Thomas Jefferson University

Steven Mckenzie

TitleProfessor
InstitutionThomas Jefferson University
DepartmentHematology - Thomas Jefferson University
Address1020 Locust Street
Philadelphia PA 19107
Phone2159558544
vCardDownload vCard

    Collapse Overview 
    Collapse overview

    REVIEW BOARD MEMBERSHIP
    1996 - present
    Review Committee Member, National Institutes of Health, National Cancer Institute
    Chair, Innovative Technologies for the Molecular Analysis of Cancer study section
    Member of reviewer reserve, Innovative Technologies
    Ad hoc, National Heart Lung and Blood Institute


    Collapse Research 
    Collapse research activities and funding
    R01HL061865     (MCKENZIE, STEVEN E.)Sep 30, 1998 - Aug 31, 2003
    NIH
    MODELS OF THROMBOCYTOPENIA PATHOLOGY &TREATMENT
    Role: Principal Investigator
    C06RR028626     (MCKENZIE, STEVEN E.)Jan 26, 2010 - Feb 28, 2013
    NIH
    Jefferson Alumni Hall 3 West Lab Modernization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wurtzel JGT, Gray BD, Pak KY, Zhao X, Ma P, McKenzie SE, Tanujaya M, Rizzo V, Del Carpio-Cano F, Rao AK, Lee-Gau Chong P, Goldfinger LE. Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice. J Thromb Haemost. 2024 Oct 16. PMID: 39423958.
      Citations:    
    2. Leung H, Ahmadi Z, Lee B, Casey J, Ratnasingam S, McKenzie SE, Perdomo J, Chong BH. Antithrombotic Efficacy and Bleeding Risks of Vaccine-Induced Immune Thrombotic Thrombocytopenia Treatments. Blood Adv. 2024 Sep 18. PMID: 39293086.
      Citations:    
    3. Han X, Knauss EA, Fuente M, Li W, Conlon RA, LePage DF, Jiang W, Renna SA, McKenzie SE, Nieman MT. A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity. J Thromb Haemost. 2024 Mar 18. PMID: 38508397.
      Citations:    
    4. Wurtzel JGT, Lazar S, Askari S, Zhao X, Severa JR, Ayombil F, Michael JV, Camire RM, McKenzie SE, Stalker TJ, Ma P, Goldfinger LE. Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential. Blood Adv. 2024 Jan 01. PMID: 38163324.
      Citations:    
    5. Boelig RC, Kaushal G, Rochani A, McKenzie S, Kraft WK. Aspirin pharmacokinetics and pharmacodymamics through gestation. Am J Obstet Gynecol. 2023 Dec 23. PMID: 38145726.
      Citations:    
    6. Kostyak JC, McKenzie SE, Naik UP. The Function of ASK1 in Sepsis and Stress-Induced Disorders. Int J Mol Sci. 2023 Dec 22; 25(1). PMID: 38203381.
      Citations:    
    7. Han X, Knauss EA, de la Fuente M, Li W, Conlon RA, LePage DF, Jiang W, Renna SA, McKenzie SE, Nieman MT. A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity. bioRxiv. 2023 Dec 01. PMID: 38077081.
      Citations:    
    8. Aid M, Stephenson KE, Collier AY, Nkolola JP, Michael JV, McKenzie SE, Barouch DH. Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination. Nat Commun. 2023 Oct 23; 14(1):6703. PMID: 37872311.
      Citations:    
    9. Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA. The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. J Clin Invest. 2023 Jul 20. PMID: 37471144.
      Citations:    
    10. Renna SA, Zhao X, Kunapuli SP, Ma P, Holinstat M, Boxer MB, Maloney DJ, Michael JV, McKenzie SE. Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition. Arterioscler Thromb Vasc Biol. 2023 Jun 22. PMID: 37345522.
      Citations:    
    11. Renna SA, McKenzie SE, Michael JV. Species Differences in Platelet Protease-Activated Receptors. Int J Mol Sci. 2023 May 05; 24(9). PMID: 37176005.
      Citations:    
    12. Rhoades R, French Z, Yang A, Walsh K, Drelich DA, McKenzie SE. Perioperative Outcomes of Patients with Bleeding Disorders Undergoing Major Surgery at an Academic Hemophilia Treatment Center. Clin Appl Thromb Hemost. 2023 Jan-Dec; 29:10760296231165056. PMID: 36972481.
