"Receptors, KIR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of receptors found on NK CELLS that have specificity for a variety of HLA ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like domains referred to as D0, D1, and D2 and play an important role in blocking NK cell activation against cells expressing the appropriate HLA antigens thus preventing cell lysis. Although they are often referred to as being inhibitory receptors, a subset of KIR receptors may also play an activating role in NK cells.
| Descriptor ID |
D054340
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| MeSH Number(s) |
D12.776.543.750.705.895.500
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| Concept/Terms |
Receptors, KIR- Receptors, KIR
- Killer Inhibitory Receptors
- Inhibitory Receptors, Killer
- Receptors, Killer Inhibitory
- Receptor, p58 NK Cell
- p58 Natural Killer Cell Receptor
- KIR Receptor
- Receptor, KIR
- p58 NK Cell Inhibitory Receptor
- Receptor, Killer Inhibitory
- Killer Inhibitory Receptor
- Inhibitory Receptor, Killer
- Killer Immunoglobulin-Like Receptor
- Immunoglobulin-Like Receptor, Killer
- Killer Immunoglobulin Like Receptor
- Receptor, Killer Immunoglobulin-Like
- Killer Cell Immunoglobulin-Like Receptor
- Killer Cell Immunoglobulin Like Receptor
- KIR Family Receptors
- Family Receptors, KIR
- Receptors, KIR Family
- KIR Receptors
- Killer Immunoglobulin-Like Receptor (KIR) Family of Receptors
- Killer Cell Immunoglobulin-Like Receptors
- Killer Cell Immunoglobulin Like Receptors
- p58 NK Cell Receptor
- p58 NK Cell Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, KIR".
Below are MeSH descriptors whose meaning is more specific than "Receptors, KIR".
This graph shows the total number of publications written about "Receptors, KIR" by people in this website by year, and whether "Receptors, KIR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, KIR" by people in Profiles.
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Campbell KS. Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2. Cancer Immunol Res. 2021 02; 9(2):128.
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Franasiak JM, Scott RT. Contribution of immunology to implantation failure of euploid embryos. Fertil Steril. 2017 06; 107(6):1279-1283.
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Gauthiez E, Habfast-Robertson I, R?eger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim MH, Malinverni R, Moradpour D, M?llhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud PY. A systematic review and meta-analysis of HCV clearance. Liver Int. 2017 10; 37(10):1431-1445.
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Morin SJ, Treff NR, Tao X, Scott RT, Franasiak JM, Juneau CR, Maguire M, Scott RT. Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences the risk of pregnancy loss: a retrospective cohort analysis of direct embryo genotyping data from euploid transfers. Fertil Steril. 2017 Mar; 107(3):677-683.e2.
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Purdy AK, Alvarez Arias DA, Oshinsky J, James AM, Serebriiskii I, Campbell KS. The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells. J Immunol. 2014 Nov 01; 193(9):4675-83.
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Campbell KS, Purdy AK. Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations. Immunology. 2011 Mar; 132(3):315-25.
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Purdy AK, Campbell KS. [Natural killer cells and cancer. Regulation by the killer cell Ig-like receptors (KIR)]. Zhongguo Fei Ai Za Zhi. 2010 Jul; 13(7):731-6.
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Purdy AK, Campbell KS. Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR). Cancer Biol Ther. 2009 Dec; 8(23):2211-20.
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Purdy AK, Campbell KS. SHP-2 expression negatively regulates NK cell function. J Immunol. 2009 Dec 01; 183(11):7234-43.
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Burt BM, Plitas G, Zhao Z, Bamboat ZM, Nguyen HM, Dupont B, DeMatteo RP. The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors. J Immunol. 2009 Aug 01; 183(3):1789-96.