Voltage-Gated Sodium Channel Blockers
"Voltage-Gated Sodium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
| Descriptor ID |
D061567
|
| MeSH Number(s) |
D27.505.519.562.750.500 D27.505.954.411.720.500
|
| Concept/Terms |
Voltage-Gated Sodium Channel Blockers- Voltage-Gated Sodium Channel Blockers
- Voltage Gated Sodium Channel Blockers
- Voltage-Gated Sodium Channel Inhibitors
- Voltage Gated Sodium Channel Inhibitors
- Channel Blockers, Voltage-Gated Sodium
- Channel Blockers, Voltage Gated Sodium
- Voltage-Gated Sodium Channel Antagonists
- Voltage Gated Sodium Channel Antagonists
|
Below are MeSH descriptors whose meaning is more general than "Voltage-Gated Sodium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Voltage-Gated Sodium Channel Blockers".
This graph shows the total number of publications written about "Voltage-Gated Sodium Channel Blockers" by people in this website by year, and whether "Voltage-Gated Sodium Channel Blockers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Voltage-Gated Sodium Channel Blockers" by people in Profiles.
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Burashnikov A, Barajas-Martinez H, Cox R, Demitrack MA, Fossler MJ, Kramer M, Kleiman RB, Kowey P, Antzelevitch C. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk. Heart Rhythm. 2021 12; 18(12):2177-2186.
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Swain NA, Batchelor D, Beaudoin S, Bechle BM, Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML, Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS, Lin Z, Markworth CJ, Marron BE, Millan DS, Nakagawa S, Pike A, Printzenhoff D, Rawson DJ, Ransley SJ, Reister SM, Sasaki K, Storer RI, Stupple PA, West CW. Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7. J Med Chem. 2017 08 24; 60(16):7029-7042.
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Qi D, Yang Z, Robinson VM, Li J, Gao C, Guo D, Kowey PR, Yan GX. Heterogeneous distribution of INa-L determines interregional differences in rate adaptation of repolarization. Heart Rhythm. 2015 Jun; 12(6):1295-303.
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Gao Y, Xue X, Hu D, Liu W, Yuan Y, Sun H, Li L, Timothy KW, Zhang L, Li C, Yan GX. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome. Circ Arrhythm Electrophysiol. 2013 Jun; 6(3):614-22.