Xinqiao Jia

TitleAssociate Professor
InstitutionUniversity of Delaware
DepartmentMaterials Science & Engineering
Address127 The Green
Newark DE 19716
Phone302-831-6553
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Delaware
    DepartmentDelaware Biotechnology Institute (DBI)

    TitleAssociate Professor
    InstitutionUniversity of Delaware
    DepartmentBiological Sciences


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ravikrishnan A, Fowler EW, Stuffer AJ, Jia X. Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium. ACS Biomater Sci Eng. 2021 Feb 26. PMID: 33635635.
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    2. Scott RA, Fowler EW, Jia X, Kiick KL, Akins RE. Regulation of neovasculogenesis in co-cultures of aortic adventitial fibroblasts and microvascular endothelial cells by cell-cell interactions and TGF-ß/ALK5 signaling. PLoS One. 2020; 15(12):e0244243. PMID: 33370415.
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    3. Paik B, Calero-Rubio C, Lee JY, Jia X, Kiick KL, Roberts CJ. Characterizing aggregate growth and morphology of alanine-rich polypeptides as a function of sequence chemistry and solution temperature from scattering, spectroscopy, and microscopy. Biophys Chem. 2020 12; 267:106481. PMID: 33035751.
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    4. Zerdoum AB, Saberi P, Stuffer AJ, Kelly DJ, Duncan RL, Mongeau L, Jia X. Regulation of Stem Cell Function in an Engineered Vocal Fold-Mimetic Environment. Regen Eng Transl Med. 2020 Jun; 6(2):164-178. PMID: 33184607.
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    5. Zerdoum AB, Fowler EW, Jia X. Induction of Fibrogenic Phenotype in Human Mesenchymal Stem Cells by Connective Tissue Growth Factor in a Hydrogel Model of Soft Connective Tissue. ACS Biomater Sci Eng. 2019 Sep 09; 5(9):4531-4541. PMID: 33178886.
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    6. Zerdoum AB, Stuffer AJ, Heris HK, Liu S, Mongeau L, Duncan RL, Jia X. Culture of Mesenchymal Stem Cells in a Hydrogel Model of Vocal Fold Lamina Propria. Regen Eng Transl Med. 2019 Dec; 5(4):387-401. PMID: 33184606.
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    7. Liu S, Moore AC, Zerdoum AB, Zhang H, Scinto SL, Zhang H, Gong L, Burris DL, Rajasekaran AK, Fox JM, Jia X. Cellular interactions with hydrogel microfibers synthesized via interfacial tetrazine ligation. Biomaterials. 2018 Oct; 180:24-35. PMID: 30014964.
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    8. Dicker KT, Song J, Moore AC, Zhang H, Li Y, Burris DL, Jia X, Fox JM. Core-shell patterning of synthetic hydrogels via interfacial bioorthogonal chemistry for spatial control of stem cell behavior. Chem Sci. 2018 Jun 28; 9(24):5394-5404. PMID: 30009011.
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    9. Paik BA, Mane SR, Jia X, Kiick KL. Responsive Hybrid (Poly)peptide-Polymer Conjugates. J Mater Chem B. 2017; 5(42):8274-8288. PMID: 29430300.
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    10. Ozdemir T, Srinivasan PP, Zakheim DR, Harrington DA, Witt RL, Farach-Carson MC, Jia X, Pradhan-Bhatt S. Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function. Biomaterials. 2017 Oct; 142:124-135. PMID: 28734180.
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    11. Hao Y, Fowler EW, Jia X. Chemical Synthesis of Biomimetic Hydrogels for Tissue Engineering. Polym Int. 2017 Dec; 66(12):1787-1799. PMID: 31080322.
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    12. Hao Y, Zerdoum AB, Stuffer AJ, Rajasekaran AK, Jia X. Biomimetic Hydrogels Incorporating Polymeric Cell-Adhesive Peptide To Promote the 3D Assembly of Tumoroids. Biomacromolecules. 2016 Nov 14; 17(11):3750-3760. PMID: 27723964.
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    13. Ozdemir T, Fowler EW, Liu S, Harrington DA, Witt RL, Farach-Carson MC, Pradhan-Bhatt S, Jia X. Tuning Hydrogel Properties to Promote the Assembly of Salivary Gland Spheroids in 3D. ACS Biomater Sci Eng. 2016 Dec 12; 2(12):2217-2230. PMID: 27990487.
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    14. Li L, Stiadle JM, Lau HK, Zerdoum AB, Jia X, Thibeault SL, Kiick KL. Tissue engineering-based therapeutic strategies for vocal fold repair and regeneration. Biomaterials. 2016 Nov; 108:91-110. PMID: 27619243.
