Core Binding Factor Alpha 1 Subunit

"Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

Descriptor ID	D050659
MeSH Number(s)	D12.776.930.155.200.100
Concept/Terms	Core Binding Factor Alpha 1 Subunit Core Binding Factor Alpha 1 Subunit AML3 Transcription Factor CBFA-1 Protein CBFA 1 Protein CBFA1 Protein CBFalpha Runt Domain Transcription Factor 1 Osf2 Transcription Factor PEBP2alphaA Protein Runx2 Protein SEF1 Protein SL3-3 Enhancer Factor 1 SL3 3 Enhancer Factor 1 Acute Myeloid Leukemia 3 Protein CBFalpha1 Protein

Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 1 Subunit".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Core Binding Factors [D12.776.930.155]
Core Binding Factor alpha Subunits [D12.776.930.155.200]
Core Binding Factor Alpha 1 Subunit [D12.776.930.155.200.100]

Below are MeSH descriptors whose meaning is related to "Core Binding Factor Alpha 1 Subunit".

Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 1 Subunit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 1 Subunit" was a major or minor topic of these publications.

Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2011 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2005	1	0	1
2007	0	1	1
2009	1	0	1
2010	1	0	1
2011	0	2	2
2012	0	1	1
2013	0	1	1
2017	2	0	2

Below are the most recent publications written about "Core Binding Factor Alpha 1 Subunit" by people in Profiles.

Hsu CK, Lin HH, Harn HI, Ogawa R, Wang YK, Ho YT, Chen WR, Lee YC, Lee JY, Shieh SJ, Cheng CM, McGrath JA, Tang MJ. Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation?in Keloid Fibroblasts. J Invest Dermatol. 2018 01; 138(1):208-218.

View in: PubMed
Buo AM, Tomlinson RE, Eidelman ER, Chason M, Stains JP. Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function. J Bone Miner Res. 2017 Aug; 32(8):1727-1738.

View in: PubMed
Kramann R, Kunter U, Brandenburg VM, Leisten I, Ehling J, Klinkhammer BM, Kn?chel R, Floege J, Schneider RK. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. J Bone Miner Res. 2013 Dec; 28(12):2523-34.

View in: PubMed
Branchetti E, Sainger R, Poggio P, Grau JB, Patterson-Fortin J, Bavaria JE, Chorny M, Lai E, Gorman RC, Levy RJ, Ferrari G. Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):e66-74.

View in: PubMed
Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60.

View in: PubMed
McCarthy TL, Kallen CB, Centrella M. ß-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts. Gene. 2011 Jun 15; 479(1-2):16-28.

View in: PubMed
van der Deen M, Akech J, Wang T, FitzGerald TJ, Altieri DC, Languino LR, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells. J Cell Biochem. 2010 Mar 1; 109(4):828-37.

View in: PubMed
Akech J, Wixted JJ, Bedard K, van der Deen M, Hussain S, Guise TA, van Wijnen AJ, Stein JL, Languino LR, Altieri DC, Pratap J, Keller E, Stein GS, Lian JB. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene. 2010 Feb 11; 29(6):811-21.

View in: PubMed
Risbud MV, Guttapalli A, Tsai TT, Lee JY, Danielson KG, Vaccaro AR, Albert TJ, Gazit Z, Gazit D, Shapiro IM. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976). 2007 Nov 1; 32(23):2537-44.

View in: PubMed
Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005 Oct; 25(19):8581-91.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement