Thomas Jefferson University

Thomas Shaffer

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    P20RR020173     (SHAFFER, THOMAS H)Sep 7, 2004 - Jun 30, 2015
    NIH
    Center for Pediatric Research
    Role: Principal Investigator
    P20GM103464     (SHAFFER, THOMAS H)Sep 7, 2004 - Jun 30, 2016
    NIH
    Center for Pediatric Research
    Role: Principal Investigator
    P30GM114736     (SHAFFER, THOMAS H)Aug 1, 2015 - Jul 31, 2021
    NIH
    Center for Pediatric Research (CPR)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yue X, Stauff E, Boyapati S, Langhans SA, Xu W, Makrogiannis S, Okorie UJ, Okorie AM, Kandula VVR, Kecskemethy HH, Nikam RM, Averill LW, Shaffer TH. PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer. Pharmaceuticals (Basel). 2024 May 27; 17(6). PMID: 38931352.
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    2. Lutz J, Levenbrown Y, Hossain MJ, Hesek A, Massa KE, Keith JP, Shaffer TH. Impact of intravenous fluid administration on cardiac output and oxygenation during cardiopulmonary resuscitation. Intensive Care Med Exp. 2023 Mar 24; 11(1):13. PMID: 36959337.
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    3. Miller TL, Raab LM, Shaffer TH, Schweikert A, Diana F, Fort P, Frum AS, Pergolizzi J, Raffa RB. A Novel Agnostic Respiratory Stimulant as a Treatment for Apnea of Prematurity: A Proof-of-Concept Study. Cureus. 2022 Sep; 14(9):e28900. PMID: 36237747.
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    4. Murala DK, Levenbrown Y, Xiao W, Hossain J, Shaffer TH. Utilising pneuRIP device in determining the adequacy of respiratory support when weaning high-flow nasal cannula in paediatric patients with acute respiratory distress: A pilot study. J Paediatr Child Health. 2022 09; 58(9):1548-1553. PMID: 35652438.
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    5. Alapati D, Shaffer TH. Administration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids. Front Physiol. 2022; 13:871893. PMID: 35620598.
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    6. Levenbrown Y, Hossain MJ, Keith JP, Burr K, Hesek A, Shaffer TH. Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model. Intensive Care Med Exp. 2021 Jul 26; 9(1):37. PMID: 34308496.
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    7. Ratnagiri MV, Zhu Y, Rahman T, Theroux M, Tomatsu S, Shaffer TH. Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome. Diagnostics (Basel). 2021 May 15; 11(5). PMID: 34063456.
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    8. Kovatis KZ, Locke RG, Mackley AB, Subedi K, Shaffer TH. Adjustment of high flow nasal cannula rates using real-time work of breathing indices in premature infants with respiratory insufficiency. J Perinatol. 2021 07; 41(7):1711-1717. PMID: 33664469.
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    9. Shrestha D, Ye GX, Stabley D, Betal SGN, Zhu Y, Glazewski L, Holbrook J, Sethi M, Hesek A, Shaffer TH, Aghai ZH, Addya S, Alapati D. Pulmonary immune cell transcriptome changes in double-hit model of BPD induced by chorioamnionitis and postnatal hyperoxia. Pediatr Res. 2021 09; 90(3):565-575. PMID: 33446917.
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    10. Zhu Y, Aghai ZH, Betal SGN, Favara M, Fong G, Rahman T, Shaffer TH. A novel noninvasive approach for evaluating work of breathing indices in a developmental rat model using respiratory inductance plethysmography. Sci Rep. 2020 11 26; 10(1):20730. PMID: 33244048.
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    11. Fong G, Gayen Nee' Betal S, Murthy S, Favara M, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Li D, Rahman I, Aghai ZH. DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis. Front Pediatr. 2020; 8:437. PMID: 32850550.
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    12. Levenbrown Y, Hossain MJ, Keith JP, Burr K, Hesek A, Shaffer T. The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation. Intensive Care Med Exp. 2020 Jul 25; 8(1):36. PMID: 32712733.
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    13. Ratnagiri MV, Ryan L, Strang A, Heinle R, Rahman T, Shaffer TH. Machine learning for automatic identification of thoracoabdominal asynchrony in children. Pediatr Res. 2021 04; 89(5):1232-1238. PMID: 32620007.
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    14. Ritchey MD, Maresh S, McNeely J, Shaffer T, Jackson SL, Keteyian SJ, Brawner CA, Whooley MA, Chang T, Stolp H, Schieb L, Wright J. Tracking Cardiac Rehabilitation Participation and Completion Among Medicare Beneficiaries to Inform the Efforts of a National Initiative. Circ Cardiovasc Qual Outcomes. 2020 01; 13(1):e005902. PMID: 31931615.
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    15. Ryan L, Rahman T, Strang A, Heinle R, Shaffer TH. Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy. PLoS One. 2020; 15(1):e0226980. PMID: 31923192.
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    16. Wolfson MR, Enkhbaatar P, Fukuda S, Nelson CL, Williams RO, Surasarang SH, Sahakijpijarn S, Calendo G, Komissarov AA, Florova G, Sarva K, Idell SI, Shaffer TH. Perfluorochemical-facilitated plasminogen activator delivery to the airways: A novel treatment for inhalational smoke-induced acute lung injury. Clin Transl Med. 2020 Jan; 10(1):258-274. PMID: 32508014.
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    17. Gayen Nee' Betal S, Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH. Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. Sci Rep. 2019 04 10; 9(1):5862. PMID: 30971730.
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    18. Costa J, Zhu Y, Cox T, Fawcett P, Shaffer T, Alapati D. Inflammatory Response of Pulmonary Artery Smooth Muscle Cells Exposed to Oxidative and Biophysical Stress. Inflammation. 2018 Aug; 41(4):1250-1258. PMID: 29656317.
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    19. Kenaley KM, Blackson T, Boylan L, Ciarlo J, Antunes M, Shaffer TH, Locke R. Impact of endotracheal tube biofilm and respiratory secretions on airway resistance and mechanics of breathing in a neonatal lung model. J Appl Physiol (1985). 2018 07 26. PMID: 30048200.
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    20. Bronstein JZ, Xie L, Shaffer TH, Chidekel A, Heinle R. Quantitative Analysis of Thoracoabdominal Asynchrony in Pediatric Polysomnography. J Clin Sleep Med. 2018 07 15; 14(7):1169-1176. PMID: 29991414.
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    21. Strang A, Ryan L, Rahman T, Balasubramanian S, Hossain J, Heinle R, Shaffer TH. Measures of respiratory inductance plethysmography (RIP) in children with neuromuscular disease. Pediatr Pulmonol. 2018 09; 53(9):1260-1268. PMID: 29999598.
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    22. Fukuda S, Enkhbaatar P, Nelson C, Cox RA, Wolfson MR, Shaffer TH, Williams RO, Surasarang SH, Sawittree S, Florova G, Komissarov AA, Koenig K, Sarva K, Ndetan HT, Singh KP, Idell S. Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator. Clin Transl Med. 2018 Jun 18; 7(1):17. PMID: 29916009.
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    23. Balasubramaniam SL, Wang Y, Ryan L, Hossain J, Rahman T, Shaffer TH. Age-related ranges of respiratory inductance plethysmography (RIP) reference values for infants and children. Paediatr Respir Rev. 2019 Feb; 29:60-67. PMID: 30799137.
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    24. Surasarang SH, Sahakijpijarn S, Florova G, Komissarov AA, Nelson CL, Perenlei E, Fukuda S, Wolfson MR, Shaffer TH, Idell S, Williams RO. Nebulization of Single-Chain Tissue-Type and Single-Chain Urokinase Plasminogen Activator for Treatment of Inhalational Smoke-Induced Acute Lung Injury. J Drug Deliv Sci Technol. 2018 Aug; 48:19-27. PMID: 30123328.
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    25. Alapati D, Shaffer TH. Skeletal dysplasia: Respiratory management during infancy. Respir Med. 2017 10; 131:18-26. PMID: 28947027.
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    26. Alapati D, Aghai ZH, Hossain MJ, Dirnberger DR, Ogino MT, Shaffer TH. Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. Pediatr Crit Care Med. 2017 Jul; 18(7):667-674. PMID: 28504997.
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    27. Rahman T, Page R, Page C, Bonnefoy JR, Cox T, Shaffer TH. pneuRIPTM: A Novel Respiratory Inductance Plethysmography Monitor. J Med Device. 2017 Mar; 11(1):0110101-110106. PMID: 28289485.
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    28. Doherty C, Kubaski F, Tomatsu S, Shaffer TH. Non-invasive pulmonary function test on Morquio patients. J Rare Dis Res Treat. 2017; 2(2):55-62. PMID: 30294725.
