Scott Waldman

Title	Professor & Chair JMC
Institution	Thomas Jefferson University
Department	Chair SKMC
Address	1020 Locust St. Philadelphia PA 19107
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Research

research activities and funding

R55DK043805 (WALDMAN, SCOTT A.)Sep 30, 1992 - Sep 29, 1994 NIH MOLECULAR CHARACTERIZATION OF E COLI TOXIN RECEPTORS Role: Principal Investigator

T32GM008562 (KRAFT, WALTER K)Jul 1, 1995 - Jun 30, 2025 NIH Clinical Pharmacology Training Program Role: Principal Investigator

R01GM050290 (WALDMAN, SCOTT A.)Jul 1, 1996 - Jun 30, 2001 NIH VITAMIN D3 25-HYDROXYLASE CHARACTERIZATION ®ULATION Role: Principal Investigator

R25CA069277 (WALDMAN, SCOTT A.)Aug 1, 1997 - Mar 31, 2009 NIH Short-term Training Program in Translational Cancer Rese Role: Principal Investigator

R01CA075123 (WALDMAN, SCOTT A.)Jun 5, 1998 - Jan 31, 2009 NIH GUANYLYL CYCLASE C AS A BI0MARKER FOR COLORECTAL CANCER Role: Principal Investigator

R01HL059214 (WALDMAN, SCOTT A.)Jul 1, 1998 - Jun 30, 2002 NIH ALLOSTERIC INHIBITION OF GUANYLYL CYCLASE BY NUCLEOTIDES Role: Principal Investigator

R21CA079663 (WALDMAN, SCOTT A.)Jan 1, 1999 - Dec 31, 2002 NIH GUANYLYL CYCLASE C IN BLOOD AND COLORECTAL CANCER Role: Principal Investigator

K30HL004522 (WALDMAN, SCOTT A.)Sep 30, 2000 - Aug 31, 2005 NIH TRAINING PROGRAM IN HUMAN INVESTIGATION Role: Principal Investigator

K30RR022299 (WALDMAN, SCOTT A.)Sep 30, 2000 - Jun 30, 2011 NIH Training Program in Human Investigation Role: Principal Investigator

R01CA095026 (WALDMAN, SCOTT A.)Aug 1, 2003 - May 31, 2010 NIH Guanylyl Cyclase C in Blood and Colorectal Cancer Role: Principal Investigator

RC1CA146033 (WALDMAN, SCOTT A.)Sep 30, 2009 - Aug 31, 2011 NIH Occult lymph node metastases and racial disparities in colon cancer outcomes Role: Principal Investigator

R01CA170533 (WALDMAN, SCOTT A)Aug 1, 2012 - Nov 30, 2016 NIH GUCY2C hormone signaling at the intersection of obesity and colorectal cancer(PQ1 Role: Principal Investigator

R01CA206026 (WALDMAN, SCOTT A)May 9, 2016 - Apr 30, 2021 NIH (PQ1) GUCY2C hormone loss translates APC-Beta-catenin mutations into epithelial transformation Role: Principal Investigator

R01CA204481 (WALDMAN, SCOTT A)Jan 1, 2017 - Dec 31, 2021 NIH Guanylin GUCY2C axis in Colorectal Cancer Initiation Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Flickinger JC, Staudt RE, Singh J, Carlson RD, Barton JR, Baybutt TR, Rappaport JA, Zalewski A, Pattison A, Waldman SA, Snook AE. Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy. NPJ Vaccines. 2022 Jun 23; 7(1):61. PMID: 35739202.

Citations:
Sayuk GS, Waldman SA, Brenner DM. Mechanisms of Action of Current Pharmacologic Options for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation. Am J Gastroenterol. 2022 Apr 01; 117(4S):S6-S13. PMID: 35354770.

Citations:
Brenner DM, Harris LA, Chang CH, Waldman SA, Poppers DM, Kassebaum-Ladewski A, Sayuk GS. Real-World Treatment Strategies to Improve Outcomes in Patients With Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation. Am J Gastroenterol. 2022 Apr 01; 117(4S):S21-S26. PMID: 35354772.

Citations:
Flickinger JC, Singh J, Yarman Y, Carlson RD, Barton JR, Waldman SA, Snook AE. T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C. Front Immunol. 2022; 13:855759. PMID: 35355987.

Citations:
Crutcher MM, Baybutt TR, Kopenhaver JS, Snook AE, Waldman SA. Emerging drug targets for colon cancer: A preclinical assessment. Expert Opin Ther Targets. 2022 Feb 10; 1-10. PMID: 35129035.

Citations:
Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. A ß-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2021 Dec 22. PMID: 34954189.

Citations:
Weinberg DS, Foster NR, Della'Zanna G, McMurray RP, Kraft WK, Pallotto A, Kastenberg DM, Katz LC, Henry CH, Moleski SM, Limburg PJ, Waldman SA. Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers. Cancer Biol Ther. 2021 Oct 10; 1-10. PMID: 34632925.

Citations:
Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Beuve A, Brouckaert P, Bryant C, Burnett JC, Farndale RW, Friebe A, Garthwaite J, Hobbs AJ, Jarvis GE, Kuhn M, MacEwan D, Monie TP, Papapetropoulos A, Potter LR, Schmidt HHHW, Szabo C, Waldman SA. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S264-S312. PMID: 34529829.

Citations:
Entezari AA, Snook AE, Waldman SA. Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential. Expert Opin Ther Targets. 2021 May; 25(5):335-346. PMID: 34056991.

Citations:
Kopenhaver J, Crutcher M, Waldman SA, Snook AE. The shifting paradigm of colorectal cancer treatment: a look into emerging cancer stem cell-directed therapeutics to lead the charge toward complete remission. Expert Opin Biol Ther. 2021 Oct; 21(10):1335-1345. PMID: 33977849.

Citations:
Cheslow L, Snook AE, Waldman SA. Emerging targets for the diagnosis of Parkinson's disease: examination of systemic biomarkers. Biomark Med. 2021 06; 15(8):597-608. PMID: 33988462.

Citations:
Sharma A, Rao SSC, Kearns K, Orleck KD, Waldman SA. Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders. Aliment Pharmacol Ther. 2021 Apr 28. PMID: 33909919.

