Bruce Boman

TitleAdjunct Faculty
InstitutionThomas Jefferson University
DepartmentPharmacology & Exp Therapeutic
Address132 S. 10th St.
Philadelphia PA 19107
Phone215-955-8874
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    R21CA071531     (BOMAN, BRUCE M)Sep 16, 1996 - Aug 31, 1999
    NIH
    APPROACH FOR COLON CANCER THERAPY USING APC PEPTIDES
    Role: Principal Investigator

    R21DK063014     (BOMAN, BRUCE M)Jan 21, 2003 - Jun 30, 2006
    NIH
    Proteomic Analyses for GI Stem Cell Markers &Mechanisms
    Role: Principal Investigator

    R21CA095667     (BOMAN, BRUCE M)May 1, 2003 - Apr 30, 2007
    NIH
    CHARACTERIZING MURINE GI STEM CELLS: NEW MOLECULAR TOOLS
    Role: Principal Investigator

    R21DK062146     (BOMAN, BRUCE M)May 15, 2003 - Aug 31, 2007
    NIH
    MARKERS FOR STEM CELL-LIKE COLONIC CRYPT BASE CELLS
    Role: Principal Investigator

    U56CA110248     (BOMAN, BRUCE M)Jul 1, 2004 - Jun 30, 2005
    NIH
    AP4 Center for Studies on Hereditary Colorectal Cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Facey COB, Hunsu VO, Zhang C, Osmond B, Opdenaker LM, Boman BM. CYP26A1 Links WNT and Retinoic Acid Signaling: A Target to Differentiate ALDH+ Stem Cells in APC-Mutant CRC. Cancers (Basel). 2024 Jan 07; 16(2). PMID: 38254755.
      Citations:    
    2. Boman BM, Viswanathan V, Facey COB, Fields JZ, Stave JW. The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development. Cancer Biol Ther. 2023 12 31; 24(1):2195363. PMID: 37005380.
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    3. Lausten MA, Boman BM. A Review of IsomiRs in Colorectal Cancer. Noncoding RNA. 2023 Jun 07; 9(3). PMID: 37368334.
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    4. Boman BM, Dinh TN, Decker K, Emerick B, Modarai S, Opdenaker L, Fields JZ, Raymond C, Schleiniger G. Beyond the Genetic Code: A Tissue Code? bioRxiv. 2023 Mar 06. PMID: 36945600.
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    5. Stark VA, Facey COB, Opdenaker L, Fields JZ, Boman BM. Differential miRNA Expression Contributes to Emergence of Multiple Cancer Stem Cell Subpopulations in Human Colorectal Cancer. bioRxiv. 2023 Feb 06. PMID: 36798319.
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    6. Osmond B, Facey COB, Zhang C, Boman BM. HOXA9 Overexpression Contributes to Stem Cell Overpopulation That Drives Development and Growth of Colorectal Cancer. Int J Mol Sci. 2022 Jun 18; 23(12). PMID: 35743243.
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    7. Hunsu VO, Facey COB, Fields JZ, Boman BM. Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies. Int J Mol Sci. 2021 Jul 20; 22(14). PMID: 34299349.
      Citations:    
    8. Stark VA, Facey COB, Viswanathan V, Boman BM. The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer. Int J Mol Sci. 2021 Jan 31; 22(3). PMID: 33572600.
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    9. Zhang T, Ahn K, Emerick B, Modarai SR, Opdenaker LM, Palazzo J, Schleiniger G, Fields JZ, Boman BM. APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development. PLoS One. 2020; 15(10):e0239601. PMID: 33112876.
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    10. Viswanathan V, Opdenaker L, Modarai S, Fields JZ, Gonye G, Boman BM. MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies miRNA92a as a Regulator of the LRIG1 Stem Cell Gene. Int J Mol Sci. 2020 Apr 17; 21(8). PMID: 32316543.
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    11. Boman BM, Guetter A, Boman RM, Runquist OA. Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth. Cancers (Basel). 2020 Feb 17; 12(2). PMID: 32079164.
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    12. Bhatlekar S, Ertel A, Gonye GE, Fields JZ, Boman BM. Gene expression signatures for HOXA4, HOXA9, and HOXD10 reveal alterations in transcriptional regulatory networks in colon cancer. J Cell Physiol. 2018 Dec 14. PMID: 30552679.
      Citations:    
    13. Modarai SR, Gupta A, Opdenaker LM, Kowash R, Masters G, Viswanathan V, Zhang T, Fields JZ, Boman BM. The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells. Oncotarget. 2018 Oct 05; 9(78):34658-34669. PMID: 30410666.
      Citations:    
    14. Opdenaker LM, Kowash R, Masters G, Boman BM, Zhang T, Modarai SR. Increased Musashi-2 and Decreased NUMB Protein Levels Observed in Human Colorectal Cancer are reverted to Normal Levels by ATRA-Induced Cell Differentiation. Int J Cancer Res Ther. 2018; 3(2). PMID: 32984754.
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    15. Bhatlekar S, Fields JZ, Boman BM. Role of HOX Genes in Stem Cell Differentiation and Cancer. Stem Cells Int. 2018; 2018:3569493. PMID: 30154863.
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    16. Emerick B, Schleiniger G, Boman BM. Multi-scale modeling of APC and [Formula: see text]-catenin regulation in the human colonic crypt. J Math Biol. 2018 Jun; 76(7):1797-1830. PMID: 29302705.
