Steven Roberts

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentCardiology
Address2607 Rhawn Street
Philadelphia PA 19114
Phone215-676-8300
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R00ES022633     (ROBERTS, STEVEN A)Jan 1, 2015 - Dec 31, 2018
    NIH
    Environmentally-modulated cytosine deamination in genome instability and cancer
    Role: Principal Investigator

    R01CA218112     (ROBERTS, STEVEN A)Jun 15, 2017 - May 31, 2022
    NIH
    Mechanisms of genome instability induced by APOBEC Cytidine Deaminases and its impacts during cancer development.
    Role: Principal Investigator

    R21ES027937     (WYRICK, JOHN J)Aug 1, 2017 - Jun 30, 2020
    NIH
    Genome-wide analysis of UV damage formation, repair, and mutagenesis
    Role: Co-Principal Investigator

    R01ES032814     (WYRICK, JOHN J)Apr 1, 2021 - Jan 31, 2026
    NIH
    Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Osia B, Elango R, Kramara J, Roberts SA, Malkova A. Investigation of Break-Induced Replication in Yeast. Methods Mol Biol. 2021; 2153:307-328. PMID: 32840789.
      Citations:    
    2. Laughery MF, Brown AJ, Bohm KA, Sivapragasam S, Morris HS, Tchmola M, Washington AD, Mitchell D, Mather S, Malc EP, Mieczkowski PA, Roberts SA, Wyrick JJ. Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma. Cell Rep. 2020 Nov 17; 33(7):108401. PMID: 33207206.
      Citations:    
    3. Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA. Polymerase d promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27566-27577. PMID: 33077594.
      Citations:    
    4. Carvajal-Garcia J, Cho JE, Carvajal-Garcia P, Feng W, Wood RD, Sekelsky J, Gupta GP, Roberts SA, Ramsden DA. Mechanistic basis for microhomology identification and genome scarring by polymerase theta. Proc Natl Acad Sci U S A. 2020 Apr 14; 117(15):8476-8485. PMID: 32234782.
      Citations:    
    5. Mao P, Smerdon MJ, Roberts SA, Wyrick JJ. Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer. Genome Res. 2020 Jan; 30(1):12-21. PMID: 31871068.
      Citations:    
    6. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. APOBEC3A is a prominent cytidine deaminase in breast cancer. PLoS Genet. 2019 Dec; 15(12):e1008545. PMID: 31841499.
      Citations:    
    7. Elango R, Osia B, Harcy V, Malc E, Mieczkowski PA, Roberts SA, Malkova A. Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements. Nucleic Acids Res. 2019 Aug 08. PMID: 31392335.
      Citations:    
    8. Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019 Aug 05; 10(1):3515. PMID: 31383866.
      Citations:    
    9. Saini N, Roberts SA, Sterling JF, Malc EP, Mieczkowski PA, Gordenin DA. Corrigendum to "APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast" [DNA Repair 53 (2017) 4-14]. DNA Repair (Amst). 2019 Aug; 80:94-95. PMID: 31182349.
      Citations:    
    10. Dong S, Roberts SA, Chen S, Zhong X, Yang S, Qu X, Xu S. Survival after lobectomy versus sub-lobar resection in elderly with stage I NSCLC: a meta-analysis. BMC Surg. 2019 Apr 15; 19(1):38. PMID: 30987622.
      Citations:    
    11. Roberts SA, Brown AJ, Wyrick JJ. Recurrent Noncoding Mutations in Skin Cancers: UV Damage Susceptibility or Repair Inhibition as Primary Driver? Bioessays. 2019 Mar; 41(3):e1800152. PMID: 30801747.
      Citations:    
    12. Hodges AJ, Roberts SA, Wyrick JJ. Using Yeast as a Model Organism to Study the Functional Roles of Histone Acetylation in DNA Excision Repair. Methods Mol Biol. 2019; 1983:175-190. PMID: 31087298.
      Citations:    
    13. Brown AJ, Mao P, Smerdon MJ, Wyrick JJ, Roberts SA. Nucleosome positions establish an extended mutation signature in melanoma. PLoS Genet. 2018 11; 14(11):e1007823. PMID: 30485262.
      Citations:    
    14. Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA. Parp3 promotes long-range end joining in murine cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10076-10081. PMID: 30213852.
      Citations:    
    15. Mao P, Brown AJ, Esaki S, Lockwood S, Poon GMK, Smerdon MJ, Roberts SA, Wyrick JJ. ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma. Nat Commun. 2018 Jul 06; 9(1):2626. PMID: 29980679.
      Citations:    
    16. Martin M, Hiroyasu A, Guzman RM, Roberts SA, Goodman AG. Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function. Cell Rep. 2018 Jun 19; 23(12):3537-3550.e6. PMID: 29924997.
      Citations:    
    17. Brown AJ, Al-Soodani AT, Saul M, Her S, Garcia JC, Ramsden DA, Her C, Roberts SA. High-Throughput Analysis of DNA Break-Induced Chromosome Rearrangements by Amplicon Sequencing. Methods Enzymol. 2018; 601:111-144. PMID: 29523230.
      Citations:    
    18. Khodaverdian VY, Hanscom T, Yu AM, Yu TL, Mak V, Brown AJ, Roberts SA, McVey M. Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks. Nucleic Acids Res. 2017 Dec 15; 45(22):12848-12861. PMID: 29121353.
      Citations:    
    19. Khan DH, Roberts SA, Cressman JR, Agrawal N. Rapid Generation and Detection of Biomimetic Oxygen Concentration Gradients In Vitro. Sci Rep. 2017 Oct 18; 7(1):13487. PMID: 29044222.
      Citations:    
    20. Roberts SA, Parikh N, Blower RJ, Agrawal N. SPIN: rapid synthesis, purification, and concentration of small drug-loaded liposomes. J Liposome Res. 2017 Oct 05; 1-10. PMID: 28920496.
      Citations:    
    21. Mao P, Brown AJ, Malc EP, Mieczkowski PA, Smerdon MJ, Roberts SA, Wyrick JJ. Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity. Genome Res. 2017 Oct; 27(10):1674-1684. PMID: 28912372.
      Citations:    
    22. DiVito KA, Daniele MA, Roberts SA, Ligler FS, Adams AA. "Data characterizing microfabricated human blood vessels created via hydrodynamic focusing". Data Brief. 2017 Oct; 14:156-162. PMID: 28795092.
      Citations:    
    23. DiVito KA, Daniele MA, Roberts SA, Ligler FS, Adams AA. Microfabricated blood vessels undergo neoangiogenesis. Biomaterials. 2017 Sep; 138:142-152. PMID: 28570946.
      Citations:    
    24. Hoopes JI, Hughes AL, Hobson LA, Cortez LM, Brown AJ, Roberts SA. Avoidance of APOBEC3B-induced mutation by error-free lesion bypass. Nucleic Acids Res. 2017 May 19; 45(9):5243-5254. PMID: 28334887.
      Citations:    
    25. Saini N, Roberts SA, Sterling JF, Malc EP, Mieczkowski PA, Gordenin DA. APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast. DNA Repair (Amst). 2017 May; 53:4-14. PMID: 28351647.
      Citations:    
    26. Mertz TM, Harcy V, Roberts SA. Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity. Genes (Basel). 2017 Jan 22; 8(1). PMID: 28117753.
      Citations:    
    27. Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA, Gordenin DA. The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS Genet. 2016 10; 12(10):e1006385. PMID: 27788131.
      Citations:    
    28. Mao P, Wyrick JJ, Roberts SA, Smerdon MJ. UV-Induced DNA Damage and Mutagenesis in Chromatin. Photochem Photobiol. 2016 Sep 26. PMID: 27716995.
      Citations:    
    29. Roberts SA, DiVito KA, Ligler FS, Adams AA, Daniele MA. Microvessel manifold for perfusion and media exchange in three-dimensional cell cultures. Biomicrofluidics. 2016 Sep; 10(5):054109. PMID: 27703595.
      Citations:    
    30. Mao P, Smerdon MJ, Roberts SA, Wyrick JJ. Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution. Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32):9057-62. PMID: 27457959.
      Citations:    
    31. Wyatt DW, Feng W, Conlin MP, Yousefzadeh MJ, Roberts SA, Mieczkowski P, Wood RD, Gupta GP, Ramsden DA. Essential Roles for Polymerase ?-Mediated End Joining in the Repair of Chromosome Breaks. Mol Cell. 2016 Aug 18; 63(4):662-73. PMID: 27453047.
      Citations:    
    32. Roberts SA, Waziri AE, Agrawal N. Development of a Single-Cell Migration and Extravasation Platform through Selective Surface Modification. Anal Chem. 2016 Mar 1; 88(5):2770-6. PMID: 26833093.
      Citations:    
    33. Hoopes JI, Cortez LM, Mertz TM, Malc EP, Mieczkowski PA, Roberts SA. APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication. Cell Rep. 2016 Feb 16; 14(6):1273-82. PMID: 26832400.
      Citations:    
    34. Kazanov MD, Roberts SA, Polak P, Stamatoyannopoulos J, Klimczak LJ, Gordenin DA, Sunyaev SR. APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell Rep. 2015 Nov 10; 13(6):1103-9. PMID: 26527001.
      Citations:    
    35. Wyrick JJ, Roberts SA. Genomic approaches to DNA repair and mutagenesis. DNA Repair (Amst). 2015 Dec; 36:146-55. PMID: 26411877.
      Citations:    
    36. Chan K, Roberts SA, Klimczak LJ, Sterling JF, Saini N, Malc EP, Kim J, Kwiatkowski DJ, Fargo DC, Mieczkowski PA, Getz G, Gordenin DA. An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers. Nat Genet. 2015 Sep; 47(9):1067-72. PMID: 26258849.
      Citations:    
    37. Daniele MA, Knight AJ, Roberts SA, Radom K, Erickson JS. Sweet substrate: a polysaccharide nanocomposite for conformal electronic decals. Adv Mater. 2015 Mar 4; 27(9):1600-6. PMID: 25472799.
      Citations:    
    38. Roberts SA, Gordenin DA. Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer. 2014 Dec; 14(12):786-800. PMID: 25568919.
      Citations:    
    39. Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA. Requirements for 5'dRP/AP lyase activity in Ku. Nucleic Acids Res. 2014; 42(17):11136-43. PMID: 25200085.
      Citations:    
    40. Sakofsky CJ, Roberts SA, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA, Malkova A. Break-induced replication is a source of mutation clusters underlying kataegis. Cell Rep. 2014 Jun 12; 7(5):1640-8. PMID: 24882007.
      Citations:    
    41. Roberts SA, Gordenin DA. Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness. Bioessays. 2014 Feb 26. PMID: 24615916.
      Citations:    
    42. Roberts SA, Lawrence MS, Klimczak LJ, Grimm SA, Fargo D, Stojanov P, Kiezun A, Kryukov GV, Carter SL, Saksena G, Harris S, Shah RR, Resnick MA, Getz G, Gordenin DA. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet. 2013 Sep; 45(9):970-6. PMID: 23852170.
      Citations:    
    43. Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CW, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-8. PMID: 23770567.
      Citations:    
    44. Chan K, Sterling JF, Roberts SA, Bhagwat AS, Resnick MA, Gordenin DA. Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS Genet. 2012; 8(12):e1003149. PMID: 23271983.
      Citations:    
    45. Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell. 2012 May 25; 46(4):424-35. PMID: 22607975.
      Citations:    
    46. Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA. Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends. J Biol Chem. 2012 Apr 20; 287(17):13686-93. PMID: 22362780.
      Citations:    
    47. Burch LH, Yang Y, Sterling JF, Roberts SA, Chao FG, Xu H, Zhang L, Walsh J, Resnick MA, Mieczkowski PA, Gordenin DA. Damage-induced localized hypermutability. Cell Cycle. 2011 Apr 1; 10(7):1073-85. PMID: 21406975.
      Citations:    
    48. Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA. Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 2010 Apr 22; 464(7292):1214-7. PMID: 20383123.
      Citations:    
    49. Lestner JM, Roberts SA, Moore CB, Howard SJ, Denning DW, Hope WW. Toxicodynamics of itraconazole: implications for therapeutic drug monitoring. Clin Infect Dis. 2009 Sep 15; 49(6):928-30. PMID: 19681707.
      Citations:    
    50. Burkhalter MD, Roberts SA, Havener JM, Ramsden DA. Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks. DNA Repair (Amst). 2009 Nov 2; 8(11):1258-63. PMID: 19713159.
      Citations:    
    51. Roberts SA, Ramsden DA. Loading of the nonhomologous end joining factor, Ku, on protein-occluded DNA ends. J Biol Chem. 2007 Apr 6; 282(14):10605-13. PMID: 17289670.
      Citations:    
    52. Ward KA, Ashby RL, Roberts SA, Adams JE, Zulf Mughal M. UK reference data for the Hologic QDR Discovery dual-energy x ray absorptiometry scanner in healthy children and young adults aged 6-17 years. Arch Dis Child. 2007 Jan; 92(1):53-9. PMID: 16943261.
      Citations:    
    53. Roberts SA, Guruswamy V, Galvez I. Caudal injectate can be reliably imaged using portable ultrasound--a preliminary study. Paediatr Anaesth. 2005 Nov; 15(11):948-52. PMID: 16238555.
      Citations:    
    Roberts's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (160)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _