Off-Label Use

"Off-Label Use" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.

Descriptor ID	D056687
MeSH Number(s)	E02.319.307.500
Concept/Terms	Off-Label Use Off-Label Use Off Label Use Off-Label Uses Use, Off-Label Uses, Off-Label Off-Label Prescribing Off Label Prescribing Off-Label Prescribings Prescribing, Off-Label Prescribings, Off-Label Unlabeled Indication Indication, Unlabeled Indications, Unlabeled Unlabeled Indications

Below are MeSH descriptors whose meaning is more general than "Off-Label Use".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Drug Therapy [E02.319]
Drug Prescriptions [E02.319.307]
Off-Label Use [E02.319.307.500]

Below are MeSH descriptors whose meaning is related to "Off-Label Use".

Below are MeSH descriptors whose meaning is more specific than "Off-Label Use".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Off-Label Use" by people in this website by year, and whether "Off-Label Use" was a major or minor topic of these publications.

Bar chart showing 15 publications over 9 distinct years, with a maximum of 4 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	2	2	4
2011	0	1	1
2012	2	1	3
2013	1	0	1
2016	1	0	1
2017	0	1	1
2019	1	0	1
2020	1	1	2
2022	0	1	1

Below are the most recent publications written about "Off-Label Use" by people in Profiles.

Wiecek W, Ahuja A, Chaudhuri E, Kremer M, Simoes Gomes A, Snyder CM, Tabarrok A, Tan BJ. Testing fractional doses of COVID-19 vaccines. Proc Natl Acad Sci U S A. 2022 02 22; 119(8).

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Gopal AD, Wallach JD, Shah SA, Regillo C, Ross JS. On-Label and Off-Label Clinical Studies of FDA-Approved Ophthalmic Therapeutics. Ophthalmology. 2021 02; 128(2):332-334.

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Sedhom R, Abdelmaseeh P, Megaly M, Asinger R. Use of Direct Oral Anticoagulants in the Treatment of Left Ventricular Thrombi: A Systematic Review. Am J Med. 2020 11; 133(11):1266-1273.e6.

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Igelman S, Kurta AO, Sheikh U, McWilliams A, Armbrecht E, Jackson Cullison SR, Kress DW, Smith A, Castelo-Soccio L, Treat J, Boothe WD, Diaz LZ, Levy ML, Patel A, Lee LW, Fraile-Alonso MC, Antaya RJ, Shah S, Kittler N, Arkin L, Siegfried E. Off-label use of dupilumab for pediatric patients with atopic dermatitis: A multicenter retrospective review. J Am Acad Dermatol. 2020 Feb; 82(2):407-411.

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Garg S, McCarthy JJ, Goodwin R, Kolmodin J, Sankar WN, Franklin C, Armstrong D, Fryzel D, Hassenbein S, Meder C. Complication Rates After Bone Morphogenetic Protein (BMP) Use in Orthopaedic Surgery in Children: A Concise Multicenter Retrospective Cohort Study. J Pediatr Orthop. 2017 Sep; 37(6):e375-e378.

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Steinberg BA, Shrader P, Thomas L, Ansell J, Fonarow GC, Gersh BJ, Kowey PR, Mahaffey KW, Naccarelli G, Reiffel J, Singer DE, Peterson ED, Piccini JP. Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry. J Am Coll Cardiol. 2016 Dec 20; 68(24):2597-2604.

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Sobel RM, Wu DT, Hester K, Anda K. Tissue plasminogen activator for transient ischemic attack: the case for "off-label" use of thrombolytics. Am J Emerg Med. 2014 Mar; 32(3):277-9.

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Carragee EJ, Baker RM, Benzel EC, Bigos SJ, Cheng I, Corbin TP, Deyo RA, Hurwitz EL, Jarvik JG, Kang JD, Lurie JD, Mroz TE, Oner FC, Peul WC, Rainville J, Ratliff JK, Rihn JA, Rothman DJ, Schoene ML, Spengler DM, Weiner BK. A biologic without guidelines: the YODA project and the future of bone morphogenetic protein-2 research. Spine J. 2012 Oct; 12(10):877-80.

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Jones CM. Frequency of prescription pain reliever nonmedical use: 2002-2003 and 2009-2010. Arch Intern Med. 2012 Sep 10; 172(16):1265-7.

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McCullough LB, Chervenak FA, Brent RL, Hippen B. Dr. Goold's (2011) observations and criticisms. Letter to the editors. Am J Bioeth. 2012; 12(1):47-8.

View in: PubMed

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