Large-Conductance Calcium-Activated Potassium Channels
"Large-Conductance Calcium-Activated Potassium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major class of calcium activated potassium channels whose members are voltage-dependent. MaxiK channels are activated by either membrane depolarization or an increase in intracellular Ca(2+). They are key regulators of calcium and electrical signaling in a variety of tissues.
| Descriptor ID |
D051036
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| MeSH Number(s) |
D12.776.157.530.400.600.150.500 D12.776.543.550.450.750.150.500 D12.776.543.585.400.750.150.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Large-Conductance Calcium-Activated Potassium Channels".
Below are MeSH descriptors whose meaning is more specific than "Large-Conductance Calcium-Activated Potassium Channels".
This graph shows the total number of publications written about "Large-Conductance Calcium-Activated Potassium Channels" by people in this website by year, and whether "Large-Conductance Calcium-Activated Potassium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Large-Conductance Calcium-Activated Potassium Channels" by people in Profiles.
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Jepson JE, Shahidullah M, Lamaze A, Peterson D, Pan H, Koh K. dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genet. 2012; 8(4):e1002671.
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Sheldon AL, Zhang J, Fei H, Levitan IB. SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila. PLoS One. 2011; 6(8):e23343.
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Bukiya AN, Belani JD, Rychnovsky S, Dopico AM. Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions. J Gen Physiol. 2011 Jan; 137(1):93-110.
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Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med. 2010 Nov; 16(11):1299-304.
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Zeng H, Weiger TM, Fei H, Levitan IB. Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel. J Gen Physiol. 2006 Nov; 128(5):583-91.
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Jaramillo AM, Zeng H, Fei H, Zhou Y, Levitan IB. Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila. J Neurophysiol. 2006 Mar; 95(3):1957-65.
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Zeng H, Weiger TM, Fei H, Jaramillo AM, Levitan IB. The amino terminus of Slob, Slowpoke channel binding protein, critically influences its modulation of the channel. J Gen Physiol. 2005 Jun; 125(6):631-40.
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Cibulsky SM, Fei H, Levitan IB. Syntaxin-1A binds to and modulates the Slo calcium-activated potassium channel via an interaction that excludes syntaxin binding to calcium channels. J Neurophysiol. 2005 Mar; 93(3):1393-405.
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Zhou Y, Fei H, Levitan IB. An interaction domain in Slob necessary for its binding to the slowpoke calcium-dependent potassium channel. Neuropharmacology. 2003 Nov; 45(6):714-9.
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Zhou Y, Reddy S, Murrey H, Fei H, Levitan IB. Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel. J Biol Chem. 2003 Mar 21; 278(12):10073-80.