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    17. Bhatlekar S, Viswanathan V, Fields JZ, Boman BM. Overexpression of HOXA4 and HOXA9 genes promotes self-renewal and contributes to colon cancer stem cell overpopulation. J Cell Physiol. 2018 Feb; 233(2):727-735. PMID: 28464221.
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    18. Viswanathan V, Damle S, Zhang T, Opdenaker L, Modarai S, Accerbi M, Schmidt S, Green P, Galileo D, Palazzo J, Fields J, Haghighat S, Rigoutsos I, Gonye G, Boman BM. An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia. Cancer Res. 2017 May 09. PMID: 28487386.
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    19. Fortuna D, Boman B, O'Neill R, Palazzo J. MCM2 expression in serrated polyps demonstrates aberrant cellular proliferation. Hum Pathol. 2017 May; 63:177-183. PMID: 28302537.
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    20. Emerick B, Schleiniger G, Boman BM. A kinetic model to study the regulation of ?-catenin, APC, and Axin in the human colonic crypt. J Math Biol. 2017 11; 75(5):1171-1202. PMID: 28271271.
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    21. Modarai SR, Opdenaker LM, Viswanathan V, Fields JZ, Boman BM. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. BMC Cancer. 2016 12 07; 16(1):941. PMID: 27927191.
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    22. Leichman L, Groshen S, O'Neil BH, Messersmith W, Berlin J, Chan E, Leichman CG, Cohen SJ, Cohen D, Lenz HJ, Gold P, Boman B, Fielding A, Locker G, Cason RC, Hamilton SR, Hochster HS. Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer. Oncologist. 2016 Feb; 21(2):172-7. PMID: 26786262.
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    23. Hassen S, Ali AA, Kilaparty SP, Al-Anbaky QA, Majeed W, Boman BM, Fields JZ, Ali N. Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell lines. Mol Cell Biochem. 2016 Jan; 412(1-2):297-305. PMID: 26728996.
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    24. Opdenaker LM, Modarai SR, Boman BM. The Proportion of ALDEFLUOR-Positive Cancer Stem Cells Changes with Cell Culture Density Due to the Expression of Different ALDH Isoforms. Cancer Stud Mol Med. 2015; 2(2):87-95. PMID: 28280782.
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    25. Sugimori M, Hayakawa Y, Boman BM, Fields JZ, Awaji M, Kozano H, Tamura R, Yamamoto S, Ogata T, Yamada M, Endo S, Kurimoto M, Kuroda S. Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations. PLoS One. 2015; 10(8):e0135760. PMID: 26284929.
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    26. Viswanathan V, Fields J, Boman BM. The miRNA23b-regulated signaling network as a key to cancer development--implications for translational research and therapeutics. J Mol Med (Berl). 2014 Nov; 92(11):1129-38. PMID: 25301113.
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    27. Bhatlekar S, Fields JZ, Boman BM. HOX genes and their role in the development of human cancers. J Mol Med (Berl). 2014 Aug; 92(8):811-23. PMID: 24996520.
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    28. Boman BM, Fields JZ. An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development. Front Oncol. 2013 Nov 07; 3:244. PMID: 24224156.
      Citations:    
    29. Bhatlekar S, Addya S, Salunek M, Orr CR, Surrey S, McKenzie S, Fields JZ, Boman BM. Identification of a Developmental Gene Expression Signature, Including HOX Genes, for the Normal Human Colonic Crypt Stem Cell Niche: Overexpression of the Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis. Stem Cells Dev. 2014 Jan 15; 23(2):167-79. PMID: 23980595.
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    30. Boman B. Henry Fitzgerald Maudsley: our forgotten founder. Australas Psychiatry. 2013 Oct; 21(5):435-41. PMID: 23996794.
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    31. Hubosky SG, Boman BM, Charles S, Bibbo M, Bagley DH. Ureteroscopic management of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (hereditary nonpolyposis colorectal cancer syndrome). BJU Int. 2013 Oct; 112(6):813-9. PMID: 23452166.
      Citations:    
    32. Hassen S, Boman BM, Ali N, Parker M, Somerman C, Ali-Khan Catts ZJ, Ali AA, Fields JZ. Detection of DNA mismatch repair proteins in fresh human blood lymphocytes--towards a novel method for hereditary non-polyposis colorectal cancer (Lynch syndrome) screening. J Exp Clin Cancer Res. 2011 Oct 21; 30:100. PMID: 22017758; PMCID: PMC3216249.
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    33. Toll AD, Boman BM, Palazzo JP. Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase. Hum Pathol. 2012 Feb; 43(2):238-42. PMID: 21820149.
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    34. Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L. APC +/- alters colonic fibroblast proteome in FAP. Oncotarget. 2011 Mar; 2(3):197-208. PMID: 21411865.
