Thomas Jefferson University

Daniel O'Sullivan

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address1025 Walnut St.
Philadelphia PA 19107
Phone215-481-4355
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim YT, Kwon JG, O'Sullivan DJ, Lee JH. Regulatory mechanism of cysteine-dependent methionine biosynthesis in Bifidobacterium longum: insights into sulfur metabolism in gut microbiota. Gut Microbes. 2024 Jan-Dec; 16(1):2419565. PMID: 39468828.
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    2. O'Sullivan EN, O'Sullivan DJ. Viability and Diversity of the Microbial Cultures Available in Retail Kombucha Beverages in the USA. Foods. 2024 May 29; 13(11). PMID: 38890935.
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    3. G?ley Z, Fallico V, Cabrera-Rubio R, O'Sullivan D, Marotta M, Pennone V, Smith S, Beresford T. Diversity of the Microbiota of Traditional Izmir Tulum and Izmir Brined Tulum Cheeses and Selection of Potential Probiotics. Foods. 2023 Sep 19; 12(18). PMID: 37761191.
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    4. Cho JH, Kwon JG, O'Sullivan DJ, Ryu S, Lee JH. Development of an endolysin enzyme and its cell wall-binding domain protein and their applications for biocontrol and rapid detection of Clostridium perfringens in food. Food Chem. 2021 May 30; 345:128562. PMID: 33189482.
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    5. Yu L, Liu X, O'Sullivan DJ. Use of Lactococcus lactis as a production system for peptides and enzymes encoded by a Lantibiotic gene cluster from Bifidobacterium longum. Microbiology (Reading). 2018 12; 164(12):1481-1490. PMID: 30339118.
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    6. Yu L, O'Sullivan DJ. Immobilization of whole cells of Lactococcus lactis containing high levels of a hyperthermostable ?-galactosidase enzyme in chitosan beads for efficient galacto-oligosaccharide production. J Dairy Sci. 2018 Apr; 101(4):2974-2983. PMID: 29397172.
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    7. Quigley L, O'Sullivan DJ, Daly D, O'Sullivan O, Burdikova Z, Vana R, Beresford TP, Ross RP, Fitzgerald GF, McSweeney PL, Giblin L, Sheehan JJ, Cotter PD. Thermus and the Pink Discoloration Defect in Cheese. mSystems. 2016 May-Jun; 1(3). PMID: 27822529.
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    8. Danaher M, Shanahan C, Butler F, Evans R, O'Sullivan D, Glynn D, Camon T, Lawlor P, O'Keeffe M. Risk-based approach to developing a national residue sampling plan for testing under European Union regulation for veterinary medicinal products and coccidiostat feed additives in domestic animal production. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Jul; 33(7):1155-65. PMID: 27189753.
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    9. O'Sullivan DJ, McSweeney PLH, Cotter PD, Giblin L, Sheehan JJ. Compromised Lactobacillus helveticus starter activity in the presence of facultative heterofermentative Lactobacillus casei DPC6987 results in atypical eye formation in Swiss-type cheese. J Dairy Sci. 2016 Apr; 99(4):2625-2640. PMID: 26805985.
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    10. O'Sullivan DJ, Fallico V, O'Sullivan O, McSweeney PL, Sheehan JJ, Cotter PD, Giblin L. High-throughput DNA sequencing to survey bacterial histidine and tyrosine decarboxylases in raw milk cheeses. BMC Microbiol. 2015 Nov 17; 15:266. PMID: 26577209.
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    11. O'Sullivan DJ, Cotter PD, O'Sullivan O, Giblin L, McSweeney PL, Sheehan JJ. Temporal and spatial differences in microbial composition during the manufacture of a continental-type cheese. Appl Environ Microbiol. 2015 Apr; 81(7):2525-33. PMID: 25636841.
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    12. O'Sullivan D, McLaughlin RP, Clemitshaw KC, Sodeau JR. Cold-surface photochemistry of selected organic nitrates. J Phys Chem A. 2014 Oct 23; 118(42):9890-900. PMID: 25232898.
