S, Harrington DA, Hoffman MP, Jia X, Witt RL, Farach-Carson MC, Pradhan-Bhatt S. Primary Salivary Human Stem/Progenitor Cells Undergo Microenvironment-Driven Acinar-Like Differentiation in Hyaluronate Hydrogel Culture. Stem Cells Transl Med. 2017 Jan; 6(1):110-120. PMID: 28170182.
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    20. Condamine T, Dominguez GA, Youn JI, Kossenkov AV, Mony S, Alicea-Torres K, Tcyganov E, Hashimoto A, Nefedova Y, Lin C, Partlova S, Garfall A, Vogl DT, Xu X, Knight SC, Malietzis G, Lee GH, Eruslanov E, Albelda SM, Wang X, Mehta JL, Bewtra M, Rustgi A, Hockstein N, Witt R, Masters G, Nam B, Smirnov D, Sepulveda MA, Gabrilovich DI. Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci Immunol. 2016 Aug; 1(2). PMID: 28417112.
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    21. Witt RL. What is the best treatment of incidental papillary thyroid microcarcinoma? Laryngoscope. 2016 10; 126(10):2203-4. PMID: 27107211.
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    22. Witt RL, Nicolai P. Recurrent Benign Salivary Gland Neoplasms. Adv Otorhinolaryngol. 2016; 78:63-70. PMID: 27093568.
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    23. Witt RL. Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors. Otolaryngol Head Neck Surg. 2016 Mar; 154(3):572-4. PMID: 26884366.
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    24. Ozdemir T, Fowler EW, Hao Y, Ravikrishnan A, Harrington DA, Witt RL, Farach-Carson MC, Pradhan-Bhatt S, Jia X. Biomaterials-based strategies for salivary gland tissue regeneration. Biomater Sci. 2016 Apr 22; 4(4):592-604. PMID: 26878077.
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    25. Witt RL. Outcome of thyroid gene expression classifier testing in clinical practice. Laryngoscope. 2016 Feb; 126(2):524-7. PMID: 26343268.
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    26. Dan TD, Raben D, Schneider CJ, Hockstein NG, Witt RL, Dzeda M, Cormier JF, Raben A. Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: updated results of an institutional clinical management approach. Oral Oncol. 2015 Jun; 51(6):616-21. PMID: 25868716.
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    27. Witt RL, Sukumar VR, Gerges F. Surgeon-performed ultrasound-guided FNAC with on-site cytopathology improves adequacy and accuracy. Laryngoscope. 2015 Jul; 125(7):1633-6. PMID: 25703413.
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    28. Witt RL, Iacocca M, Gerges F. Contemporary diagnosis and management of Warthin's tumor. Del Med J. 2015 Jan; 87(1):13-6. PMID: 25799607.
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    29. Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zb?ren P. Etiology and management of recurrent parotid pleomorphic adenoma. Laryngoscope. 2015 Apr; 125(4):888-93. PMID: 25289881.
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    30. Witt RL. Thyroid cancer: current diagnosis, management, and prognostication. Otolaryngol Clin North Am. 2014 Aug; 47(4):xv-xvi. PMID: 25041962.
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    31. Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014 Jun; 124(6):2626-39. PMID: 24789911.
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    32. Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X. Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater. 2014 Apr; 10(4):1558-70. PMID: 24361428.
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    33. Lombaert IM, Abrams SR, Li L, Eswarakumar VP, Sethi AJ, Witt RL, Hoffman MP. Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis. Stem Cell Reports. 2013; 1(6):604-19. PMID: 24371813.
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    34. Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope. 2014 Feb; 124(2):456-61. PMID: 23832678.
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    35. Pradhan-Bhatt S, Harrington DA, Duncan RL, Jia X, Witt RL, Farach-Carson MC. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A. 2013 Jul; 19(13-14):1610-20. PMID: 23442148.
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    36. Witt RL, Pribitkin EA. How can Frey's syndrome be prevented or treated following parotid surgery? Laryngoscope. 2013 Jul; 123(7):1573-4. PMID: 23468273.
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    37. Witt RL, Ferris RL, Pribitkin EA, Sherman SI, Steward DL, Nikiforov YE. Diagnosis and management of differentiated thyroid cancer using molecular biology. Laryngoscope. 2013 Apr; 123(4):1059-64. PMID: 23404751.
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    38. Zb?ren P, Vander Poorten V, Witt RL, Woolgar JA, Shaha AR, Triantafyllou A, Takes RP, Rinaldo A, Ferlito A. Pleomorphic adenoma of the parotid: formal parotidectomy or limited surgery? Am J Surg. 2013 Jan; 205(1):109-18. PMID: 23062782.
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    39. Witt RL, Iacocca M. Comparing capsule exposure using extracapsular dissection with partial superficial parotidectomy for pleomorphic adenoma. Am J Otolaryngol. 2012 Sep-Oct; 33(5):581-4. PMID: 22516183.
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    40. Witt RL, Iro H, Koch M, McGurk M, Nahlieli O, Zenk J. Minimally invasive options for salivary calculi. Laryngoscope. 2012 Jun; 122(6):1306-11. PMID: 22460664.
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    41. Witt RL. What is the best operative practice for small benign parotid pleomorphic adenoma? Del Med J. 2011 Jun; 83(6):175-6. PMID: 21882497.
