Gan-Xin Yan

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gao Y, Dong K, Gao Y, Jin X, Yang J, Yan G, Liu Q. Unified cross-modality integration and analysis of T?cell receptors and T?cell transcriptomes by low-resource-aware representation learning. Cell Genom. 2024 May 08; 4(5):100553. PMID: 38688285.
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    2. Olleik F, Kamareddine MH, Spears J, Tse G, Liu T, Yan GX. Mexiletine: Antiarrhythmic mechanisms, emerging clinical applications and mortality. Pacing Clin Electrophysiol. 2023 Oct 17. PMID: 37846818.
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    3. Kamareddine MH, Yan GX. Ventricular repolarization dispersion: Friend or foe. Heart Rhythm. 2023 Aug 18. PMID: 37597599.
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    4. Al Saiegh Y, Liskov S, Yan GX. Spiked Helmet Sign in the Inferior Leads. JAMA Intern Med. 2023 Jul 10. PMID: 37428496.
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    5. Sauerwein S, Spears J, Yan GX. One Beat Is All It Takes-Wide Complex Tachycardia in a Middle-aged Man. JAMA Cardiol. 2023 Jan 04. PMID: 36598780.
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    6. Qi D, Li W, Quan XQ, Gao Y, Wang J, Guo L, Zhao W, Liu T, Gao C, Yan GX. Alternating Early Afterdepolarizations Underlying Bradycardia-Dependent Macroscopic T Wave and Discordant Mechanical Alternans. Circ Arrhythm Electrophysiol. 2023 01; 16(1):e011453. PMID: 36595630.
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    7. Milman A, Sabbag A, Conte G, Postema PG, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Juang JJ, Michowitz Y, Leshem E, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS. Circ Arrhythm Electrophysiol. 2023 01; 16(1):e011360. PMID: 36595628.
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    8. Omondi A, Sirinvaravong N, Spears J, Sauerwein S, Taoutel R, Liskov S, Gao C, Liu T, Kowey PR, Yan GX. Marked QTc Reduction Immediately Following Direct Current Cardioversion of Atrial Fibrillation: Clinical Implications and Mechanisms. JACC Clin Electrophysiol. 2022 Nov 16. PMID: 36752461.
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    9. Sirinvaravong N, Heimann M, Liskov S, Yan GX. Dual atrial rhythms: a case report of an unusual cause of pacemaker syndrome. Eur Heart J Case Rep. 2022 Jan; 6(1):ytab531. PMID: 35059558.
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    10. Ooi YS, Amer M, Qi D, Yang Z, Gao C, Yan GX. Delta QRS distinguishes Ito -mediated J waves from pseudo J waves produced by conduction delay on body surface electrocardiographic. Pacing Clin Electrophysiol. 2021 Nov; 44(11):1832-1841. PMID: 34498737.
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    11. Yan GX. Inverse decremental conduction heralds complete atrioventricular block following transcatheter aortic valve replacement. HeartRhythm Case Rep. 2021 Dec; 7(12):820-824. PMID: 34987967.
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    12. Sirinvaravong N, Qi D, Yan GX. Beat-to-Beat Variation in QRS Morphology Following Transcatheter Aortic Valve Replacement. JAMA Intern Med. 2021 07 01; 181(7):990-991. PMID: 34047772.
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    13. Ooi YS, Drosou ME, Yan GX. Sustained Postural Wide QRS Complex Tachycardia in an Intensive Care Unit Patient. JAMA Intern Med. 2021 05 01; 181(5):693-694. PMID: 33555308.
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    14. Liu T, Liu J, Lu HR, Li H, Gallacher DJ, Chaudhary K, Wang Y, Yan GX. Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs. Clin Pharmacol Ther. 2021 06; 109(6):1606-1617. PMID: 33283267.
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    15. Milman A, Andorin A, Postema PG, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Juang JJM, Leshem E, Michowitz Y, Fogelman R, Hochstadt A, Mizusawa Y, Giustetto C, Arbelo E, Huang Z, Corrado D, Delise P, Allocca G, Takagi M, Wijeyeratne YD, Mazzanti A, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Jespersen CH, Tfelt-Hansen J, Veltmann C, Priori SG, Behr ER, Yan GX, Brugada J, Gaita F, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B. Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome. Heart Rhythm. 2019 10; 16(10):1468-1474. PMID: 31284050.
