David Epstein

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Machin M, Peerbux S, Whittley S, Hunt BJ, Everington T, Gohel M, Norrie J, Epstein D, Warwick DJ, Baker C, Hamady Z, Smith S, Bolton L, Stephens-Boal A, Gray B, Shalhoub J, Davies AH. Examining the benefit of graduated compression stockings in the prevention of hospital-associated venous thromboembolism in low-risk surgical patients: a multicentre cluster randomised controlled trial (PETS trial). BMJ Open. 2023 01 17; 13(1):e069802. PMID: 36653057.
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    2. Perez-Troncoso D, Epstein D, Davies AH, Thapar A. Cost-effectiveness of carotid endarterectomy in symptomatic patients. Br J Surg. 2023 01 10; 110(2):193-199. PMID: 36422995.
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    3. Normahani P, Burgess L, Norrie J, Epstein DM, Kandiyil N, Saratzis A, Smith S, Khunti K, Edmonds M, Ahluwalia R, Coward T, Hartshorne T, Ashwell S, Shalhoub J, Pigott E, Davies AH, Jaffer U. Study protocol for a multicentre comparative diagnostic accuracy study of tools to establish the presence and severity of peripheral arterial disease in people with diabetes mellitus: the DM PAD study. BMJ Open. 2022 11 03; 12(11):e066950. PMID: 36328388.
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    4. Romo-Avil?s N, Zapata JF, Keuneke A, Petroff D, Etz CD, Epstein D. "There is nothing better than participating in this study": Living the PAPAartis cardiovascular randomised controlled trial. Contemp Clin Trials Commun. 2022 Oct; 29:100987. PMID: 36111175.
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    5. Olry de Labry-Lima A, Ponce-Polo A, Garc?a-Moch?n L, Ortega-Ortega M, P?rez-Troncoso D, Epstein D. Challenges for Economic Evaluations of Advanced Therapy Medicinal Products: A Systematic Review. Value Health. 2023 Jan; 26(1):138-150. PMID: 36031480.
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    6. Ngabonzima A, Asingizwe D, Cechetto D, Mukunde G, Nyalihama A, Gakwerere M, Epstein DM. Evaluating the medical direct costs associated with prematurity during the initial hospitalization in Rwanda: a prevalence based cost of illness study. BMC Health Serv Res. 2022 Jul 27; 22(1):953. PMID: 35897023.
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    7. Diop M, Epstein D. Comparing methods for handling missing cost and quality of life data in the Early Endovenous Ablation in Venous Ulceration trial. Cost Eff Resour Alloc. 2022 Apr 07; 20(1):18. PMID: 35392924.
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    8. Kim LG, Sweeting MJ, Epstein D, Venermo M, Rohlffs FEV, Greenhalgh RM. Optimizing Surveillance and Re-intervention Strategy Following Elective Endovascular Repair of Abdominal Aortic Aneurysms. Ann Surg. 2021 12 01; 274(6):e589-e598. PMID: 31592810.
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    9. Epstein D, Bootun R, Diop M, Ortega-Ortega M, Lane TRA, Davies AH. Cost-effectiveness analysis of current varicose veins treatments. J Vasc Surg Venous Lymphat Disord. 2022 03; 10(2):504-513.e7. PMID: 34450353.
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    10. P?rez-Troncoso D, Epstein DM, Casta?eda-Garc?a JA. Consumers' Preferences and Willingness to Pay for Personalised Nutrition. Appl Health Econ Health Policy. 2021 09; 19(5):757-767. PMID: 33900567.
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    11. Thapar A, Lawton R, Burgess L, Shalhoub J, Bradbury A, Cullum N, Epstein D, Gohel M, Horne R, Hunt BJ, Norrie J, Davies AH. Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168). BMJ Open. 2021 04 12; 11(4):e044285. PMID: 33846151.
