RNA-Binding Protein FUS

"RNA-Binding Protein FUS" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

Descriptor ID	D034702
MeSH Number(s)	D12.776.157.725.813.750.905 D12.776.624.664.700.915 D12.776.664.962.813.750.902
Concept/Terms	RNA-Binding Protein FUS RNA-Binding Protein FUS RNA Binding Protein FUS TLS Protein POMp75 Protein Translocated in Liposarcoma Protein FUS RNA-Binding Protein FUS RNA Binding Protein RNA-Binding Protein, FUS Fusion Protein in Myxoid Liposarcoma FUS Protein hnRNP P2

Below are MeSH descriptors whose meaning is more general than "RNA-Binding Protein FUS".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
RNA Recognition Motif Proteins [D12.776.157.725.813]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.157.725.813.750]
RNA-Binding Protein FUS [D12.776.157.725.813.750.905]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
RNA-Binding Protein FUS [D12.776.624.664.700.915]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
RNA Recognition Motif Proteins [D12.776.664.962.813]
Heterogeneous-Nuclear Ribonucleoproteins [D12.776.664.962.813.750]
RNA-Binding Protein FUS [D12.776.664.962.813.750.902]

Below are MeSH descriptors whose meaning is related to "RNA-Binding Protein FUS".

Below are MeSH descriptors whose meaning is more specific than "RNA-Binding Protein FUS".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RNA-Binding Protein FUS" by people in this website by year, and whether "RNA-Binding Protein FUS" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2012 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	0	1
2011	1	0	1
2012	1	1	2
2017	1	1	2
2018	1	0	1
2021	0	1	1
2024	1	0	1
2025	0	1	1

Below are the most recent publications written about "RNA-Binding Protein FUS" by people in Profiles.

Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

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Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 Sep 10; 15(1):7887.

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Righi A, Pacheco M, Pipola V, Gambarotti M, Benini S, Sbaraglia M, Frisoni T, Boriani S, Dei Tos AP, Gasbarrini A. Primary sclerosing epithelioid fibrosarcoma of the spine: a single-institution experience. Histopathology. 2021 Jun; 78(7):976-986.

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Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL. Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy. Stem Cell Reports. 2018 02 13; 10(2):375-389.

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Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, Murray ME, Kato M, Fryer JD, Petrucelli L, Zinman L, Weintraub S, Mesulam M, Keith J, Zivkovic SA, Hirsch-Reinshagen V, Roos RP, Züchner S, Graff-Radford NR, Petersen RC, Caselli RJ, Wszolek ZK, Finger E, Lippa C, Lacomis D, Stewart H, Dickson DW, Kim HJ, Rogaeva E, Bigio E, Boylan KB, Taylor JP, Rademakers R. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017 Aug 16; 95(4):808-816.e9.

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Ilieva H, Maragakis NJ. Motoneuron Disease: Basic Science. Adv Neurobiol. 2017; 15:163-190.

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Huang C, Tong J, Bi F, Wu Q, Huang B, Zhou H, Xia XG. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats. Hum Mol Genet. 2012 Nov 1; 21(21):4602-14.

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Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet. 2012 Jul 01; 21(13):2899-911.

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Huang C, Zhou H, Tong J, Chen H, Liu YJ, Wang D, Wei X, Xia XG. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet. 2011 Mar; 7(3):e1002011.

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Huang C, Xia PY, Zhou H. Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime. Int J Biol Sci. 2010; 6(4):396-406.

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