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    13. Yu L, O'Sullivan DJ. Production of galactooligosaccharides using a hyperthermophilic ?-galactosidase in permeabilized whole cells of Lactococcus lactis. J Dairy Sci. 2014 Feb; 97(2):694-703. PMID: 24359820.
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    14. Lujan HL, Krishnan S, O'Sullivan DJ, Hermiz DJ, Janbaih H, DiCarlo SE. Student construction of anatomic models for learning complex, seldom seen structures. Adv Physiol Educ. 2013 Dec; 37(4):440-1. PMID: 24292924.
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    15. Jones RK, Hampton D, O'Sullivan DJ, Phillips AO. Diabetes and renal disease: who does what? Clin Med (Lond). 2013 Oct; 13(5):460-4. PMID: 24115702.
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    16. Celik OF, O'Sullivan DJ. Factors influencing the stability of freeze-dried stress-resilient and stress-sensitive strains of bifidobacteria. J Dairy Sci. 2013 Jun; 96(6):3506-16. PMID: 23587387.
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    17. O'Sullivan DJ, Giblin L, McSweeney PL, Sheehan JJ, Cotter PD. Nucleic acid-based approaches to investigate microbial-related cheese quality defects. Front Microbiol. 2013; 4:1. PMID: 23346082.
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    18. Dominguez W, O'Sullivan DJ. Developing an efficient and reproducible conjugation-based gene transfer system for bifidobacteria. Microbiology (Reading). 2013 Feb; 159(Pt 2):328-338. PMID: 23197173.
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    19. Li X, O'Sullivan DJ. Contribution of the Actinobacteria to the growing diversity of lantibiotics. Biotechnol Lett. 2012 Dec; 34(12):2133-45. PMID: 22927113.
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    20. McLaughlin RP, O'Sullivan D, Sodeau JR. Cold-surface photochemistry of primary and tertiary alkyl nitrites. J Phys Chem A. 2012 Jun 28; 116(25):6759-70. PMID: 22606955.
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    21. O'Concubhair R, O'Sullivan D, Sodeau JR. Dark oxidation of dissolved gaseous mercury in polar ice mimics. Environ Sci Technol. 2012 May 01; 46(9):4829-36. PMID: 22482942.
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    22. Palaria A, Johnson-Kanda I, O'Sullivan DJ. Effect of a synbiotic yogurt on levels of fecal bifidobacteria, clostridia, and enterobacteria. Appl Environ Microbiol. 2012 Feb; 78(4):933-40. PMID: 22101054.
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    23. Lee JH, Li X, O'Sullivan DJ. Transcription analysis of a lantibiotic gene cluster from Bifidobacterium longum DJO10A. Appl Environ Microbiol. 2011 Sep; 77(17):5879-87. PMID: 21742926.
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    24. Scheller M, O'Sullivan DJ. Comparative analysis of an intestinal strain of Bifidobacterium longum and a strain of Bifidobacterium animalis subspecies lactis in Cheddar cheese. J Dairy Sci. 2011 Mar; 94(3):1122-31. PMID: 21338778.
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    25. Hermiz DJ, O'Sullivan DJ, Lujan HL, DiCarlo SE. Constructivist learning of anatomy: gaining knowledge by creating anatomical casts. Anat Sci Educ. 2011 Mar-Apr; 4(2):98-104. PMID: 21337719.
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    26. Hellebust S, O'Sullivan D, Sodeau JR. Protonated nitrosamide and its potential role in the release of HONO from snow and ice in the dark. J Phys Chem A. 2010 Nov 04; 114(43):11632-7. PMID: 20939592.
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    27. O'Sullivan D, Sodeau JR. Freeze-induced reactions: formation of iodine-bromine interhalogen species from aqueous halide ion solutions. J Phys Chem A. 2010 Nov 25; 114(46):12208-15. PMID: 21043531.
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    28. Lee JH, O'Sullivan DJ. Genomic insights into bifidobacteria. Microbiol Mol Biol Rev. 2010 Sep; 74(3):378-416. PMID: 20805404.
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    29. Lee JH, Karamychev VN, Kozyavkin SA, Mills D, Pavlov AR, Pavlova NV, Polouchine NN, Richardson PM, Shakhova VV, Slesarev AI, Weimer B, O'Sullivan DJ. Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics. 2008 May 27; 9:247. PMID: 18505588.
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    30. Morita H, Toh H, Fukuda S, Horikawa H, Oshima K, Suzuki T, Murakami M, Hisamatsu S, Kato Y, Takizawa T, Fukuoka H, Yoshimura T, Itoh K, O'Sullivan DJ, McKay LL, Ohno H, Kikuchi J, Masaoka T, Hattori M. Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production. DNA Res. 2008 Jun 30; 15(3):151-61. PMID: 18487258.
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    31. O'Sullivan DJ. Genomics can advance the potential for probiotic cultures to improve liver and overall health. Curr Pharm Des. 2008; 14(14):1376-81. PMID: 18537660.
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    32. Lee JH, Halgerson JS, Kim JH, O'Sullivan DJ. Comparative sequence analysis of plasmids from Lactobacillus delbrueckii and construction of a shuttle cloning vector. Appl Environ Microbiol. 2007 Jul; 73(14):4417-24. PMID: 17526779.
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    33. Li H, O'Sullivan DJ. Identification of a nisI promoter within the nisABCTIP operon that may enable establishment of nisin immunity prior to induction of the operon via signal transduction. J Bacteriol. 2006 Dec; 188(24):8496-503. PMID: 17012392.
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    34. Yang JM, Deurraza PJ, Matvienko N, O'Sullivan DJ. Involvement of the LlaKR2I methylase in expression of the AbiR bacteriophage defense system in Lactococcus lactis subsp. lactis biovar diacetylactis KR2. J Bacteriol. 2006 Mar; 188(5):1920-8. PMID: 16484203.
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    35. Lee JH, O'Sullivan DJ. Sequence analysis of two cryptic plasmids from Bifidobacterium longum DJO10A and construction of a shuttle cloning vector. Appl Environ Microbiol. 2006 Jan; 72(1):527-35. PMID: 16391088.
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    36. Ventura M, Lee JH, Canchaya C, Zink R, Leahy S, Moreno-Munoz JA, O'Connell-Motherway M, Higgins D, Fitzgerald GF, O'Sullivan DJ, van Sinderen D. Prophage-like elements in bifidobacteria: insights from genomics, transcription, integration, distribution, and phylogenetic analysis. Appl Environ Microbiol. 2005 Dec; 71(12):8692-705. PMID: 16332864.
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    37. Phister TG, O'Sullivan DJ, McKay LL. Identification of bacilysin, chlorotetaine, and iturin a produced by Bacillus sp. strain CS93 isolated from pozol, a Mexican fermented maize dough. Appl Environ Microbiol. 2004 Jan; 70(1):631-4. PMID: 14711701.
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    38. Chandrapati S, O'Sullivan DJ. Characterization of the promoter regions involved in galactose- and nisin-mediated induction of the nisA gene in Lactococcus lactis ATCC 11454. Mol Microbiol. 2002 Oct; 46(2):467-77. PMID: 12406222.
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    39. Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmore D, Saier M, van Sinderen D, Sorokin A, Steele J, O'Sullivan D, de Vos W, Weimer B, Zagorec M, Siezen R. Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 2002 Aug; 82(1-4):29-58. PMID: 12369195.
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    40. Li H, O'Sullivan DJ. Heterologous expression of the Lactococcus lactis bacteriocin, nisin, in a dairy Enterococcus strain. Appl Environ Microbiol. 2002 Jul; 68(7):3392-400. PMID: 12089020.
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    41. O'Sullivan DJ. Screening of intestinal microflora for effective probiotic bacteria. J Agric Food Chem. 2001 Apr; 49(4):1751-60. PMID: 11308322.
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    42. Swearingen PA, O'Sullivan DJ, Warthesen JJ. Isolation, characterization, and influence of native, nonstarter lactic acid bacteria on Cheddar cheese quality. J Dairy Sci. 2001 Jan; 84(1):50-9. PMID: 11210049.
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    43. Wang H, Baldwin KA, O'Sullivan DJ, McKay LL. Identification of a gene cluster encoding Krebs cycle oxidative enzymes linked to the pyruvate carboxylase gene in Lactococcus lactis ssp. lactis C2. J Dairy Sci. 2000 Sep; 83(9):1912-8. PMID: 11003218.
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    44. Ray P, Sanchez C, O'Sullivan DJ, McKay LL. Classification of a bacterial isolate, from pozol, exhibiting antimicrobial activity against several gram-positive and gram-negative bacteria, yeasts, and molds. J Food Prot. 2000 Aug; 63(8):1123-32. PMID: 10945591.
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    45. Twomey DP, De Urraza PJ, McKay LL, O'Sullivan DJ. Characterization of AbiR, a novel multicomponent abortive infection mechanism encoded by plasmid pKR223 of Lactococcus lactis subsp. lactis KR2. Appl Environ Microbiol. 2000 Jun; 66(6):2647-51. PMID: 10831451.
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    46. Cusick SM, O'Sullivan DJ. Use of a single, triplicate arbitrarily primed-PCR procedure for molecular fingerprinting of lactic acid bacteria. Appl Environ Microbiol. 2000 May; 66(5):2227-31. PMID: 10788406.
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    47. Ibrahim SA, O'Sullivan DJ. Use of chemical mutagenesis for the isolation of food grade beta-galactosidase overproducing mutants of bifidobacteria, lactobacilli and Streptococcus thermophilus. J Dairy Sci. 2000 May; 83(5):923-30. PMID: 10821566.
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    48. Wang H, O'Sullivan DJ, Baldwin KA, McKay LL. Cloning, sequencing, and expression of the pyruvate carboxylase gene in Lactococcus lactis subsp. lactis C2. Appl Environ Microbiol. 2000 Mar; 66(3):1223-7. PMID: 10698798.
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    49. Chandrapati S, O'Sullivan DJ. Nisin independent induction of the nisA promoter in Lactococcus lactis during growth in lactose or galactose. FEMS Microbiol Lett. 1999 Jan 01; 170(1):191-8. PMID: 9919668.
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    50. Twomey DP, McKay LL, O'Sullivan DJ. Molecular characterization of the Lactococcus lactis LlaKR2I restriction-modification system and effect of an IS982 element positioned between the restriction and modification genes. J Bacteriol. 1998 Nov; 180(22):5844-54. PMID: 9811640.
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    51. Chandrapati S, O'Sullivan DJ. Procedure for quantifiable assessment of nutritional parameters influencing nisin production by Lactococcus lactis subsp. lactis. J Biotechnol. 1998 Aug 27; 63(3):229-33. PMID: 9803535.
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    52. Dinsmore PK, O'Sullivan DJ, Klaenhammer TR. A leucine repeat motif in AbiA is required for resistance of Lactococcus lactis to phages representing three species. Gene. 1998 May 28; 212(1):5-11. PMID: 9661658.
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    53. O'Sullivan DJ, Klaenhammer TR. Control of expression of LlaI restriction in Lactococcus lactis. Mol Microbiol. 1998 Mar; 27(5):1009-20. PMID: 9535090.
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    54. Djordjevic GM, O'Sullivan DJ, Walker SA, Conkling MA, Klaenhammer TR. A triggered-suicide system designed as a defense against bacteriophages. J Bacteriol. 1997 Nov; 179(21):6741-8. PMID: 9352925.
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    55. Kullen MJ, Brady LJ, O'Sullivan DJ. Evaluation of using a short region of the recA gene for rapid and sensitive speciation of dominant bifidobacteria in the human large intestine. FEMS Microbiol Lett. 1997 Sep 15; 154(2):377-83. PMID: 9311137.
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    56. Kullen MJ, Amann MM, O'Shaughnessy MJ, O'Sullivan DJ, Busta FF, Brady LJ. Differentiation of ingested and endogenous bifidobacteria by DNA fingerprinting demonstrates the survival of an unmodified strain in the gastrointestinal tract of humans. J Nutr. 1997 Jan; 127(1):89-94. PMID: 9040550.
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    57. O'Sullivan DJ, Walker SA, West SG, Klaenhammer TR. Development of an expression strategy using a lytic phage to trigger explosive plasmid amplification and gene expression. Biotechnology (N Y). 1996 Jan; 14(1):82-7. PMID: 9636317.
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    58. O'Sullivan DJ, Klaenhammer TR. C.LlaI is a bifunctional regulatory protein of the llaI restriction modification operon from Lactococcus lactis. Dev Biol Stand. 1995; 85:591-5. PMID: 8586237.
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    59. Sexton R, Gill PR, Callanan MJ, O'Sullivan DJ, Dowling DN, O'Gara F. Iron-responsive gene expression in Pseudomonas fluorescens M114: cloning and characterization of a transcription-activating factor, PbrA. Mol Microbiol. 1995 Jan; 15(2):297-306. PMID: 7746151.
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    60. O'Sullivan DJ, Zagula K, Klaenhammer TR. In vivo restriction by LlaI is encoded by three genes, arranged in an operon with llaIM, on the conjugative Lactococcus plasmid pTR2030. J Bacteriol. 1995 Jan; 177(1):134-43. PMID: 7528201.
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    61. Adams C, Dowling DN, O'Sullivan DJ, O'Gara F. Isolation of a gene (pbsC) required for siderophore biosynthesis in fluorescent Pseudomonas sp. strain M114. Mol Gen Genet. 1994 Jun 03; 243(5):515-24. PMID: 8208243.
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    62. O'Sullivan DJ, Dowling DN, deLorenzo V, O'Gara F. Escherichia coli ferric uptake regulator (Fur) can mediate regulation of a pseudomonad iron-regulated promoter. FEMS Microbiol Lett. 1994 Apr 15; 117(3):327-32. PMID: 8200508.
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    63. Morris J, O'sullivan DJ, Koster M, Leong J, Weisbeek PJ, O'gara F. Characterization of Fluorescent Siderophore-Mediated Iron Uptake in Pseudomonas sp. Strain M114: Evidence for the Existence of an Additional Ferric Siderophore Receptor. Appl Environ Microbiol. 1992 Feb; 58(2):630-5. PMID: 16348650.
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    64. Shanahan P, O'sullivan DJ, Simpson P, Glennon JD, O'gara F. Isolation of 2,4-diacetylphloroglucinol from a fluorescent pseudomonad and investigation of physiological parameters influencing its production. Appl Environ Microbiol. 1992 Jan; 58(1):353-8. PMID: 16348633.
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    65. O'Sullivan DJ, O'Gara F. Regulation of iron assimilation: nucleotide sequence analysis of an iron-regulated promoter from a fluorescent pseudomonad. Mol Gen Genet. 1991 Aug; 228(1-2):1-8. PMID: 1679522.
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    66. O'Sullivan DJ, Morris J, O'Gara F. Identification of an additional ferric-siderophore uptake gene clustered with receptor, biosynthesis, and fur-like regulatory genes in fluorescent Pseudomonas sp. strain M114. Appl Environ Microbiol. 1990 Jul; 56(7):2056-64. PMID: 2143887.
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    67. O'Sullivan DJ, O'Gara F. Delivery system for creation of one-step in vivo lac gene fusions in Pseudomonas spp. involved in biological control. Appl Environ Microbiol. 1988 Nov; 54(11):2877-80. PMID: 2850764.
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