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    12. Onida S, Heatley F, Peerbux S, Bolton L, Lane T, Epstein D, Gohel M, Poskitt K, Cullum N, Norrie J, Lee RJ, Bradbury A, Dhillon K, Chandrasekar A, Lomas R, Davies AH. Study protocol for a multicentre, randomised controlled trial to compare the use of the decellularised dermis allograft in addition to standard care versus standard care alone for the treatment of venous leg ulceration: DAVE trial. BMJ Open. 2021 04 02; 11(4):e041748. PMID: 33811051.
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    13. Aslanis S, Amr?n U, Lindberg C, Epstein D. Recurrent Neovascular Age-Related Macular Degeneration after Discontinuation of Vascular Endothelial Growth Factor Inhibitors Managed in a Treat-and-Extend Regimen. Ophthalmol Retina. 2022 01; 6(1):15-20. PMID: 33775926.
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    14. Normahani P, Epstein DM, Gaggero A, Davies AH, Sounderajah V, Jaffer U. Cost-effectiveness of Diagnostic Tools to Establish the Presence of Peripheral Arterial Disease in People With Diabetes. Ann Surg. 2023 Jan 01; 277(1):e184-e191. PMID: 33630439.
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    15. Epstein D. Nutrition Economics: Celebrating Cross-Disciplinary Collaboration. Value Health. 2021 03; 24(3):313-316. PMID: 33641763.
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    16. Gohel MS, Mora MSc J, Szigeti M, Epstein DM, Heatley F, Bradbury A, Bulbulia R, Cullum N, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH. Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial. JAMA Surg. 2020 12 01; 155(12):1113-1121. PMID: 32965493.
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    17. Yu J, Yusoff PAM, Woutersen DTJ, Goh P, Harmston N, Smits R, Epstein DM, Virshup DM, Madan B. The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition. Cancer Res. 2020 12 15; 80(24):5619-5632. PMID: 33067269.
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    18. Ray D, Epstein DM. Tumorigenic de-differentiation: the alternative splicing way. Mol Cell Oncol. 2020 Sep 09; 7(6):1809959. PMID: 33235913.
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    19. Cordovilla-Guardia S, Ortega-Ortega M, Epstein D, Fern?ndez-Mond?jar E, Vilar-L?pez R. Economic Analysis of Brief Motivational Intervention Following Trauma Related to Drugs and Alcohol. Nurs Res. 2020 Sep/Oct; 69(5):358-366. PMID: 32555008.
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    20. Ray D, Yun YC, Idris M, Cheng S, Boot A, Iain TBH, Rozen SG, Tan P, Epstein DM. A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16391-16400. PMID: 32601196.
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    21. Cheng S, Ray D, Lee RTH, Naripogu KB, Yusoff PABM, Goh PBL, Liu Y, Suzuki Y, Das K, Chan HS, Wong WK, Chan WH, Chow PK, Ong HS, Raj P, Soo KC, Tan P, Epstein DM, Rozen SG. A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors. NAR Genom Bioinform. 2020 Jun; 2(2):lqaa013. PMID: 33575575.
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    22. Vallejo-Torres L, Rivero-Santana A, Martin-Saborido C, Epstein D, Perestelo-P?rez L, Castellano-Fuentes CL, Escobar-Mart?nez A, Serrano-Aguilar P. Cost-effectiveness analysis of a surveillance program to prevent hip dislocation in children with cerebral palsy. Gac Sanit. 2020 Jul - Aug; 34(4):377-384. PMID: 31530485.
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    23. Yoshikawa T, Aoyama T, Sakamaki K, Oshima T, Lin J, Zhang S, Sapari NS, Soong R, Tan I, Chan XB, Bottomley D, Hewitt LC, Arai T, Teh BT, Epstein D, Ogata T, Kameda Y, Miyagi Y, Tsuburaya A, Morita S, Grabsch HI, Tan P. Comprehensive biomarker analyses identifies HER2, EGFR, MET RNA expression and thymidylate synthase 5'UTR SNP as predictors of benefit from S-1 adjuvant chemotherapy in Japanese patients with stage II/III gastric cancer. J Cancer. 2019; 10(21):5130-5138. PMID: 31602266.