      Citations:    
    13. McKenzie SE. A vision for a quicker definitive diagnosis of HIT. Blood. 2022 12 22; 140(25):2657-2658. PMID: 36548019.
      Citations:    
    14. Boelig RC, Cahanap TJ, Ma L, Zhan T, Berghella V, Chan JSY, Kraft WK, Mckenzie SE. Platelet protease activated receptor 4 (PAR 4) Receptor Genotype is Associated with an Increased Risk of Preterm Birth. J Thromb Haemost. 2022 Jul 11. PMID: 35815338.
      Citations:    
    15. Zhao X, Cooper M, Michael JV, Yarman Y, Baltz A, Chuprun JK, Koch WJ, McKenzie SE, Tomaiuolo M, Stalker TJ, Zhu L, Ma P. GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12. Blood Adv. 2022 06 17. PMID: 35793439.
      Citations:    
    16. Huynh A, Arnold DM, Michael JV, Clare R, Smith JW, Daka M, Ianosi-Irimie M, McKenzie SE, Kelton JG, Nazy I. Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S. Blood Adv. 2022 Apr 04. PMID: 35377937.
      Citations:    
    17. Renna SA, Michael JV, Kong X, Ma L, Ma P, Nieman MT, Edelstein LC, McKenzie SE. Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice. J Thromb Haemost. 2022 Feb 13. PMID: 35152546.
      Citations:    
    18. McKenzie SE. Sugar and spike: not so nice. Blood. 2021 Oct 21; 138(16):1386-1387. PMID: 34673948.
      Citations:    
    19. Downes K, Zhao X, Gleadall NS, McKinney H, Kempster C, Batista J, Thomas P, Cooper M, Michael JV, Kreuzhuber R, Wedderburn K, Waller K, Varney B, Verdier H, Kriek N, Ashford SE, Stirrups KE, Dunster JL, McKenzie SE, Ouwehand WH, Gibbins JM, Yang J, Astle WJ, Ma P. G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1. Blood Adv. 2021 Sep 28. PMID: 34581777.
      Citations:    
    20. Leung H, Perdomo J, Ahmadi Z, Yan F, McKenzie SE, Chong BH. Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia. Blood Adv. 2021 Sep 03. PMID: 34478504.
      Citations:    
    21. Choi PY, Grace RF, Therese Ahlen M, Nazy I, Sachs UJ, Arnold DM, McKenzie SE, Althaus K, Sharma R, Bakchoul T. The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters. J Thromb Haemost. 2021 08; 19(8):2094-2095. PMID: 34076338.
      Citations:    
    22. Nazy I, Sachs UJ, Arnold DM, McKenzie SE, Choi P, Althaus K, Ahlen MT, Sharma R, Grace RF, Bakchoul T. Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology. J Thromb Haemost. 2021 06; 19(6):1585-1588. PMID: 34018298.
      Citations:    
    23. Rhoades R, Leong R, Kopenitz J, Thoma B, McDermott L, Dovidio J, Barletti S, Gong JZ, Massey HT, McKenzie SE, Rame JE, Al-Rawas N. Coagulopathy monitoring and anticoagulation management in COVID-19 patients on ECMO: Advantages of a heparin anti-Xa-based titration strategy. Thromb Res. 2021 Apr 19; 203:1-4. PMID: 33894473.
      Citations:    
    24. Patel P, Michael JV, Naik UP, McKenzie SE. Platelet Fc?RIIA in immunity and thrombosis: Adaptive immunothrombosis. J Thromb Haemost. 2021 May; 19(5):1149-1160. PMID: 33587783.
      Citations:    
    25. Abraham S, Ma L, Kong X, Askari S, Edelstein LC, McKenzie SE. PCTP contributes to human platelet activation by enhancing dense granule secretion. Thromb Res. 2021 Mar 08; 202:67-73. PMID: 33770537.
      Citations:    
    26. Melki I, Allaeys I, Tessandier N, Lévesque T, Cloutier N, Laroche A, Vernoux N, Becker Y, Benk-Fortin H, Zufferey A, Rollet-Labelle E, Pouliot M, Poirier G, Patey N, Belleannee C, Soulet D, McKenzie SE, Brisson A, Tremblay ME, Lood C, Fortin PR, Boilard E. Platelets release mitochondrial antigens in systemic lupus erythematosus. Sci Transl Med. 2021 Feb 17; 13(581). PMID: 33597264.
