Limit of Detection

"Limit of Detection" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.

Descriptor ID	D057230
MeSH Number(s)	E05.318.740.872.374 N05.715.360.750.725.500 N06.850.520.830.872.500
Concept/Terms	Limit of Detection Limit of Detection Detection Limit Detection Limits Limits of Detection

Below are MeSH descriptors whose meaning is more general than "Limit of Detection".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Epidemiologic Methods [E05.318]
Statistics as Topic [E05.318.740]
Sensitivity and Specificity [E05.318.740.872]
Limit of Detection [E05.318.740.872.374]
Health Care [N]
Health Care Quality, Access, and Evaluation [N05]
Quality of Health Care [N05.715]
Health Care Evaluation Mechanisms [N05.715.360]
Statistics as Topic [N05.715.360.750]
Sensitivity and Specificity [N05.715.360.750.725]
Limit of Detection [N05.715.360.750.725.500]
Environment and Public Health [N06]
Public Health [N06.850]
Epidemiologic Methods [N06.850.520]
Statistics as Topic [N06.850.520.830]
Sensitivity and Specificity [N06.850.520.830.872]
Limit of Detection [N06.850.520.830.872.500]

Below are MeSH descriptors whose meaning is related to "Limit of Detection".

Below are MeSH descriptors whose meaning is more specific than "Limit of Detection".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Limit of Detection" by people in this website by year, and whether "Limit of Detection" was a major or minor topic of these publications.

Bar chart showing 54 publications over 12 distinct years, with a maximum of 13 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	0	3	3
2011	0	3	3
2012	0	4	4
2013	0	6	6
2014	0	13	13
2015	0	4	4
2016	0	2	2
2017	0	2	2
2018	1	5	6
2019	0	3	3
2020	0	7	7
2021	0	1	1

Below are the most recent publications written about "Limit of Detection" by people in Profiles.

Rodrigues TB, Morais DR, Gianvecchio VAP, Aquino EM, Cunha RL, Huestis MA, Costa JL. Development and Validation of a Method for Quantification of 28 Psychotropic Drugs in Postmortem Blood Samples by Modified Micro-QuEChERS and LC-MS-MS. J Anal Toxicol. 2021 Aug 14; 45(7):644-656.

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da Cunha KF, Oliveira KD, Huestis MA, Costa JL. Screening of 104 New Psychoactive Substances (NPS) and Other Drugs of Abuse in Oral Fluid by LC-MS-MS. J Anal Toxicol. 2020 Oct 12; 44(7):697-707.

View in: PubMed
Sofalvi S, Lavins ES, Kaspar CK, Michel HM, Mitchell-Mata CL, Huestis MA, Apollonio LG. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction. J Anal Toxicol. 2020 Oct 12; 44(7):708-717.

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Kudo E, Israelow B, Vogels CBF, Lu P, Wyllie AL, Tokuyama M, Venkataraman A, Brackney DE, Ott IM, Petrone ME, Earnest R, Lapidus S, Muenker MC, Moore AJ, Casanovas-Massana A, Omer SB, Dela Cruz CS, Farhadian SF, Ko AI, Grubaugh ND, Iwasaki A. Detection of SARS-CoV-2 RNA by multiplex RT-qPCR. PLoS Biol. 2020 10; 18(10):e3000867.

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Wu AHB, Kavsak PA, Aakre KM, Christenson RH, Greene DN, Apple FS, Peacock WF, Hollander JE, de Lemos JA, Morrow D, Januzzi J, Jaffe AS. Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay's Limit of Detection? Clin Chem. 2020 09 01; 66(9):1146-1149.

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da Cunha KF, Rodrigues LC, Huestis MA, Costa JL. Miniaturized extraction method for analysis of synthetic opioids in urine by microextraction with packed sorbent and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2020 Aug 02; 1624:461241.

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Fiorentin TR, Logan BK, Martin DM, Browne T, Rieders EF. Assessment of a portable quadrupole-based gas chromatography mass spectrometry for seized drug analysis. Forensic Sci Int. 2020 Aug; 313:110342.

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Hubbard JA, Smith BE, Sobolesky PM, Kim S, Hoffman MA, Stone J, Huestis MA, Grelotti DJ, Grant I, Marcotte TD, Fitzgerald RL. Validation of a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to detect cannabinoids in whole blood and breath. Clin Chem Lab Med. 2020 04 28; 58(5):673-681.

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Nisbet LA, Wylie FM, Logan BK, Scott KS. Gas Chromatography-Mass Spectrometry Method for the Quantitative Identification of 23 New Psychoactive Substances in Blood and Urine. J Anal Toxicol. 2019 Jun 01; 43(5):346-352.

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Fitzgerald RL, Hollander JE, Peacock WF, Limkakeng AT, Breitenbeck N, Blechschmidt K, Laimighofer M, deFilippi C. Analytical performance evaluation of the Elecsys? Troponin T Gen 5 STAT assay. Clin Chim Acta. 2019 Aug; 495:522-528.

View in: PubMed

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