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    24. Epstein D. Beyond the cost-effectiveness acceptability curve: The appropriateness of rank probabilities for presenting the results of economic evaluation in multiple technology appraisal. Health Econ. 2019 06; 28(6):801-807. PMID: 31050043.
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    25. Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, Epstein DM, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH. Early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration: the EVRA RCT. Health Technol Assess. 2019 05; 23(24):1-96. PMID: 31140402.
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    26. Epstein D, Esp?n J. Evaluation of new medicines in Spain and comparison with other European countries. Gac Sanit. 2020 Mar - Apr; 34(2):133-140. PMID: 31027840.
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    27. Petroff D, Czerny M, K?lbel T, Melissano G, Lonn L, Haunschild J, von Aspern K, Neuhaus P, Pelz J, Epstein DM, Romo-Avil?s N, Piotrowski K, Etz CD. Paraplegia prevention in aortic aneurysm repair by thoracoabdominal staging with 'minimally invasive staged segmental artery coil embolisation' (MIS?ACE): trial protocol for a randomised controlled multicentre trial. BMJ Open. 2019 03 04; 9(3):e025488. PMID: 30837256.
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    28. Lawton R, Babber A, Braithwaite B, Burgess L, Burgess LJ, Chetter I, Coulston J, Epstein D, Fiorentino F, Gohel M, Heatley F, Hinchliffe R, Horgan S, Pal N, Shalhoub J, Simpson R, Stansby G, Davies AH. A multicenter randomized controlled study to evaluate whether neuromuscular electrical stimulation improves the absolute walking distance in patients with intermittent claudication compared with best available treatment. J Vasc Surg. 2019 05; 69(5):1567-1573. PMID: 30792054.
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    29. Raza SEA, Cheung L, Shaban M, Graham S, Epstein D, Pelengaris S, Khan M, Rajpoot NM. Micro-Net: A unified model for segmentation of various objects in microscopy images. Med Image Anal. 2019 02; 52:160-173. PMID: 30580111.
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    30. ?pac?rov? Z, Epstein D, Garc?a-Moch?n L, Aparicio VA, Borges-Cosic M, L?pez Del Amo MP, Mart?n-Mart?n JJ. Cost-effectiveness of a primary care-based exercise intervention in perimenopausal women. The FLAMENCO Project. Gac Sanit. 2019 Nov - Dec; 33(6):529-535. PMID: 30340794.
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    31. Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, Epstein DM, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH. A Randomized Trial of Early Endovenous Ablation in Venous Ulceration. N Engl J Med. 2018 May 31; 378(22):2105-2114. PMID: 29688123.
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    32. Ciani O, Epstein D, Rothery C, Taylor RS, Sculpher M. Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms. Cost Eff Resour Alloc. 2018; 16:15. PMID: 29686541.
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    33. Epstein D, Onida S, Bootun R, Ortega-Ortega M, Davies AH. Cost-Effectiveness of Current and Emerging Treatments of Varicose Veins. Value Health. 2018 08; 21(8):911-920. PMID: 30098668.
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    34. Patel R, Powell JT, Sweeting MJ, Epstein DM, Barrett JK, Greenhalgh RM. The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up and cost-effectiveness analysis. Health Technol Assess. 2018 01; 22(5):1-132. PMID: 29384470.
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    35. Epstein D, Amr?n U. LONG-TIME OUTCOME IN PATIENTS TREATED WITH RANIBIZUMAB FOR DIABETIC MACULAR EDEMA: A 4-Year Study. Retina. 2018 Jan; 38(1):183-186. PMID: 28323678.
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    36. Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nat Commun. 2017 12 19; 8(1):2200. PMID: 29259156.
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    37. Trahearn N, Epstein D, Cree I, Snead D, Rajpoot N. Hyper-Stain Inspector: A Framework for Robust Registration and Localised Co-Expression Analysis of Multiple Whole-Slide Images of Serial Histology Sections. Sci Rep. 2017 07 17; 7(1):5641. PMID: 28717124.