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    29. Mowes A, de Jongh BE, Cox T, Zhu Y, Shaffer TH. A translational cellular model to study the impact of high-frequency oscillatory ventilation on human epithelial cell function. J Appl Physiol (1985). 2017 01 01; 122(1):198-205. PMID: 27834669.
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    30. Alapati D, Jassar R, Shaffer TH. Management of Supplemental Oxygen for Infants with Persistent Pulmonary Hypertension of Newborn: A Survey. Am J Perinatol. 2017 Feb; 34(3):276-282. PMID: 27490772.
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    31. Yasuda E, Suzuki Y, Shimada T, Sawamoto K, Mackenzie WG, Theroux MC, Pizarro C, Xie L, Miller F, Rahman T, Kecskemethy HH, Nagao K, Morlet T, Shaffer TH, Chinen Y, Yabe H, Tanaka A, Shintaku H, Orii KE, Orii KO, Mason RW, Monta?o AM, Fukao T, Orii T, Tomatsu S. Activity of daily living for Morquio A syndrome. Mol Genet Metab. 2016 06; 118(2):111-22. PMID: 27161890.
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    32. Sherman TI, Moya F, Simmons PD, Kurtz D, Shaffer TH. Parental preferences regarding administration of an animal-derived versus a synthetic medication to newborn infants. J Neonatal Perinatal Med. 2016; 9(1):7-14. PMID: 27002267.
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    33. Kubaski F, Tomatsu S, Patel P, Shimada T, Xie L, Yasuda E, Mason R, Mackenzie WG, Theroux M, Bober MB, Oldham HM, Orii T, Shaffer TH. Non-invasive pulmonary function test on Morquio patients. Mol Genet Metab. 2015 Aug; 115(4):186-92. PMID: 26116954.
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    34. Theroux MC, Fisher AO, Rodriguez ME, Brislin RP, Reichard KW, Shah SA, McCoy M, Brown M, Dabney KW, Mackenzie WG, Katz DA, Shaffer TH. Prophylactic methylprednisolone to reduce inflammation and improve outcomes from one lung ventilation in children: a randomized clinical trial. Paediatr Anaesth. 2015 Jun; 25(6):587-94. PMID: 25557228.
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    35. Hossain MJ, Xie L, Lang JE, Wysocki TT, Shaffer TH, Bunnell HT. Piecewise Mixed Effects Model to Compare the Weight-gain Patter ns Before and After Diagnosis of Asthma in Children Younger than 5 Years. J Biom Biostat. 2015 Jan; 6(4):248. PMID: 26942042.
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    36. McQueen M, Rojas J, Sun SC, Tero R, Ives K, Bednarek F, Owens L, Dysart K, Dungan G, Shaffer TH, Miller TL. Safety and Long Term Outcomes with High Flow Nasal Cannula Therapy in Neonatology: A Large Retrospective Cohort Study. J Pulm Respir Med. 2014 Dec; 4(6). PMID: 26167395.
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    37. Rodriguez E, Sakowski L, Hobson GM, Armani MH, Kreiger PA, Zhu Y, Waldman SA, Shaffer TH. Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation. Pulm Pharmacol Ther. 2015 Feb; 30:22-31. PMID: 25445931.
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    38. Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH. The orl rat is more responsive to methacholine challenge than wild type. Pulm Pharmacol Ther. 2014 Dec; 29(2):199-208. PMID: 25218882.
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    39. Jassar RK, Vellanki H, Zhu Y, Hesek A, Wang J, Rodriguez E, Wu J, Shaffer TH, Wolfson MR. High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model. Pediatr Pulmonol. 2014 Dec; 49(12):1214-22. PMID: 24500982.
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    40. Levenbrown Y, Penfil S, Rodriguez E, Zhu Y, Hossain J, Bhat AM, Hesek A, O'Neil KB, Tobin K, Shaffer TH. Use of insulin to decrease septic shock-induced myocardial depression in a porcine model. Inflammation. 2013 Dec; 36(6):1494-502. PMID: 23887895.
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    41. Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH. Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques. Pulm Med. 2013; 2013:618576. PMID: 23691308.
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    42. Giordano K, Rodriguez E, Green N, Armani M, Richards J, Shaffer TH, Attia MW. Pulmonary function tests in emergency department pediatric patients with acute wheezing/asthma exacerbation. Pulm Med. 2012; 2012:724139. PMID: 23304496.