      Citations:    
    35. Zhang T, Fields JZ, Opdenaker L, Otevrel T, Masuda E, Palazzo JP, Isenberg GA, Goldstein SD, Brand M, Boman BM. Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. Am J Pathol. 2010 Dec; 177(6):2816-26. PMID: 21057000.
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    36. Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ, Otevrel T. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Mol Carcinog. 2009 Sep; 48(9):821-31. PMID: 19263440.
      Citations:    
    37. Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 2009 Apr 15; 69(8):3382-9. PMID: 19336570.
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    38. Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. Cancer Res. 2008 Sep 15; 68(18):7579-86. PMID: 18794146.
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    39. Boman BM, Huang E. Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. 2008 Jun 10; 26(17):2828-38. PMID: 18539961.
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    40. Boman BM, Wicha MS. Cancer stem cells: a step toward the cure. J Clin Oncol. 2008 Jun 10; 26(17):2795-9. PMID: 18539956.
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    41. Boman BM, Fields JZ, Cavanaugh KL, Guetter A, Runquist OA. How dysregulated colonic crypt dynamics cause stem cell overpopulation and initiate colon cancer. Cancer Res. 2008 May 01; 68(9):3304-13. PMID: 18451157.
      Citations:    
    42. Patel BB, Li XM, Dixon MP, Blagoi EL, Seeholzer SH, Chen Y, Miller CG, He YA, Tetruashvily M, Chaudhry AH, Ke E, Xie J, Cooper H, Bellacosa A, Clapper ML, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A, Yeung AT. Searchable high-resolution 2D gel proteome of the human colon crypt. J Proteome Res. 2007 Jun; 6(6):2232-8. PMID: 17444668.
      Citations:    
    43. Church J, Berk T, Boman BM, Guillem J, Lynch C, Lynch P, Rodriguez-Bigas M, Rusin L, Weber T. Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease. Dis Colon Rectum. 2005 Aug; 48(8):1528-34. PMID: 15906134.
      Citations:    
    44. Stoyanova R, Clapper ML, Bellacosa A, Henske EP, Testa JR, Ross EA, Yeung AT, Nicolas E, Tsichlis N, Li YS, Linehan WM, Howard S, Campbell KS, Godwin AK, Boman BM, Crowell JA, Kopelovich L, Knudson AG. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol Ther. 2004 Dec; 3(12):1313-21. PMID: 15662135.
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    45. Stoyanova R, Upson JJ, Patriotis C, Ross EA, Henske EP, Datta K, Boman B, Clapper ML, Knudson AG, Bellacosa A. Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays. J Cell Physiol. 2004 Dec; 201(3):359-65. PMID: 15389558.
      Citations:    
    46. Upson JJ, Stoyanova R, Cooper HS, Patriotis C, Ross EA, Boman B, Clapper ML, Knudson AG, Bellacosa A. Optimized procedures for microarray analysis of histological specimens processed by laser capture microdissection. J Cell Physiol. 2004 Dec; 201(3):366-73. PMID: 15389559.
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    47. Boman BM, Walters R, Fields JZ, Kovatich AJ, Zhang T, Isenberg GA, Goldstein SD, Palazzo JP. Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population. Am J Pathol. 2004 Nov; 165(5):1489-98. PMID: 15509520.
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    48. Charara M, Edmonston TB, Burkholder S, Walters R, Anne P, Mitchell E, Fry R, Boman B, Rose D, Fishel R, Curran W, Palazzo J. Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. Anticancer Res. 2004 Sep-Oct; 24(5B):3161-7. PMID: 15510606.
      Citations:    
    49. Li XM, Patel BB, Blagoi EL, Patterson MD, Seeholzer SH, Seehozer SH, Zhang T, Damle S, Gao Z, Boman B, Yeung AT. Analyzing alkaline proteins in human colon crypt proteome. J Proteome Res. 2004 Jul-Aug; 3(4):821-33. PMID: 15359737.
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    50. Forsyth NR, Morales CP, Damle S, Boman B, Wright WE, Kopelovich L, Shay JW. Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient. Neoplasia. 2004 May-Jun; 6(3):258-65. PMID: 15153338.
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    51. Fields JZ, Gao Z, Gao Z, Lewis M, Maimonis P, Harvey J, Lynch HT, Boman BM. Immunoassay for wild-type protein in lymphocytes predicts germline mutations in patients at risk for hereditary colorectal cancer. J Lab Clin Med. 2004 Jan; 143(1):59-66. PMID: 14749686.
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    52. Zhang T, Fields JZ, Ehrlich SM, Boman BM. The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells. J Pharmacol Exp Ther. 2004 Feb; 308(2):434-7. PMID: 14610217.
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    53. Cutler NS, Graves-Deal R, LaFleur BJ, Gao Z, Boman BM, Whitehead RH, Terry E, Morrow JD, Coffey RJ. Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. Cancer Res. 2003 Apr 15; 63(8):1748-51. PMID: 12702555.
      Citations:    
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