Receptors, KIR

"Receptors, KIR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like domains referred to as D0, D1, and D2 and play an important role in blocking NK cell activation against cells expressing the appropriate HLA antigens thus preventing cell lysis. Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role in NK cells.

Descriptor ID	D054340
MeSH Number(s)	D12.776.543.750.705.895.500
Concept/Terms	Receptors, KIR Receptors, KIR Killer Inhibitory Receptors Inhibitory Receptors, Killer Receptors, Killer Inhibitory Receptor, p58 NK Cell p58 Natural Killer Cell Receptor KIR Receptor Receptor, KIR p58 NK Cell Inhibitory Receptor Receptor, Killer Inhibitory Killer Inhibitory Receptor Inhibitory Receptor, Killer Killer Immunoglobulin-Like Receptor Immunoglobulin-Like Receptor, Killer Killer Immunoglobulin Like Receptor Receptor, Killer Immunoglobulin-Like Killer Cell Immunoglobulin-Like Receptor Killer Cell Immunoglobulin Like Receptor KIR Family Receptors Family Receptors, KIR Receptors, KIR Family KIR Receptors Killer Immunoglobulin-Like Receptor (KIR) Family of Receptors Killer Cell Immunoglobulin-Like Receptors Killer Cell Immunoglobulin Like Receptors p58 NK Cell Receptor p58 NK Cell Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, KIR".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Natural Killer Cell [D12.776.543.750.705.895]
Receptors, KIR [D12.776.543.750.705.895.500]

Below are MeSH descriptors whose meaning is related to "Receptors, KIR".

Below are MeSH descriptors whose meaning is more specific than "Receptors, KIR".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, KIR" by people in this website by year, and whether "Receptors, KIR" was a major or minor topic of these publications.

Bar chart showing 21 publications over 13 distinct years, with a maximum of 3 publications in 2009 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	2	2
2004	0	1	1
2005	0	2	2
2007	1	1	2
2008	0	1	1
2009	2	1	3
2010	1	0	1
2011	1	0	1
2014	1	0	1
2015	0	1	1
2017	3	0	3
2021	1	1	2

Below are the most recent publications written about "Receptors, KIR" by people in Profiles.

Bonaccorsi I, Carrega P, Venanzi Rullo E, Ducatelli R, Falco M, Freni J, Miceli M, Cavaliere R, Fontana V, Versace A, Caramori G, David A, Nunnari G, Ferlazzo G. HLA-C*17 in COVID-19 patients: Hints for associations with severe clinical outcome and cardiovascular risk. Immunol Lett. 2021 06; 234:44-46.

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Campbell KS. Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2. Cancer Immunol Res. 2021 02; 9(2):128.

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Franasiak JM, Scott RT. Contribution of immunology to implantation failure of euploid embryos. Fertil Steril. 2017 06; 107(6):1279-1283.

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Gauthiez E, Habfast-Robertson I, R?eger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim MH, Malinverni R, Moradpour D, M?llhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud PY. A systematic review and meta-analysis of HCV clearance. Liver Int. 2017 10; 37(10):1431-1445.

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Morin SJ, Treff NR, Tao X, Scott RT, Franasiak JM, Juneau CR, Maguire M, Scott RT. Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences the risk of pregnancy loss: a retrospective cohort analysis of direct embryo genotyping data from euploid transfers. Fertil Steril. 2017 Mar; 107(3):677-683.e2.

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Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ. Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. Genome Med. 2015 Oct 01; 7:90.

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Purdy AK, Alvarez Arias DA, Oshinsky J, James AM, Serebriiskii I, Campbell KS. The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells. J Immunol. 2014 Nov 01; 193(9):4675-83.

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Campbell KS, Purdy AK. Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology. 2011 Mar; 132(3):315-25.

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Purdy AK, Campbell KS. [Natural killer cells and cancer. Regulation by the killer cell Ig-like receptors (KIR)]. Zhongguo Fei Ai Za Zhi. 2010 Jul; 13(7):731-6.

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Purdy AK, Campbell KS. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol Ther. 2009 Dec; 8(23):2211-20.

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