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    43. Tomatsu S, Mackenzie WG, Theroux MC, Mason RW, Thacker MM, Shaffer TH, Monta?o AM, Rowan D, Sly W, Alm?ciga-D?az CJ, Barrera LA, Chinen Y, Yasuda E, Ruhnke K, Suzuki Y, Orii T. Current and emerging treatments and surgical interventions for Morquio A syndrome: a review. Res Rep Endocr Disord. 2012 Dec; 2012(2):65-77. PMID: 24839594.
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    44. Chidekel A, Zhu Y, Wang J, Mosko JJ, Rodriguez E, Shaffer TH. The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells. Pulm Med. 2012; 2012:380686. PMID: 22988501.
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    45. Wolfson MR, Wu J, Hubert TL, Gregory TJ, Mazela J, Shaffer TH. Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS. Pediatr Res. 2012 Oct; 72(4):375-83. PMID: 22821059.
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    46. Shaffer TH, Alapati D, Greenspan JS, Wolfson MR. Neonatal non-invasive respiratory support: physiological implications. Pediatr Pulmonol. 2012 Sep; 47(9):837-47. PMID: 22777738.
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    47. Jeng MJ, Yeh TF, Dargaville PA, Shaffer TH, Wung JT. Neonatal respiratory care. Int J Pediatr. 2012; 2012:213974. PMID: 22666274.
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    48. Shaffer TH, Wolfson MR. Translational research: matching experimental models with therapeutic interventions. Pediatr Crit Care Med. 2012 May; 13(3):369-70. PMID: 22561272.
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    49. Davidoff A, Lopert R, Stuart B, Shaffer T, Lloyd JT, Shoemaker JS. Simulated value-based insurance design applied to statin use by Medicare beneficiaries with diabetes. Value Health. 2012 May; 15(3):404-11. PMID: 22583449.
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    50. Olivant Fisher A, Husain K, Wolfson MR, Hubert TL, Rodriguez E, Shaffer TH, Theroux MC. Hyperoxia during one lung ventilation: inflammatory and oxidative responses. Pediatr Pulmonol. 2012 Oct; 47(10):979-86. PMID: 22431368.
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    51. Rodriguez E, Bober MB, Davey L, Zamora A, Li Puma AB, Chidekel A, Shaffer TH. Respiratory mechanics in an infant with perinatal lethal hypophosphatasia treated with human recombinant enzyme replacement therapy. Pediatr Pulmonol. 2012 Sep; 47(9):917-22. PMID: 22328548.
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    52. Kim M, Pugarelli J, Miller TL, Wolfson MR, Dodge GR, Shaffer TH. Brief mechanical ventilation impacts airway cartilage properties in neonatal lambs. Pediatr Pulmonol. 2012 Aug; 47(8):763-70. PMID: 22170596.
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    53. Henrichsen T, Lindenskov PH, Shaffer TH, Loekke RJ, Fugelseth D, Lindemann R. Perfluorodecalin lavage of a longstanding lung atelectasis in a child with spinal muscle atrophy. Pediatr Pulmonol. 2012 Apr; 47(4):415-9. PMID: 22006656.
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    54. Kazzaz JA, Strayer MS, Wu J, Malone DJ, Koo HC, Shaffer TH, Davis JM, Strayer DS, Wolfson MR. Perfluorochemical liquid-adenovirus suspensions enhance gene delivery to the distal lung. Pulm Med. 2011; 2011:918036. PMID: 21876799.
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    55. Bhatia R, Shaffer TH, Hossain J, Fisher AO, Horner LM, Rodriguez ME, Penfil S, Theroux MC. Surfactant administration prior to one lung ventilation: physiological and inflammatory correlates in a piglet model. Pediatr Pulmonol. 2011 Nov; 46(11):1069-78. PMID: 21618717.
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    56. Ramirez ER, Ramirez Nessetti DK, Nessetti MB, Khatamee M, Wolfson MR, Shaffer TH, Ramirez VZ, Ramirez HA. Pregnancy and outcome of uterine allotransplantation and assisted reproduction in sheep. J Minim Invasive Gynecol. 2011 Mar-Apr; 18(2):238-45. PMID: 21354071.
