Konstantin Komolov

TitleInstructor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-4610
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phadte AS, Bhatia M, Ebert H, Abdullah H, Elrazaq EA, Komolov KE, Pluciennik A. FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2302103120. PMID: 37549289.
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    2. Ippolito M, De Pascali F, Hopfinger N, Komolov KE, Laurinavichyute D, Reddy PAN, Sakkal LA, Rajkowski KZ, Nayak AP, Lee J, Lee J, Cao G, Donover PS, Reichman M, An SS, Salvino JM, Penn RB, Armen RS, Scott CP, Benovic JL. Identification of a ?-arrestin-biased negative allosteric modulator for the ?2-adrenergic receptor. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302668120. PMID: 37490535.
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    3. De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. ß-agonist profiling reveals biased signalling phenotypes for the ß2 -adrenergic receptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022 Jun 22. PMID: 35732075.
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    4. Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol Cell. 2020 Dec 09. PMID: 33321095.
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    5. Komolov KE, Benovic JL. G protein-coupled receptor kinases: Past, present and future. Cell Signal. 2018 Jan; 41:17-24. PMID: 28711719.
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    6. Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a ß2-Adrenergic Receptor Complex with GRK5. Cell. 2017 Apr 20; 169(3):407-421.e16. PMID: 28431242.
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    7. Komolov KE, Bhardwaj A, Benovic JL. Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem. 2015 Aug 21; 290(34):20629-47. PMID: 26032409.
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    8. So CH, Michal A, Komolov KE, Luo J, Benovic JL. G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. Mol Biol Cell. 2013 Sep; 24(18):2795-806. PMID: 23904266.
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    9. Grigoriev II, Senin II, Tikhomirova NK, Komolov KE, Permyakov SE, Zernii EY, Koch KW, Philippov PP. Synergetic effect of recoverin and calmodulin on regulation of rhodopsin kinase. Front Mol Neurosci. 2012; 5:28. PMID: 22408603.
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    10. Zernii EY, Komolov KE, Permyakov SE, Kolpakova T, Dell'orco D, Poetzsch A, Knyazeva EL, Grigoriev II, Permyakov EA, Senin II, Philippov PP, Koch KW. Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase. Biochem J. 2011 Apr 15; 435(2):441-50. PMID: 21299498.
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    11. Komolov KE, Aguil? M, Toledo D, Manyosa J, Garriga P, Koch KW. On-chip photoactivation of heterologously expressed rhodopsin allows kinetic analysis of G-protein signaling by surface plasmon resonance spectroscopy. Anal Bioanal Chem. 2010 Aug; 397(7):2967-76. PMID: 20544180.
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    12. Komolov KE, Koch KW. Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signalling. Methods Mol Biol. 2010; 627:249-60. PMID: 20217627.
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    13. Komolov KE, Senin II, Kovaleva NA, Christoph MP, Churumova VA, Grigoriev II, Akhtar M, Philippov PP, Koch KW. Mechanism of rhodopsin kinase regulation by recoverin. J Neurochem. 2009 Jul; 110(1):72-9. PMID: 19457073.
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    14. Gensch T, Komolov KE, Senin II, Philippov PP, Koch KW. Ca2+-dependent conformational changes in the neuronal Ca2+-sensor recoverin probed by the fluorescent dye Alexa647. Proteins. 2007 Feb 01; 66(2):492-9. PMID: 17078090.
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    15. Komolov KE, Senin II, Philippov PP, Koch KW. Surface plasmon resonance study of g protein/receptor coupling in a lipid bilayer-free system. Anal Chem. 2006 Feb 15; 78(4):1228-34. PMID: 16478116.
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    16. Komolov KE, Zinchenko DV, Churumova VA, Vaganova SA, Weiergr?ber OH, Senin II, Philippov PP, Koch KW. One of the Ca2+ binding sites of recoverin exclusively controls interaction with rhodopsin kinase. Biol Chem. 2005 Mar; 386(3):285-9. PMID: 15843174.
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    17. Komolov KE, Senin II, Filippov PP. [Visual transduction and calcium ions]. Biofizika. 2004 Mar-Apr; 49(2):265-77. PMID: 15129627.
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    18. Komolov KE, Senin II, Filippov PP. [The effect of proteolytic removal of the C-terminal fragment of rhodopsin on its ability to activate visual cascade]. Bioorg Khim. 2002 Jan-Feb; 28(1):16-22. PMID: 11875969.
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