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    42. Witt RL. What is the treatment of the lateral neck in clinically localized sporadic medullary thyroid cancer? Laryngoscope. 2010 Jul; 120(7):1286-7. PMID: 20583117.
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    43. Witt RL, Wilson P. Successful elective surgery in a patient with a positive preoperative cocaine toxicology screen. Ear Nose Throat J. 2010 Feb; 89(2):E14-6. PMID: 20155664.
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    44. Pradhan S, Liu C, Zhang C, Jia X, Farach-Carson MC, Witt RL. Lumen formation in three-dimensional cultures of salivary acinar cells. Otolaryngol Head Neck Surg. 2010 Feb; 142(2):191-5. PMID: 20115973.
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    45. Pradhan S, Zhang C, Jia X, Carson DD, Witt R, Farach-Carson MC. Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro. Tissue Eng Part A. 2009 Nov; 15(11):3309-20. PMID: 19382872.
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    46. Witt RL. Sialendoscopy in Delaware. Del Med J. 2009 Jun; 81(6):227-9. PMID: 19772078.
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    47. Witt RL. The incidence and management of siaolocele after parotidectomy. Otolaryngol Head Neck Surg. 2009 Jun; 140(6):871-4. PMID: 19467406.
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    48. Witt RL, Rejto L. Pleomorphic adenoma: extracapsular dissection versus partial superficial parotidectomy with facial nerve dissection. Del Med J. 2009 Mar; 81(3):119-25. PMID: 19507761.
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    49. Witt RL, Wilson PA. Vocal fold immobility from a primary minor salivary gland small-cell carcinoma: case report. Ear Nose Throat J. 2009 Feb; 88(2):E13-6. PMID: 19224469.
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    50. Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A. Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys. 2009 Aug 01; 74(5):1365-70. PMID: 19168295.
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    51. Witt RL. Initial surgical management of thyroid cancer. Surg Oncol Clin N Am. 2008 Jan; 17(1):71-91, viii. PMID: 18177801.
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    52. Witt RL, Wilson P. Missed opportunity for larynx preservation? Failure to distinguish verrucous and squamous cell carcinoma on microlaryngoscopy and biopsy. J Voice. 2009 Jan; 23(1):140-2. PMID: 18082368.
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    53. Witt RL, Rejto L. Spinal accessory nerve monitoring in selective and modified neck dissection. Laryngoscope. 2007 May; 117(5):776-80. PMID: 17473667.
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    54. Witt RL, Gillis T, Pratt R. Spinal accessory nerve monitoring with clinical outcome measures. Ear Nose Throat J. 2006 Aug; 85(8):540-4. PMID: 16999064.
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    55. Witt RL. Comparing the long-term outcome of immediate postoperative facial nerve dysfunction and vocal fold immobility after parotid and thyroid surgery. J Voice. 2006 Sep; 20(3):461-5. PMID: 16236482.
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    56. Witt RL. Recurrent laryngeal nerve electrophysiologic monitoring in thyroid surgery: the standard of care? J Voice. 2005 Sep; 19(3):497-500. PMID: 16102675.
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    57. Witt RL, Frelick RW. Head and neck cancer care at a community-based teaching hospital. Head Neck. 2005 Jul; 27(7):613-5. PMID: 15825202.
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    58. Witt RL. Minimally invasive surgery for parotid pleomorphic adenoma. Ear Nose Throat J. 2005 May; 84(5):308, 310-1. PMID: 15971755.
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    59. Witt RL, Weinstein GS, Rejto LK. Tympanomastoid suture and digastric muscle in cadaver and live parotidectomy. Laryngoscope. 2005 Apr; 115(4):574-7. PMID: 15805861.
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    60. Witt RL. A comparison of the results of monolayer versus smear cytopreparatory techniques for fine-needle aspiration in 100 consecutive patients undergoing thyroidectomy: a surgeon's perspective. Otolaryngol Head Neck Surg. 2004 Dec; 131(6):964-7. PMID: 15577798.
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    61. Witt RL. Electrophysiologic monitoring of the recurrent laryngeal nerves may not predict bilateral vocal fold immobility after thyroid surgery. J Voice. 2004 Jun; 18(2):256-60. PMID: 15193661.
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    62. Witt RL. Major salivary gland cancer. Surg Oncol Clin N Am. 2004 Jan; 13(1):113-27. PMID: 15062365.
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    63. Witt R, Schneider C, Raben A, Arm R, Kendall J, Symes K, Waddington C, Dolinger E, Casper J, Harrington M. Head and neck cancer care in Delaware: the advent of the Helen F. Graham Head and Neck Multi-Disciplinary Center. Del Med J. 2003 Dec; 75(12):455-9. PMID: 14964992.
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    64. Witt RL. Colonic adenocarcinoma metastatic to thyroid H?rthle cell carcinoma presenting with airway obstruction. Del Med J. 2003 Aug; 75(8):285-8. PMID: 12971227.
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    65. Witt RL. Sarcoidosis presenting as bilateral vocal fold paralysis. J Voice. 2003 Jun; 17(2):265-8. PMID: 12825658.
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    66. Witt RL, McNamara AM. Prognostic factors in mortality and morbidity in patients with differentiated thyroid cancer. Ear Nose Throat J. 2002 Dec; 81(12):856-63. PMID: 12516384.
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