G-Protein-Coupled Receptor Kinase 5

"G-Protein-Coupled Receptor Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions.

Descriptor ID	D054774
MeSH Number(s)	D08.811.913.696.620.682.700.364.775 D12.644.360.293.875 D12.776.476.293.875
Concept/Terms	G-Protein-Coupled Receptor Kinase 5 G-Protein-Coupled Receptor Kinase 5 G Protein Coupled Receptor Kinase 5 GRK5 Kinase

Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinase 5".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
G-Protein-Coupled Receptor Kinase 5 [D08.811.913.696.620.682.700.364.775]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
G-Protein-Coupled Receptor Kinases [D12.644.360.293]
G-Protein-Coupled Receptor Kinase 5 [D12.644.360.293.875]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
G-Protein-Coupled Receptor Kinases [D12.776.476.293]
G-Protein-Coupled Receptor Kinase 5 [D12.776.476.293.875]

Below are MeSH descriptors whose meaning is related to "G-Protein-Coupled Receptor Kinase 5".

Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinase 5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinase 5" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinase 5" was a major or minor topic of these publications.

Bar chart showing 47 publications over 21 distinct years, with a maximum of 6 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	3	3
1998	0	3	3
1999	0	1	1
2000	0	5	5
2001	0	1	1
2003	0	2	2
2004	0	2	2
2005	0	2	2
2006	1	2	3
2007	0	1	1
2008	1	1	2
2009	2	2	4
2011	4	2	6
2012	3	0	3
2013	1	0	1
2014	2	0	2
2015	2	0	2
2016	1	0	1
2017	1	0	1
2019	1	0	1
2020	1	0	1

Below are the most recent publications written about "G-Protein-Coupled Receptor Kinase 5" by people in Profiles.

Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol Cell. 2021 01 21; 81(2):323-339.e11.

View in: PubMed
Lagman J, Sayegh P, Lee CS, Sulon SM, Jacinto AZ, Sok V, Peng N, Alp D, Benovic JL, So CH. G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel. Mol Cell Biochem. 2019 Nov; 461(1-2):103-118.

View in: PubMed
Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL. Structural and Functional Analysis of a ?2-Adrenergic Receptor Complex with GRK5. Cell. 2017 04 20; 169(3):407-421.e16.

View in: PubMed
DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017 01; 118(1):66-73.

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Traynham CJ, Cannavo A, Zhou Y, Vouga AG, Woodall BP, Hullmann J, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ. Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circ Res. 2015 Dec 04; 117(12):1001-12.

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Komolov KE, Bhardwaj A, Benovic JL. Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem. 2015 Aug 21; 290(34):20629-20647.

View in: PubMed
Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res. 2014 Dec 05; 115(12):976-85.

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Xu H, Jiang X, Shen K, Fischer CC, Wedegaertner PB. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function. Mol Biol Cell. 2014 Jul 01; 25(13):2105-15.

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Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ. Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One. 2013; 8(3):e57324.

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Gold JI, Gao E, Shang X, Premont RT, Koch WJ. Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Circ Res. 2012 Sep 28; 111(8):1048-53.

View in: PubMed

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