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    38. Jones E, Epstein D, Garc?a-Moch?n L. A Procedure for Deriving Formulas to Convert Transition Rates to Probabilities for Multistate Markov Models. Med Decis Making. 2017 10; 37(7):779-789. PMID: 28379779.
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    39. Rothery C, Claxton K, Palmer S, Epstein D, Tarricone R, Sculpher M. Characterising Uncertainty in the Assessment of Medical Devices and Determining Future Research Needs. Health Econ. 2017 02; 26 Suppl 1:109-123. PMID: 28139090.
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    40. Trahearn N, Tsang YW, Cree IA, Snead D, Epstein D, Rajpoot N. Simultaneous automatic scoring and co-registration of hormone receptors in tumor areas in whole slide images of breast cancer tissue slides. Cytometry A. 2017 06; 91(6):585-594. PMID: 28009468.
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    41. Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NS, Singh MK, Epstein D, Guan Y, Hou?tek J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA. Wars2 is a determinant of angiogenesis. Nat Commun. 2016 07 08; 7:12061. PMID: 27389904.
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    42. Hinde S, Epstein D, Cook A, Embleton A, Perren T, Sculpher M. The Cost-Effectiveness of Bevacizumab in Advanced Ovarian Cancer Using Evidence from the ICON7 Trial. Value Health. 2016 Jun; 19(4):431-9. PMID: 27325335.
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    43. Das K, Chan XB, Epstein D, Te Teh B, Kim KM, Kim ST, Park SH, Kang WK, Rozen S, Lee J, Tan P. NanoString expression profiling identifies candidate biomarkers of RAD001 response in metastatic gastric cancer. ESMO Open. 2016; 1(1):e000009. PMID: 27843583.
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    44. Shepherd AC, Ortega-Ortega M, Gohel MS, Epstein D, Brown LC, Davies AH. COST-EFFECTIVENESS OF RADIOFREQUENCY ABLATION VERSUS LASER FOR VARICOSE VEINS. Int J Technol Assess Health Care. 2015 Jan; 31(5):289-96. PMID: 26715372.
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    45. Epstein D, Garc?a-Moch?n L, Kaptoge S, Thompson SG. Modeling the costs and long-term health benefits of screening the general population for risks of cardiovascular disease: a review of methods used in the literature. Eur J Health Econ. 2016 Nov; 17(8):1041-1053. PMID: 26682549.
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    46. Epstein DM, Buck E. Old dog, new tricks: extracellular domain arginine methylation regulates EGFR function. J Clin Invest. 2015 Dec; 125(12):4320-2. PMID: 26571394.
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    47. Moen I, Gebre M, Alonso-Camino V, Chen D, Epstein D, McDonald DM. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec; 32(8):799-817. PMID: 26445848.
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    48. Epstein D, Kvanta A, Lindqvist PG. Seasonality and incidence of central retinal vein occlusion in Sweden: a 6-year study. Ophthalmic Epidemiol. 2015 Apr; 22(2):94-7. PMID: 25777308.
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    49. Epstein DM, Black BS, Sherman SL. Anterior ankle arthroscopy: indications, pitfalls, and complications. Foot Ankle Clin. 2015 Mar; 20(1):41-57. PMID: 25726482.
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    50. Faria R, Gomes M, Epstein D, White IR. A guide to handling missing data in cost-effectiveness analysis conducted within randomised controlled trials. Pharmacoeconomics. 2014 Dec; 32(12):1157-70. PMID: 25069632.
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    51. Epstein DM. Special delivery: microRNA-200-containing extracellular vesicles provide metastatic message to distal tumor cells. J Clin Invest. 2014 Dec; 124(12):5107-8. PMID: 25401465.
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    52. Mulcahey MK, David TS, Epstein DM, Alaia MJ, Montgomery KD. Transtibial versus anteromedial portal anterior cruciate ligament reconstruction using soft-tissue graft and expandable fixation. Arthroscopy. 2014 Nov; 30(11):1461-7. PMID: 25124481.
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    53. J?dar-S?nchez F, Mart?n JJ, L?pez del Amo MP, Garc?a L, Ara?jo-Santos JM, Epstein D. Cost-utility analysis of a pharmacotherapy follow-up for elderly nursing home residents in Spain. J Am Geriatr Soc. 2014 Jul; 62(7):1272-80. PMID: 24891096.
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    54. Epstein D. Comment on 'heterogeneity in action: the role of passive personalization in comparative effectiveness research'. Health Econ. 2014 Mar; 23(3):374-5. PMID: 24435932.
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    55. Wolfson TS, Epstein DM, Day MS, Joshi BB, McGee A, Strauss EJ, Jazrawi LM. Outcomes of anterior cruciate ligament reconstruction in patients older than 50 years of age. Bull Hosp Jt Dis (2013). 2014; 72(4):277-83. PMID: 25986352.
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    56. Steinig AG, Li AH, Wang J, Chen X, Dong H, Ferraro C, Jin M, Kadalbajoo M, Kleinberg A, Stolz KM, Tavares-Greco PA, Wang T, Albertella MR, Peng Y, Crew L, Kahler J, Kan J, Schulz R, Cooke A, Bittner M, Turton RW, Franklin M, Gokhale P, Landfair D, Mantis C, Workman J, Wild R, Pachter J, Epstein D, Mulvihill MJ. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett. 2013 Aug 01; 23(15):4381-7. PMID: 23773865.
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    57. Jin M, Petronella BA, Cooke A, Kadalbajoo M, Siu KW, Kleinberg A, May EW, Gokhale PC, Schulz R, Kahler J, Bittner MA, Foreman K, Pachter JA, Wild R, Epstein D, Mulvihill MJ. Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics. ACS Med Chem Lett. 2013 Jul 11; 4(7):627-31. PMID: 24900721.
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    58. Epstein D, Moch?n LG, Esp?n J, Soares MO. Use of multiparameter evidence synthesis to assess the appropriateness of data and structure in decision models. Med Decis Making. 2013 07; 33(5):715-30. PMID: 23542161.
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    59. Richardson G, Epstein D, Chew-Graham C, Dowrick C, Bentall RP, Morriss RK, Peters S, Riste L, Lovell K, Dunn G, Wearden AJ. Cost-effectiveness of supported self-management for CFS/ME patients in primary care. BMC Fam Pract. 2013 Jan 18; 14:12. PMID: 23327355.
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    60. Jin M, Wang J, Kleinberg A, Kadalbajoo M, Siu KW, Cooke A, Bittner MA, Yao Y, Thelemann A, Ji Q, Bhagwat S, Mulvihill KM, Rechka JA, Pachter JA, Crew AP, Epstein D, Mulvihill MJ. Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg Med Chem Lett. 2013 Feb 15; 23(4):979-84. PMID: 23317569.
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    61. Epstein DM, McHugh M, Yorio M, Neri B. Intra-articular hip injuries in national hockey league players: a descriptive epidemiological study. Am J Sports Med. 2013 Feb; 41(2):343-8. PMID: 23193146.
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    62. Evans RG, Naidu B, Rajpoot NM, Epstein D, Khan M. Toponome imaging system: multiplex biomarkers in oncology. Trends Mol Med. 2012 Dec; 18(12):723-31. PMID: 23122853.
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    63. Epstein DM, Choung E, Ashraf I, Greenspan D, Klein D, McHugh M, Nicholas S. Comparison of mini-open versus arthroscopic harvesting of osteochondral autografts in the knee: a cadaveric study. Arthroscopy. 2012 Dec; 28(12):1867-72. PMID: 23084150.
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    64. Powell JT, Epstein D. Invited commentary. J Vasc Surg. 2012 Oct; 56(4):910. PMID: 23026420.
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    65. Zhou L, Pelengaris S, Abouna S, Young J, Epstein D, Herold J, Nattkemper TW, Nakhai H, Khan M. Re-expression of IGF-II is important for beta cell regeneration in adult mice. PLoS One. 2012; 7(9):e43623. PMID: 22970135.