Citations:
Zalewski A, Snook AE, Waldman SA. Stem cells as therapeutic targets in colorectal cancer. Per Med. 2021 Mar; 18(2):171-183. PMID: 33565332.

Citations:
Lisby AN, Flickinger JC, Bashir B, Weindorfer M, Shelukar S, Crutcher M, Snook AE, Waldman SA. GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer. Expert Rev Precis Med Drug Dev. 2021; 6(2):117-129. PMID: 34027103.

Citations:
Barton JR, Snook AE, Waldman SA. From leptin to lasers: the past and present of mouse models of obesity. Expert Opin Drug Discov. 2021 Jan 29; 1-14. PMID: 33472452.

Citations:
Flickinger JC, Rappaport JA, Barton JR, Baybutt TR, Pattison AM, Snook AE, Waldman SA. Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomark Med. 2021 Feb; 15(3):201-217. PMID: 33470843.

Citations:
Bartunek J, Terzic A, Davison BA, Behfar A, Sanz-Ruiz R, Wojakowski W, Sherman W, Heyndrickx GR, Metra M, Filippatos GS, Waldman SA, Teerlink JR, Henry TD, Gersh BJ, Hajjar R, Tendera M, Senger S, Cotter G, Povsic TJ, Wijns W. Cardiopoietic stem cell therapy in ischaemic heart failure: long-term clinical outcomes. ESC Heart Fail. 2020 Oct 23. PMID: 33094909.

Citations:
Rappaport JA, Waldman SA. An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer. Expert Rev Clin Pharmacol. 2020 Oct; 13(10):1125-1137. PMID: 32945718.

Citations:
Flickinger JC, Singh J, Carlson R, Leong E, Baybutt TR, Barton J, Caparosa E, Pattison A, Rappaport JA, Roh J, Zhan T, Bashir B, Waldman SA, Snook AE. Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity. J Immunother Cancer. 2020 Aug; 8(2). PMID: 32819976.

Citations:
Pattison AM, Barton JR, Entezari AA, Zalewski A, Rappaport JA, Snook AE, Waldman SA. Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biol Ther. 2020 Jun 28; 1-7. PMID: 32594830.

Citations:
Blomain ES, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA. APC-ß-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. Cancer Biol Ther. 2020 Feb 09; 1-11. PMID: 32037952.

Citations:
Caparosa EM, Stem J, Snook AE, Waldman SA. Biomarker targeting of colorectal cancer stem cells. Biomark Med. 2019 Aug; 13(11):891-894. PMID: 31385523.

Citations:
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells. Am J Physiol Cell Physiol. 2019 Jul 31. PMID: 31365292.

Citations:
Waldman SA, Tenenbaum R, Foehl HC, Winkle P, Griffin P. Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation. Clin Transl Gastroenterol. 2019 Jul; 10(7):e00016. PMID: 31318728.

Citations:
Stem J, Flickinger JC, Merlino D, Caparosa EM, Snook AE, Waldman SA. Therapeutic targeting of gastrointestinal cancer stem cells. Regen Med. 2019 Apr 26. PMID: 31025613.

Citations:
Snook AE, Baybutt TR, Xiang B, Abraham TS, Flickinger JC, Hyslop T, Zhan T, Kraft WK, Sato T, Waldman SA. Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. J Immunother Cancer. 2019 Apr 23; 7(1):104. PMID: 31010434.

Citations:
Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA. Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated and MSI colorectal neoplasia. Hum Pathol. 2019 Feb 01. PMID: 30716341.

Citations:
Abraham TS, Flickinger JC, Waldman SA, Snook AE. TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C. J Immunol. 2019 Feb 15; 202(4):1301-1310. PMID: 30642983.

Citations:
Waldman SA, Terzic A. Health Care Evolves From Reactive to Proactive. Clin Pharmacol Ther. 2019 Jan; 105(1):10-13. PMID: 30597564.

Citations:
Rappaport JA, Waldman SA. The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Front Oncol. 2018; 8:299. PMID: 30131940.

Citations:
Waldman SA. Prenatal Regeneration in Clinical Practice. Mayo Clin Proc. 2018 Jun; 93(6):673-675. PMID: 29803314.

Citations:
Magee MS, Abraham TS, Baybutt TR, Flickinger JC, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE. Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer Immunol Res. 2018 Apr 03. PMID: 29615399.

Citations:
Waldman SA, Camilleri M. Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut. 2018 Mar 21. PMID: 29563144.

Citations:
Caracciolo V, Young J, Gonzales D, Ni Y, Flowers SJ, Summer R, Waldman SA, Kim JK, Jung DY, Noh HL, Kim T, Blackshear PJ, O'Connell D, Bauer RC, Kallen CB. Myeloid-Specific Deletion of Zfp36 Protects Against Insulin Resistance and Fatty Liver in Diet-Induced Obese Mice. Am J Physiol Endocrinol Metab. 2018 Mar 06. PMID: 29509432.

Citations:
Sherman W, Bartunek J, Dolatabadi D, Sanz-Ruiz R, Beleslin B, Wojakowski W, Heyndrickx G, Kimpalou JZ, Waldman SA, Laarman GJ, Seron A, Behfar A, Latere JP, Terzic A, Wijns W. First-in-Human Use of a Retention-Enhanced Catheter for Endomyocardial Cell Delivery. JACC Cardiovasc Interv. 2018 Feb 26; 11(4):412-414. PMID: 29471956.

Citations:
Waldman SA, Terzic A. Process Improvement for Maximized Therapeutic Innovation Outcome. Clin Pharmacol Ther. 2018 Jan; 103(1):8-12. PMID: 29265398.

Citations:
Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget. 2017 Nov 28; 8(61):102923-102933. PMID: 29262534.

Citations:
Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep 15; 77(18):5095-5106. PMID: 28916678.

Citations:
Li P, Lin JE, Snook AE, Waldman SA. ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. Toxins (Basel). 2017 Sep 12; 9(9). PMID: 28895923.

Citations:
Weinberg DS, Lin JE, Foster NR, Della'Zanna G, Umar A, Seisler D, Kraft WK, Kastenberg DM, Katz LC, Limburg PJ, Waldman SA. Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention. Cancer Prev Res (Phila). 2017 Jun; 10(6):345-354. PMID: 28396341.

Citations:
Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol. 2017 May; 10(5):549-557. PMID: 28162021.

Citations:
Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE. Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells. J Immunol. 2017 May 01; 198(9):3507-3514. PMID: 28341670.

Citations:
Bartunek J, Terzic A, Davison BA, Filippatos GS, Radovanovic S, Beleslin B, Merkely B, Musialek P, Wojakowski W, Andreka P, Horvath IG, Katz A, Dolatabadi D, El Nakadi B, Arandjelovic A, Edes I, Seferovic PM, Obradovic S, Vanderheyden M, Jagic N, Petrov I, Atar S, Halabi M, Gelev VL, Shochat MK, Kasprzak JD, Sanz-Ruiz R, Heyndrickx GR, Nyolczas N, Legrand V, Guédès A, Heyse A, Moccetti T, Fernandez-Aviles F, Jimenez-Quevedo P, Bayes-Genis A, Hernandez-Garcia JM, Ribichini F, Gruchala M, Waldman SA, Teerlink JR, Gersh BJ, Povsic TJ, Henry TD, Metra M, Hajjar RJ, Tendera M, Behfar A, Alexandre B, Seron A, Stough WG, Sherman W, Cotter G, Wijns W. Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. Eur Heart J. 2017 Mar 01; 38(9):648-660. PMID: 28025189.

Citations:
Chervoneva I, Freydin B, Hyslop T, Waldman SA. Modeling qRT-PCR dynamics with application to cancer biomarker quantification. Stat Methods Med Res. 2017 Jan 01; 962280216683204. PMID: 28504051.

Citations:
Snook AE, Baybutt TR, Hyslop T, Waldman SA. Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope. Hum Gene Ther Methods. 2016 Dec; 27(6):238-250. PMID: 27903079.

Citations:
Myers RE, Wolf T, Shwae P, Hegarty S, Peiper SC, Waldman SA. A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients. BMC Cancer. 2016 Oct 03; 16(1):766. PMID: 27716119.

Citations:
Pattison AM, Merlino DJ, Blomain ES, Waldman SA. Guanylyl cyclase C signaling axis and colon cancer prevention. World J Gastroenterol. 2016 Sep 28; 22(36):8070-7. PMID: 27688649.

Citations:
Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Infect Immun. 2016 Oct; 84(10):3083-91. PMID: 27481254.

Citations:
Magee MS, Kraft CL, Abraham TS, Baybutt TR, Marszalowicz GP, Li P, Waldman SA, Snook AE. GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity. Oncoimmunology. 2016; 5(10):e1227897. PMID: 27853651.

Citations:
Blomain ES, Merlino DJ, Pattison AM, Snook AE, Waldman SA. Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer. Mol Pharmacol. 2016 Sep; 90(3):199-204. PMID: 27251363.

Citations:
Cantarin MP, Keith SW, Lin Z, Doria C, Frank AM, Maley WR, Ramirez C, Lallas CD, Shah A, Waldman SA, Falkner B. Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus. Cardiorenal Med. 2016 Aug; 6(4):289-300. PMID: 27648010.

Citations:
Blomain ES, Pattison AM, Waldman SA. GUCY2C ligand replacement to prevent colorectal cancer. Cancer Biol Ther. 2016 Jul 2; 17(7):713-8. PMID: 27104761.

Citations:
Blomain ES, Waldman SA. Does obesity promote the development of colorectal cancer? Expert Rev Anticancer Ther. 2016 May; 16(5):465-7. PMID: 26943700.

Citations:
Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA. Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. Cancer Res. 2016 Jan 15; 76(2):339-46. PMID: 26773096.

Citations:
Waldman SA. Editorial (Thematic Issue: Ferid Murad, at 80: A Legacy of Science, Medicine, and Mentorship). Curr Med Chem. 2016; 23(24):2556-2558. PMID: 27776470.

Citations:
Krishnan V, Xu X, Kelly D, Snook A, Waldman SA, Mason RW, Jia X, Rajasekaran AK. CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia. Mol Pharm. 2015 Jun 1; 12(6):2101-11. PMID: 25898125.

Citations:
Waldman SA, Terzic A. Companion diagnostics at the intersection of personalized medicine and healthcare delivery. Biomark Med. 2015 Jan; 9(1):1-3. PMID: 25605449.

Citations:
Rodriguez E, Sakowski L, Hobson GM, Armani MH, Kreiger PA, Zhu Y, Waldman SA, Shaffer TH. Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation. Pulm Pharmacol Ther. 2015 Feb; 30:22-31. PMID: 25445931.

Citations:
Marszalowicz GP, Snook AE, Magee MS, Merlino D, Berman-Booty LD, Waldman SA. GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. Oncotarget. 2014 Oct 15; 5(19):9460-71. PMID: 25294806.

Citations:
Wilson C, Lin JE, Li P, Snook AE, Gong J, Sato T, Liu C, Girondo MA, Rui H, Hyslop T, Waldman SA. The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2328-37. PMID: 25304930.

Citations:
Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH. The orl rat is more responsive to methacholine challenge than wild type. Pulm Pharmacol Ther. 2014 Dec; 29(2):199-208. PMID: 25218882.

Citations:
Witek ME, Snook AE, Lin JE, Blomain ES, Xiang B, Magee M, Waldman SA. A Novel CDX2 Isoform Regulates Alternative Splicing. PLoS One. 2014; 9(8):e104293. PMID: 25101906.

Citations:
Martinez Cantarin MP, Keith SW, Waldman SA, Falkner B. Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease. Nephrol Dial Transplant. 2014 Dec; 29(12):2268-77. PMID: 25049200.

Citations:
Merlino DJ, Blomain ES, Aing AS, Waldman SA. Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy. J Clin Med. 2014; 3(3):763-94. PMID: 26237477.

Citations:
Snook AE, Magee MS, Schulz S, Waldman SA. Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy. Eur J Immunol. 2014 Jul; 44(7):1956-66. PMID: 24771148.

Citations:
Witek M, Blomain ES, Magee MS, Xiang B, Waldman SA, Snook AE. Tumor Radiation Therapy Creates Therapeutic Vaccine Responses to the Colorectal Cancer Antigen GUCY2C. Int J Radiat Oncol Biol Phys. 2014 Apr 1; 88(5):1188-95. PMID: 24661671.

Citations:
Nofziger C, Papaluca M, Terzic A, Waldman S, Paulmichl M. Policies to aid the adoption of personalized medicine. Nat Rev Drug Discov. 2014 Feb 28; 13(3):159-60. PMID: 24577385.

Citations:
Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A. Reply: The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE). J Am Coll Cardiol. 2013 Dec 24; 62(25):2454-6. PMID: 24355591.

Citations:
Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the american heart association. Circulation. 2013 Dec 24; 128(25):2813-51. PMID: 24297835.

Citations:
Gibbons AV, Lin JE, Kim GW, Marszalowicz GP, Li P, Stoecker BA, Blomain ES, Rattan S, Snook AE, Schulz S, Waldman SA. Intestinal GUCY2C Prevents TGF-ß Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer. Cancer Res. 2013 Nov 15; 73(22):6654-66. PMID: 24085786.

Citations:
Blomain ES, Lin JE, Kraft CL, Trela UT, Rock JM, Aing AS, Snook AE, Waldman SA. Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis. Expert Rev Clin Pharmacol. 2013 Sep; 6(5):557-64. PMID: 23971873.

Citations:
Xiang B, Snook AE, Magee MS, Waldman SA. Colorectal cancer immunotherapy. Discov Med. 2013 May; 15(84):301-8. PMID: 23725603.

Citations:
Kim GW, Lin JE, Blomain ES, Waldman SA. New advances in models and strategies for developing anti-obesity drugs. Expert Opin Drug Discov. 2013 Jun; 8(6):655-71. PMID: 23621300.

Citations:
Blomain ES, Dirhan DA, Valentino MA, Kim GW, Waldman SA. Mechanisms of Weight Regain following Weight Loss. ISRN Obes. 2013; 2013:210524. PMID: 24533218.

Citations:
Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, El Nakadi B, Banovic M, Beleslin B, Vrolix M, Legrand V, Vrints C, Vanoverschelde JL, Crespo-Diaz R, Homsy C, Tendera M, Waldman S, Wijns W, Terzic A. Cardiopoietic Stem Cell Therapy in Heart Failure: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) Multicenter Randomized Trial With Lineage-Specified Biologics. J Am Coll Cardiol. 2013 Jun 11; 61(23):2329-38. PMID: 23583246.

Citations:
Avital I, Summers TA, Steele SR, Waldman S, Nissan A, Bilchik AJ, Protic M, Man YG, Brücher BL, Stojadinovic A. Colorectal cancer stem cells as biomarkers: Where it all starts? J Surg Oncol. 2013 Jun; 107(8):791-3. PMID: 23512573.

Citations:
Avital I, Langan RC, Summers TA, Steele SR, Waldman SA, Backman V, Yee J, Nissan A, Young P, Womeldorph C, Mancusco P, Mueller R, Noto K, Grundfest W, Bilchik AJ, Protic M, Daumer M, Eberhardt J, Man YG, Brücher BL, Stojadinovic A. Evidence-based Guidelines for Precision Risk Stratification-Based Screening (PRSBS) for Colorectal Cancer: Lessons learned from the US Armed Forces: Consensus and Future Directions. J Cancer. 2013; 4(3):172-92. PMID: 23459409.

Citations:
Hyslop T, Waldman SA. Molecular staging of node negative patients with colorectal cancer. J Cancer. 2013; 4(3):193-9. PMID: 23459453.

Citations:
Snook AE, Waldman SA. Advances in cancer immunotherapy. Discov Med. 2013 Feb; 15(81):120-5. PMID: 23449114.

Citations:
Waldman SA, Terzic A. Translational medicine individualizes healthcare discovery, development and delivery. Biomark Med. 2013 Feb; 7(1):1-3. PMID: 23387479.

Citations:
Magee MS, Snook AE, Marszalowicz GP, Waldman SA. Immunotherapeutic strategies to target prognostic and predictive markers of cancer. Biomark Med. 2013 Feb; 7(1):23-35. PMID: 23387482.

Citations:
Hyslop T, Waldman SA. Guanylyl cyclase C as a biomarker in colorectal cancer. Biomark Med. 2013 Feb; 7(1):159-67. PMID: 23387497.

Citations:
Kim GW, Lin JE, Waldman SA. GUCY2C: at the intersection of obesity and cancer. Trends Endocrinol Metab. 2013 Apr; 24(4):165-73. PMID: 23375388.

Citations:
Martinez Cantarin MP, Waldman SA, Doria C, Frank AM, Maley WR, Ramirez CB, Keith SW, Falkner B. The adipose tissue production of adiponectin is increased in end-stage renal disease. Kidney Int. 2013 Mar; 83(3):487-94. PMID: 23283133.

Citations:
Krishnan V, Xu X, Barwe SP, Yang X, Czymmek K, Waldman SA, Mason RW, Jia X, Rajasekaran AK. Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine. Mol Pharm. 2013 Jun 3; 10(6):2199-210. PMID: 23194373.

Citations:
Colon-Gonzalez F, Kim GW, Lin JE, Valentino MA, Waldman SA. Obesity pharmacotherapy: What is next? Mol Aspects Med. 2013 Feb; 34(1):71-83. PMID: 23103610.

Citations:
Gong JP, Schulz S, Hyslop T, Waldman SA. GUCY2C molecular staging personalizes colorectal cancer patient management. Biomark Med. 2012 Jun; 6(3):339-48. PMID: 22731908.

Citations:
Mejia A, Schulz S, Hyslop T, Weinberg DS, Waldman SA. Molecular staging individualizing cancer management. J Surg Oncol. 2012 Apr 1; 105(5):468-74. PMID: 22441898.

Citations:
Waldman SA, Terzic A. The value proposition of molecular medicine. Clin Transl Sci. 2012 Feb; 5(1):108-10. PMID: 22376267.

Citations:
Lin JE, Snook AE, Li P, Stoecker BA, Kim GW, Magee MS, Garcia AV, Valentino MA, Hyslop T, Schulz S, Waldman SA. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One. 2012; 7(2):e31686. PMID: 22384056.

Citations:
Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer. J Surg Oncol. 2012 Jul 1; 106(1):24-30. PMID: 22252429.

Citations:
Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. PMID: 22458515.

Citations:
Waldman SA, Terzic A. Patient-centric clinical pharmacology advances the path to personalized medicine. Biomark Med. 2011 Dec; 5(6):697-700. PMID: 22103605.

Citations:
Snook AE, Magee MS, Waldman SA. GUCY2C-targeted cancer immunotherapy: past, present and future. Immunol Res. 2011 Dec; 51(2-3):161-9. PMID: 22038530.

Citations:
Snook AE, Magee MS, Marszalowicz GP, Schulz S, Waldman SA. Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C. Cancer Immunol Immunother. 2012 May; 61(5):713-23. PMID: 22057677.

Citations:
Waldman SA, Terzic A. Widening the path to personalized medicine. Clin Transl Sci. 2011 Oct; 4(5):392-4. PMID: 22029815.

Citations:
Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes. Cancer. 2012 May 1; 118(9):2532-40. PMID: 21887684.

Citations:
Valentino MA, Lin JE, Snook AE, Li P, Kim GW, Marszalowicz G, Magee MS, Hyslop T, Schulz S, Waldman SA. A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. J Clin Invest. 2011 Sep; 121(9):3578-88. PMID: 21865642.

Citations:
Crist RC, Roth JJ, Waldman SA, Buchberg AM. A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer. PLoS One. 2011; 6(8):e23665. PMID: 21858198.

Citations:
Zuzga DS, Pelta-Heller J, Li P, Bombonati A, Waldman SA, Pitari GM. Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer. Int J Cancer. 2012 Jun 1; 130(11):2539-48. PMID: 21702043.

Citations:
Terzic A, Waldman S. Chronic diseases: the emerging pandemic. Clin Transl Sci. 2011 Jun; 4(3):225-6. PMID: 21707955.

Citations:
Waldman SA, Terzic A. Clinical pharmacology at the core of translational science. Expert Rev Clin Pharmacol. 2011 May; 4(3):303-5. PMID: 22114776.

Citations:
Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, Schulz S, Schanche R, Murphy GF, Waldman SA. Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model. J Ultrasound Med. 2011 Apr; 30(4):441-53. PMID: 21460143.

Citations:
Waldman SA, Terzic A. Bionic technologies transforming the science of healthcare delivery. Clin Transl Sci. 2011 Apr; 4(2):84-6. PMID: 21463492.

Citations:
Kim GW, Lin JE, Valentino MA, Colon-Gonzalez F, Waldman SA. Regulation of appetite to treat obesity. Expert Rev Clin Pharmacol. 2011 Mar; 4(2):243-59. PMID: 21666781.

Citations:
Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer. Clin Cancer Res. 2011 May 15; 17(10):3293-303. PMID: 21307149.

Citations:
Waldman SA, Terzic A. Clinical translational science 2020: disruptive innovation redefines the discovery-application enterprise. Clin Transl Sci. 2011 Feb; 4(1):69-71. PMID: 21348959.

Citations:
Terzic A, Waldman SA. Translational medicine: path to personalized and public health. Biomark Med. 2010 Dec; 4(6):787-90. PMID: 21133696.

Citations:
Waldman SA, Terzic A. Clinical and translational science: from bench-bedside to global village. Clin Transl Sci. 2010 Oct; 3(5):254-7. PMID: 20973923.

Citations:
Valentino MA, Colon-Gonzalez F, Lin JE, Waldman SA. Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity. Expert Rev Endocrinol Metab. 2010 Sep 1; 5(5):765-783. PMID: 21297878.

Citations:
Li P, Waldman SA. Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis. Cancer Biol Ther. 2010 Aug; 10(3):211-8. PMID: 20592492.

Citations:
Lin JE, Valentino M, Marszalowicz G, Magee MS, Li P, Snook AE, Stoecker BA, Chang C, Waldman SA. Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics. Toxins (Basel). 2010 Aug; 2(8):2028-54. PMID: 22069671.

Citations:
Waldman SA, Terzic A. Molecular therapy drives patient-centric health care paradigms. Clin Transl Sci. 2010 Aug; 3(4):170-1. PMID: 20718817.

Citations:
Valentino MA, Terzic A, Waldman SA. Sizing up pharmacotherapy for obesity. Clin Transl Sci. 2010 Jun; 3(3):123-5. PMID: 20590683.

Citations:
Chervoneva I, Li Y, Schulz S, Croker S, Wilson C, Waldman SA, Hyslop T. Selection of optimal reference genes for normalization in quantitative RT-PCR. BMC Bioinformatics. 2010; 11:253. PMID: 20470420.

Citations:
Bharucha AE, Waldman SA. Taking a lesson from microbial diarrheagenesis in the management of chronic constipation. Gastroenterology. 2010 Mar; 138(3):813-7. PMID: 20114092.

Citations:
Mejia A, Schulz S, Hyslop T, Weinberg DS, Waldman SA. Molecular staging estimates occult tumor burden in colorectal cancer. Adv Clin Chem. 2010; 52:19-39. PMID: 21275338.

Citations:
Waldman SA, Kraft WK, Nelson TJ, Terzic A. Clinical pharmacology: a paradigm for individualized medicine. Biomark Med. 2009 Dec; 3(6):679-84. PMID: 20477706.

Citations:
Waldman SA, Kraft WK, Nelson TJ, Terzic A. Experimental therapeutics: a paradigm for personalized medicine. Clin Transl Sci. 2009 Dec; 2(6):436-8. PMID: 20443936.

Citations:
Mejia A, Schulz S, Hyslop T, Weinberg DS, Waldman SA. GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients. Expert Rev Mol Diagn. 2009 Nov; 9(8):777-85. PMID: 19895223.

Citations:
Park JY, Kirn TJ, Artis D, Waldman SA, Kricka LJ. Chemiluminescence-based detection of gastrointestinal malignancies. Luminescence. 2010 Nov-Dec; 25(6):463-5. PMID: 19827005.

Citations:
Winn B, Tavares R, Matoso A, Noble L, Fanion J, Waldman SA, Resnick MB. Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas. Hum Pathol. 2010 Jan; 41(1):123-8. PMID: 19800103.

Citations:
Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA. The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. Gastroenterology. 2010 Jan; 138(1):241-54. PMID: 19737566.

Citations:
Ciocca V, Bombonati A, Palazzo JP, Schulz S, Waldman SA. Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms. Histopathology. 2009 Aug; 55(2):182-8. PMID: 19694825.

Citations:
Gong L, Debruyne PR, Witek M, Nielsen K, Snook A, Lin JE, Bombonati A, Palazzo J, Schulz S, Waldman SA. Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis. Clin Transl Sci. 2009 Aug; 2(4):286-93. PMID: 20443907.

Citations:
Li P, Lin JE, Marszlowicz GP, Valentino MA, Chang C, Schulz S, Pitari GM, Waldman SA. GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome? Drug News Perspect. 2009 Jul-Aug; 22(6):313-8. PMID: 19771320.

Citations:
Waldman SA, Terzic A. Applications of microRNA in cancer: Exploring the advantages of miRNA. Clin Transl Sci. 2009 Jun; 2(3):248-9. PMID: 20443899.

Citations:
Lin JE, Li P, Pitari GM, Schulz S, Waldman SA. Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. Future Oncol. 2009 May; 5(4):509-22. PMID: 19450179.

Citations:
Snook AE, Li P, Stafford BJ, Faul EJ, Huang L, Birbe RC, Bombonati A, Schulz S, Schnell MJ, Eisenlohr LC, Waldman SA. Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease. Cancer Res. 2009 Apr 15; 69(8):3537-44. PMID: 19351847.

Citations:
Waldman SA, Terzic A. Translational medicine in the era of health care reform. Clin Transl Sci. 2009 Apr; 2(2):96-7. PMID: 20443877.

Citations:
Lubbe WJ, Zuzga DS, Zhou Z, Fu W, Pelta-Heller J, Muschel RJ, Waldman SA, Pitari GM. Guanylyl cyclase C prevents colon cancer metastasis by regulating tumor epithelial cell matrix metalloproteinase-9. Cancer Res. 2009 Apr 15; 69(8):3529-36. PMID: 19336567.

Citations:
Waldman SA, Terzic A. A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer. FEBS J. 2009 Apr; 276(8):2157-64. PMID: 19250312.

Citations:
Waldman SA, Hyslop T, Schulz S, Barkun A, Nielsen K, Haaf J, Bonaccorso C, Li Y, Weinberg DS. Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. JAMA. 2009 Feb 18; 301(7):745-52. PMID: 19224751.

Citations:
Waldman SA, Terzic A. Molecular diagnostics. At the nexus of individualized medicine, health care delivery, and public policy. Clin Transl Sci. 2009 Feb; 2(1):6-8. PMID: 20443861.

Citations:
Chang C, Marszlowicz G, Waldman Z, Li P, Snook AE, Lin JE, Schulz S, Waldman SA. Guanylyl cyclase C as a biomarker for targeted imaging and therapy of metastatic colorectal cancer. Biomark Med. 2009 Feb; 3(1):33-45. PMID: 20477494.

Citations:
Waldman SA. Transitioning biomarkers into the clinic. Expert Rev Clin Pharmacol. 2009 Jan; 2(1):9-13. PMID: 24422768.

Citations:
Snook AE, Waldman SA. CANCER MUCOSA ANTIGENS A NOVEL PARADIGM IN CANCER IMMUNOTHERAPEUTICS. Bioforum Eur. 2009; 3:14-16. PMID: 26855637.

Citations:
Snook AE, Huang L, Schulz S, Eisenlohr LC, Waldman SA. Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens. Clin Transl Sci. 2008 Dec; 1(3):263-4. PMID: 19956776.

Citations:
Waldman SA, Terzic A. The roadmap to personalized medicine. Clin Transl Sci. 2008 Sep; 1(2):93. PMID: 20443827.

Citations:
Li P, Schulz S, Pitari GM, Waldman SA. Sex modulates intestinal transformation by the tumor-suppressor GCC. Clin Transl Sci. 2008 Sep; 1(2):146-50. PMID: 20443837.

Citations:
Li P, Schulz S, Pitari GM, Waldman SA. Sex modulates intestinal transformation by the tumor-suppressor GCC. Clin Transl Sci. 2008 Sep; 1(2):150. PMID: 20443838.

Citations:
Snook AE, Stafford BJ, Li P, Tan G, Huang L, Birbe R, Schulz S, Schnell MJ, Thakur M, Rothstein JL, Eisenlohr LC, Waldman SA. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. J Natl Cancer Inst. 2008 Jul 2; 100(13):950-61. PMID: 18577748.

Citations:
Pitari GM, Lin JE, Shah FJ, Lubbe WJ, Zuzga DS, Li P, Schulz S, Waldman SA. Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. Carcinogenesis. 2008 Aug; 29(8):1601-7. PMID: 18566015.

Citations:
Waldman SA, Terzic A. MicroRNA signatures as diagnostic and therapeutic targets. Clin Chem. 2008 Jun; 54(6):943-4. PMID: 18509012.

Citations:
Waldman SA, Terzic A. Clinical and translational sciences: at the intersection of molecular and individualized medicine. Clin Transl Sci. 2008 May; 1(1):6-8. PMID: 20443812.

Citations:
Plesa G, Snook AE, Waldman SA, Eisenlohr LC. Derivation and fluidity of acutely induced dysfunctional CD8+ T cells. J Immunol. 2008 Apr 15; 180(8):5300-8. PMID: 18390711.

Citations:
Waldman SA, Terzic A. Therapeutic burden in cancer revealed by molecular staging. Biomark Med. 2008 Feb; 2(1):1-3. PMID: 20477357.

Citations:
Tian X, Michal AM, Li P, Wolfe HR, Waldman SA, Wickstrom E. STa peptide analogs for probing guanylyl cyclase C. Biopolymers. 2008; 90(5):713-23. PMID: 18615494.

Citations:
Kraft WK, Waldman SA. Bridging the therapeutic continuum of drug development, regulation and use. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):1-3. PMID: 24410503.

Citations:
Larusso J, Waldman SA, Kraft WK. Aprepitant for the prevention of nausea and vomiting associated with chemotherapy and postoperative recovery. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):27-37. PMID: 24410507.

Citations:
Chervoneva I, Li Y, Iglewicz B, Waldman S, Hyslop T. Relative quantification based on logistic models for individual polymerase chain reactions. Stat Med. 2007 Dec 30; 26(30):5596-611. PMID: 17968873.

Citations:
Li P, Lin JE, Chervoneva I, Schulz S, Waldman SA, Pitari GM. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am J Pathol. 2007 Dec; 171(6):1847-58. PMID: 17974601.

Citations:
Terzic A, Moore RL, Waldman SA. Acquired and innate cardioprotection. J Appl Physiol. 2007 Oct; 103(4):1436-7. PMID: 17690193.

Citations:
Li P, Schulz S, Bombonati A, Palazzo JP, Hyslop TM, Xu Y, Baran AA, Siracusa LD, Pitari GM, Waldman SA. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007 Aug; 133(2):599-607. PMID: 17681179.

Citations:
Waldman S, Terzic A. Targeted diagnostics and therapeutics for individualized patient management. Biomark Med. 2007 Jun; 1(1):3-8. PMID: 20477454.

Citations:
Snook AE, Stafford BJ, Eisenlohr LC, Rothstein JL, Waldman SA. Mucosally restricted antigens as novel immunological targets for antitumor therapy. Biomark Med. 2007 Jun; 1(1):187-202. PMID: 20477468.

Citations:
Waldman SA, Terzic A. Translating MicroRNA discovery into clinical biomarkers in cancer. JAMA. 2007 May 2; 297(17):1923-5. PMID: 17473304.

Citations:
Gong L, Greenberg HE, Perhach JL, Waldman SA, Kraft WK. The pharmacokinetics of taurolidine metabolites in healthy volunteers. J Clin Pharmacol. 2007 Jun; 47(6):697-703. PMID: 17395893.

Citations:
Fortina P, Kricka LJ, Graves DJ, Park J, Hyslop T, Tam F, Halas N, Surrey S, Waldman SA. Applications of nanoparticles to diagnostics and therapeutics in colorectal cancer. Trends Biotechnol. 2007 Apr; 25(4):145-52. PMID: 17316852.

Citations:
Wilson CL, Schultz S, Waldman SA. Where medicine, business, and public policy intersect. Biotechnol Healthc. 2007 Feb; 4(1):33-42. PMID: 23397413.

Citations:
de Godoy MA, Patel CA, Waldman SA, Katsuki M, Regan RF, Rattan S. H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter. Gastroenterology. 2007 Apr; 132(4):1401-9. PMID: 17408635.

Citations:
Waldman SA, Fortina P, Surrey S, Hyslop T, Kricka LJ, Graves DJ. Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshells. Future Oncol. 2006 Dec; 2(6):705-16. PMID: 17155897.

Citations:
Schulz S, Hyslop T, Haaf J, Bonaccorso C, Nielsen K, Witek ME, Birbe R, Palazzo J, Weinberg D, Waldman SA. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Clin Cancer Res. 2006 Aug 1; 12(15):4545-52. PMID: 16899600.

Citations:
Pitari GM, Li T, Baksh RI, Waldman SA. Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells. Mol Cancer Ther. 2006 May; 5(5):1190-6. PMID: 16731751.

Citations:
Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P, Pitari GM, Schulz S, Waldman SA. Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology. 2006 Apr; 130(4):1191-206. PMID: 16618413.

Citations:
Lubbe WJ, Zhou ZY, Fu W, Zuzga D, Schulz S, Fridman R, Muschel RJ, Waldman SA, Pitari GM. Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer. Clin Cancer Res. 2006 Mar 15; 12(6):1876-82. PMID: 16551873.

Citations:
Majumdar AK, Howard L, Goldberg MR, Hickey L, Constanzer M, Rothenberg PL, Crumley TM, Panebianco D, Bradstreet TE, Bergman AJ, Waldman SA, Greenberg HE, Butler K, Knops A, De Lepeleire I, Michiels N, Petty KJ. Pharmacokinetics of aprepitant after single and multiple oral doses in healthy volunteers. J Clin Pharmacol. 2006 Mar; 46(3):291-300. PMID: 16490805.

Citations:
Witek ME, Nielsen K, Walters R, Hyslop T, Palazzo J, Schulz S, Waldman SA. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res. 2005 Dec 15; 11(24 Pt 1):8549-56. PMID: 16361536.

Citations:
Pitari GM, Baksh RI, Harris DM, Li P, Kazerounian S, Waldman SA. Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res. 2005 Dec 1; 65(23):11129-35. PMID: 16322263.

Citations:
Chervoneva I, Hyslop T, Iglewicz B, Johns L, Wolfe HR, Schulz S, Leong E, Waldman S. Statistical algorithm for assuring similar efficiency in standards and samples for absolute quantification by real-time reverse transcription polymerase chain reaction. Anal Biochem. 2006 Jan 15; 348(2):198-208. PMID: 16336939.

Citations:
Frick GS, Pitari GM, Weinberg DS, Hyslop T, Schulz S, Waldman SA. Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer. Expert Rev Mol Diagn. 2005 Sep; 5(5):701-13. PMID: 16149873.

Citations:
Kazerounian S, Pitari GM, Shah FJ, Frick GS, Madesh M, Ruiz-Stewart I, Schulz S, Hajnóczky G, Waldman SA. Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. J Pharmacol Exp Ther. 2005 Sep; 314(3):1013-22. PMID: 15937149.

Citations:
Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol. 2005 Feb; 36(2):170-9. PMID: 15754294.

Citations:
Stone JA, Migoya EM, Hickey L, Winchell GA, Deutsch PJ, Ghosh K, Freeman A, Bi S, Desai R, Dilzer SC, Lasseter KC, Kraft WK, Greenberg H, Waldman SA. Potential for interactions between caspofungin and nelfinavir or rifampin. Antimicrob Agents Chemother. 2004 Nov; 48(11):4306-14. PMID: 15504857.

Citations:
Waldman SA. Markers of cell cycle-mediated drug resistance and prognosis of patients receiving preoperative combined modality therapy for rectal cancer. Ann Surg Oncol. 2004 Nov; 11(11):949-50. PMID: 15525820.

Citations:
Agrawal NG, Matthews CZ, Mazenko RS, Woolf EJ, Porras AG, Chen X, Miller JL, Michiels N, Wehling M, Schultz A, Gottlieb AB, Kraft WK, Greenberg HE, Waldman SA, Curtis SP, Gottesdiener KM. The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity. J Clin Pharmacol. 2004 Oct; 44(10):1125-31. PMID: 15342613.

Citations:
Kraft WK, McCrea JB, Winchell GA, Carides A, Lowry R, Woolf EJ, Kusma SE, Deutsch PJ, Greenberg HE, Waldman SA. Indinavir and rifabutin drug interactions in healthy volunteers. J Clin Pharmacol. 2004 Mar; 44(3):305-13. PMID: 14973305.

Citations:
Tiyyagura SR, Kazerounian S, Schulz S, Waldman SA, Pitari GM. Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP. Vitam Horm. 2004; 69:69-94. PMID: 15196879.

Citations:
Gong L, Pitari GM, Schulz S, Waldman SA. Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity. Curr Opin Hematol. 2004 Jan; 11(1):7-14. PMID: 14676622.

Citations:
Kraft WK, Steiger B, Beussink D, Quiring JN, Fitzgerald N, Greenberg HE, Waldman SA. The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers. J Clin Pharmacol. 2004 Jan; 44(1):67-72. PMID: 14681343.

Citations:
Lasseter KC, Dilzer SC, Vargas R, Waldman S, Noveck RJ. Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study. Clin Pharmacokinet. 2004; 43(2):121-9. PMID: 14748620.

Citations:
Veronese ML, Gillen LP, Dorval EP, Hauck WW, Waldman SA, Greenberg HE. Effect of mibefradil on CYP3A4 in vivo. J Clin Pharmacol. 2003 Oct; 43(10):1091-100. PMID: 14517191.

Citations:
Burke J, Kraft WK, Greenberg HE, Gleave M, Pitari GM, VanBuren S, Wagner JA, Waldman SA. Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation. J Clin Pharmacol. 2003 Sep; 43(9):983-9. PMID: 12971030.

Citations:
Veronese ML, Gillen LP, Burke JP, Dorval EP, Hauck WW, Pequignot E, Waldman SA, Greenberg HE. Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. J Clin Pharmacol. 2003 Aug; 43(8):831-9. PMID: 12953340.

Citations:
Debruyne PR, Waldman SA, Schulz S. Pathological staging and therapy of oesophageal and gastric cancer. Expert Opin Pharmacother. 2003 Jul; 4(7):1083-96. PMID: 12831335.

Citations:
Dallob A, Hawkey CJ, Greenberg H, Wight N, De Schepper P, Waldman S, Wong P, DeTora L, Gertz B, Agrawal N, Wagner J, Gottesdiener K. Characterization of etoricoxib, a novel, selective COX-2 inhibitor. J Clin Pharmacol. 2003 Jun; 43(6):573-85. PMID: 12817520.

Citations:
Blum RA, Majumdar A, McCrea J, Busillo J, Orlowski LH, Panebianco D, Hesney M, Petty KJ, Goldberg MR, Murphy MG, Gottesdiener KM, Hustad CM, Lates C, Kraft WK, Van Buren S, Waldman SA, Greenberg HE. Effects of aprepitant on the pharmacokinetics of ondansetron and granisetron in healthy subjects. Clin Ther. 2003 May; 25(5):1407-19. PMID: 12867217.

Citations:
Musson DG, Majumdar A, Birk K, Holland S, Wickersham P, Li SX, Mistry G, Fisher A, Waldman S, Greenberg H, Deutsch P, Rogers JD. Pharmacokinetics of intramuscularly administered ertapenem. Antimicrob Agents Chemother. 2003 May; 47(5):1732-5. PMID: 12709348.

Citations:
Casale TB, Blaiss MS, Gelfand E, Gilmore T, Harvey PD, Hindmarch I, Simons FE, Spangler DL, Szefler SJ, Terndrup TE, Waldman SA, Weiler J, Wong DF. First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol. 2003 May; 111(5):S835-42. PMID: 12743547.

Citations:
Rathi S, Kazerounian S, Banwait K, Schulz S, Waldman SA, Rattan S. Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. J Pharmacol Exp Ther. 2003 May; 305(2):615-24. PMID: 12606629.

Citations:
Park J, Schulz S, Haaf J, Kairys JC, Waldman SA. Ectopic expression of guanylyl cyclase C in adenocarcinomas of the esophagus and stomach. Cancer Epidemiol Biomarkers Prev. 2002 Aug; 11(8):739-44. PMID: 12163327.

Citations:
Waldman SA. Does potency predict clinical efficacy? Illustration through an antihistamine model. Ann Allergy Asthma Immunol. 2002 Jul; 89(1):7-11; quiz 11-2, 77. PMID: 12141724.

Citations:
Wolfe HR, Waldman SA. A comparative molecular field analysis (COMFA) of the structural determinants of heat-stable enterotoxins mediating activation of guanylyl cyclase C. J Med Chem. 2002 Apr 11; 45(8):1731-4. PMID: 11931628.

Citations:
Ruiz-Stewart I, Kazerounian S, Pitari GM, Schulz S, Waldman SA. Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides. Eur J Biochem. 2002 Apr; 269(8):2186-93. PMID: 11985597.

Citations:
Kazerounian S, Pitari GM, Ruiz-Stewart I, Schulz S, Waldman SA. Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium. Biochemistry. 2002 Mar 12; 41(10):3396-404. PMID: 11876648.

Citations:
Wolfe HR, Mendizabal M, Lleong E, Cuthbertson A, Desai V, Pullan S, Fujii DK, Morrison M, Pither R, Waldman SA. In vivo imaging of human colon cancer xenografts in immunodeficient mice using a guanylyl cyclase C--specific ligand. J Nucl Med. 2002 Mar; 43(3):392-9. PMID: 11884500.

Citations:
Stone JA, Holland SD, Wickersham PJ, Sterrett A, Schwartz M, Bonfiglio C, Hesney M, Winchell GA, Deutsch PJ, Greenberg H, Hunt TL, Waldman SA. Single- and multiple-dose pharmacokinetics of caspofungin in healthy men. Antimicrob Agents Chemother. 2002 Mar; 46(3):739-45. PMID: 11850256.

Citations:

Year	Publications
2002	7
2003	9
2004	8
2005	6
2006	6
2007	11
2008	13
2009	20
2010	10
2011	15
2012	8
2013	17
2014	10
2015	2
2016	11
2017	8
2018	7
2019	8
2020	5
2021	11
2022	5

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