t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL.
Kumar AR, Yao Q, Li Q, Sam TA, Kersey JH. t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL. Leuk Res. 2011 Mar; 35(3):305-9.
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Apoptosis
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Blotting, Western
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Cell Cycle
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Cell Proliferation
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 4
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DNA-Binding Proteins
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Histone-Lysine N-Methyltransferase
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Humans
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Leukemia
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Myeloid-Lymphoid Leukemia Protein
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Nuclear Proteins
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Oncogene Proteins, Fusion
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger
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RNA, Small Interfering
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Transcriptional Elongation Factors
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Translocation, Genetic
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Tumor Cells, Cultured