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    66. Yang H, Craig D, Epstein D, Bojke L, Light K, Bruce IN, Sculpher M, Woolacott N. Golimumab for the treatment of psoriatic arthritis: a NICE single technology appraisal. Pharmacoeconomics. 2012 Apr; 30(4):257-70. PMID: 22283690.
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    67. Richardson F, Young GD, Sennello R, Wolf J, Argast GM, Mercado P, Davies A, Epstein DM, Wacker B. The evaluation of E-Cadherin and vimentin as biomarkers of clinical outcomes among patients with non-small cell lung cancer treated with erlotinib as second- or third-line therapy. Anticancer Res. 2012 Feb; 32(2):537-52. PMID: 22287743.
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    68. Epstein D, Day M, Rokito A. Current concepts in the surgical management of acromioclavicular joint injuries. Bull NYU Hosp Jt Dis. 2012; 70(1):11-24. PMID: 22894691.
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    69. Zhao H, Desai V, Wang J, Epstein DM, Miglarese M, Buck E. Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines. Mol Cancer Ther. 2012 Feb; 11(2):503-13. PMID: 22161861.
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    70. Bojke L, Epstein D, Craig D, Rodgers M, Woolacott N, Yang H, Sculpher M. Modelling the cost-effectiveness of biologic treatments for psoriatic arthritis. Rheumatology (Oxford). 2011 Sep; 50 Suppl 4:iv39-iv47. PMID: 21859705.
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    71. Takemoto RC, Epstein D, McLaurin TM. Intra- and periarticular heterotopic ossification in the knee after a low-velocity gunshot wound treated with retrograde intramedullary nailing of the femur. J Orthop Trauma. 2011 Jul; 25(7):e77-82. PMID: 21577157.
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    72. Epstein D, Sutton A. Modelling correlated clinical outcomes in health technology appraisal. Value Health. 2011 Sep-Oct; 14(6):793-9. PMID: 21914498.
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    73. Bhagwat SV, Gokhale PC, Crew AP, Cooke A, Yao Y, Mantis C, Kahler J, Workman J, Bittner M, Dudkin L, Epstein DM, Gibson NW, Wild R, Arnold LD, Houghton PJ, Pachter JA. Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. Mol Cancer Ther. 2011 Aug; 10(8):1394-406. PMID: 21673091.
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    74. Argast GM, Krueger JS, Thomson S, Sujka-Kwok I, Carey K, Silva S, O'Connor M, Mercado P, Mulford IJ, Young GD, Sennello R, Wild R, Pachter JA, Kan JL, Haley J, Rosenfeld-Franklin M, Epstein DM. Inducible expression of TGF?, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model. Clin Exp Metastasis. 2011 Oct; 28(7):593-614. PMID: 21643654.
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    75. Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM. Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol. 2011 Jun; 178(6):2897-909. PMID: 21550017.
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    76. Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 2011 Mar 01; 71(5):1573-83. PMID: 21363918.
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    77. Thomson S, Petti F, Sujka-Kwok I, Mercado P, Bean J, Monaghan M, Seymour SL, Argast GM, Epstein DM, Haley JD. A systems view of epithelial-mesenchymal transition signaling states. Clin Exp Metastasis. 2011 Feb; 28(2):137-55. PMID: 21194007.
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    78. Argast GM, Mercado P, Mulford IJ, O'Connor M, Keane DM, Shaaban S, Epstein DM, Pachter JA, Kan JL. Cooperative signaling between oncostatin M, hepatocyte growth factor and transforming growth factor-? enhances epithelial to mesenchymal transition in lung and pancreatic tumor models. Cells Tissues Organs. 2011; 193(1-2):114-32. PMID: 21041998.
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    79. Buck E, Gokhale PC, Koujak S, Brown E, Eyzaguirre A, Tao N, Rosenfeld-Franklin M, Lerner L, Chiu MI, Wild R, Epstein D, Pachter JA, Miglarese MR. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. Mol Cancer Ther. 2010 Oct; 9(10):2652-64. PMID: 20924128.
