EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
Bindels EM, Havermans M, Lugthart S, Erpelinck C, Wocjtowicz E, Krivtsov AV, Rombouts E, Armstrong SA, Taskesen E, Haanstra JR, Beverloo HB, D?hner H, Hudson WA, Kersey JH, Delwel R, Kumar AR. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood. 2012 Jun 14; 119(24):5838-49.
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Animals
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Bone Marrow Cells
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Cell Proliferation
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Cell Transformation, Neoplastic
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Chromosomes, Human, Pair 11
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Colony-Forming Units Assay
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DNA-Binding Proteins
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Gene Expression Profiling
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Gene Expression Regulation, Leukemic
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Gene Knockdown Techniques
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Gene Rearrangement
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Histones
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Humans
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Leukemia, Myeloid, Acute
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Lysine
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MDS1 and EVI1 Complex Locus Protein
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Mice
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Mice, Inbred C57BL
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Myeloid-Lymphoid Leukemia Protein
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Oncogene Proteins, Fusion
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Promoter Regions, Genetic
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Proto-Oncogenes
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RNA, Messenger
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Transcription Factors