Ribosomal Protein S6 Kinases, 70-kDa

"Ribosomal Protein S6 Kinases, 70-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

Descriptor ID	D038762
MeSH Number(s)	D08.811.913.696.620.682.700.862.249 D12.644.360.600.249 D12.776.476.600.249
Concept/Terms	Ribosomal Protein S6 Kinases, 70-kDa Ribosomal Protein S6 Kinases, 70-kDa Ribosomal Protein S6 Kinases, 70 kDa p70 S6 Kinase S6 Kinase, p70 p70s6k

Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 70-kDa".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
Ribosomal Protein S6 Kinases, 70-kDa [D08.811.913.696.620.682.700.862.249]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Ribosomal Protein S6 Kinases [D12.644.360.600]
Ribosomal Protein S6 Kinases, 70-kDa [D12.644.360.600.249]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Ribosomal Protein S6 Kinases [D12.776.476.600]
Ribosomal Protein S6 Kinases, 70-kDa [D12.776.476.600.249]

Below are MeSH descriptors whose meaning is related to "Ribosomal Protein S6 Kinases, 70-kDa".

Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 70-kDa".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 70-kDa" was a major or minor topic of these publications.

Bar chart showing 13 publications over 7 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	2	3
2004	1	0	1
2005	1	1	2
2006	0	2	2
2007	0	2	2
2011	1	1	2
2024	0	1	1

Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in Profiles.

Calderon-Aparicio A, He J, Simone NL. S6K1 Controls DNA Damage Signaling Modulated by the MRN Complex to Induce Radioresistance in Lung Cancer. Int J Mol Sci. 2024 Sep 28; 25(19).

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Carpenter RL, Jiang Y, Jing Y, He J, Rojanasakul Y, Liu LZ, Jiang BH. Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. Biochem Biophys Res Commun. 2011 Oct 28; 414(3):533-8.

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Bhola NE, Thomas SM, Freilino M, Joyce S, Sahu A, Maxwell J, Argiris A, Seethala R, Grandis JR. Targeting GPCR-mediated p70S6K activity may improve head and neck cancer response to cetuximab. Clin Cancer Res. 2011 Aug 01; 17(15):4996-5004.

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Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Mol Pharmacol. 2008 Mar; 73(3):778-88.

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Schaafsma D, McNeill KD, Stelmack GL, Gosens R, Baarsma HA, Dekkers BG, Frohwerk E, Penninks JM, Sharma P, Ens KM, Nelemans SA, Zaagsma J, Halayko AJ, Meurs H. Insulin increases the expression of contractile phenotypic markers in airway smooth muscle. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C429-39.

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Vaira V, Lee CW, Goel HL, Bosari S, Languino LR, Altieri DC. Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. 2007 Apr 26; 26(19):2678-84.

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Han S, Roman J. Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways. Mol Cancer Ther. 2006 Feb; 5(2):430-7.

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Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA, Chan TO, Penn RB. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry. 2005 Nov 8; 44(44):14595-605.

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Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene. 2005 Apr 28; 24(19):3154-65.

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Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C281-91.

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