Receptors, TNF-Related Apoptosis-Inducing Ligand

"Receptors, TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved DEATH DOMAINS that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Descriptor ID	D053220
MeSH Number(s)	D12.776.543.750.690.600 D12.776.543.750.705.852.760.396
Concept/Terms	Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, TNF Related Apoptosis Inducing Ligand Tumor Necrosis Factor Receptor Superfamily, Member 10 TRAIL Receptors Receptors, TRAIL Receptors, Tumor Necrosis Factor, Member 10 TNF-Related Apoptosis-Inducing Ligand Receptors TNF Related Apoptosis Inducing Ligand Receptors Receptors, Tumor Necrosis Factor, Member 10d Receptors, Tumor Necrosis Factor, Member 10d Decoy Receptor 2, Tumor Necrosis Factor Receptor, TRAIL-4 Receptor, TRAIL 4 TRAIL-4 Receptor DCR2 Receptor Receptor, DCR2 CD264 Antigen Antigen, CD264 TRAIL Receptor 4 Receptor 4, TRAIL Receptors, Tumor Necrosis Factor, Member 10a Receptors, Tumor Necrosis Factor, Member 10a Tumor Necrosis Factor Receptor Superfamily, Member 10a APO2 Receptor Receptor, APO2 Receptor, TRAIL-1 Receptor, TRAIL 1 TRAIL-1 Receptor TRAIL Receptor 1 DR4 Receptor Receptor, DR4 CD261 Antigen Antigen, CD261 Death Receptor-4 Death Receptor 4 Receptor-4, Death Receptors, Tumor Necrosis Factor, Member 10b Receptors, Tumor Necrosis Factor, Member 10b TRAIL Receptor 2 Receptor, TRAIL-2 Receptor, TRAIL 2 TRAIL-2 Receptor DR5 Receptor Receptor, DR5 Tumor Necrosis Factor Receptor Superfamily, Member 10b TNF-Related Apoptosis-Inducing Ligand Receptor 2 TNF Related Apoptosis Inducing Ligand Receptor 2 CD262 Antigen Antigen, CD262 Death Receptor-5 Death Receptor 5

Below are MeSH descriptors whose meaning is more general than "Receptors, TNF-Related Apoptosis-Inducing Ligand".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Death Domain [D12.776.543.750.690]
Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.690.600]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.705.852.760.396]

Below are MeSH descriptors whose meaning is related to "Receptors, TNF-Related Apoptosis-Inducing Ligand".

Below are MeSH descriptors whose meaning is more specific than "Receptors, TNF-Related Apoptosis-Inducing Ligand".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "Receptors, TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1997 and 1999 and 2002 and 2009 and 2012 and 2013 and 2014 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2002	0	1	1
2009	0	1	1
2012	1	0	1
2013	1	0	1
2014	1	0	1
2016	1	0	1

Below are the most recent publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.

Dominguez GA, Condamine T, Mony S, Hashimoto A, Wang F, Liu Q, Forero A, Bendell J, Witt R, Hockstein N, Kumar P, Gabrilovich DI. Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody. Clin Cancer Res. 2017 Jun 15; 23(12):2942-2950.

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Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J Clin Invest. 2014 Jun; 124(6):2626-39.

View in: PubMed
Sharma S, de Vries EG, Infante JR, Oldenhuis CN, Gietema JA, Yang L, Bilic S, Parker K, Goldbrunner M, Scott JW, Burris HA. Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors. Invest New Drugs. 2014 Feb; 32(1):135-44.

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Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. J Biol Chem. 2012 Jun 15; 287(25):21265-78.

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Chehimi J, Papasavvas E, Tomescu C, Gekonge B, Abdulhaqq S, Raymond A, Hancock A, Vinekar K, Carty C, Reynolds G, Pistilli M, Mounzer K, Kostman J, Montaner LJ. Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligand. J Virol. 2010 Mar; 84(6):2762-73.

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Robertson NM, Zangrilli JG, Steplewski A, Hastie A, Lindemeyer RG, Planeta MA, Smith MK, Innocent N, Musani A, Pascual R, Peters S, Litwack G. Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival. J Immunol. 2002 Nov 15; 169(10):5986-96.

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Wu GS, Burns TF, Zhan Y, Alnemri ES, El-Deiry WS. Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 1999 Jun 15; 59(12):2770-5.

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MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997 Oct 10; 272(41):25417-20.

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