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    16. Milman A, Hochstadt A, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Conte G, Arbelo E, Kamakura T, Aiba T, Napolitano C, Giustetto C, Denjoy I, Juang JJM, Maeda S, Takahashi Y, Leshem E, Michowitz Y, Rahkovich M, Jespersen CH, Wijeyeratne YD, Champagne J, Calo L, Huang Z, Mizusawa Y, Postema PG, Brugada R, Wilde AAM, Yan GX, Behr ER, Tfelt-Hansen J, Hirao K, Veltmann C, Leenhardt A, Corrado D, Gaita F, Priori SG, Kusano KF, Takagi M, Delise P, Brugada J, Brugada P, Nam GB, Probst V, Belhassen B. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). Europace. 2019 May 01; 21(5):796-802. PMID: 30590530.
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    17. Michowitz Y, Milman A, Andorin A, Sarquella-Brugada G, Gonzalez Corcia MC, Gourraud JB, Conte G, Sacher F, Juang JJM, Kim SH, Leshem E, Mabo P, Postema PG, Hochstadt A, Wijeyeratne YD, Denjoy I, Giustetto C, Mizusawa Y, Huang Z, Jespersen CH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Arbelo E, Mazzanti A, Allocca G, Brugada R, Casado-Arroyo R, Champagne J, Priori SG, Veltmann C, Delise P, Corrado D, Brugada J, Kusano KF, Hirao K, Calo L, Takagi M, Tfelt-Hansen J, Yan GX, Gaita F, Leenhardt A, Behr ER, Wilde AAM, Nam GB, Brugada P, Probst V, Belhassen B. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome. J Am Coll Cardiol. 2019 04 16; 73(14):1756-1765. PMID: 30975291.
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    18. Qi D, Gao Y, Yan GX. Electrocardiographic J wave: Early repolarization, Brugada wave, and conduction delay. Heart Rhythm. 2019 01; 16(1):81-82. PMID: 30118884.
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    19. Milman A, Gourraud JB, Andorin A, Postema PG, Sacher F, Mabo P, Conte G, Giustetto C, Sarquella-Brugada G, Hochstadt A, Kim SH, Juang JJM, Maeda S, Takahashi Y, Kamakura T, Aiba T, Leshem E, Michowitz Y, Rahkovich M, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Wijeyeratne YD, Napolitano C, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B. Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients. Heart Rhythm. 2018 10; 15(10):1457-1465. PMID: 29908370.
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    20. Tse G, Gong M, Meng L, Wong CW, Georgopoulos S, Bazoukis G, Wong MCS, Letsas KP, Vassiliou VS, Xia Y, Baranchuk AM, Yan GX, Liu T. Meta-analysis of Tpeak-Tend and Tpeak-Tend/QT ratio for risk stratification in congenital long QT syndrome. J Electrocardiol. 2018 May - Jun; 51(3):396-401. PMID: 29550106.
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    21. Milman A, Andorin A, Gourraud JB, Postema PG, Sacher F, Mabo P, Kim SH, Juang JJM, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Sarquella-Brugada G, Leshem E, Rahkovich M, Hochstadt A, Mizusawa Y, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Napolitano C, Michowitz Y, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B. Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). Heart Rhythm. 2018 05; 15(5):716-724. PMID: 29325976.
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    22. Georgopoulos S, Letsas KP, Liu T, Kalafateli M, Korantzopoulos P, B?rkle G, Vlachos K, Giannopoulos G, Efremidis M, Deftereos S, Sideris A, Takagi M, Yan GX, Ehrlich JR. A meta-analysis on the prognostic significance of inferolateral early repolarization pattern in Brugada syndrome. Europace. 2018 01 01; 20(1):134-139. PMID: 28087596.
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    23. Milman A, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, Conte G, Juang JJM, Leshem E, Rahkovich M, Hochstadt A, Mizusawa Y, Postema PG, Arbelo E, Huang Z, Denjoy I, Giustetto C, Wijeyeratne YD, Napolitano C, Michowitz Y, Brugada R, Casado-Arroyo R, Champagne J, Calo L, Sarquella-Brugada G, Tfelt-Hansen J, Priori SG, Takagi M, Veltmann C, Delise P, Corrado D, Behr ER, Gaita F, Yan GX, Brugada J, Leenhardt A, Wilde AAM, Brugada P, Kusano KF, Hirao K, Nam GB, Probst V, Belhassen B. Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. Circ Arrhythm Electrophysiol. 2017 Dec; 10(12). PMID: 29254945.
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    24. Tse G, Gong M, Nunez J, Sanchis J, Li G, Ali-Hasan-Al-Saegh S, Wong WT, Wong SH, Wu WKK, Bazoukis G, Yan GX, Lampropoulos K, Baranchuk AM, Tse LA, Xia Y, Liu T, Woo J. Frailty and Mortality Outcomes After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2017 Dec 01; 18(12):1097.e1-1097.e10. PMID: 29079033.
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    25. Tse G, Gong M, Wong WT, Georgopoulos S, Letsas KP, Vassiliou VS, Chan YS, Yan BP, Wong SH, Wu WKK, Ciobanu A, Li G, Shenthar J, Saguner AM, Ali-Hasan-Al-Saegh S, Bhardwaj A, Sawant AC, Whittaker P, Xia Y, Yan GX, Liu T. The Tpeak - Tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: A systematic review and meta-analysis. Heart Rhythm. 2017 08; 14(8):1131-1137. PMID: 28552749.
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    26. Liu G, Xue X, Gao C, Huang J, Qi D, Zhang Y, Dong JZ, Ma CS, Yan GX. Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation. J Am Heart Assoc. 2017 May 18; 6(5). PMID: 28522677.
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    27. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AAM. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Europace. 2017 04 01; 19(4):665-694. PMID: 28431071.
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    28. Gong M, Zhang Z, Fragakis N, Korantzopoulos P, Letsas KP, Li G, Yan GX, Liu T. Role of ranolazine in the prevention and treatment of atrial fibrillation: A meta-analysis of randomized clinical trials. Heart Rhythm. 2017 01; 14(1):3-11. PMID: 27746384.
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    29. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AA. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. J Arrhythm. 2016 Oct; 32(5):315-339. PMID: 27761155.
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    30. Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AA. J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Heart Rhythm. 2016 10; 13(10):e295-324. PMID: 27423412.
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    31. Lu HR, Gallacher DJ, Yan GX. Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model. J Pharmacol Toxicol Methods. 2016 Sep-Oct; 81:151-60. PMID: 27374776.
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    32. Liu G, Liu T, Cohen D, Liu T, Yan GX. How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model. J Pharmacol Toxicol Methods. 2016 Sep-Oct; 81:161-70. PMID: 27195944.
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    33. Yan GX. MY APPROACH to early repolarization syndrome. Trends Cardiovasc Med. 2016 May; 26(4):393-4. PMID: 26944231.
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    34. Macfarlane PW, Antzelevitch C, Haissaguerre M, Huikuri HV, Potse M, Rosso R, Sacher F, Tikkanen JT, Wellens H, Yan GX. The Early Repolarization Pattern: A Consensus Paper. J Am Coll Cardiol. 2015 Jul 28; 66(4):470-7. PMID: 26205599.
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    35. Badri M, Patel A, Patel C, Liu G, Goldstein M, Robinson VM, Xue X, Yang L, Kowey PR, Yan GX. Mexiletine Prevents Recurrent Torsades?de?Pointes in Acquired Long?QT?Syndrome Refractory to Conventional Measures. JACC Clin Electrophysiol. 2015 Aug; 1(4):315-322. PMID: 29759319.
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    36. Antzelevitch C, Yan GX. J-wave syndromes: Brugada and early repolarization syndromes. Heart Rhythm. 2015 Aug; 12(8):1852-66. PMID: 25869754.
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    37. Qi D, Yang Z, Robinson VM, Li J, Gao C, Guo D, Kowey PR, Yan GX. Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarization. Heart Rhythm. 2015 Jun; 12(6):1295-303. PMID: 25684234.
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    38. Badri M, Abdelbaky A, Yan GX, Kowey PR. The impact of medical malpractice litigation on cardiovascular practice in the US and China. Int J Cardiol. 2014 Nov 15; 177(1):48-50. PMID: 25499337.
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    39. Badri M, Patel A, Yan GX. Cellular and ionic basis of J-wave syndromes. Trends Cardiovasc Med. 2015 Jan; 25(1):12-21. PMID: 25446046.
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    40. Shu J, Li Y, Ju R, Yan GX. Two types of T wave alternans in long-QT syndrome. J Cardiovasc Electrophysiol. 2014 Aug; 25(8):910-912. PMID: 24724570.
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    41. Guo D, Yu M, Liu Q, Cox RH, Liu T, Yan GX. Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium. J Electrocardiol. 2014 Sep-Oct; 47(5):642-8. PMID: 24813353.
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    42. Badri M, Bradley J, Ju R, Yan GX. Cardiac metastasis causing right bundle branch block and recurrent septal ventricular tachycardia. J Cardiovasc Electrophysiol. 2014 Jul; 25(7):793-4. PMID: 24612005.
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    43. Gao Y, Xue X, Hu D, Liu W, Yuan Y, Sun H, Li L, Timothy KW, Zhang L, Li C, Yan GX. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome. Circ Arrhythm Electrophysiol. 2013 Jun; 6(3):614-22. PMID: 23580742.
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    44. Lu HR, Yan GX, Gallacher DJ. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). J Pharmacol Toxicol Methods. 2013 Sep-Oct; 68(2):250-259. PMID: 23337247.
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    45. Liu T, Traebert M, Ju H, Suter W, Guo D, Hoffmann P, Kowey PR, Yan GX. Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation. Heart Rhythm. 2012 Oct; 9(10):1706-15. PMID: 22710481.
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    46. Antzelevitch C, Yan GX. J-wave syndromes. from cell to bedside. J Electrocardiol. 2011 Nov-Dec; 44(6):656-61. PMID: 21908004.
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    47. Jia S, Lian J, Guo D, Xue X, Patel C, Yang L, Yuan Z, Ma A, Yan GX. Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade. Br J Pharmacol. 2011 Sep; 164(2):308-16. PMID: 21182492.
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    48. Antzelevitch C, Yan GX, Viskin S. Rationale for the use of the terms J-wave syndromes and early repolarization. J Am Coll Cardiol. 2011 Apr 12; 57(15):1587-90. PMID: 21474038.
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    49. Droogan C, Patel C, Yan GX, Kowey PR. Role of antiarrhythmic drugs: frequent implantable cardioverter-defibrillator shocks, risk of proarrhythmia, and new drug therapy. Heart Fail Clin. 2011 Apr; 7(2):195-205, viii. PMID: 21439498.
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    50. Wang D, Yan GX, Antzelevitch C. The J Wave Syndromes and their Role in Sudden Cardiac Death. Card Electrophysiol Clin. 2011 Mar 01; 3(1):47-56. PMID: 21499517.
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    51. Patel C, Salahuddin M, Jones A, Patel A, Yan GX, Kowey PR. Atrial fibrillation: pharmacological therapy. Curr Probl Cardiol. 2011 Mar; 36(3):87-120. PMID: 21392636.
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    52. Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan; 57(1):79-85. PMID: 20980921.
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    53. Guo D, Lian J, Liu T, Cox R, Margulies KB, Kowey PR, Yan GX. Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. Heart Rhythm. 2011 May; 8(5):762-9. PMID: 21184845.
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    54. Sun Y, Quan XQ, Fromme S, Cox RH, Zhang P, Zhang L, Guo D, Guo J, Patel C, Kowey PR, Yan GX. A novel mutation in the KCNH2 gene associated with short QT syndrome. J Mol Cell Cardiol. 2011 Mar; 50(3):433-41. PMID: 21130771.
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    55. Patel C, Yan GX, Antzelevitch C. Short QT syndrome: from bench to bedside. Circ Arrhythm Electrophysiol. 2010 Aug; 3(4):401-8. PMID: 20716721.
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    56. Link MG, Yan GX, Kowey PR. Evaluation of toxicity for heart failure therapeutics: studying effects on the QT interval. Circ Heart Fail. 2010 Jul; 3(4):547-55. PMID: 20647490.
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    57. Lu HR, Rohrbacher J, Vlaminckx E, Van Ammel K, Yan GX, Gallacher DJ. Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers. Br J Pharmacol. 2010 May; 160(1):60-76. PMID: 20331615.
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    58. Lian J, Yan GX, Kowey PR. Born to be bradycardic? Cardiology. 2010; 115(3):229-31. PMID: 20299796.