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    80. Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP. The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. Biochemistry. 2010 Sep 21; 49(37):7972-4. PMID: 20726546.
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    81. Roussos ET, Keckesova Z, Haley JD, Epstein DM, Weinberg RA, Condeelis JS. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res. 2010 Oct 01; 70(19):7360-4. PMID: 20823151.
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    82. Day MS, Epstein DM, Young BH, Jazrawi LM. Irreducible anterior and posterior dislocation of the shoulder due to incarceration of the biceps tendon. Int J Shoulder Surg. 2010 Jul; 4(3):83-5. PMID: 21472069.
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    83. Epstein DM, Rose DJ, Philippon MJ. Arthroscopic management of recurrent low-energy anterior hip dislocation in a dancer: a case report and review of literature. Am J Sports Med. 2010 Jun; 38(6):1250-4. PMID: 20392972.
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    84. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D. Endovascular repair of aortic aneurysm in patients physically ineligible for open repair. N Engl J Med. 2010 May 20; 362(20):1872-80. PMID: 20382982.
      Citations:    
    85. Greenhalgh RM, Brown LC, Powell JT, Thompson SG, Epstein D, Sculpher MJ. Endovascular versus open repair of abdominal aortic aneurysm. N Engl J Med. 2010 May 20; 362(20):1863-71. PMID: 20382983.
      Citations:    
    86. Epstein DM, Capeci CM, Rokito AS. Patella tendon rupture after arthroscopic resection of the prepatellar bursa--a case report. Bull NYU Hosp Jt Dis. 2010; 68(4):307-10. PMID: 21162710.
      Citations:    
    87. McKenna C, Chalabi Z, Epstein D, Claxton K. Budgetary policies and available actions: a generalisation of decision rules for allocation and research decisions. J Health Econ. 2010 Jan; 29(1):170-81. PMID: 20018396.
      Citations:    
    88. Epstein D, Bojke L, Sculpher MJ. Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study. BMJ. 2009 Jul 14; 339:b2576. PMID: 19654097.
      Citations:    
    89. White B, Epstein D, Sanders S, Rokito A. Acute acromioclavicular injuries in adults. Orthopedics. 2008 Dec; 31(12). PMID: 19226062.
      Citations:    
    90. Al-Ruzzeh S, Epstein D, George S, Bustami M, Wray J, Ilsley C, Sculpher M, Amrani M. Economic evaluation of coronary artery bypass grafting surgery with and without cardiopulmonary bypass: cost-effectiveness and quality-adjusted life years in a randomized controlled trial. Artif Organs. 2008 Nov; 32(11):891-7. PMID: 18959683.
      Citations:    
    91. Buck E, Eyzaguirre A, Rosenfeld-Franklin M, Thomson S, Mulvihill M, Barr S, Brown E, O'Connor M, Yao Y, Pachter J, Miglarese M, Epstein D, Iwata KK, Haley JD, Gibson NW, Ji QS. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res. 2008 Oct 15; 68(20):8322-32. PMID: 18922904.
      Citations:    
    92. Thomson S, Petti F, Sujka-Kwok I, Epstein D, Haley JD. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin Exp Metastasis. 2008; 25(8):843-54. PMID: 18696232.
      Citations:    
    93. Barr S, Thomson S, Buck E, Russo S, Petti F, Sujka-Kwok I, Eyzaguirre A, Rosenfeld-Franklin M, Gibson NW, Miglarese M, Epstein D, Iwata KK, Haley JD. Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions. Clin Exp Metastasis. 2008; 25(6):685-93. PMID: 18236164.
      Citations:    
    94. Epstein D, Mason A, Manca A. The hospital costs of care for stroke in nine European countries. Health Econ. 2008 Jan; 17(1 Suppl):S21-31. PMID: 18186037.
      Citations:    
    95. Epstein DM, Sculpher MJ, Clayton TC, Henderson RA, Pocock SJ, Buxton MJ, Fox KA. Costs of an early intervention versus a conservative strategy in acute coronary syndrome. Int J Cardiol. 2008 Jul 04; 127(2):240-6. PMID: 17707103.