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    15. Srinivasan PP, Patel VN, Liu S, Harrington DA, Hoffman MP, Jia X, Witt RL, Farach-Carson MC, Pradhan-Bhatt S. Primary Salivary Human Stem/Progenitor Cells Undergo Microenvironment-Driven Acinar-Like Differentiation in Hyaluronate Hydrogel Culture. Stem Cells Transl Med. 2017 Jan; 6(1):110-120. PMID: 28170182.
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    16. Calero-Rubio C, Paik B, Jia X, Kiick KL, Roberts CJ. Predicting unfolding thermodynamics and stable intermediates for alanine-rich helical peptides with the aid of coarse-grained molecular simulation. Biophys Chem. 2016 Oct; 217:8-19. PMID: 27486699.
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    17. Zhang H, Trout WS, Liu S, Andrade GA, Hudson DA, Scinto SL, Dicker KT, Li Y, Lazouski N, Rosenthal J, Thorpe C, Jia X, Fox JM. Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation. J Am Chem Soc. 2016 May 11; 138(18):5978-83. PMID: 27078610.
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    18. Ozdemir T, Fowler EW, Hao Y, Ravikrishnan A, Harrington DA, Witt RL, Farach-Carson MC, Pradhan-Bhatt S, Jia X. Biomaterials-based strategies for salivary gland tissue regeneration. Biomater Sci. 2016 Apr 22; 4(4):592-604. PMID: 26878077.
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    19. Li L, Mahara A, Tong Z, Levenson EA, McGann CL, Jia X, Yamaoka T, Kiick KL. Recombinant Resilin-Based Bioelastomers for Regenerative Medicine Applications. Adv Healthc Mater. 2016 Jan; 5(2):266-75. PMID: 26632334.
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    20. Li L, Zhang P, Wang WM, Lin H, Zerdoum AB, Geiger SJ, Liu Y, Xiao N, Zou Y, Ogbuu O, Du Q, Jia X, Li J, Hu J. Foldable and Cytocompatible Sol-gel TiO2 Photonics. Sci Rep. 2015; 5:13832. PMID: 26344823.
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    21. Krishnan V, Xu X, Kelly D, Snook A, Waldman SA, Mason RW, Jia X, Rajasekaran AK. CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia. Mol Pharm. 2015 Jun 1; 12(6):2101-11. PMID: 25898125.
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    22. Liu S, Zhang H, Remy RA, Deng F, Mackay ME, Fox JM, Jia X. Meter-long multiblock copolymer microfibers via interfacial bioorthogonal polymerization. Adv Mater. 2015 May; 27(17):2783-90. PMID: 25824805.
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    23. Liu S, Dicker KT, Jia X. Modular and orthogonal synthesis of hybrid polymers and networks. Chem Commun (Camb). 2015 Mar 12; 51(25):5218-37. PMID: 25572255.
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    24. Liu S, Dicker KT, Jia X. Correction: Modular and orthogonal synthesis of hybrid polymers and networks. Chem Commun (Camb). 2015 Mar 12; 51(25):5534. PMID: 25609173.
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    25. Paik BA, Blanco MA, Jia X, Roberts CJ, Kiick KL. Aggregation of poly(acrylic acid)-containing elastin-mimetic copolymers. Soft Matter. 2015 Feb 18; 11(9):1839-50. PMID: 25611563.
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    26. Xu X, Farach-Carson MC, Jia X. Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv. 2014 Nov 15; 32(7):1256-68. PMID: 25116894.
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    27. Zerdoum AB, Tong Z, Bachman B, Jia X. Construction and characterization of a novel vocal fold bioreactor. J Vis Exp. 2014; (90). PMID: 25145349.
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    28. Zhang H, Dicker KT, Xu X, Jia X, Fox JM. Interfacial Bioorthogonal Cross-Linking. ACS Macro Lett. 2014 Aug 19; 3(8):727-731. PMID: 25177528.
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    29. Tong Z, Zerdoum AB, Duncan RL, Jia X. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue Eng Part A. 2014 Jul; 20(13-14):1922-34. PMID: 24456068.
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    30. Xu X, Sabanayagam CR, Harrington DA, Farach-Carson MC, Jia X. A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics. Biomaterials. 2014 Mar; 35(10):3319-30. PMID: 24447463.
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    31. Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X. Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater. 2014 Apr; 10(4):1558-70. PMID: 24361428.
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    32. Xiao L, Tong Z, Chen Y, Pochan DJ, Sabanayagam CR, Jia X. Hyaluronic Acid-based hydrogels containing covalently integrated drug depots: implication for controlling inflammation in mechanically stressed tissues. Biomacromolecules. 2013 Nov 11; 14(11):3808-19. PMID: 24093583.
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    33. Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope. 2014 Feb; 124(2):456-61. PMID: 23832678.
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    34. Yang X, Cui C, Tong Z, Sabanayagam CR, Jia X. Poly(e-caprolactone)-based copolymers bearing pendant cyclic ketals and reactive acrylates for the fabrication of photocrosslinked elastomers. Acta Biomater. 2013 Sep; 9(9):8232-44. PMID: 23770222.
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    35. Pradhan-Bhatt S, Harrington DA, Duncan RL, Jia X, Witt RL, Farach-Carson MC. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A. 2013 Jul; 19(13-14):1610-20. PMID: 23442148.
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    36. Tong Z, Duncan RL, Jia X. Modulating the behaviors of mesenchymal stem cells via the combination of high-frequency vibratory stimulations and fibrous scaffolds. Tissue Eng Part A. 2013 Aug; 19(15-16):1862-78. PMID: 23516973.
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    37. Grieshaber SE, Paik BA, Bai S, Kiick KL, Jia X. Nanoparticle Formation from Hybrid, Multiblock Copolymers of Poly(Acrylic Acid) and VPGVG Peptide. Soft Matter. 2013 Feb 7; 9(5):1589-1599. PMID: 23976897.
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    38. Krishnan V, Xu X, Barwe SP, Yang X, Czymmek K, Waldman SA, Mason RW, Jia X, Rajasekaran AK. Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine. Mol Pharm. 2013 Jun 3; 10(6):2199-210. PMID: 23194373.
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    39. Gurski LA, Xu X, Labrada LN, Nguyen NT, Xiao L, van Golen KL, Jia X, Farach-Carson MC. Hyaluronan (HA) Interacting Proteins RHAMM and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA-Based Hydrogels. PLoS One. 2012; 7(11):e50075. PMID: 23166824.
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    40. Li L, Tong Z, Jia X, Kiick KL. Resilin-Like Polypeptide Hydrogels Engineered for Versatile Biological Functions. Soft Matter. 2013 Jan 1; 9(3):665-673. PMID: 23505396.
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    41. Xiao L, Zhu J, Londono DJ, Pochan DJ, Jia X. Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles. Soft Matter. 2012 Oct 28; 8(40):10233-10237. PMID: 23024698.
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    42. Xu X, Gurski LA, Zhang C, Harrington DA, Farach-Carson MC, Jia X. Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids. Biomaterials. 2012 Dec; 33(35):9049-60. PMID: 22999468.
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    43. Tong Z, Jia X. Biomaterials-Based Strategies for the Engineering of Mechanically Active Soft Tissues. MRS Commun. 2012 Jun 1; 2(2):31-39. PMID: 25250199.
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    44. Grieshaber SE, Farran AJ, Bai S, Kiick KL, Jia X. Tuning the properties of elastin mimetic hybrid copolymers via a modular polymerization method. Biomacromolecules. 2012 Jun 11; 13(6):1774-86. PMID: 22533503.
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    45. Srinivasan PP, McCoy SY, Jha AK, Yang W, Jia X, Farach-Carson MC, Kirn-Safran CB. Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis. Biomed Mater. 2012 Apr; 7(2):024109. PMID: 22455987.
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    46. Xu X, Jha AK, Harrington DA, Farach-Carson MC, Jia X. Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks. Soft Matter. 2012; 8(12):3280-3294. PMID: 22419946.
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    47. Farran AJ, Teller SS, Jia F, Clifton RJ, Duncan RL, Jia X. Design and characterization of a dynamic vibrational culture system. J Tissue Eng Regen Med. 2013 Mar; 7(3):213-25. PMID: 22095782.
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    48. Tong Z, Sant S, Khademhosseini A, Jia X. Controlling the fibroblastic differentiation of mesenchymal stem cells via the combination of fibrous scaffolds and connective tissue growth factor. Tissue Eng Part A. 2011 Nov; 17(21-22):2773-85. PMID: 21689062.
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    49. Krishna OD, Jha AK, Jia X, Kiick KL. Integrin-mediated adhesion and proliferation of human MSCs elicited by a hydroxyproline-lacking, collagen-like peptide. Biomaterials. 2011 Sep; 32(27):6412-24. PMID: 21658756.
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    50. Li L, Teller S, Clifton RJ, Jia X, Kiick KL. Tunable mechanical stability and deformation response of a resilin-based elastomer. Biomacromolecules. 2011 Jun 13; 12(6):2302-10. PMID: 21553895.
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    51. Xu X, Jha AK, Duncan RL, Jia X. Heparin-decorated, hyaluronic acid-based hydrogel particles for the controlled release of bone morphogenetic protein 2. Acta Biomater. 2011 Aug; 7(8):3050-9. PMID: 21550426.
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    52. Greene AC, Zhu J, Pochan DJ, Jia X, Kiick KL. Poly(Acrylic Acid-b-Styrene) Amphiphilic Multiblock Copolymers as Building Blocks for the Assembly of Discrete Nanoparticles. Macromolecules. 2011 Mar 4; 44(7):1942-1951. PMID: 21552373.
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    53. Wang X, Gurski LA, Zhong S, Xu X, Pochan DJ, Farach-Carson MC, Jia X. Amphiphilic Block Co-polyesters Bearing Pendant Cyclic Ketal Groups as Nanocarriers for Controlled Release of Camptothecin. J Biomater Sci Polym Ed. 2011 Mar; 22(10):1275-98. PMID: 20594408.
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    54. Grieshaber SE, Nie T, Yan C, Zhong S, Teller SS, Clifton RJ, Pochan DJ, Kiick KL, Jia X. Assembly Properties of an Alanine-Rich, Lysine-Containing Peptide and the Formation of Peptide/Polymer Hybrid Hydrogels. Macromol Chem Phys. 2011 Feb 1; 212(3):229-239. PMID: 21359141.
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    55. Jha AK, Xu X, Duncan RL, Jia X. Controlling the adhesion and differentiation of mesenchymal stem cells using hyaluronic acid-based, doubly crosslinked networks. Biomaterials. 2011 Apr; 32(10):2466-78. PMID: 21216457.
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    56. Xiao L, Liu C, Zhu J, Pochan DJ, Jia X. Hybrid, elastomeric hydrogels crosslinked by multifunctional block copolymer micelles. Soft Matter. 2010 Nov 7; 6(21):5293-5297. PMID: 21278815.
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    57. Jha AK, Malik MS, Farach-Carson MC, Duncan RL, Jia X. Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks. Soft Matter. 2010 Jun 15; 6(20):5045-5055. PMID: 20936090.
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    58. Farran AJ, Teller SS, Jha AK, Jiao T, Hule RA, Clifton RJ, Pochan DP, Duncan RL, Jia X. Effects of matrix composition, microstructure, and viscoelasticity on the behaviors of vocal fold fibroblasts cultured in three-dimensional hydrogel networks. Tissue Eng Part A. 2010 Apr; 16(4):1247-61. PMID: 20064012.
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    59. Pradhan S, Liu C, Zhang C, Jia X, Farach-Carson MC, Witt RL. Lumen formation in three-dimensional cultures of salivary acinar cells. Otolaryngol Head Neck Surg. 2010 Feb; 142(2):191-5. PMID: 20115973.
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    60. Pradhan S, Zhang C, Jia X, Carson DD, Witt R, Farach-Carson MC. Perlecan domain IV peptide stimulates salivary gland cell assembly in vitro. Tissue Eng Part A. 2009 Nov; 15(11):3309-20. PMID: 19382872.
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    61. Jha AK, Yang W, Kirn-Safran CB, Farach-Carson MC, Jia X. Perlecan domain I-conjugated, hyaluronic acid-based hydrogel particles for enhanced chondrogenic differentiation via BMP-2 release. Biomaterials. 2009 Dec; 30(36):6964-75. PMID: 19775743.
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    62. Gurski LA, Jha AK, Zhang C, Jia X, Farach-Carson MC. Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells. Biomaterials. 2009 Oct; 30(30):6076-85. PMID: 19695694.
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    63. Grieshaber SE, Farran AJ, Lin-Gibson S, Kiick KL, Jia X. Synthesis and Characterization of Elastin-Mimetic Hybrid Polymers with Multiblock, Alternating Molecular Architecture and Elastomeric Properties. Macromolecules. 2009 Apr; 42(7):2532-2541. PMID: 19763157.
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    64. Jia X, Kiick KL. Hybrid multicomponent hydrogels for tissue engineering. Macromol Biosci. 2009 Feb 11; 9(2):140-56. PMID: 19107720.
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    65. Jha AK, Hule RA, Jiao T, Teller SS, Clifton RJ, Duncan RL, Pochan DJ, Jia X. Structural Analysis and Mechanical Characterization of Hyaluronic Acid-Based Doubly Cross-Linked Networks. Macromolecules. 2009; 42(2):537-546. PMID: 20046226.
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    66. Sahiner N, Jha AK, Nguyen D, Jia X. Fabrication and characterization of cross-linkable hydrogel particles based on hyaluronic acid: potential application in vocal fold regeneration. J Biomater Sci Polym Ed. 2008; 19(2):223-43. PMID: 18237494.
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    67. Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler JB, Zeitels SM, Langer R. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44. PMID: 17154461.
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