      Citations:    
    27. Dykes KC, Johnson CA, Gong JZ, McKenzie SE, Husseinzadeh HD. Bleeding and Thrombotic Adverse Events in Hospitalized Patients Under Empiric Treatment for Suspected Heparin-Induced Thrombocytopenia While Awaiting Confirmatory Testing. Clin Appl Thromb Hemost. 2021 Jan-Dec; 27:1076029621996473. PMID: 33848189.
      Citations:    
    28. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lévesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin PR, Boilard E. Fc?RIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood. 2020 Dec 17; 136(25):2933-2945. PMID: 33331924.
      Citations:    
    29. Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP. ASK1 Regulates Immune-Mediated Thrombocytopenia, Thrombosis, and Systemic Shock. J Thromb Haemost. 2020 Aug 07. PMID: 32767736.
      Citations:    
    30. Tessandier N, Melki I, Cloutier N, Allaeys I, Miszta A, Tan S, Milasan A, Michel S, Benmoussa A, Lévesque T, Côté F, McKenzie SE, Gilbert C, Provost P, Brisson AR, Wolberg AS, Fortin PR, Martel C, Boilard É. Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis. Arterioscler Thromb Vasc Biol. 2020 Apr; 40(4):929-942. PMID: 32102567.
      Citations:    
    31. Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik MU, Wurtzel JGT, Stalker TJ, Goldfinger LE, Benovic J, Brass LF, McKenzie SE, Naik UP, Ma P. GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. Blood Adv. 2020 Jan 14; 4(1):76-86. PMID: 31899801.
      Citations:    
    32. Rizk S, Axelrod D, Riddick-Burden G, Congdon-Martin E, McKenzie S, Haines C, Ward L, McAna J, Crawford AG. Clinical Transformation in Care for Patients With Sickle Cell Disease at an Urban Academic Medical Center. Am J Med Qual. 2019 Sep 09; 1062860619873402. PMID: 31496258.
      Citations:    
    33. Kizlik-Masson C, Deveuve Q, Zhou Y, Vayne C, Thibault G, McKenzie SE, Pouplard C, Loyau S, Gruel Y, Rollin J. Cleavage of anti-PF4/Heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia. Blood. 2019 Mar 27. PMID: 30917957.
      Citations:    
    34. Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP. TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists. TH Open. 2018 Oct; 2(4):e411-e419. PMID: 31249969.
      Citations:    
    35. Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF. The Protease-Activated Receptor 4 Ala120Thr Variant Alters Platelet Responsiveness to Low-Dose Thrombin, Protease-Activated Receptor 4 Desensitization and Is Blocked by Noncompetitive P2Y12 Inhibition. J Thromb Haemost. 2018 Oct 22. PMID: 30347494.
      Citations:    
    36. Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7):E1550-E1559. PMID: 29386381.
      Citations:    
    37. Kizlik-Masson C, Vayne C, McKenzie SE, Poupon A, Zhou Y, Champier G, Pouplard C, Gruel Y, Rollin J. 5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies. J Thromb Haemost. 2017 10; 15(10):2065-2075. PMID: 28771917.
      Citations:    
    38. Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk. J Biol Chem. 2017 Mar 10; 292(10):4360. PMID: 28283589.
      Citations:    
    39. Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M. Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. J Clin Invest. 2017 Mar 01; 127(3):1090-1098. PMID: 28218620.
      Citations:    
    40. Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (Fc?RIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice. Arterioscler Thromb Vasc Biol. 2016 Dec; 36(12):2315-2323. PMID: 27765766.
      Citations:    
    41. Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016 Oct 21; 291(43):22427-22441. PMID: 27609517.
      Citations:    
    42. Piatt R, Paul DS, Lee RH, McKenzie SE, Parise LV, Cowley DO, Cooley BC, Bergmeier W. Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1838-46. PMID: 27417588.
      Citations:    
    43. Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM. The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood. 2016 Jul 13. PMID: 27412887.
      Citations:    
    44. McKenzie SE. Syk Inhibition in Ischemic Stroke. Arterioscler Thromb Vasc Biol. 2016 Jun; 36(6):1054-5. PMID: 27225787.
      Citations:    
    45. Buitrago L, Manne BK, Andre P, McKenzie S, Kunapuli S. Identification of novel Syk-independent functional roles of Fc?RIIa in platelet outside-in signaling using transgenic mice expressing human Fc?RIIa. Platelets. 2016 Jul; 27(5):488-90. PMID: 26809427.
