Thomas Jefferson University

William Johnson

TitleAdjunct Faculty
InstitutionPhiladelphia University
DepartmentUndergraduate Programs
Address3243 School House Lane
Philadelphia PA 19144
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lancaster EB, Johnson WH, LeVieux JA, Hardtke HA, Zhang YJ, Whitman CP. A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway. Arch Biochem Biophys. 2023 01 01; 733:109471. PMID: 36522814.
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    2. Lancaster EB, Yang W, Johnson WH, Baas BJ, Zhang YJ, Whitman CP. Kinetic, Inhibition, and Structural Characterization of a Malonate Semialdehyde Decarboxylase-like Protein from Calothrix sp. PCC 6303: A Gateway to the non-Pro1 Tautomerase Superfamily Members. Biochemistry. 2022 May 13. PMID: 35559608.
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    3. Baas BJ, Medellin BP, LeVieux JA, Erwin K, Lancaster EB, Johnson WH, Kaoud TS, Moreno RY, de Ruijter M, Babbitt PC, Zhang YJ, Whitman CP. Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications. Biochemistry. 2021 06 08; 60(22):1776-1786. PMID: 34019384.
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    4. Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, Ren P, Anslyn EV, Tsai KY, Ghose R, Dalby KN. Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 11 19; 10(1):5232. PMID: 31745079.
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    5. Erwin KL, Johnson WH, Meichan AJ, Whitman CP. Preparation of dihydroxy polycyclic aromatic hydrocarbons and activities of two dioxygenases in the phenanthrene degradative pathway. Arch Biochem Biophys. 2019 09 30; 673:108081. PMID: 31445023.
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    6. Haugland JO, Kinney KA, Johnson WH, Camino MMA, Whitman CP, Lawler DF. Laccase removal of 2-chlorophenol and sulfamethoxazole in municipal wastewater. Water Environ Res. 2019 Apr; 91(4):281-291. PMID: 30802358.
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    7. LeVieux JA, Medellin B, Johnson WH, Erwin K, Li W, Johnson IA, Zhang YJ, Whitman CP. Structural Characterization of the Hydratase-Aldolases, NahE and PhdJ: Implications for the Specificity, Catalysis, and N-Acetylneuraminate Lyase Subgroup of the Aldolase Superfamily. Biochemistry. 2018 06 26; 57(25):3524-3536. PMID: 29856600.
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    8. Stack TMM, Li W, Johnson WH, Zhang YJ, Whitman CP. Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. Biochemistry. 2018 Feb 13; 57(6):1012-1021. PMID: 29303557.
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    9. Stack TMM, Johnson WH, Whitman CP. Synthesis and enzymatic ketonization of the 5-(halo)-2-hydroxymuconates and 5-(halo)-2-hydroxy-2,4-pentadienoates. Beilstein J Org Chem. 2017; 13:1022-1031. PMID: 28684981.
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    10. Johnson WH, Stack TM, Taylor SM, Burks EA, Whitman CP. Stereochemical Consequences of Vinylpyruvate Hydratase-Catalyzed Reactions. Biochemistry. 2016 07 26; 55(29):4055-64. PMID: 27362840.
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    11. Ara?jo SS, Neves CM, Guimar?es SL, Whitman CP, Johnson WH, Aparicio R, Nagem RA. Structural and kinetic characterization of recombinant 2-hydroxymuconate semialdehyde dehydrogenase from Pseudomonas putida G7. Arch Biochem Biophys. 2015 Aug 01; 579:8-17. PMID: 26032336.
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    12. Huddleston JP, Johnson WH, Schroeder GK, Whitman CP. Reactions of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue, with Acetylene and Allene Substrates: Evidence for a Hydration-Dependent Decarboxylation. Biochemistry. 2015 May 19; 54(19):3009-23. PMID: 25894805.
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    13. Warthaka M, Adelmann CH, Kaoud TS, Edupuganti R, Yan C, Johnson WH, Ferguson S, Tavares CD, Pence LJ, Anslyn EV, Ren P, Tsai KY, Dalby KN. Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine. ACS Med Chem Lett. 2015 Jan 08; 6(1):47-52. PMID: 25589929.
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    14. Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. High-throughput screens for eEF-2 kinase. J Biomol Screen. 2014 Mar; 19(3):445-52. PMID: 24078616.
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    15. Poelarends GJ, Serrano H, Huddleston JP, Johnson WH, Whitman CP. A mutational analysis of active site residues in trans-3-chloroacrylic acid dehalogenase. FEBS Lett. 2013 Sep 02; 587(17):2842-50. PMID: 23851010.
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    16. Guo Y, Serrano H, Poelarends GJ, Johnson WH, Hackert ML, Whitman CP. Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities. Biochemistry. 2013 Jul 16; 52(28):4830-41. PMID: 23781927.
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    17. Schroeder GK, Huddleston JP, Johnson WH, Whitman CP. A mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase. Biochemistry. 2013 Jun 18; 52(24):4204-16. PMID: 23692140.
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    18. Schroeder GK, Johnson WH, Huddleston JP, Serrano H, Johnson KA, Whitman CP. Reaction of cis-3-chloroacrylic acid dehalogenase with an allene substrate, 2,3-butadienoate: hydration via an enamine. J Am Chem Soc. 2012 Jan 11; 134(1):293-304. PMID: 22129074.
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    19. Burks EA, Yan W, Johnson WH, Li W, Schroeder GK, Min C, Gerratana B, Zhang Y, Whitman CP. Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway. Biochemistry. 2011 Sep 06; 50(35):7600-11. PMID: 21809870.
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    20. Guo Y, Serrano H, Johnson WH, Ernst S, Hackert ML, Whitman CP. Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanisms. Bioorg Chem. 2011 Feb; 39(1):1-9. PMID: 21074239.
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    21. Srivastava D, Zhu W, Johnson WH, Whitman CP, Becker DF, Tanner JJ. The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction. Biochemistry. 2010 Jan 26; 49(3):560-9. PMID: 19994913.
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    22. Robertson BA, Johnson WH, Lo HH, Whitman CP. Inactivation of Cg10062, a cis-3-chloroacrylic acid dehalogenase homologue in Corynebacterium glutamicum, by (R)- and (S)-oxirane-2-carboxylate: analysis and implications. Biochemistry. 2008 Aug 19; 47(33):8796-803. PMID: 18646866.
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    23. Poelarends GJ, Serrano H, Person MD, Johnson WH, Whitman CP. Characterization of Cg10062 from Corynebacterium glutamicum: implications for the evolution of cis-3-chloroacrylic acid dehalogenase activity in the tautomerase superfamily. Biochemistry. 2008 Aug 05; 47(31):8139-47. PMID: 18598055.
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    24. White TA, Johnson WH, Whitman CP, Tanner JJ. Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine. Biochemistry. 2008 May 20; 47(20):5573-80. PMID: 18426222.
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    25. Wang SC, Johnson WH, Czerwinski RM, Stamps SL, Whitman CP. Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions. Biochemistry. 2007 Oct 23; 46(42):11919-29. PMID: 17902707.
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    26. Poelarends GJ, Johnson WH, Serrano H, Whitman CP. Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction? Biochemistry. 2007 Aug 21; 46(33):9596-604. PMID: 17661448.
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    27. de Jong RM, Bazzacco P, Poelarends GJ, Johnson WH, Kim YJ, Burks EA, Serrano H, Thunnissen AM, Whitman CP, Dijkstra BW. Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase. Structural basis for substrate specificity and inactivation by (R)-oxirane-2-carboxylate. J Biol Chem. 2007 Jan 26; 282(4):2440-9. PMID: 17121835.
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    28. Poelarends GJ, Almrud JJ, Serrano H, Darty JE, Johnson WH, Hackert ML, Whitman CP. Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase. Biochemistry. 2006 Jun 27; 45(25):7700-8. PMID: 16784221.
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    29. Golubkov PA, Johnson WH, Czerwinski RM, Person MD, Wang SC, Whitman CP, Hackert ML. Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate. Bioorg Chem. 2006 Aug; 34(4):183-99. PMID: 16780921.
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    30. Almrud JJ, Poelarends GJ, Johnson WH, Serrano H, Hackert ML, Whitman CP. Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities. Biochemistry. 2005 Nov 15; 44(45):14818-27. PMID: 16274229.
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    31. Poelarends GJ, Serrano H, Johnson WH, Whitman CP. Inactivation of malonate semialdehyde decarboxylase by 3-halopropiolates: evidence for hydratase activity. Biochemistry. 2005 Jul 05; 44(26):9375-81. PMID: 15982004.
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    32. Poelarends GJ, Serrano H, Johnson WH, Hoffman DW, Whitman CP. The hydratase activity of malonate semialdehyde decarboxylase: mechanistic and evolutionary implications. J Am Chem Soc. 2004 Dec 08; 126(48):15658-9. PMID: 15571384.
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    33. Johnson WH, Wang SC, Stanley TM, Czerwinski RM, Almrud JJ, Poelarends GJ, Murzin AG, Whitman CP. 4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues. Biochemistry. 2004 Aug 17; 43(32):10490-501. PMID: 15301547.
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    34. Poelarends GJ, Serrano H, Johnson WH, Whitman CP. Stereospecific alkylation of cis-3-chloroacrylic acid dehalogenase by (R)-oxirane-2-carboxylate: analysis and mechanistic implications. Biochemistry. 2004 Jun 08; 43(22):7187-96. PMID: 15170356.
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    35. Wang SC, Johnson WH, Czerwinski RM, Whitman CP. Reactions of 4-oxalocrotonate tautomerase and YwhB with 3-halopropiolates: analysis and implications. Biochemistry. 2004 Jan 27; 43(3):748-58. PMID: 14730980.
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    36. Poelarends GJ, Serrano H, Person MD, Johnson WH, Murzin AG, Whitman CP. Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases. Biochemistry. 2004 Jan 27; 43(3):759-72. PMID: 14730981.
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    37. Wang SC, Johnson WH, Whitman CP. The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities. J Am Chem Soc. 2003 Nov 26; 125(47):14282-3. PMID: 14624569.
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    38. Poelarends GJ, Johnson WH, Murzin AG, Whitman CP. Mechanistic characterization of a bacterial malonate semialdehyde decarboxylase: identification of a new activity on the tautomerase superfamily. J Biol Chem. 2003 Dec 05; 278(49):48674-83. PMID: 14506256.
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    39. Wang SC, Person MD, Johnson WH, Whitman CP. Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction. Biochemistry. 2003 Jul 29; 42(29):8762-73. PMID: 12873137.
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    40. Almrud JJ, Kern AD, Wang SC, Czerwinski RM, Johnson WH, Murzin AG, Hackert ML, Whitman CP. The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity. Biochemistry. 2002 Oct 08; 41(40):12010-24. PMID: 12356301.
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