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    57. Chang GY, Cox CA, Shaffer TH. Nasal cannula, CPAP, and high-flow nasal cannula: effect of flow on temperature, humidity, pressure, and resistance. Biomed Instrum Technol. 2011 Jan-Feb; 45(1):69-74. PMID: 21322815.
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    58. Oshodi A, Dysart K, Cook A, Rodriguez E, Zhu Y, Shaffer TH, Miller TL. Airway injury resulting from repeated endotracheal intubation: Possible prevention strategies. Pediatr Crit Care Med. 2011 Jan; 12(1):e34-9. PMID: 20375754.
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    59. Frizzola M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, Stump A, Shaffer TH, Dysart K. High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol. 2011 Jan; 46(1):67-74. PMID: 21171186.
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    60. Hubert TL, Lindemann R, Wu J, Agnew C, Shaffer TH, Wolfson MR. Prototype hybrid systems for neonatal warming: in vitro comparisons to standard of care devices. Biomed Instrum Technol. 2010 Nov-Dec; 44(6):523-7. PMID: 21142524.
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    61. Stuart BC, Simoni-Wastila L, Zuckerman IH, Davidoff A, Shaffer T, Yang HW, Qian J, Dalal AA, Mapel DW, Bryant-Comstock L. Impact of maintenance therapy on hospitalization and expenditures for Medicare beneficiaries with chronic obstructive pulmonary disease. Am J Geriatr Pharmacother. 2010 Oct; 8(5):441-53. PMID: 21335297.
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    62. Rodriguez ME, Mackenzie WG, Ditro C, Miller TL, Chidekel A, Shaffer TH. Skeletal dysplasias: evaluation with impulse oscillometry and thoracoabdominal motion analysis. Pediatr Pulmonol. 2010 Jul; 45(7):679-86. PMID: 20575094.
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    63. Zhu Y, Chidekel A, Shaffer TH. Cultured human airway epithelial cells (calu-3): a model of human respiratory function, structure, and inflammatory responses. Crit Care Res Pract. 2010; 2010. PMID: 20948883.
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    64. Stuart B, Davidoff A, Lloyd J, Shaffer T, Shoemaker JS, Kemner J. Does influenza vaccination of older adult Medicare beneficiaries lower treatment costs for acute and chronic respiratory disease? Am J Geriatr Pharmacother. 2010 Jun; 8(3):201-14. PMID: 20624610.
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    65. Theroux MC, Fisher AO, Horner LM, Rodriguez ME, Costarino AT, Miller TL, Shaffer TH. Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model. Paediatr Anaesth. 2010 Apr; 20(4):356-64. PMID: 19919624.
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    66. Laudadio RE, Wolfson MR, Shaffer TH, Driska SP. Developmental differences in the contractile response of isolated ovine tracheal smooth muscle cells. Pediatr Pulmonol. 2009 Jun; 44(6):602-12. PMID: 19434687.
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    67. Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med. 2009 Oct; 103(10):1400-5. PMID: 19467849.
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    68. Costantino ML, Micheau P, Shaffer TH, Tredici S, Wolfson MR. Clinical design functions: round table discussions on the bioengineering of liquid ventilators. ASAIO J. 2009 May-Jun; 55(3):206-8. PMID: 19282746.
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    69. Chong E, Dysart KC, Chidekel A, Locke R, Shaffer TH, Miller TL. Heat shock protein 70 secretion by neonatal tracheal tissue during mechanical ventilation: association with indices of tissue function and modeling. Pediatr Res. 2009 Apr; 65(4):387-91. PMID: 19127221.
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    70. Wolfson MR, Funanage VL, Kirwin SM, Pilon AL, Shashikant BN, Miller TL, Shaffer TH. Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome. Am J Perinatol. 2008 Nov; 25(10):637-45. PMID: 18841530.
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    71. Theroux MC, Olivant A, Lim D, Bernardi JP, Costarino AT, Shaffer TH, Miller TL. Low dose methylprednisolone prophylaxis to reduce inflammation during one-lung ventilation. Paediatr Anaesth. 2008 Sep; 18(9):857-64. PMID: 18768046.
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    72. Miller TL, Zhu Y, Markwardt S, Singhaus CJ, Chidekel AS, Shaffer TH. Dissociation between the effects of oxygen and pressure on matrix metalloproteinase-2, -7, and -9 expression in human airway epithelial cells. Am J Perinatol. 2008 Sep; 25(8):481-9. PMID: 18720322.
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    73. Zhu Y, Miller TL, Chidekel A, Shaffer TH. KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia. Pediatr Res. 2008 Aug; 64(2):154-8. PMID: 18391844.
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    74. Wolfson MR, Hirschl RB, Jackson JC, Gauvin F, Foley DS, Lamm WJ, Gaughan J, Shaffer TH. Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep. ASAIO J. 2008 May-Jun; 54(3):256-69. PMID: 18496275.
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    75. Zhu Y, Miller TL, Singhaus CJ, Shaffer TH, Chidekel A. Effects of oxygen concentration and exposure time on cultured human airway epithelial cells. Pediatr Crit Care Med. 2008 Mar; 9(2):224-9. PMID: 18477937.
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    76. Wolfson MR, Malone DJ, Wu J, Hoffman J, Rozenberg A, Shaffer TH, Barbut D. Intranasal perfluorochemical spray for preferential brain cooling in sheep. Neurocrit Care. 2008; 8(3):437-47. PMID: 18266110.
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    77. Sturtz WJ, Touch SM, Locke RG, Greenspan JS, Shaffer TH. Assessment of neonatal ventilation during high-frequency oscillatory ventilation. Pediatr Crit Care Med. 2008 Jan; 9(1):101-4. PMID: 18477922.
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    78. Cullen AB, Cooke PH, Driska SP, Wolfson MR, Shaffer TH. Correlation of tracheal smooth muscle function with structure and protein expression during early development. Pediatr Pulmonol. 2007 May; 42(5):421-32. PMID: 17436327.
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    79. Miller TL, Zhu Y, Altman AR, Dysart K, Shaffer TH. Sequential alterations of tracheal mechanical properties in the neonatal lamb: effect of mechanical ventilation. Pediatr Pulmonol. 2007 Feb; 42(2):141-9. PMID: 17123318.
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    80. Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR. Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress. Pediatr Crit Care Med. 2007 Jan; 8(1):40-6. PMID: 17149150.
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    81. Jeng MJ, Yang SS, Hwang B, Wolfson MR, Shaffer TH. Effects of perfluorochemical evaporative properties on oxygenation during partial liquid ventilation. Pediatr Int. 2006 Dec; 48(6):608-15. PMID: 17168983.
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    82. Singhaus CJ, Utidjian LH, Akins RE, Miller TL, Shaffer TH, Touch SM. Growth and development in a heliox incubator environment: a long-term safety study. Neonatology. 2007; 91(1):28-35. PMID: 17344649.
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    83. Miller TL, Altman AR, Tsuda T, Shaffer TH. An ultrasound imaging method for in vivo tracheal bulk and Young's moduli of elasticity. J Biomech. 2007; 40(7):1615-21. PMID: 17045275.
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    84. Miller TL, Cox T, Blackson T, Paul D, Weiss K, Shaffer TH. Pulmonary function assessment in an infant with Barnes syndrome: proactive evaluation for surgical intervention. Pediatrics. 2006 Oct; 118(4):e1264-7. PMID: 16950944.
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    85. Sherman TI, Greenspan JS, St Clair N, Touch SM, Shaffer TH. Optimizing the neonatal thermal environment. Neonatal Netw. 2006 Jul-Aug; 25(4):251-60. PMID: 16913236.
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    86. Brunelli L, Hamilton E, Davis JM, Koo HC, Joseph A, Kazzaz JA, Wolfson MR, Shaffer TH. Perfluorochemical liquids enhance delivery of superoxide dismutase to the lungs of juvenile rabbits. Pediatr Res. 2006 Jul; 60(1):65-70. PMID: 16690961.
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    87. Greenspan JS, Shaffer TH. Ventilator-induced airway injury: a critical consideration during mechanical ventilation of the infant. Neonatal Netw. 2006 May-Jun; 25(3):159-66. PMID: 16749370.
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    88. Cullen AB, Cooke PH, Driska SP, Wolfson MR, Shaffer TH. The impact of mechanical ventilation on immature airway smooth muscle: functional, structural, histological, and molecular correlates. Biol Neonate. 2006; 90(1):17-27. PMID: 16534184.
      Citations:    
    89. Singhaus CJ, Touch SM, Greenspan JS, Wolfson MR, Shaffer TH. A prototype infant incubator for heliox therapy. Biomed Instrum Technol. 2006 Mar-Apr; 40(2):150-63. PMID: 16649483.