      Citations:    
    46. Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L. Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood. 2016 Jan 28; 127(4):464-72. PMID: 26518435.
      Citations:    
    47. Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. Anti-miR-148a regulates platelet Fc?RIIA signaling and decreases thrombosis in vivo in mice. Blood. 2015 Dec 24; 126(26):2871-81. PMID: 26516227.
      Citations:    
    48. Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, Liu S, Song Y. Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015 Jul; 4(7). PMID: 26116691.
      Citations:    
    49. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
      Citations:    
    50. Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP. Protein Kinase C d Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2579-85. PMID: 25359855.
      Citations:    
    51. Amirkhosravi A, Boulaftali Y, Robles-Carrillo L, Meyer T, McKenzie SE, Francis JL, Bergmeier W. CalDAG-GEFI deficiency protects mice from Fc?RIIa-mediated thrombotic thrombocytopenia induced by CD40L and ?2GPI immune complexes. J Thromb Haemost. 2014 Dec; 12(12):2113-9. PMID: 25287077.
      Citations:    
    52. McKenzie SE, Sachais BS. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia. Curr Opin Hematol. 2014 Sep; 21(5):380-7. PMID: 24992313.
      Citations:    
    53. Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation. Blood. 2014 Oct 2; 124(14):2271-9. PMID: 25100742.
      Citations:    
    54. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA Expression Differences in Human Hematopoietic Cell Lineages Enable Regulated Transgene Expression. PLoS One. 2014; 9(7):e102259. PMID: 25029370.
      Citations:    
    55. Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 2014; 9(1):3. PMID: 24524654.
      Citations:    
    56. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
      Citations:    
    57. Pulte ED, McKenzie SE, Caro J, Ballas SK. Erythropoietin levels in patients with sickle cell disease do not correlate with known inducers of erythropoietin. Hemoglobin. 2014; 38(6):385-9. PMID: 25405915.
      Citations:    
    58. Bhatlekar S, Addya S, Salunek M, Orr CR, Surrey S, McKenzie S, Fields JZ, Boman BM. Identification of a Developmental Gene Expression Signature, Including HOX Genes, for the Normal Human Colonic Crypt Stem Cell Niche: Overexpression of the Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis. Stem Cells Dev. 2014 Jan 15; 23(2):167-79. PMID: 23980595.
      Citations:    
    59. Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013 Oct 4; 288(40):29160-9. PMID: 23960082.
      Citations:    
    60. Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF. MicroRNAs in platelet production and activation. J Thromb Haemost. 2013 Jun; 11 Suppl 1:340-50. PMID: 23809137.
      Citations:    
    61. Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013; 14:1. PMID: 23323973.
      Citations:    
    62. Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood. 2013 Mar 7; 121(10):1858-67. PMID: 23264598.
      Citations:    
    63. McKenzie SE. Monocytes in HIT: an evolving story. Blood. 2012 May 31; 119(22):5065-6. PMID: 22653954.
      Citations:    
    64. Stolla M, Stefanini L, André P, Ouellette TD, Reilly MP, McKenzie SE, Bergmeier W. CalDAG-GEFI deficiency protects mice in a novel model of Fc? RIIA-mediated thrombosis and thrombocytopenia. Blood. 2011 Jul 28; 118(4):1113-20. PMID: 21652673.
      Citations:    
    65. Reilly MP, Sinha U, André P, Taylor SM, Pak Y, Deguzman FR, Nanda N, Pandey A, Stolla M, Bergmeier W, McKenzie SE. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood. 2011 Feb 17; 117(7):2241-6. PMID: 21088136.
      Citations:    
    66. Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood. 2011 Jan 20; 117(3):971-4. PMID: 21045192.
      Citations:    
    67. Flores M, Desai DD, Downie M, Liang B, Reilly MP, McKenzie SE, Clynes R. Dominant expression of the inhibitory FcgammaRIIB prevents antigen presentation by murine plasmacytoid dendritic cells. J Immunol. 2009 Dec 1; 183(11):7129-39. PMID: 19917701.
      Citations:    
    68. McKenzie SE, Reilly MP. The clot thickens (or not). Blood. 2009 Aug 27; 114(9):1722-3. PMID: 19713476.
      Citations:    
    69. Rauova L, Arepally G, McKenzie SE, Konkle BA, Cines DB, Poncz M. Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT). J Thromb Haemost. 2009 Jul; 7 Suppl 1:249-52. PMID: 19630810.