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    59. Guo D, Young L, Wu Y, Belardinelli L, Kowey PR, Yan GX. Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1375-81. PMID: 20190097.
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    60. Antzelevitch C, Yan GX. J wave syndromes. Heart Rhythm. 2010 Apr; 7(4):549-58. PMID: 20153265.
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    61. Patel C, Yan GX, Kocovic D, Kowey PR. Should catheter ablation be the preferred therapy for reducing ICD shocks?: Ventricular tachycardia ablation versus drugs for preventing ICD shocks: role of adjuvant antiarrhythmic drug therapy. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):705-11; discussion 712. PMID: 20009081.
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    62. Shu J, Zhou J, Patel C, Yan GX. Pharmacotherapy of cardiac arrhythmias--basic science for clinicians. Pacing Clin Electrophysiol. 2009 Nov; 32(11):1454-65. PMID: 19744278.
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    63. Patel C, Yan GX, Kowey PR. Dronedarone. Circulation. 2009 Aug 18; 120(7):636-44. PMID: 19687370.
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    64. Huang Z, Patel C, Li W, Xie Q, Wu R, Zhang L, Tang R, Wan X, Ma Y, Zhen W, Gao L, Yan GX. Role of signal-averaged electrocardiograms in arrhythmic risk stratification of patients with Brugada syndrome: a prospective study. Heart Rhythm. 2009 Aug; 6(8):1156-62. PMID: 19632627.
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    65. Patel C, Burke JF, Patel H, Gupta P, Kowey PR, Antzelevitch C, Yan GX. Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: a century of controversy. Circ Arrhythm Electrophysiol. 2009 Feb; 2(1):80-8. PMID: 19808446.
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    66. Zhu TG, Patel C, Martin S, Quan X, Wu Y, Burke JF, Chernick M, Kowey PR, Yan GX. Ventricular transmural repolarization sequence: its relationship with ventricular relaxation and role in ventricular diastolic function. Eur Heart J. 2009 Feb; 30(3):372-80. PMID: 19147608.
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    67. Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT, Yan GX. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008 Nov-Dec; 41(6):567-74. PMID: 18790499.
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    68. Wu L, Guo D, Li H, Hackett J, Yan GX, Jiao Z, Antzelevitch C, Shryock JC, Belardinelli L. Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. Heart Rhythm. 2008 Dec; 5(12):1726-34. PMID: 19084812.
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    69. Guo D, Young L, Patel C, Jiao Z, Wu Y, Liu T, Kowey PR, Yan GX. Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H97-H104. PMID: 18441200.
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    70. Wang D, Patel C, Cui C, Yan GX. Preclinical assessment of drug-induced proarrhythmias: role of the arterially perfused rabbit left ventricular wedge preparation. Pharmacol Ther. 2008 Aug; 119(2):141-51. PMID: 18423604.
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    71. Patel C, Narayanaswamy S, Medina-Ravell VA, Yan GX. A rare cause of 2:1 AV block: long QT syndrome. J Cardiovasc Electrophysiol. 2008 Sep; 19(9):990. PMID: 18284491.
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    72. Kowey PR, Yan GX. Discarding the baby with the bathwater. Pacing Clin Electrophysiol. 2007 Dec; 30(12):1429-31. PMID: 18070294.
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    73. Guo D, Zhou J, Zhao X, Gupta P, Kowey PR, Martin J, Wu Y, Liu T, Yan GX. L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species. Heart Rhythm. 2008 Feb; 5(2):271-9. PMID: 18242553.
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    74. Patel C, Yan GX. Race and gender equality in health care: are we there yet? Heart Rhythm. 2007 Nov; 4(11):1427-9. PMID: 17954402.
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    75. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W, Yan GX, Kowey P, Zhang L. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007 Aug; 4(8):1114-6; author reply 1116-9. PMID: 17675094.
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    76. Guo D, Zhao X, Wu Y, Liu T, Kowey PR, Yan GX. L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. J Cardiovasc Electrophysiol. 2007 Feb; 18(2):196-203. PMID: 17212595.
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    77. Kowey PR, Yan GX. The meta-analysis: supportive or illuminating? Eur Heart J. 2006 Dec; 27(23):2744-5. PMID: 17107979.
      Citations:    
    78. Liu T, Brown BS, Wu Y, Antzelevitch C, Kowey PR, Yan GX. Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias. Heart Rhythm. 2006 Aug; 3(8):948-56. PMID: 16876745.
      Citations:    
    79. Kowey PR, Yan GX. "Doctor, why didn't you tell me about this before the ICD?". J Cardiovasc Electrophysiol. 2006 Mar; 17(3):296-7. PMID: 16643404.
      Citations:    
    80. Lankipalli RS, Zhu T, Guo D, Yan GX. Mechanisms underlying arrhythmogenesis in long QT syndrome. J Electrocardiol. 2005 Oct; 38(4 Suppl):69-73. PMID: 16226078.
      Citations:    
    81. Hlaing T, Guo D, Zhao X, DiMino T, Greenspon L, Kowey PR, Yan GX. The QT and Tp-e intervals in left and right chest leads: comparison between patients with systemic and pulmonary hypertension. J Electrocardiol. 2005 Oct; 38(4 Suppl):154-8. PMID: 16226092.
      Citations:    
    82. Kowey PR, Yan GX. Proarrhythmias and antiarrhythmias: two sides of the same coin. Heart Rhythm. 2005 Sep; 2(9):957-9. PMID: 16171750.
      Citations:    
    83. Kowey PR, Yan GX. Making a silk purse out of a sow's ear. J Am Coll Cardiol. 2005 Aug 16; 46(4):688-9. PMID: 16098436.
      Citations:    
    84. Wu Y, Carlsson L, Liu T, Kowey PR, Yan GX. Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes. J Cardiovasc Electrophysiol. 2005 Aug; 16(8):898-904. PMID: 16101634.
      Citations:    
    85. Hlaing T, DiMino T, Kowey PR, Yan GX. ECG repolarization waves: their genesis and clinical implications. Ann Noninvasive Electrocardiol. 2005 Apr; 10(2):211-23. PMID: 15842434.
      Citations:    
    86. Yan GX, Joshi A, Guo D, Hlaing T, Martin J, Xu X, Kowey PR. Phase 2 reentry as a trigger to initiate ventricular fibrillation during early acute myocardial ischemia. Circulation. 2004 Aug 31; 110(9):1036-41. PMID: 15302777.
      Citations:    
    87. Joshi A, Dimino T, Vohra Y, Cui C, Yan GX. Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models. J Electrocardiol. 2004; 37 Suppl:7-14. PMID: 15534787.
      Citations:    
    88. Kowey PR, Yan GX, Dimino TL, Kocovic DZ. Overview of the management of atrial fibrillation: what is the current state of the art? J Cardiovasc Electrophysiol. 2003 Dec; 14(12 Suppl):S275-80; discussion S280. PMID: 15005214.
      Citations:    
    89. Yan GX, Lankipalli RS, Burke JF, Musco S, Kowey PR. Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance. J Am Coll Cardiol. 2003 Aug 06; 42(3):401-9. PMID: 12906963.
      Citations:    
    90. Yan GX, Martin J. Electrocardiographic T wave: a symbol of transmural dispersion of repolarization in the ventricles. J Cardiovasc Electrophysiol. 2003 Jun; 14(6):639-40. PMID: 12875426.
      Citations:    
    91. Kowey PR, Yan GX, Winkel E, Kao W. Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches. Am J Cardiol. 2003 Mar 20; 91(6A):33D-38D. PMID: 12670640.
      Citations:    
    92. Xu X, Yan GX, Wu Y, Liu T, Kowey PR. Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar; 41(3):414-21. PMID: 12605020.
      Citations:    
    93. Medina-Ravell VA, Lankipalli RS, Yan GX, Antzelevitch C, Medina-Malpica NA, Medina-Malpica OA, Droogan C, Kowey PR. Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes? Circulation. 2003 Feb 11; 107(5):740-6. PMID: 12578878.
      Citations:    
    94. Sharma H, Sharma N, Burke JF, Yan GX, Kowey PR. Ischemia versus amiodarone induced polymorphic ventricular tachycardia. Pacing Clin Electrophysiol. 2002 Sep; 25(9):1382-4. PMID: 12380775.
      Citations:    
    95. Xu X, Salata JJ, Wang J, Wu Y, Yan GX, Liu T, Marinchak RA, Kowey PR. Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H664-70. PMID: 12124214.
      Citations:    
    96. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002 Mar 12; 105(10):1247-53. PMID: 11889021.
      Citations:    
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