      Citations:    
    90. Miller TL, Singhaus CJ, Sherman TI, Greenspan JS, Shaffer TH. Physiologic implications of helium as a carrier gas for inhaled nitric oxide in a neonatal model of Bethanecol-induced bronchoconstriction. Pediatr Crit Care Med. 2006 Mar; 7(2):159-64. PMID: 16531948.
      Citations:    
    91. Miller TL, Touch SM, Shaffer TH. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: observations from an animal model. Pediatr Crit Care Med. 2006 Jan; 7(1):63-9. PMID: 16395077.
      Citations:    
    92. Nawab US, Touch SM, Irwin-Sherman T, Blackson TJ, Greenspan JS, Zhu G, Shaffer TH, Wolfson MR. Heliox attenuates lung inflammation and structural alterations in acute lung injury. Pediatr Pulmonol. 2005 Dec; 40(6):524-32. PMID: 16193495.
      Citations:    
    93. Miller TL, Touch SM, Singhaus CJ, Ramesh Babu PB, Chidekel A, Shaffer TH. Expression of matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2, in developing rabbit tracheae. Biol Neonate. 2006; 89(4):236-43. PMID: 16319450.
      Citations:    
    94. Miller TL, Shashikant BN, Melby JM, Pilon AL, Shaffer TH, Wolfson MR. Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration. Pediatr Crit Care Med. 2005 Nov; 6(6):698-706. PMID: 16276338.
      Citations:    
    95. Miller TL, Shashikant BN, Pilon AL, Pierce RA, Shaffer TH, Wolfson MR. Effects of an intratracheally delivered anti-inflammatory protein (rhCC10) on physiological and lung structural indices in a juvenile model of acute lung injury. Biol Neonate. 2006; 89(3):159-70. PMID: 16210850.
      Citations:    
    96. Greenspan JS, Miller TL, Shaffer TH. The neonatal respiratory pump: a developmental challenge with physiologic limitations. Neonatal Netw. 2005 Sep-Oct; 24(5):15-22. PMID: 16279051.
      Citations:    
    97. Shashikant BN, Miller TL, Welch RW, Pilon AL, Shaffer TH, Wolfson MR. Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles. J Appl Physiol (1985). 2005 Dec; 99(6):2204-11. PMID: 16081627.
      Citations:    
    98. Miller TL, Palmer C, Shaffer TH, Wolfson MR. Neonatal chest wall suspension splint: a novel and noninvasive method for support of lung volume. Pediatr Pulmonol. 2005 Jun; 39(6):512-20. PMID: 15678504.
      Citations:    
    99. Wolfson MR, Shaffer TH. Pulmonary applications of perfluorochemical liquids: ventilation and beyond. Paediatr Respir Rev. 2005 Jun; 6(2):117-27. PMID: 15911457.
      Citations:    
    100. Shashikant BN, Miller TL, Jeng MJ, Davis J, Shaffer TH, Wolfson MR. Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury. Crit Care Med. 2005 May; 33(5):1096-103. PMID: 15891342.
      Citations:    
    101. Levine CR, Gewolb IH, Allen K, Welch RW, Melby JM, Pollack S, Shaffer T, Pilon AL, Davis JM. The safety, pharmacokinetics, and anti-inflammatory effects of intratracheal recombinant human Clara cell protein in premature infants with respiratory distress syndrome. Pediatr Res. 2005 Jul; 58(1):15-21. PMID: 15774846.
      Citations:    
    102. Babu PB, Chidekel A, Shaffer TH. Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron. Pediatr Crit Care Med. 2005 Mar; 6(2):188-94. PMID: 15730607.
      Citations:    
    103. Oliver RE, Rozycki HJ, Greenspan JS, Wolfson MR, Shaffer TH. Tracheal gas insufflation as a lung-protective strategy: physiologic, histologic, and biochemical markers. Pediatr Crit Care Med. 2005 Jan; 6(1):64-9. PMID: 15636662.
      Citations:    
    104. Babu PB, Chidekel A, Shaffer TH. Association of interleukin-8 with inflammatory and innate immune components in bronchoalveolar lavage of children with chronic respiratory diseases. Clin Chim Acta. 2004 Dec; 350(1-2):195-200. PMID: 15530478.
      Citations:    
    105. Miller TL, Blackson TJ, Shaffer TH, Touch SM. Tracheal gas insufflation-augmented continuous positive airway pressure in a spontaneously breathing model of neonatal respiratory distress. Pediatr Pulmonol. 2004 Nov; 38(5):386-95. PMID: 15390348.
      Citations:    
    106. Babu PB, Chidekel A, Shaffer TH. Protein composition of apical surface fluid from the human airway cell line Calu-3: effect of ion transport mediators. Clin Chim Acta. 2004 Sep; 347(1-2):81-8. PMID: 15313144.
      Citations:    
    107. Ramesh Babu PB, Chidekel A, Utidjian L, Shaffer TH. Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3. Biochem Biophys Res Commun. 2004 Jul 09; 319(4):1132-7. PMID: 15194485.
      Citations:    
    108. Williams LJ, Shaffer TH, Greenspan JS. Inhaled nitric oxide therapy in the near-term or term neonate with hypoxic respiratory failure. Neonatal Netw. 2004 Jan-Feb; 23(1):5-13. PMID: 14974765.
      Citations:    
    109. Wolfson MR, Shaffer TH. Liquid ventilation: an adjunct for respiratory management. Paediatr Anaesth. 2004 Jan; 14(1):15-23. PMID: 14717869.
      Citations:    
    110. Shaffer TH, Wolfson MR, Panitch HB. Airway structure, function and development in health and disease. Paediatr Anaesth. 2004 Jan; 14(1):3-14. PMID: 14717868.
      Citations:    
    111. Zhu G, Shaffer TH, Wolfson MR. Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury. J Appl Physiol (1985). 2004 Apr; 96(4):1415-24. PMID: 14688036.
      Citations:    
    112. Sherman TI, Blackson T, Touch SM, Greenspan JS, Shaffer TH. Physiologic effects of CPAP: application and monitoring. Neonatal Netw. 2003 Nov-Dec; 22(6):7-16. PMID: 14700177.
      Citations:    
    113. Cox C, Stavis RL, Wolfson MR, Shaffer TH. Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates. Biol Neonate. 2003; 84(3):232-42. PMID: 14504447.
      Citations:    
    114. Jeng MJ, Yang SS, Wolfson MR, Shaffer TH. Perfluorochemical (PFC) combinations for acute lung injury: an in vitro and in vivo study in juvenile rabbits. Pediatr Res. 2003 Jan; 53(1):81-8. PMID: 12508085.
      Citations:    
    115. Shaffer TH, Wolfson MR, Shaffer TH. If art imitates life, can laboratory models imitate clinical disease processes? Crit Care Med. 2002 Oct; 30(10):2399-400. PMID: 12394986.
      Citations:    
    116. Shashikant MP, Badellino MM, Cooper B, Shaffer TH, Myers SI, Wolfson MR. Physicochemical properties of perfluorochemical liquids influence ventilatory requirements, pulmonary mechanics, and microvascular permeability during partial liquid ventilation following intestinal ischemia/reperfusion injury. Crit Care Med. 2002 Oct; 30(10):2300-5. PMID: 12394959.
      Citations:    
    117. Touch SM, Shaffer TH, Greenspan JS. Managing our first breaths: a reflection on the past several decades of neonatal pulmonary therapy. Neonatal Netw. 2002 Aug; 21(5):13-20. PMID: 12240452.
      Citations:    
    118. Cox CA, Fox WW, Weiss CM, Wolfson MR, Shaffer TH. Liquid ventilation: Gas exchange, perfluorochemical uptake, and biodistribution in an acute lung injury. Pediatr Crit Care Med. 2002 Jul; 3(3):288-296. PMID: 12780971.
      Citations:    
    119. Mantell LL, Shaffer TH, Horowitz S, Foust R, Wolfson MR, Cox C, Khullar P, Zakeri Z, Lin L, Kazzaz JA, Palaia T, Scott W, Davis JM. Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L31-41. PMID: 12060558.
      Citations:    
    120. Jeng MJ, Oliver R, Wolfson MR, Shaffer TH. Partial liquid ventilation: Effect of initial dose and redosing strategy in acute lung injury. Pediatr Crit Care Med. 2002 Apr; 3(2):163-170. PMID: 12780988.
      Citations:    
    121. Foust R, Cox C, Davis JM, Wolfson MR, Miller TF, Horowitz S, Shaffer TH. Pulmonary antioxidant enzyme activity during early development: Effect of ventilation. Pediatr Crit Care Med. 2001 Jan; 2(1):63-68. PMID: 12797891.
      Citations:    
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