      Citations:    
    96. Sennino B, Falc?n BL, McCauley D, Le T, McCauley T, Kurz JC, Haskell A, Epstein DM, McDonald DM. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res. 2007 Aug 01; 67(15):7358-67. PMID: 17671206.
      Citations:    
    97. Epstein DM, Chalabi Z, Claxton K, Sculpher M. Efficiency, equity, and budgetary policies: informing decisions using mathematical programming. Med Decis Making. 2007 Mar-Apr; 27(2):128-37. PMID: 17409363.
      Citations:    
    98. Epstein D, Mason A. Costs and prices for inpatient care in England: mirror twins or distant cousins? Health Care Manag Sci. 2006 Aug; 9(3):233-42. PMID: 17016929.
      Citations:    
    99. Akiyama H, Kachi S, Silva RL, Umeda N, Hackett SF, McCauley D, McCauley T, Zoltoski A, Epstein DM, Campochiaro PA. Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies. J Cell Physiol. 2006 May; 207(2):407-12. PMID: 16419035.
      Citations:    
    100. Chan R, Gilbert M, Thompson KM, Marsh HN, Epstein DM, Pendergrast PS. Co-expression of anti-NFkappaB RNA aptamers and siRNAs leads to maximal suppression of NFkappaB activity in mammalian cells. Nucleic Acids Res. 2006 Mar 03; 34(5):e36. PMID: 16517938.
      Citations:    
    101. McCauley TG, Kurz JC, Merlino PG, Lewis SD, Gilbert M, Epstein DM, Marsh HN. Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor. Pharm Res. 2006 Feb; 23(2):303-11. PMID: 16411148.
      Citations:    
    102. Manca A, Epstein DM, Torgerson DJ, Klaber Moffett JA, Coulton S, Farrin AJ, Hahn S, Jackson DA, Richmond SJ. Randomized trial of a brief physiotherapy intervention compared with usual physiotherapy for neck pain patients: cost-effectiveness analysis. Int J Technol Assess Health Care. 2006; 22(1):67-75. PMID: 16673682.
      Citations:    
    103. Hawkins N, Epstein D, Drummond M, Wilby J, Kainth A, Chadwick D, Sculpher M. Assessing the cost-effectiveness of new pharmaceuticals in epilepsy in adults: the results of a probabilistic decision model. Med Decis Making. 2005 Sep-Oct; 25(5):493-510. PMID: 16160206.
      Citations:    
    104. Hawkins N, Sculpher M, Epstein D. Cost-effectiveness analysis of treatments for chronic disease: using R to incorporate time dependency of treatment response. Med Decis Making. 2005 Sep-Oct; 25(5):511-9. PMID: 16160207.
      Citations:    
    105. Epstein D. Intensive rehabilitation may be more cost effective than surgical stabilization for chronic low back pain. Aust J Physiother. 2005; 51(4):269. PMID: 16358451.
      Citations:    
    106. Burmeister PE, Lewis SD, Silva RF, Preiss JR, Horwitz LR, Pendergrast PS, McCauley TG, Kurz JC, Epstein DM, Wilson C, Keefe AD. Direct in vitro selection of a 2'-O-methyl aptamer to VEGF. Chem Biol. 2005 Jan; 12(1):25-33. PMID: 15664512.
      Citations:    
    107. Hartman MS, Epstein DM, Geyer SJ, Keenan RJ. Alveolar adenoma. Ann Thorac Surg. 2004 Nov; 78(5):1842-3. PMID: 15511494.
      Citations:    
    108. Srinivasan J, Cload ST, Hamaguchi N, Kurz J, Keene S, Kurz M, Boomer RM, Blanchard J, Epstein D, Wilson C, Diener JL. ADP-specific sensors enable universal assay of protein kinase activity. Chem Biol. 2004 Apr; 11(4):499-508. PMID: 15123244.
      Citations:    
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