      Citations:    
    70. Kline A, Mackley A, Taylor SM, McKenzie SE, Paul DA. Thrombopoietin following transfusion of platelets in preterm neonates. Platelets. 2008 Sep; 19(6):428-31. PMID: 18925510.
      Citations:    
    71. Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. J Clin Apher. 2007 Feb; 22(1):31-6. PMID: 17285619.
      Citations:    
    72. Liu ML, Reilly MP, Casasanto P, McKenzie SE, Williams KJ. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles. Arterioscler Thromb Vasc Biol. 2007 Feb; 27(2):430-5. PMID: 17158353.
      Citations:    
    73. Worth RG, Chien CD, Chien P, Reilly MP, McKenzie SE, Schreiber AD. Platelet FcgammaRIIA binds and internalizes IgG-containing complexes. Exp Hematol. 2006 Nov; 34(11):1490-5. PMID: 17046568.
      Citations:    
    74. Reilly MP, Taylor SM, Franklin C, Sachais BS, Cines DB, Williams KJ, McKenzie SE. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model. J Thromb Haemost. 2006 Dec; 4(12):2687-94. PMID: 16961586.
      Citations:    
    75. Tan Sardjono C, Mottram PL, van de Velde NC, Powell MS, Power D, Slocombe RF, Wicks IP, Campbell IK, McKenzie SE, Brooks M, Stevenson AW, Hogarth PM. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice. Arthritis Rheum. 2005 Oct; 52(10):3220-9. PMID: 16200626.
      Citations:    
    76. van Royen-Kerkhof A, Sanders EA, Walraven V, Voorhorst-Ogink M, Saeland E, Teeling JL, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Vitale L, Keler T, McKenzie SE, Leusen JH, van de Winkel JG. A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice. Br J Haematol. 2005 Jul; 130(1):130-7. PMID: 15982355.
      Citations:    
    77. Suvarna S, Rauova L, McCracken EK, Goss CM, Sachais BS, McKenzie SE, Reilly MP, Gunn MD, Cines DB, Poncz M, Arepally G. PF4/heparin complexes are T cell-dependent antigens. Blood. 2005 Aug 1; 106(3):929-31. PMID: 15845897.
      Citations:    
    78. McKenzie SE, Reilly MP. Heparin-induced thrombocytopenia and other immune thrombocytopenias: lessons from mouse models. Semin Thromb Hemost. 2004 Oct; 30(5):559-68. PMID: 15497098.
      Citations:    
    79. Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005 Jan 1; 105(1):131-8. PMID: 15304392.
      Citations:    
    80. Coleman MM, Spear ML, Finkelstein M, Leef KH, Pearlman SA, Chien C, Taylor SM, McKenzie SE. Short-term use of umbilical artery catheters may not be associated with increased risk for thrombosis. Pediatrics. 2004 Apr; 113(4):770-4. PMID: 15060226.
      Citations:    
    81. Cines DB, McKenzie SE, Siegel DL. Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol. 2003 Dec; 25 Suppl 1:S52-6. PMID: 14668641.
      Citations:    
    82. Guida JD, Kunig AM, Leef KH, McKenzie SE, Paul DA. Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response? Pediatrics. 2003 Jun; 111(6 Pt 1):1411-5. PMID: 12777561.
      Citations:    
    83. Reilly MP, McKenzie SE. Insights from mouse models of heparin-induced thrombocytopenia and thrombosis. Curr Opin Hematol. 2002 Sep; 9(5):395-400. PMID: 12172457.
      Citations:    
    84. Reilly MP, McKenzie SE. Mechanisms of action of IVIg: physiology of Fc receptors. Vox Sang. 2002 Aug; 83 Suppl 1:57-63. PMID: 12617105.
      Citations:    
    85. Paul DA, Leef KH, Taylor S, McKenzie S. Thrombopoietin in preterm infants: gestational age-dependent response. J Pediatr Hematol Oncol. 2002 May; 24(4):304-9. PMID: 11972101.
      Citations:    
    86. Su HJ, Surrey S, McKenzie SE, Fortina P, Graves DJ. Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential. Electrophoresis. 2002 May; 23(10):1551-7. PMID: 12116168.
