RNA-Induced Silencing Complex
"RNA-Induced Silencing Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
| Descriptor ID |
D034743
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| MeSH Number(s) |
D08.811.277.352.355.350.810 D08.811.277.352.700.350.810 D12.776.157.725.500.906 D12.776.664.962.500.906
|
| Concept/Terms |
RNA-Induced Silencing Complex- RNA-Induced Silencing Complex
- Complex, RNA-Induced Silencing
- RNA Induced Silencing Complex
- Silencing Complex, RNA-Induced
- RISC Multicomponent Nuclease
- Multicomponent Nuclease, RISC
- Nuclease, RISC Multicomponent
|
Below are MeSH descriptors whose meaning is more general than "RNA-Induced Silencing Complex".
Below are MeSH descriptors whose meaning is more specific than "RNA-Induced Silencing Complex".
This graph shows the total number of publications written about "RNA-Induced Silencing Complex" by people in this website by year, and whether "RNA-Induced Silencing Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 1 | 3 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "RNA-Induced Silencing Complex" by people in Profiles.
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Honda S, Kirino Y, Maragkakis M, Alexiou P, Ohtaki A, Murali R, Mourelatos Z, Kirino Y. Mitochondrial protein BmPAPI modulates the length of mature piRNAs. RNA. 2013 Oct; 19(10):1405-18.
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Tan GS, Chiu CH, Garchow BG, Metzler D, Diamond SL, Kiriakidou M. Small molecule inhibition of RISC loading. ACS Chem Biol. 2012 Feb 17; 7(2):403-10.
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Tan GS, Garchow BG, Liu X, Metzler D, Kiriakidou M. Clarifying mammalian RISC assembly in vitro. BMC Mol Biol. 2011; 12:19.
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Kirino Y. [Role of arginine methylation in the Piwi-interacting RNA pathway]. Seikagaku. 2011 Apr; 83(4):312-6.
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Vourekas A, Kirino Y, Mourelatos Z. Elective affinities: a Tudor-Aubergine tale of germline partnership. Genes Dev. 2010 Sep 15; 24(18):1963-6.
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Tan GS, Garchow BG, Liu X, Yeung J, Morris JP, Cuellar TL, McManus MT, Kiriakidou M. Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res. 2009 Dec; 37(22):7533-45.
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Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, Klein PS, Rigoutsos I, Jongens TA, Mourelatos Z. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol. 2009 May; 11(5):652-8.