Alexander Burashnikov

TitleVolunteer Faculty
InstitutionThomas Jefferson University
DepartmentFaculty Records
Address833 Chestnut Street
Philadelphia PA 19107
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    1. Burashnikov A, Di Diego JM, Patocskai B, Echt DS, Belardinelli L, Antzelevitch C. Effect of Flecainide and Ibutilide Alone and in Combination to Terminate and Prevent Recurrence of Atrial Fibrillation. Circ Arrhythm Electrophysiol. 2023 Dec 26; e012454. PMID: 38146652.
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    2. Burashnikov A, Antzelevitch C. Mild elevation of extracellular potassium greatly potentiates the effect of sodium channel block to cardiovert atrial fibrillation: The Lankenau approach. Heart Rhythm. 2023 May 09. PMID: 37169158.
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    3. Hu D, Barajas-Martinez H, Zhang ZH, Duan HY, Zhao QY, Bao MW, Du YM, Burashnikov A, Monasky MM, Pappone C, Huang CX, Antzelevitch C, Jiang H. Advances in basic and translational research in atrial fibrillation. Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19; 378(1879):20220174. PMID: 37122214.
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    4. Burashnikov A, Abbate A, Booz GW. Cardiovascular Complications of Anticancer Therapy: A Developing Storm in Medicine. J Cardiovasc Pharmacol. 2022 10 01; 80(4):491-492. PMID: 36001886.
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    5. Burashnikov A. Atrial Fibrillation Induced by Anticancer Drugs and Underling Mechanisms. J Cardiovasc Pharmacol. 2022 10 01; 80(4):540-546. PMID: 34803149.
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    6. Burashnikov A, Barajas-Martinez H, Cox R, Demitrack MA, Fossler MJ, Kramer M, Kleiman RB, Kowey P, Antzelevitch C. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. Heart Rhythm. 2021 12; 18(12):2177-2186. PMID: 34481984.
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    7. Burashnikov A. Depolarization of the atrial resting membrane potential as an approach to enhance the anti-atrial fibrillation efficacy of sodium channel blockers. Heart Rhythm. 2021 07; 18(7):1221-1222. PMID: 33785461.
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    8. Di Diego JM, Patocskai B, Barajas-Martinez H, Borb?th V, Ackerman MJ, Burashnikov A, Clatot J, Li GR, Robinson VM, Hu D, Antzelevitch C. Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes. PLoS One. 2020; 15(11):e0242747. PMID: 33232375.
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    9. Burashnikov A. Investigational Anti-Atrial Fibrillation Pharmacology and Mechanisms by Which Antiarrhythmics Terminate the Arrhythmia: Where Are We in 2020? J Cardiovasc Pharmacol. 2020 11; 76(5):492-505. PMID: 33165131.
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    10. Burashnikov A, Barajas-Martinez H, Hu D, Robinson VM, Grunnet M, Antzelevitch C. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020 08; 76(2):164-172. PMID: 32453071.
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    11. Burashnikov A, Antzelevitch C. Is extensive atrial fibrosis in the setting of heart failure associated with a reduced atrial fibrillation burden? Pacing Clin Electrophysiol. 2018 10; 41(10):1289-1297. PMID: 30152017.
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    12. Burashnikov A. Late INa Inhibition as an Antiarrhythmic Strategy. J Cardiovasc Pharmacol. 2017 Sep; 70(3):159-167. PMID: 28654510.
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    13. Burashnikov A, Antzelevitch C. Effectiveness of Late INa Versus Peak INa Block in the Setting of Ventricular Fibrillation. Circ Arrhythm Electrophysiol. 2017 03; 10(3). PMID: 28314847.
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    14. Hu D, Barajas-Mart?nez H, Burashnikov A, Panama BK, Cordeiro JM, Antzelevitch C. Mechanisms underlying atrial-selective block of sodium channels by Wenxin Keli: Experimental and theoretical analysis. Int J Cardiol. 2016 Mar 15; 207:326-34. PMID: 26820362.
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    15. Burashnikov A, Di Diego JM, Goodrow RJ, Belardinelli L, Antzelevitch C. Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current. J Cardiovasc Pharmacol Ther. 2015 Sep; 20(5):501-8. PMID: 25652294.
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    16. Burashnikov A, Belardinelli L, Antzelevitch C. Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation. Heart Rhythm. 2015 Apr; 12(4):836-44. PMID: 25546810.
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    17. Burashnikov A, Di Diego JM, Barajas-Mart?nez H, Hu D, Zygmunt AC, Cordeiro JM, Moise NS, Kornreich BG, Belardinelli L, Antzelevitch C. Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure. Circ Heart Fail. 2014 Jul; 7(4):627-33. PMID: 24874201.
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    18. Burashnikov A, Di Diego JM, Sicouri S, Doss MX, Sachinidis A, Barajas-Mart?nez H, Hu D, Minoura Y, Sydney Moise N, Kornreich BG, Chi L, Belardinelli L, Antzelevitch C. A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure. Eur J Heart Fail. 2014 Mar; 16(3):271-80. PMID: 24464846.
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    19. Cordeiro JM, Panama BK, Goodrow R, Zygmunt AC, White C, Treat JA, Zeina T, Nesterenko VV, Di Diego JM, Burashnikov A, Antzelevitch C. Developmental changes in expression and biophysics of ion channels in the canine ventricle. J Mol Cell Cardiol. 2013 Nov; 64:79-89. PMID: 24035801.
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    20. Burashnikov A, Antzelevitch C. Role of late sodium channel current block in the management of atrial fibrillation. Cardiovasc Drugs Ther. 2013 Feb; 27(1):79-89. PMID: 23108433.
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    21. Burashnikov A, Barajas-Martinez H, Hu D, Nof E, Blazek J, Antzelevitch C. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity. J Cardiovasc Pharmacol. 2012 Jun; 59(6):539-46. PMID: 22370957.
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    22. Burashnikov A, Pourrier M, Gibson JK, Lynch JJ, Antzelevitch C. Rate-dependent effects of vernakalant in the isolated non-remodeled canine left atria are primarily due to block of the sodium channel: comparison with ranolazine and dl-sotalol. Circ Arrhythm Electrophysiol. 2012 Apr; 5(2):400-8. PMID: 22322366.
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    23. Burashnikov A, Antzelevitch C. Ranolazine versus amiodarone for prevention of postoperative atrial fibrillation. Future Cardiol. 2011 Nov; 7(6):733-7. PMID: 22050058.
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    24. Burashnikov A, Belardinelli L, Antzelevitch C. Atrial-selective sodium channel block strategy to suppress atrial fibrillation: ranolazine versus propafenone. J Pharmacol Exp Ther. 2012 Jan; 340(1):161-8. PMID: 22005044.
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    25. Burashnikov A, Petroski A, Hu D, Barajas-Martinez H, Antzelevitch C. Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation. Heart Rhythm. 2012 Jan; 9(1):125-31. PMID: 21884675.
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    26. Burashnikov A, Antzelevitch C. Novel pharmacological targets for the rhythm control management of atrial fibrillation. Pharmacol Ther. 2011 Dec; 132(3):300-13. PMID: 21867730.
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    27. Antzelevitch C, Burashnikov A, Sicouri S, Belardinelli L. Electrophysiologic basis for the antiarrhythmic actions of ranolazine. Heart Rhythm. 2011 Aug; 8(8):1281-90. PMID: 21421082.
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    28. Burashnikov A, Antzelevitch C. Advances in the Pharmacologic Management of Atrial Fibrillation. Card Electrophysiol Clin. 2011 Mar; 3(1):157-167. PMID: 21731596.
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    29. Antzelevitch C, Burashnikov A. Overview of Basic Mechanisms of Cardiac Arrhythmia. Card Electrophysiol Clin. 2011 Mar 01; 3(1):23-45. PMID: 21892379.
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    30. Burashnikov A, Sicouri S, Di Diego JM, Belardinelli L, Antzelevitch C. Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. J Am Coll Cardiol. 2010 Oct 05; 56(15):1216-24. PMID: 20883928.
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    31. Burashnikov A, Zygmunt AC, Di Diego JM, Linhardt G, Carlsson L, Antzelevitch C. AZD1305 exerts atrial predominant electrophysiological actions and is effective in suppressing atrial fibrillation and preventing its reinduction in the dog. J Cardiovasc Pharmacol. 2010 Jul; 56(1):80-90. PMID: 20386458.
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    32. Burashnikov A, Belardinelli L, Antzelevitch C. Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria. Heart Rhythm. 2010 Sep; 7(9):1273-9. PMID: 20478403.
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    33. Burashnikov A, Antzelevitch C. New developments in atrial antiarrhythmic drug therapy. Nat Rev Cardiol. 2010 Mar; 7(3):139-48. PMID: 20179721.
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    34. Antzelevitch C, Burashnikov A. Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. Ann N Y Acad Sci. 2010 Feb; 1188:78-86. PMID: 20201889.
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    35. Burashnikov A, Antzelevitch C. Advances in the Pharmacological Treatment of Atrial Fibrillation. Curr Med Lit Cardiol. 2010 Jan 01; 29(1):1-5. PMID: 21152111.
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    36. Chamberland C, Barajas-Martinez H, Haufe V, Fecteau MH, Delabre JF, Burashnikov A, Antzelevitch C, Lesur O, Chraibi A, Sarret P, Dumaine R. Modulation of canine cardiac sodium current by Apelin. J Mol Cell Cardiol. 2010 Apr; 48(4):694-701. PMID: 20036246.
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    37. Sicouri S, Burashnikov A, Belardinelli L, Antzelevitch C. Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ Arrhythm Electrophysiol. 2010 Feb; 3(1):88-95. PMID: 19952329.
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    38. Nof E, Burashnikov A, Antzelevitch C. Cellular basis for atrial fibrillation in an experimental model of short QT1: implications for a pharmacological approach to therapy. Heart Rhythm. 2010; 7(2):251-7. PMID: 20042373.
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    39. Antzelevitch C, Burashnikov A. Atrial-selective sodium channel block as a novel strategy for the management of atrial fibrillation. J Electrocardiol. 2009 Nov-Dec; 42(6):543-8. PMID: 19698954.
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    40. Burashnikov A, Antzelevitch C. New pharmacological strategies for the treatment of atrial fibrillation. Ann Noninvasive Electrocardiol. 2009 Jul; 14(3):290-300. PMID: 19614642.
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    41. Burashnikov A, Antzelevitch C. Atrial-selective sodium channel block for the treatment of atrial fibrillation. Expert Opin Emerg Drugs. 2009 Jun; 14(2):233-49. PMID: 19466903.
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    42. Burashnikov A, Di Diego JM, Sicouri S, Ferreiro M, Carlsson L, Antzelevitch C. Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation. Heart Rhythm. 2008 Dec; 5(12):1735-42. PMID: 19084813.
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    43. Burashnikov A, Antzelevitch C. Can inhibition of IKur promote atrial fibrillation? Heart Rhythm. 2008 Sep; 5(9):1304-9. PMID: 18774108.
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    44. Burashnikov A, Antzelevitch C. Atrial-selective sodium channel blockers: do they exist? J Cardiovasc Pharmacol. 2008 Aug; 52(2):121-8. PMID: 18670368.
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    45. Burashnikov A, Shimizu W, Antzelevitch C. Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions. Circ Arrhythm Electrophysiol. 2008 Aug; 1(3):202-8. PMID: 19649147.
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    46. Burashnikov A. Are there atrial selective/predominant targets for "upstream" atrial fibrillation therapy? Heart Rhythm. 2008 Sep; 5(9):1294-5. PMID: 18774105.
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    47. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrial-selective sodium channel block as a strategy for suppression of atrial fibrillation. Ann N Y Acad Sci. 2008 Mar; 1123:105-12. PMID: 18375582.
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    48. Burashnikov A, Antzelevitch C. How Do Atrial-Selective Drugs Differ From Antiarrhythmic Drugs Currently Used in the Treatment of Atrial Fibrillation? J Atr Fibrillation. 2008; 1(2):98-107. PMID: 21057583.
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    49. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007 Sep 25; 116(13):1449-57. PMID: 17785620.
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    50. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W, Yan GX, Kowey P, Zhang L. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007 Aug; 4(8):1114-6; author reply 1116-9. PMID: 17675094.
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    51. Burashnikov A, Antzelevitch C. Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation. Pacing Clin Electrophysiol. 2006 Mar; 29(3):290-5. PMID: 16606397.
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    52. Burashnikov A, Antzelevitch C. Role of repolarization restitution in the development of coarse and fine atrial fibrillation in the isolated canine right atria. J Cardiovasc Electrophysiol. 2005 Jun; 16(6):639-45. PMID: 15946365.
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    53. Nam GB, Burashnikov A, Antzelevitch C. Cellular mechanisms underlying the development of catecholaminergic ventricular tachycardia. Circulation. 2005 May 31; 111(21):2727-33. PMID: 15911700.
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    54. Antzelevitch C, Belardinelli L, Wu L, Fraser H, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Goodrow RJ, Scornik F, Perez G. Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent. J Cardiovasc Pharmacol Ther. 2004 Sep; 9 Suppl 1:S65-83. PMID: 15378132.
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    55. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. 2004 Aug 24; 110(8):904-10. PMID: 15302796.
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    56. Burashnikov A, Mannava S, Antzelevitch C. Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect of IKr and IKur/Ito block. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2393-400. PMID: 15148061.
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    57. Burashnikov A, Antzelevitch C. Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity. Circulation. 2003 May 13; 107(18):2355-60. PMID: 12695296.
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    58. Burashnikov A, Antzelevitch C. Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations. J Cardiovasc Electrophysiol. 2002 Feb; 13(2):172-7. PMID: 11900293.
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    59. Kukushkin NI, Sidorov VIu, Medvinskii AB, Romashko DN, Burashnikov AIu, Baum OV, Sarancha DIu, Starmer CF. [Slow excitation waves and mechanisms of polymorphic ventricular tachycardia in an experimental model: isolated walls of the right ventricle from rabbit and squirrel]. Biofizika. 1998 Nov-Dec; 43(6):1043-59. PMID: 10079923.
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