      Citations:    
    87. McKenzie SE. Humanized mouse models of FcR clearance in immune platelet disorders. Blood Rev. 2002 Mar; 16(1):3-5. PMID: 11913983.
      Citations:    
    88. Reilly MP, Taylor SM, Hartman NK, Arepally GM, Sachais BS, Cines DB, Poncz M, McKenzie SE. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. Blood. 2001 Oct 15; 98(8):2442-7. PMID: 11588041.
      Citations:    
    89. Zhang C, Thornton MA, Kowalska MA, Sachis BS, Feldman M, Poncz M, McKenzie SE, Reilly MP. Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. Blood. 2001 Aug 01; 98(3):610-7. PMID: 11468158.
      Citations:    
    90. Gripp KW, McDonald-McGinn DM, La Rossa D, McGain D, Federman N, Vlachos A, Glader BE, McKenzie SE, Lipton JM, Zackai EH. Bilateral microtia and cleft palate in cousins with Diamond-Blackfan anemia. Am J Med Genet. 2001 Jul 01; 101(3):268-74. PMID: 11424144.
      Citations:    
    91. Taylor SM, Reilly MP, Schreiber AD, Chien P, Tuckosh JR, McKenzie SE. Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor. Blood. 2000 Dec 15; 96(13):4254-60. PMID: 11110699.
      Citations:    
    92. Cassel DL, Subudhi SK, Surrey S, McKenzie SE. GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic cells. Blood Cells Mol Dis. 2000 Dec; 26(6):587-97. PMID: 11112392.
      Citations:    
    93. Fortina P, Delgrosso K, Sakazume T, Santacroce R, Moutereau S, Su HJ, Graves D, McKenzie S, Surrey S. Simple two-color array-based approach for mutation detection. Eur J Hum Genet. 2000 Nov; 8(11):884-94. PMID: 11093279.
      Citations:    
    94. Manduchi E, Grant GR, McKenzie SE, Overton GC, Surrey S, Stoeckert CJ. Generation of patterns from gene expression data by assigning confidence to differentially expressed genes. Bioinformatics. 2000 Aug; 16(8):685-98. PMID: 11099255.
      Citations:    
    95. McKenzie SE, Taylor SM, Malladi P, Yuhan H, Cassel DL, Chien P, Schwartz E, Schreiber AD, Surrey S, Reilly MP. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 Apr 01; 162(7):4311-8. PMID: 10201963.
      Citations:    
    96. Graves DJ, Su HJ, McKenzie SE, Surrey S, Fortina P. System for preparing microhybridization arrays on glass slides. Anal Chem. 1998 Dec 01; 70(23):5085-92. PMID: 9852790.
      Citations:    
    97. McKenzie SE, Mansfield E, Rappaport E, Surrey S, Fortina P. Parallel molecular genetic analysis. Eur J Hum Genet. 1998 Sep-Oct; 6(5):417-29. PMID: 9801865.
      Citations:    
    98. Cui Z, Reilly MP, Surrey S, Schwartz E, McKenzie SE. -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo. Blood. 1998 Apr 01; 91(7):2326-33. PMID: 9516130.
      Citations:    
    99. Norris CF, Pricop L, Millard SS, Taylor SM, Surrey S, Schwartz E, Salmon JE, McKenzie SE. A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor. Blood. 1998 Jan 15; 91(2):656-62. PMID: 9427722.
      Citations:    
    100. McKenzie SE, Schreiber AD. Fc gamma receptors in phagocytes. Curr Opin Hematol. 1998 Jan; 5(1):16-21. PMID: 9515197.
      Citations:    
    101. Arepally G, McKenzie SE, Jiang XM, Poncz M, Cines DB. Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. Blood. 1997 Jan 15; 89(2):370-5. PMID: 9002937.
      Citations:    
    102. Jiang XM, Arepally G, Poncz M, McKenzie SE. Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). J Immunol Methods. 1996 Nov 29; 199(1):55-9. PMID: 8960098.
      Citations:    
    103. Kiss C, Surrey S, Schreiber AD, Schwartz E, McKenzie SE. Human c-kit ligand (stem cell factor) induces platelet Fc receptor expression in megakaryoblastic cells. Exp Hematol. 1996 Aug; 24(10):1232-7. PMID: 8765499.
      Citations:    
    104. Fairchild KD, Hudson RG, Douglas SD, McKenzie SE, Polin RA. Effect of gamma interferon on expression of Fc gamma receptors in monocytes of newborn infants and adults. Clin Diagn Lab Immunol. 1996 Jul; 3(4):464-9. PMID: 8807214.
      Citations:    
    105. Norris CF, Surrey S, Bunin GR, Schwartz E, Buchanan GR, McKenzie SE. Relationship between Fc receptor IIA polymorphism and infection in children with sickle cell disease. J Pediatr. 1996 Jun; 128(6):813-9. PMID: 8648541.
      Citations:    
    106. Chan V, Graves DJ, McKenzie SE. The biophysics of DNA hybridization with immobilized oligonucleotide probes. Biophys J. 1995 Dec; 69(6):2243-55. PMID: 8599632.
      Citations:    
    107. Mansfield ES, Worley JM, McKenzie SE, Surrey S, Rappaport E, Fortina P. Nucleic acid detection using non-radioactive labelling methods. Mol Cell Probes. 1995 Jun; 9(3):145-56. PMID: 7477006.
      Citations:    
    108. Keller MA, McKenzie SE, Cassel DL, Rappaport EF, Schwartz E, Surrey S. Lineage-specific alternative splicing of the human Fc gamma RIIA transmembrane exon requires sequences near the 3' splice site. Gene Expr. 1995; 4(4-5):217-25. PMID: 7787414.
      Citations:    
    109. Reilly AF, Norris CF, Surrey S, Bruchak FJ, Rappaport EF, Schwartz E, McKenzie SE. Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism. Clin Diagn Lab Immunol. 1994 Nov; 1(6):640-4. PMID: 8556514.
      Citations:    
    110. Indik ZK, Pan XQ, Huang MM, McKenzie SE, Levinson AI, Schreiber AD. Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function. Blood. 1994 Apr 15; 83(8):2072-80. PMID: 8161778.
      Citations:    
    111. McKenzie SE, Schreiber AD. Biological advances and clinical applications of Fc receptors for IgG. Curr Opin Hematol. 1994 Jan; 1(1):45-52. PMID: 9371259.
      Citations:    
    112. Reilly AF, Surrey S, Rappaport EF, Schwartz E, McKenzie SE. Variation in human FCGR2C gene copy number. Immunogenetics. 1994; 40(6):456. PMID: 7959956.
      Citations:    
    113. Keller MA, Cassel DL, Rappaport EF, McKenzie SE, Schwartz E, Surrey S. Fluorescence-based RT PCR analysis: determination of the ratio of soluble to membrane-bound forms of Fc gamma RIIA transcripts in hematopoietic cell lines. PCR Methods Appl. 1993 Aug; 3(1):32-8. PMID: 8220183.
      Citations:    
    114. McKenzie SE, Kline J, Douglas SD, Polin RA. Enhancement in vitro of the low interferon-gamma production of leukocytes from human newborn infants. J Leukoc Biol. 1993 Jun; 53(6):691-6. PMID: 8315352.
      Citations:    
    115. Rappaport EF, Cassel DL, Walterhouse DO, McKenzie SE, Surrey S, Keller MA, Schreiber AD, Schwartz E. A soluble form of the human Fc receptor Fc gamma RIIA: cloning, transcript analysis and detection. Exp Hematol. 1993 May; 21(5):689-96. PMID: 8513871.
      Citations:    
    116. Cassel DL, Keller MA, Surrey S, Schwartz E, Schreiber AD, Rappaport EF, McKenzie SE. Differential expression of Fc gamma RIIA, Fc gamma RIIB and Fc gamma RIIC in hematopoietic cells: analysis of transcripts. Mol Immunol. 1993 Apr; 30(5):451-60. PMID: 8464427.
      Citations:    
    117. McKenzie SE, Keller MA, Cassel DL, Schreiber AD, Schwartz E, Surrey S, Rappaport EF. Characterization of the 5'-flanking transcriptional regulatory region of the human Fc gamma receptor gene, Fc gamma RIIA. Mol Immunol. 1992 Oct; 29(10):1165-74. PMID: 1382218.
      Citations:    
    118. Indik ZK, Salehuddin M, McKenzie SE, Kelly C, Levinson AI, Schreiber AD. Human Fc gamma RII: the structure of the Fc gamma RII cytosolic domain governs phagocytic function. Trans Assoc Am Physicians. 1992; 105:214-21. PMID: 1308999.
      Citations:    
    Mckenzie's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (346)
    Explore
    _
    Co-Authors (50)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _